Jill Barber

2024

Complementarity of two proteomic data analysis tools in the identification of drug-metabolising enzymes and transporters in human liver

Vasilogianni, A. M., Alrubia, S., El-Khateeb, E., Al-Majdoub, Z. M., Couto, N., Achour, B., Rostami-Hodjegana, A. & Barber, J., 19 Feb 2024, In: Molecular Omics. 20, 2, p. 115-127 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Establishing a physiologically-based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase-CYP substrates

Izat, N., Bolleddula , J., Carione, P., Huertas Valentin, L., Jones, R. S., Kulkarni, P., Moss, D., Peterkin, V. C., Tian, D.-D., Treyer, A., Venkatakrishnan, K., Zientek, M. A., Barber, J., Houston, J., Galetin, A. & Scotcher, D., 27 Sept 2024, (Accepted/In press) In: CPT: Pharmacometrics and Systems Pharmacology.

Research output: Contribution to journal › Article › peer-review

2023

Challenges and opportunities for in vitro-in vivo extrapolation of aldehyde oxidase-mediated clearance: Towards a roadmap for quantitative translation

Izat, N., Bolleddula, J., Abbasi, A., Cheruzel, L., Jones, R., Moss, D., Ortega-Muro, F., Parmentier, Y., Peterkin, V. C., Tian, D.-D., Venkatakrishnan, K., Zientek, M., Barber, J., Houston, J., Galetin, A. & Scotcher, D., 28 Aug 2023, (Accepted/In press) In: Drug Metabolism and Disposition.

Research output: Contribution to journal › Article › peer-review

Open Access

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Proteomic quantification of receptor tyrosine kinases involved in the development and progression of colorectal cancer liver metastasis

Vasilogianni, A.-M., Al-Majdoub, Z. M., Achour, B., Peters, S. A., Rostami-Hodjegan, A. & Barber, J., 20 Feb 2023, In: Frontiers in Oncology. 13, 1010563.

Research output: Contribution to journal › Article › peer-review

Open Access

Toward systems-informed models for biologics disposition: covariates of the abundance of the neonatal Fc Receptor (FcRn) in human tissues and implications for pharmacokinetic modelling

Barber, J., Al-Majdoub, Z. M., Couto, N., Howard, M., Elmorsi, Y., Scotcher, D., Alizai, N., de Wildt, S., Stader, F., Sepp, A., Rostami-Hodjegan, A. & Achour, B., 1 Mar 2023, In: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 182, p. 106375

Research output: Contribution to journal › Article › peer-review

2022

A family of QconCATs (Quantification conCATemers) for the quantification of human pharmacological target proteins

Vasilogianni, A. M., El-Khateeb, E., Achour, B., Alrubia, S., Rostami-Hodjegan, A., Barber, J. & Al-Majdoub, Z. M., 15 Jun 2022, In: Journal of Proteomics. 261, 104572.

Research output: Contribution to journal › Article › peer-review

Examining Physiologically-Based Pharmacokinetic (PBPK) Model Assumptions for Cross-Tissue Similarity of Kcat: The Case Example of Uridine 5'-diphosphate Glucuronosyltransferase (UGT)

Ahmed, A. N., Rostami-Hodjegan, A., Barber, J. & Al-Majdoub, Z. M., 30 May 2022, In: Drug Metabolism and Disposition.

Research output: Contribution to journal › Article › peer-review

Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters

Barber, J., Al-Majdoub, Z. M., Couto, N., Vasilogianni, A.-M., Tillmann, A., Alrubia, S., Rostami-Hodjegan, A. & Achour, B., 6 Jun 2022, In: Drug Metabolism and Disposition. 50, 6, p. 762-769 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Proteomics of Colorectal Cancer Liver Metastasis: a Quantitative Focus on Drug Elimination and Pharmacodynamics Effects

Vasilogianni, A., Al‐Majdoub, Z. M., Achour, B., Peters, S. A., Rostami‐Hodjegan, A. & Barber, J., 1 Apr 2022, In: British Journal of Clinical Pharmacology. 88, 4, p. 1811-1823 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Quantitative Assessment of the Impact of Crohn's Disease on Protein Abundance of Human Intestinal Drug-Metabolising Enzymes and Transporters

Alrubia, S., Al-Majdoub, Z. M., Achour, B., Rostami-Hodjegan, A. & Barber, J., Oct 2022, In: Journal of Pharmaceutical Sciences.

