Jeremy Derrick

2024

Profiling IgG and IgA antibody responses during vaccination and infection in a high-risk gonorrhoea population

Stejskal, L., Thistlethwaite, A., Ramirez Bencomo, F., Rashmi, S., Harrison, O., Feavers, I. M., Maiden, M. C. J., Jerse, A., Barnes, G., Chirro, O., Chemweno, J., Nduati, E., Cehovin, A., Tang, C., Sanders, E. J. & Derrick, J., 7 Aug 2024, In: Nature Communications. 15, 6712.

Research output: Contribution to journal › Article › peer-review

Open Access

Synergistic bactericidal activity of a novel dual β-lactam combination against methicillin-resistant Staphylococcus aureus

Altarawneh, H., Alhomra, T., Alharbi, M., Fan, Y., Derrick, J. & Xia, G., 1 Jul 2024, In: Journal of Antimicrobial Chemotherapy. 79, 7, p. 1677-1682 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

23 Downloads (Pure)

2023

Chemometrics in Protein Formulation: Stability Governed by Repulsion and Protein Unfolding

Roche, A., Zalar, M., Curtis, R., Derrick, J., Golovanov, A., Pluen, A., Warwicker, J. & et al., 5 Jun 2023, In: Molecular Pharmaceutics. 20, 6, p. 2951-2965 15 p.

Research output: Contribution to journal › Article › peer-review

Modulation of the Fibrillation Kinetics and Morphology of a Therapeutic Peptide by Cucurbit[7]uril

Martinez Morales, M., van der Walle, C. F. & Derrick, J., 3 Jul 2023, In: Molecular Pharmaceutics. 20, 7, p. 3559–3569 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

OpcA and PorB are novel bactericidal antigens of the 4CMenB vaccine in mice and humans

Viviani, V., Fantoni, A., Tomei, S., Marchi, S., Luzzi, E., Bodini, M., Muzzi, A., Giuliani, M. M., Maione, D., Derrick, J., Delany, I., Pizza, M., Biolchi, A. & Bartolini, E., 12 Apr 2023, In: n p j Vaccines. 8, 1, 54.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Adaptation of an ELISA assay for detection of IgG2a responses against therapeutic monoclonal antibodies in a mouse immunization model

Rane, S., Dearman, R., Kimber, I. & Derrick, J., 25 Jan 2022, In: Journal of immunotoxicology. 19, 1, p. 1-7 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

171 Downloads (Pure)

Application of a Neisseria meningitidis antigen microarray to identify candidate vaccine proteins from a human Phase I clinical trial

Derrick, J., 21 Jun 2022, In: Vaccine. 40, 28, p. 3835-3842 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Genome-Wide Association Studies Identify an Association of Transferrin Binding Protein B Variation and Invasive Serogroup Y Meningococcal Disease in Older Adults

Derrick, J., 2 Nov 2022, In: The Journal of Infectious Diseases.

Research output: Contribution to journal › Article › peer-review

Human B Cell Responses to Dominant and Subdominant Antigens Induced by a Meningococcal Outer Membrane Vesicle Vaccine in a Phase I Trial

Derrick, J., 23 Feb 2022, In: mSphere. 7, 1, e00674-21.

Research output: Contribution to journal › Article › peer-review

Open Access

Viral vectors expressing group B meningococcal outer membrane proteins induce strong antibody responses but fail to induce functional bactericidal activity

Marsay, L., Dold, C., Paterson, G. K., Yamaguchi, Y., Derrick, J., Chan, H., Feavers, I. M., Maiden, M. C. J., Wyllie, D., Hill, A. V., Pollard, A. J. & Rollier, C. S., 1 May 2022, In: Journal Of Infection. 84, 5, p. 658-667 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Adverse Immunological Responses Against Non-viral Nanoparticle (NP) Delivery Systems in the Lung

De Braganca, L., Ferguson, J., Santos, J. L. & Derrick, J., 9 Mar 2021, (Accepted/In press) In: Journal of immunotoxicology.

