John Blaikley, MBBS BSc. MRCP PhD

Search results

• 2023

  The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation in the UK: a prospective multi-centre cohort study

  Jackson, C., Cunningham, P., Hazel, A., Al-Sheklly, B., Hanley, N., Piper Hanley, K., Horsley, A., Rutter, M. K., Blaikley, J., et al. & PHOSP-COVID Study Collaborative Group , 3 Mar 2023, (Accepted/In press) In: The Lancet Respiratory Medicine.

  Research output: Contribution to journal › Article › peer-review

  • Sleep Disorder 100%
  • COVID-19 100%
  • Hospitalization 100%
  • Dyspnea 83%
  • Sleep Quality 66%
• 2022

  ClinCirc identifies alterations of the circadian peripheral oscillator in critical care patients

  Cunningham, P., Kitchen, G., Jackson, C., Papachristos, S., Springthorpe, T., Van Dellen, D., Gibbs, J., Felton, T., Wilson, A., Bannard-Smith, J., Rutter, M. K., House, T., Dark, P., Augustine, T., Akman, O., Hazel, A. & Blaikley, J., 20 Dec 2022, In: The Journal of clinical investigation.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Kidney Transplantation 100%
  • Accuracy 66%
  • Kidney 66%
  • Transplantation 66%
  • Oscillation 66%

• Residual Lung Abnormalities Following COVID-19 Hospitalization: Interim Analysis of the UKILD Post-COVID Study

  Stewart, I., Jacob, J., George, P. M., Molyneaux, P. L., Porter, J. C., Allen, R. J., Aslani, S., Baillie, J. K., Barratt, S. L., Beirne, P., Bianchi, S. M., Blaikley, J. F., Chalmers, J. D., Chambers, R. C., Chaudhuri, N., Coleman, C., Collier, G., Denneny, E. K., Docherty, A., Elneima, O., & 58 othersEvans, R. A., Fabbri, L., Gibbons, M. A., Gleeson, F. V., Gooptu, B., Greening, N. J., Guillen Guio, B., Hall, I. P., Hanley, N. A., Harris, V., Harrison, E. M., Heightman, M., Hillman, T. E., Horsley, A., Houchen-Wolloff, L., Jarrold, I., Johnson, S. R., Jones, M. G., Khan, F., Lawson, R., Leavy, O., Lone, N., Marks, M., McAuley, H., Mehta, P., Parekh, D., Piper Hanley, K., Platé, M., Pearl, J., Poinasamy, K., Quint, J. K., Raman, B., Richardson, M., Rivera-Ortega, P., Saunders, L., Saunders, R., Semple, M. G., Sereno, M., Shikotra, A., Simpson, A. J., Singapuri, A., Smith, D. J., Spears, M., Spencer, L. G., Stanel, S., Thickett, D., Thompson, A. A. R., Thorpe, M., Walsh, S. L., Walker, S., Weatherley, N. D., Weeks, M., Wild, J. M., Wootton, D. G., Brightling, C. E., Ho, L-P., Wain, L. V. & Jenkins, R. G., 1 Dec 2022, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine .

  Research output: Contribution to journal › Article › peer-review

  • Lung 100%
  • COVID-19 66%
  • Prevalence 50%
  • Follow up 33%
  • Sensitivity Analysis 33%

• The UIP/IPF fibroblastic focus is a collagen biosynthesis factory embedded in a distinct extracellular matrix

  Herrera, J. A., Dingle, L., Montero, M. A., Venkateswaran, R. V., Blaikley, J. F., Lawless, C. & Schwartz, M. A., 22 Aug 2022, In: JCI Insight.

  Research output: Contribution to journal › Article › peer-review
• 2021

  Shift work is associated with positive COVID-19 status in hospitalised patients

  Maidstone, R., Anderson, S. G., Ray, D. W., Rutter, M. K., Durrington, H. J. & Blaikley, J. F., 26 Apr 2021, In: Thorax. 76, p. 601-606 thoraxjnl-2020-216651.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Workplace 100%
  • COVID-19 100%
  • Diseases 50%
  • Job 50%
  • Patient 33%

• Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)

  Wild, J. M., Porter, J. C., Molyneaux, P. L., George, P. M., Stewart, I., Allen, R. J., Aul, R., Baillie, J. K., Barratt, S. L., Beirne, P., Bianchi, S. M., Blaikley, J. F., Brooke, J., Chaudhuri, N., Collier, G., Denneny, E. K., Docherty, A., Fabbri, L., Gibbons, M. A., Gleeson, F. V., & 34 othersGooptu, B., Hall, I. P., Hanley, N. A., Heightman, M., Hillman, T. E., Johnson, S. R., Jones, M. G., Khan, F., Lawson, R., Mehta, P., Mitchell, J. A., Platé, M., Poinasamy, K., Quint, J. K., Rivera-Ortega, P., Semple, M., Simpson, A. J., Smith, D., Spears, M., Spencer, LI. G., Stanel, S. C., Thickett, D. R., Thompson, A. A. R., Walsh, S. L., Weatherley, N. D., Weeks, M. E., Wootton, D. G., Brightling, C. E., Chambers, R. C., Ho, L-P., Jacob, J., Piper Hanley, K., Wain, L. V. & Jenkins, R. G., 23 Sep 2021, In: BMJ Open Respiratory Research. 8, 1, e001049.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • COVID-19 100%
  • Interstitial Lung Disease 77%
  • Postcovid Syndrome 44%
  • Patient 44%
  • Assessment 22%
• 2020

  Circadian asthma airway responses are gated by REV-ERBα

  Durrington, H. J., Krakowiak, K., Meijer, P., Begley, N., Maidstone, R., Goosey, L., Gibbs, J. E., Blaikley, J. F., Gregory, L. G., Lloyd, C. M., Loudon, A. S. I. & Ray, D. W., 25 Jun 2020, In: European Respiratory Journal. 56, 1902407.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  131 Downloads (Pure)

• Night Shift Work is associated with an increased Risk of Asthma

  Maidstone, R., Turner, J., Vetter, C., Dashti, H. S., Saxena, R., Scheer, F. A. J. L., Shea, S. A., Kyle, S. D., Lawlor, D. A., Loudon, A., Blaikley, J., Rutter, M. K., Ray, D. & Durrington, H., 14 Aug 2020, (Accepted/In press) In: Thorax.

