Personal profile

Overview

  • Clinical Professor - Manchester Maternal & Fetal Health Research Centre
  • Consultant Obstetrician - St Mary's Hospital, Manchester
  • Scientific Editor PlosMed
  • Secretary RCOG Blair Bell Research Society

Biography

I graduated from Nottingham University in 1997 having completed my Bachelor Medical Sciences and Medical degrees. I undertook a senior house rotation in Obstetrics & Gynaecology in Derby and Nottingham and in 2001 moved to Manchester to work as a Clinical Research Fellow in the new Maternal & Fetal Health Research Centre with Professor Phil Baker. My Phd, completed in 2005, was entitled "Circulating Factors in Pre-eclampsia" and included research focusing on vascular biology and plasma proteomics. I received the William Blair Bell Lectureship in 2009, awarded by the RCOG for outstanding contribution to research in the field of Obstetrics.

I completed my clinical training at St Mary's whilst continuing my research related to pre-eclampsia and I was appointed as Consultant Obstetrician/ Clinical Senior Lecturer in April 2011. I was awarded an NIHR Clinician Scientist award in 2012 and an ERC Consolidator Fellowship in 2020. I continue to combine clinical work with an active research programme spanning basic science, translational and clinical studies related to diabetes and hypertension in pregnancy. I lead the Maternal Medicine Service and run weekly hybrid research clinics for women with diabetes (VELOCITY clinic) and hypertension (MAViS Manchester Antenatal Vascular Service) which combine clinical care with opportunity for women to particpate in a variety of research studies. 

Away from my clinical research, I continue to be an enthusiastic musician and cyclist.

Research interests

My research is focused around the medical complications hypertension and diabetes in pregnancy and their effect on maternal and fetal health. 

Current research projects:

  • Prediction and prevention of adverse pregnancy outcomes in women with chronic hypertension 
  • Evaluation of fetal growth in pregnancies complicated by maternal diabetes combining 3D ultrasound and continuous glucose monitoring
  • MIMICH Metformin Impact Maternal and Infant Cardiometabolic Health: an RCT and prospective observational follow up study
  • Implementation of placental biomarkers for the diagnosis and management of pregnancies complicated by placental dysfunction
  • Investigation of placental function phenotypes associated with abnormal maternal angiogenic markers 

Postgraduate opportunities
We welcome enquiries from students wishing to undertake research related to the investigation of hypertension and diabetes in pregnancy. See the Faculty of MHS Postgraduate pages.

Teaching

Undergraduate teaching

I contribute to undergraduate teaching within the Families & Children Module and am an medical student Advisor.

Postgraduate Students

Completed PhD students:

  • Christal Fisher (PhD) 2012
  • Charlotte Hulme (PhD) 2015
  • Elizabeth Bonney (MD, Co-Supervisor) 2016
  • Emma Ingram (PhD)
  • David Iles (MD)
  • Emily Fairclough (MPhil)
  • Louise Simcox (MD, Co-Supervisor)
  • Steph Worton (PhD - MRC Fellowship)
  • Charlotte Mahoney (PhD - NIHR Fellowship)
  • Emma Shawkat (MD)

Active students:

  • Laura Ormesher (PhD - MRC Fellowship)
  • Matina Hakim (PhD)
  • Zoe Thurwell (MPhil)
  • Nicola Solomon (MD)
  • Alice Dempsey (MD)
  • Kirsty Vincent (PhD)
  • Thomas Willmott (PhD)
  • Flurina Michelotti (MD)

My collaborations

  • Dr Adam Grennstein (Cardiovascular Scienbces)
  • Professor Andy Traffor (Cardiovascular Sciences)
  • SCOPE consortium: Louise Kenny (UCC), Gus Dekker (Adelaide), Robyn North (KCL), Nigel Simpson (Leeds), Jimmy Walker (Leeds), Lesley McCowan (Auckland), Phil Baker (Auckland)
  • Lucilla Poston, Lucy Chappell, Andrew Shennan - Kings College London
  • Professor Brian Cox (University of Toronto)
  • Professor Stephen Tong (University of Melbourne)
  • Dr Rick Dunn - University of Birmingham

Memberships of committees and professional bodies

  • Royal College Obstetrcians & Gynaecologists
  • NICE Quality Standards Topic Expert Group - Hypertension in Pregnancy
  • NICE High Risk Intrapartum Care Guideline Deveopment Group
  • NICE Diagnostics Assessment Panel Specialist Committee Member
  • RCOG Maternal Medicine Clinical Studies Group
  • Secretary Blair Bell Research Society
  • British Maternal & Fetal Medicine Society

Methodological knowledge

  • Angiogenic biomarkers
  • Maternal hypertension and diabetes
  • Vascular biology and haemodynamic measurements
  • Mass Spectrometry and proteomic methods
  • Obstetric clinical trial design
  • Medical Statistics

Qualifications

BMedSci(Hons), BM BS, PhD, DFFP, MRCOG

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 12 - Responsible Consumption and Production
  • SDG 13 - Climate Action

External positions

Research Panel DRF, National Institute for Health and Care Research (NIHR)

Research Beacons, Institutes and Platforms

  • Lydia Becker Institute

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