Research output: Contribution to journal › Article › peer-review

Superantigen Recognition and Interactions: Functions, Mechanisms and Applications

Deacy, A., Ken-En Gan, S. & Derrick, J., 20 Sept 2021, In: Frontiers in Immunology. 12, 731845.

Research output: Contribution to journal › Article › peer-review

Open Access

The novel membrane-associated auxiliary factors auxA and auxB modulate β-lactam resistance in MRSA by stabilizing lipoteichoic acids

Mikkelsen, K., Sirisarn, W., Alharbi, O., Alharbi, M., Liu, H., Nøhr-Meldgaard, K., Mayer, K., Vestergaard, M., Gallagher , L., Derrick , J., Mcbain, A., Biboy, J., Vollmer, W., O'Gara, J., Grunert, T., Ingmer, H. & Xia, G., 1 Mar 2021, In: International Journal of Antimicrobial Agents. 57, 3, 106283.

Research output: Contribution to journal › Article › peer-review

Open Access

Use of peptide microarrays for fast and informative profiling of therapeutic antibody formulation conditions

Austerberry, J., Edwards, J., Eyes, T. & Derrick, J., 18 Oct 2021, In: Molecular Pharmaceutics.

Research output: Contribution to journal › Article › peer-review

Open Access

File

85 Downloads (Pure)

2020

Advancing therapeutic protein discovery and development through comprehensive computational and biophysical characterization

Gentiluomo, L., Svilenov, H. L., Augustijn, D., El Bialy, I., Greco, M. L., Kulakova, A., Indrakumar, S., Mahapatra, S., Morales, M. M., Pohl, C., Roche, A., Tosstorff, A., Curtis, R., Derrick, J. P., Norgaard, A., Khan, T. A., Peters, G. H. J., Pluen, A., Rinnan, A. & Streicher, W. W. & 6 others, van der Walle, C. F., Uddin, S., Winter, G., Roessner, D., Harris, P. & Friess, W., Feb 2020, In: Molecular Pharmaceutics. 17, 2, p. 426-440 15 p.

Research output: Contribution to journal › Article › peer-review

An assessment of the use of Hepatitis B Virus core protein virus-like particles to display heterologous antigens from Neisseria meningitidis

Aston-Deaville, S., Carlsson, E., Saleem, M., Thistlethwaite, A., Chan, H., Maharjan, S., Facchetti, A., Feavers, I. M., Siebert, C. A., Collins, R., Roseman, A. & Derrick, J., 13 Mar 2020, In: Vaccine. 38, 16, p. 3201-3209

Research output: Contribution to journal › Article › peer-review

Open Access

Flowering Poration—A Synergistic Multi-Mode Antibacterial Mechanism by a Bacteriocin Fold

Hammond, K., Lewis, H., Halliwell, S., Desriac, F., Nardone, B., Ravi, J., Hoogenboom, B. W., Upton, M., Derrick, J. & Ryadnov, M. G., 21 Aug 2020, In: iScience. 23, 8, p. 1-11 11 p., 101423.

Research output: Contribution to journal › Article › peer-review

Open Access

Higher mass meningococcal group C-tetanus toxoid vaccines conjugated with carbodiimide correlate with greater immunogenicity

Derrick, J. & et al., 17 Mar 2020, In: Vaccine. 38, 13

Research output: Contribution to journal › Article › peer-review

Open Access

In silico design of a T-cell epitope vaccine candidate for parasitic helminth infection

Zawawi, A., Forman, R., Smith, H., Mair, I., Jibril, M., Albaqshi, M., Brass, A., Derrick, J. & Else, K., 23 Mar 2020, In: PL o S Pathogens. 16, 3, e1008243.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Arginine to lysine mutations increase the aggregation stability of a single chain variable fragment through unfolded state interactions

Austerberry, J., Thistlethwaite, A., Fisher, K., Golovanov, A. P., Pluen, A., Esfandiary, R., van der Walle, C. F., Warwicker, J., Derrick, J. P. & Curtis, R., 2019, In: Biochemistry.

