Research output per year
Research output per year
Personal profile
Overview
In vitro type I hypersensitivity modelling using human progenitor cells derived effector cells (basophils and mast cells).
- Using proprietary technologies of generating human progenitor cells derived basophils and mast cells in high-yield.
- Passive basophil or mast cell activation tests.
Research interests
I am currently leading a collaborative study between the Respiratory and Allergy Centre and MCCIR, where I am investigating the role of basophils in allergic inflammation.
My collaborations
Collaborator: Associate Professor Aihong Meng, Respiratory Division, the Second Hospital of Hebei Medical University
Memberships of committees and professional bodies
EAACI junior member
BSACI junior member
Methodological knowledge
Differentiation of basophils from stem cells
Basophil functional analysis
FACS
RNA and protein quantification
Molecular cloning and subsequent functional analysis
Basic statistical analysis
Clustering using WEKA suite
Qualifications
Bsc Biochemistry University of Birmingham 2004
PhD in Molecular cell biology University of Manchester 2006
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Research output
- 8 Article
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Progenitor cell-derived basophils: A novel barcoded passive degranulation assay in allergic diseases
Wu, J., Bahri, R., Tsoumani, M., Semic-Jusufagic, A., Murray, CS., Custovic, A., Guibas, G. V., Bennett, M., Wang, R., Gauvreau, G., Cusack, R., Mills, C., Bulfone-Paus, S. & Simpson, A., 16 Nov 2022, In: Clinical and Experimental Allergy.Research output: Contribution to journal › Article › peer-review
Open Access -
Mast cell activation test in the diagnosis of allergic disease and anaphylaxis
Bahri, R., Custovic, A., Korosec, P., Tsoumani, M., Barron, M., Wu, J., Sayers, R., Weimann, A., Ruiz-Garcia, M., Patel, N., Robb, A., Shamji, M. H., Fontanella, S., Silar, M., Mills, ENC., Simpson, A., Turner, P. J. & Bulfone-Paus, S., 5 Mar 2018, In: Journal of Allergy and Clinical Immunology. 142, 2, p. 485-496.e16Research output: Contribution to journal › Article › peer-review
Open Access -
In vitro modeling of COPD inflammation and limitation of p38 inhibitor — SB203580
Wu, J., 29 Apr 2016, In: International Journal of COPD. 11, 1Research output: Contribution to journal › Article › peer-review
Open Access -
Additive Suppression of LPS-Induced IL-10 and TNF-α by Pre-treatment of Dexamethasone and SB203580 in a Murine Alveolar Macrophage Cell Line (MH-S).
Meng, A., Wang, B., Zhang, X., Qi, N., Liu, D. & Wu, J., 7 Jan 2015, In: Inflammation.Research output: Contribution to journal › Article › peer-review
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Relationship between cytokine expression patterns and clinical outcomes: two population-based birth cohorts.
Wu, J., Prosperi, M. C. F., Simpson, A., Hollams, E. M., Sly, P. D., Custovic, A. & Holt, P. G., Dec 2015, In: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 45, 12, p. 1801-11Research output: Contribution to journal › Article › peer-review