Research output: Contribution to journal › Article › peer-review

2021

Hepatic Scaling Factors for In Vitro-In Vivo Extrapolation (IVIVE) of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis

Vasilogianni, A.-M., Achour, B., Scotcher, D., Peters, S. A., Al-Majdoub, Z. M., Barber, J. & Rostami-Hodjegan, A., 12 May 2021, In: Drug Metabolism and Disposition.

Research output: Contribution to journal › Article › peer-review

Inhibition of aggregation of amyloid-β through covalent modification with benzylpenicillin; potential relevance to Alzheimer’s disease

Alsalahat, I., M. Al-Majdoub, Z., Taha, M., Barber, J., Aojula, H., Hodson, N. & Freeman, S., 1 Jul 2021, In: Biochemistry and Biophysics Reports. 26, 100943.

Research output: Contribution to journal › Article › peer-review

Open Access

Label-free Quantitative Proteomics and Substrate Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in ex Vivo Human Skin and a Human Living Skin Equivalent Model

Couto, N., Newton, J. R. A., Russo, C., Karunakaran, E., Achour, B., Al-Majdoub, Z., Sidaway, J., Rostami-Hodjegan, A., Clench, M. R. & Barber, J., 1 Jan 2021, In: Drug Metabolism and Disposition. 49, 1, p. 39-52 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters

Achour, B., Al-Majdoub, Z., Grybos‐Gajniak, A., Lea, K., Kilford, P., Zhang, M., Knight, D., Barber, J., Schageman, J. & Rostami-Hodjegan, A., 1 Jan 2021, In: Clinical Pharmacology & Therapeutics. 109, 1, p. 222-232 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Non-uniformity of changes in drug-metabolizing enzymes and transporters in liver cirrhosis: Implications for drug dosage adjustment

El-Khateeb, E., Achour, B., Al-Majdoub, Z., Barber, J. & Rostami-Hodjegan, A., 21 Aug 2021, In: Molecular Pharmaceutics. 18, 9, p. 3563-3577

Research output: Contribution to journal › Article › peer-review

Open Access

Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes

El-Khateeb, E., Al-Majdoub, Z. M., Rostami-Hodjegan, A., Barber, J. & Achour, B., 27 May 2021, In: Drug Metabolism and Disposition. 49, 8, p. 610-618 9 p., DMD-AR-2021-000484.

Research output: Contribution to journal › Article › peer-review

Open Access

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Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics

Al-Majdoub, Z., Couto, N., Achour, B., Harwood, M. D., Carlson, G., Warhurst, G., Barber, J. & Rostami-Hodjegan, A., Apr 2021, In: Clinical Pharmacology & Therapeutics. 109, 4, p. 1136-1146 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local Kinetics

Al-Majdoub, Z., Scotcher, D., Achour, B., Barber, J., Galetin, A. & Rostami-Hodjegan, A., 1 Nov 2021, In: Clinical Pharmacology & Therapeutics. 110, 5, p. 1389-1400 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Selected Derivatives of Erythromycin B-In Silico and Anti-Malarial Studies

Bhadra, P. K., Magwaza, R. N., Nirmalan, N., Freeman, S., Barber, J. & Arsic, B., 18 Nov 2021, In: Materials. 14, 22, 6980.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Characterization of CYP2B6 K262R Allelic Variants by Quantitative Allele-Specific Proteomics using a QconCAT Standard

Barber, J., Russell, M. R., Rostami-Hodjegan, A. & Achour, B., 30 Jan 2020, In: Journal of Pharmaceutical and Biomedical Analysis. 178, p. 1-8 8 p., 112901.

Research output: Contribution to journal › Article › peer-review

Open Access

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Mass Spectrometry‐Based Abundance Atlas of ABC Transporters in Human Liver, Gut, Kidney, Brain, and Skin

Al-Majdoub, Z., Achour, B., Couto, N., Howard, M., Elmorsi, Y., Scotcher, D., Alrubia, S., Elkhateeb, E., Vasilogianni, A. M., Alohali, N., Neuhoff, S., Schmidt, L., Rostami-Hodjegan, A. & Barber, J., 31 Oct 2020, In: FEBS Letters.

Research output: Contribution to journal › Article › peer-review

Open Access

Mass Spectrometry of Human Transporters

Achour, B., Al-Majdoub, Z., Rostami-Hodjegan, A. & Barber, J., 12 Jun 2020, In: Annual Review of Analytical Chemistry. 13, p. 223-247

Research output: Contribution to journal › Article › peer-review

Proteomic characterisation of drug metabolising enzymes and drug transporters in pig liver

Elmorsi, Y., Al Feteisi, H., Al-Majdoub, Z., Barber, J., Rostami-Hodjegan, A. & Achour, B., 2020, In: Xenobiotica.