Research output: Contribution to journal › Article › peer-review

Open Access

File

429 Downloads (Pure)

Identification of B cell epitopes enhanced by protein unfolding and aggregation

Eyes, T., Austerberry, J., Dearman, R., Johannissen, L., Kimber, I., Smith, N., Thistlethwaite, A. & Derrick, J., Jan 2019, In: Molecular immunology. 105, p. 181-189 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Immunogenicity profiling of protein antigens from capsular group B Neisseria meningitidis

Awanye, A., Chang, C.-M., Wheeler, J. X., Chan, H., Marsay, L., Dold, C., Rollier, C. S., Bird, L. E., Nettleship, J. E., Owens, R. J., Pollard, A. J. & Derrick, J., 2019, In: Scientific Reports.

Research output: Contribution to journal › Article › peer-review

Open Access

Impact of a Heat Shock Protein Impurity on the Immunogenicity of Biotherapeutic Monoclonal Antibodies

Rane, S., Dearman, R., Kimber, I., Uddin, S., Bishop, S., Shah, M., Podmore, A., Pluen, A. & Derrick, J., Apr 2019, In: Pharmaceutical Research. 36, 4, 51.

Research output: Contribution to journal › Article › peer-review

Open Access

Interaction of a macrocycle with an aggregation-prone region of a monoclonal antibody

Martinez Morales, M., Zalar, M., Sonzini, S., Golovanov, A., Van der Walle, C. & Derrick, J., 2019, In: Molecular Pharmaceutics.

Research output: Contribution to journal › Article › peer-review

Open Access

File

58 Downloads (Pure)

Structure and properties of a natural competence-associated pilin suggest a unique pilus tip-associated DNA receptor

Bin Salleh, M. Z., Karuppiah, V., Snee, M., Thistlethwaite, A., Levy, C., Knight, D. & Derrick, J., 11 Jun 2019, In: mBio. 10, e00614-19.

Research output: Contribution to journal › Article › peer-review

Open Access

The impact of thioredoxin reduction of allosteric disulfide bonds on the therapeutic potential of monoclonal antibodies

Gurjar , S. A., Wheeler, J. X., Wadwha, M., Thorpe, R., Kimber, I., Derrick, J., Dearman, R. & Metcalfe, C., 20 Dec 2019, In: Journal of Biological Chemistry. 294, 51, p. 19616-19634 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

19F NMR as a Tool for Monitoring Individual Differentially Labeled Proteins in Complex Mixtures

Edwards, J. M., Derrick, J. P., van der Walle, C. F. & Golovanov, A. P., 2 Jul 2018, In: Molecular Pharmaceutics. 15, 7, p. 2785-2796 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

376 Downloads (Pure)

Structural cycle of the Thermus thermophilus PilF ATPase: the powering of type IVa pilus assembly

Collins, R., Karuppiah, V., Siebert, C. A., Dajani, R., Thistlethwaite, A. & Derrick, J., 2018, In: Scientific Reports. 8, 14022.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

DprA from Neisseria meningitidis: Properties and role in natural competence for transformation

Hovland, E., Beyene, G. T., Frye, S. A., Homberset, H., Balasingham, S. V., Gómez-Muñoz, M., Derrick, J. P., Tønjum, T. & Ambur, O. H., 2017, In: Microbiology. 163, 7, p. 1016-1029 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Influence of E. coli chaperone DnaK on protein immunogenicity

Ratanji, K., Derrick, J., Kimber, I., Thorpe, R., Wadhwa, M. & Dearman, R., 3 Feb 2017, In: Immunology. 150, 3, p. 343-355 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Structure of the Neisseria Adhesin Complex Protein (ACP) and its role as a novel lysozyme inhibitor

Humbert, M. V., Awanye, A. M., Lian, L. Y., Derrick, J. P. & Christodoulides, M., 29 Jun 2017, In: PL o S Pathogens. 13, 6, e1006448.

Research output: Contribution to journal › Article › peer-review

Open Access

Surrogate CD16-expressing effector cell lines for determining the bioactivity of therapeutic monoclonal antibodies

Gurjar, S. A., Derrick, J. P., Dearman, R. J., Thorpe, R., Hufton, S., Kimber, I. & Wadhwa, M., 5 Sept 2017, In: Journal of Pharmaceutical and Biomedical Analysis. 143, p. 188-198 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The effect of charge mutations on the stability and aggregation of a human single chain Fv fragment

Austerberry, J., Dajani, R., Panova, S., Roberts, D., Golovanov, A., Pluen, A., van der Walle, C. F., Uddin, S., Derrick, J., Warwicker, J. & Curtis, R., 1 Jun 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 115, p. 18-30

Research output: Contribution to journal › Article › peer-review

Open Access

File

672 Downloads (Pure)

2016

A single dose of epidermicin NI01 is sufficient to eradicate MRSA from the nares of cotton rats

Halliwell, S., Warn, P., Sattar, A., Derrick, J. & Upton, M., 13 Dec 2016, In: Journal of Antimicrobial Chemotherapy. 72, 3, 10.1093/jac/dkw457.

Research output: Contribution to journal › Article › peer-review

Open Access

Characterisation of the Immunomodulatory Effects of Meningococcal Opa Proteins on Human Peripheral Blood Mononuclear Cells and CD4+ T Cells

Jones, C., Sadarangani, M., Lewis, S., Payne, I., Saleem, M., Derrick, J. & Pollard, A. J., 2016, In: PLoS ONE. 11, 4, p. e0154153

Research output: Contribution to journal › Article › peer-review

Open Access

Dissection of the function of the RmpM periplasmic protein from Neisseria meningitidis

Maharjan, S., Saleem, M., Feavers, I. M., Wheeler, J. X., Care, R. & Derrick, J. P., Feb 2016, In: Microbiology. 162, 2, p. 364-75 12 p.

Research output: Contribution to journal › Article › peer-review

Proofreading of substrate structure by the Twin-Arginine Translocase is highly dependent on substrate conformational flexibility but surprisingly tolerant of surface charge and hydrophobicity changes

Jones, A. S., Austerberry, J., Dajani, R., Warwicker, J., Curtis, R., Derrick, J. & Robinson, C., Dec 2016, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1863, 12, p. 3116-3124 9 p.

Research output: Contribution to journal › Article › peer-review

Structures of type IV pilins from Thermus thermophilus demonstrate similarities with type II secretion system pseudopilins

Karuppiah, V., Thistlethwaite, A. & Derrick, J., Dec 2016, In: Journal of Structural Biology. 196, 3

Research output: Contribution to journal › Article › peer-review

Open Access

Subvisible aggregates of immunogenic proteins promote a Th1-type response

Ratanji, K., Dearman, R., Kimber, I., Thorpe, R., Wadhwa, M. & Derrick, J., 1 Oct 2016, In: Toxicological Sciences. 153, 2, p. 258–270

Research output: Contribution to journal › Article › peer-review

Open Access

2015

An OMV vaccine derived from a capsular group B meningococcus with constitutive FetA expression: preclinical evaluation of immunogenicity and toxicity

Derrick, M. C., Norheim, [., Sanders, G., Mellesdal, H., Sundfør, J., Chan, I., Brehony, H., Vipond, C., Dold, C., Care, C., Saleem, R., Maiden, M., Feavers, J. P., Pollard, I. & AJ, [., 2015, In: P L o S One.