Research output: Contribution to journal › Article › peer-review

Open Access

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Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Inter-correlations in the Human Small Intestine

Couto, N., Al-Majdoub, Z., Gibson, S. L., Davies, P. J., Achour, B., Harwood, M. D., Carlson, G., Barber, J., Rostami-Hodjegan, A. & Warhurst, G., 20 Jan 2020, In: Drug Metabolism and Disposition. 48, 4, p. 245-254

Research output: Contribution to journal › Article › peer-review

Scaling Factors for Clearance in Adult Liver Cirrhosis

Elkhateeb, E., Achour, B., Scotcher, D., Al-Majdoub, Z., Athwal, V., Barber, J. & Rostami-Hodjegan, A., 25 Sept 2020, (E-pub ahead of print) In: Drug Metabolism and Disposition.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Proteomic Quantification of Human Blood-Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients

Al-Majdoub, Z., Al Feteisi, H., Achour, B., Warwood, S., Neuhoff, S., Rostami-Hodjegan, A. & Barber, J., 4 Mar 2019, In: Molecular Pharmaceutics. 16, 3, p. 1220-1233 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Quantification of Proteins Involved in Drug Metabolism and Disposition in the Human Liver Using Label-Free Global Proteomics

Couto, N., Al-Majdoub, Z., Achour, B., Wright, P., Rostami-Hodjegan, A. & Barber, J., 4 Feb 2019, In: Molecular Pharmaceutics. 16, 2, p. 632-647 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Quantitative mass spectrometry-based proteomics in the era of model-informed drug development: Applications in translational pharmacology and recommendations for best practice

Elkhateeb, E., Vasilogianni, A. M., Alrubia, S., Al-Majdoub, Z., Couto, N., Howard, M., Barber, J., Rostami-Hodjegan, A. & Achour, B., 2019, In: Pharmacology and Therapeutics.

Research output: Contribution to journal › Article › peer-review

Open Access

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Response to “Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method”

Achour, B., Rostami-Hodjegan, A. & Barber, J., 4 Jan 2019, In: J. Proteome Res.. 18, 1, p. 574-574

Research output: Contribution to journal › Letter › peer-review

Student Peer Assessment Using Adaptive Comparative Judgment: Grading Accuracy versus Quality of Feedback.

Demonacos, C., Ellis, S. & Barber, J., 2019, In: Practitioner Research in Higher Education Journal. 12, 1, p. 50-59

Research output: Contribution to journal › Article › peer-review

Open Access

Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Prasad, B., Achour, B., Artursson, P., Hop, C., Lai, Y., Smith, P. C., Barber, J., Wiśniewski, J. R., Spellman, D., Uchida, Y., Zientek, M., Unadkat, J. D. & Rostami-Hodjegan, A., 2019, In: Clinical Pharmacology & Therapeutics. 106, 3, p. 525-543 19 p.

Research output: Contribution to journal › Article › peer-review

2018

Data generated by quantitative LC-MS proteomics are only the start and not the endpoint: Optimization of QconCAT-based measurement of hepatic UDP-glucuronosyltransferase enzymes with reference to catalytic activity

Achour, B., Dantonio , A. L., Niosi, M., Novak, J. J., Al-Majdoub, Z., Goosen, T. C., Rostami-Hodjegan, A. & Barber, J., 1 Jun 2018, In: Drug Metabolism and Disposition. 46, 6, p. 805-812 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Dose adjustment in orphan disease populations: the quest to fulfill the requirements of physiologically based pharmacokinetics

Howard, M., Barber, J., Alizai, N. & Rostami-Hodjegan, A., 1 Dec 2018, In: Expert Opinion on Drug Metabolism & Toxicology. 14, 12, p. 1315-1330 16 p.

Research output: Contribution to journal › Review article › peer-review

GASP and FASP are Complementary for LC-MS/MS Proteomic Analysis of Drug-Metabolizing Enzymes and Transporters in Pig Liver

Howard, M., Achour, B., Al-Majdoub, Z., Rostami-Hodjegan, A. & Barber, J., 30 Nov 2018, In: Proteomics. 18, 24, 1800200.