Research output: Contribution to journal › Article › peer-review

A novel meningococcal outer membrane vesicle vaccine with constitutive expression of FetA: A phase I clinical trial

Derrick, K., Marsay, [., Dold, L., Green, C., Rollier, C. A., Norheim, C. S., Sadarangani, G., Shanyinde, M., Brehony, M., Thompson, C., Sanders, A. J., Chan, H., Haworth, H., Feavers, J. P., Maiden, I. M., Pollard, M. C. & A., J., 2015, In: Journal Of Infection. 71, 3, p. 326-337 11 p.

Research output: Contribution to journal › Article › peer-review

FetA Antibodies Induced by an Outer Membrane Vesicle Vaccine Derived from a Serogroup B Meningococcal Isolate with Constitutive FetA Expression

Sanders, H., Norheim, G., Chan, H., Dold, C., Vipond, C., Derrick, J. P., Pollard, A. J., Maiden, M. C. & Feavers, I. M., 2015, In: PLoS ONE. 10, 10

Research output: Contribution to journal › Article › peer-review

Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions

Pandalaneni, S., Karuppiah, V., Saleem, M., Haynes, L. P., Burgoyne, R. D., Mayans, O., Derrick, J. P. & Lian, L.-Y., 24 Jul 2015, In: Journal of Biological Chemistry. 290, 30, p. 18744-56 13 p.

Research output: Contribution to journal › Article › peer-review

Structural correlates of carrier protein recognition in tetanus toxoid-conjugated bacterial polysaccharide vaccines

Lockyer, K., Gao, F., Derrick, J. & Bolgiano, B., 2015, In: Vaccine. 33, p. 1345-1352 7 p.

Research output: Contribution to journal › Article › peer-review

The Cryo-EM Structure of the CorA channel from Methanocaldococcus jannaschii in low magnesium conditions.

Cleverley, R. M., Kean, J., Shintre, C. A., Baldock, C., Derrick, J. P., Ford, R. C. & Prince, S. M., 1 Oct 2015, In: Biochimica et Biophysica Acta. Biomembranes. 1848, 10 Pt A, p. 2206-2215 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

89 Downloads (Pure)

2014

EMD-2626: The Cryo-Electron Microscopy Structure of the CorA channel from Methanocaldococcus jannaschii at 21.6 Angstoms in low magnesium

Cleverley, R. M., Kean, J., Shintre, C. A., Baldock, C., Derrick, J., Ford, R. C. & Prince, S. M., 2014, In: Biochimica et biophysica acta. 1848, p. 2206-2215

Research output: Contribution to journal › Article › peer-review

Immunogenicity of therapeutic proteins: Influence of aggregation

Ratanji, K. D., Derrick, J. P., Dearman, R. J. & Kimber, I., Apr 2014, In: Journal of immunotoxicology. 11, 2, p. 99-109 10 p.

Research output: Contribution to journal › Article › peer-review

Neisseria meningitidis native outer membrane vesicles containing different lipopolysaccharide glycoforms as adjuvants for meningococcal and nonmeningococcal antigens

Nagaputra, J. C., Rollier, C. S., Sadarangani, M., Hoe, J. C., Mehta, O. H., Norheim, G., Saleem, M., Chan, H., Derrick, J. P., Feavers, I., Pollard, A. J. & Moxon, E. R., Feb 2014, In: Clinical and Vaccine Immunology. 21, 2, p. 234-242 8 p.

Research output: Contribution to journal › Article › peer-review

Structure and mechanism of the bifunctional CinA enzyme from Thermus thermophilus

Karuppiah, V., Thistlethwaite, A., Dajani, R., Warwicker, J. & Derrick, J., 28 Nov 2014, In: Journal of Biological Chemistry. 289, 48, p. 33187-33197 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Type IV pili - A numbers game

Karuppiah, V. & Derrick, J. P., 18 Aug 2014, In: EMBO Journal. 33, 16, p. 1732-1734 2 p.

Research output: Contribution to journal › Article › peer-review

Jeremy Derrick, MA, PhD

Research output

Search results