Research output: Contribution to journal › Article › peer-review

Open Access

Identification and Quantification of Blood-Brain Barrier Transporters in Isolated Rat Brain Microvessels

Al Feteisi, H., Al-Majdoub, Z., Achour, B., Couto, N., Rostami-Hodjegan, A. & Barber, J., Sept 2018, In: Journal of neurochemistry. 146, 6, p. 670-685

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

Conformational study of tylosin A in water and full assignments of 1H and 13C spectra of tylosin A in D2O and tylosin B in CDCl3

Arsic, B., Aguilar Malavia, J., Bryce, R. & Barber, J., 2017, In: Magnetic Resonance in Chemistry. 55, 4

Research output: Contribution to journal › Article › peer-review

Open Access

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Cross-laboratory evaluation of UDP-glucuronosyltransferase (UGT) abundances and correlation with catalytic activity

Achour, B., Dantonio , A. L., Niosi, M., Novak, J. J., Fallon, J. K., Barber, J., Smith, P. C., Rostami-Hochaghan, A. & Goosen, T. C., 26 Jun 2017.

Research output: Contribution to conference › Poster

Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

Achour, B., Al Feteisi, H., Lanucara, F., Rostami-Hochaghan, A. & Barber, J., 11 May 2017, In: Drug Metabolism and Disposition. 45, 6, p. 666-675 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

Achour, B., Dantonio, A., Niosi, M., Novak, J. J., Fallon, J. K., Barber, J., Smith, P. C., Rostami-Hochaghan, A. & Goosen, T. C., 1 Oct 2017, In: Drug Metabolism and Disposition. 45, 10, p. 1102-1112 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Quantitative Proteomic Analysis of Drug Transporters in Human Blood Brain Barrier

Al-Majdoub, Z., Al Feteisi, H., Achour, B., Rostami-Hodjegan, A. & Barber, J., 19 Sept 2017, HUPO2017.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Quantitative Proteomic Analysis of Drug Transporters in Human Blood Brain Barrier

Al-Majdoub, Z., Al Feteisi, H., Achour, B., Rostami-Hochaghan, A. & Barber, J., 19 Sept 2017.

Research output: Contribution to conference › Poster

2016

Enhancement of the properties of a drug by mono-deuteriation: reduction of acid-catalysed formation of a gut-motilide enol ether from 8-deuterio-erythromycin B

Bhadra, P., Hassanzadeh, A., Arsic, B., Allison, D., Morris, G. & Barber, J., 2016, In: Organic and Biomolecular Chemistry. 14, 26, p. 6289-6296 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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EXPANDING AND PERSONALISING FEEDBACK IN ONLINE ASSESSMENT: A CASE STUDY IN A SCHOOL OF PHARMACY

Ellis, S. & Barber, J., 2016, In: Practitioner Research in Higher Education Journal. 10, 1, p. 121-129 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Ontogeny of Hepatic Drug Transporters and Relevance to Drugs Used in Paediatrics

Elmorsi, Y., Barber, J. & Rostami-Hochaghan, A., 2016, In: Drug Metabolism & Disposition (Online). 44, 8

Research output: Contribution to journal › Book/Film/Article review › peer-review

Peer-to-peer learning through research: a case study in delivering a healthcare message

Barber, J., 2016, In: Journal of Learning Development in Higher Education.

Research output: Contribution to journal › Article › peer-review

Open Access

The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

Couto, N., Wood , J. & Barber, J., 1 Jun 2016, In: Free Radical Biology and Medicine. 95, p. 27-42 16 p.

Research output: Contribution to journal › Article › peer-review

2015

Choice of LC-MS methods for the absolute quantification of drug-metabolizing enzymes and transporters in human tissue: A comparative cost analysis

Al Feteisi, H., Achour, B., Barber, J. & Rostami-Hochaghan, A., Mar 2015, In: The A A P S Journal. 17, 2, p. 438-446 9 p.

Research output: Contribution to journal › Article › peer-review

Comparison of label-free and QconCAT quantitative proteomic methods for the quantification of human liver enzymes

Feteisi, H. A., Lanucara, F., Barber, J., Rostami-Hodjegan, A. & Achour, B., Dec 2015.

Research output: Contribution to conference › Poster

Critical analysis and communication: an alternative research project for Pharmacy students

Barber, J., 2015, Innovative Pedagogies in Higher Education, HEA . p. 1-22

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

INNOVATIVE ASSESSMENT AND PERSONALISED FEEDBACK IN HIGHER EDUCATION

Barber, J. & Ellis, S., 2015, ICICTE 2015 Proceedings. p. 94-104

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Jill Barber, MA, PhD Cantab, MA, DPhil Oxon, MRSC CChem, LGM

Research output

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