  Research output: Contribution to journal › Article › peer-review

  • Asthma 100%
  • Chronotype 50%
  • Health 33%
  • Inflammatory Disorder 33%
  • Severe Asthma 33%

• The circadian clock protein REVERBα inhibits pulmonary fibrosis development

  Cunningham, P., Meijer, P., Nazgiewicz, A., Anderson, S., Borthwick, L. A., Bagnall, J., Kitchen, G., Lodyga, M., Begley, N., Venkateswaran, R., Shah, R., Mercer, P. F., Durrington, H., Henderson, N., Piper Hanley, K., Fisher, A., Chambers, R. C., Bechtold, D., Gibbs, J., Loudon, A., & 4 othersRutter, M. K., Hinz, B., Ray, D. & Blaikley, J., 14 Jan 2020, In: Proceedings of the National Academy of Sciences. 117, 2, p. 1139-1147 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cells 100%
  • Idiopathic Pulmonary Fibrosis 75%
  • Pulmonary Fibrosis 75%
  • Fibrosing Alveolitis 75%
  • Lung Fibrosis 75%

• The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

  Kitchen, G. B., Cunningham, P. S., Poolman, T. M., Iqbal, M., Maidstone, R., Baxter, M., Bagnall, J., Begley, N., Saer, B., Hussell, T., Matthews, L. C., Dockrell, D. H., Durrington, H. J., Gibbs, J. E., Blaikley, J. F., Loudon, A. S. & Ray, D. W., 21 Jan 2020, In: Proceedings of the National Academy of Sciences. 117, 3, p. 1543-1551 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Macrophage 100%
  • Gene 14%
  • Nested Gene 14%
  • Phagocytosis 9%
  • Pneumonia 9%
• 2019

  Circadian rhythm of exhaled biomarkers in health and asthma

  Wilkinson, M., Maidstone, R., Loudon, A., Blaikley, J., White, I., Singh, D., Ray, D., Goodacre, R., Fowler, S. & Durrington, H., 20 Jun 2019, (E-pub ahead of print) In: The European respiratory journal.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Circadian Rhythm 100%
  • Breathing 100%
  • Biological Marker 100%
  • Asthma 60%
  • Diseases 60%

• Genome-wide effect of pulmonary airway epithelial cell–specific Bmal1 deletion

  Zhang, Z., Hunter, L., Wu, G., Maidstone, R., Mizoro, Y., Vonslow, R., Fife, M., Hopwood, T., Begley, N., Saer, B., Wang, P., Cunningham, P., Baxter, M., Durrington, H., Blaikley, J. F., Hussell, T., Rattray, M., Hogenesch, J. B., Gibbs, J., Ray, D. W., & 1 othersLoudon, A. S. I., 1 May 2019, In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 5, p. 6226-6238 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Circadian Rhythm 100%
  • Nested Gene 66%
  • Mouse 33%
  • Time 33%
  • Health 33%

• Monthly variance in United Kingdom renal transplantation activity: a national retrospective cohort study

  Lowe, M., Maidstone, R., Poulton, K., Worthington, J., Durrington, H., Ray, D., van Dellen, D., Asderakis, A., Blaikley, J. & Augustine, T., 2019, In: BMJ Open.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transplantation 100%
  • Kidney Graft 27%
  • Organ 18%
  • Kidney Transplantation 18%
  • Retrospective Cohort Study 18%
• 2018

  Incidence of Primary graft dysfunction after lung transplantation is altered by timing of allograft implantation

  Cunningham, P., Maidstone, R., Durrington, H., Venkateswaran, R., Cypel, M., Keshavjee, S., Gibbs, J., Loudon, A., Chow, C. W., Ray, D. & Blaikley, J., 9 Oct 2018, In: Thorax. 74, 4, p. 413-416 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Incidence 100%
  • Lung 100%
  • Regulatory Mechanism 50%
  • Circadian Rhythm 50%
  • Transplantation 50%

• Nintedanib in the management of idiopathic pulmonary fibrosis: clinical trial evidence and real-world experience

  Rivera-Ortega, P., Hayton, C., Blaikley, J., Leonard, C. & Chaudhuri, N., 27 Sep 2018, In: Therapeutic Advances in Respiratory Disease. 12, p. 1753466618800618

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Idiopathic Pulmonary Fibrosis 100%
  • Nintedanib 100%
  • Fibrosing Alveolitis 100%
  • Clinical Trial 85%
  • Diseases 42%

• Nintedanib in the management of idiopathic pulmonary fibrosis: clinical trial evidence and real-world experience

  Rivera-Ortega, P., Hayton, C., Blaikley, J., Leonard, C. & Chaudhuri, N., 25 Sep 2018, In: Therapeutic Advances in Respiratory Disease.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and treatment

  Durrington, H. J., Gioan-tavernier, G. O., Maidstone, R. J., Krakowiak, K., Loudon, A. S. I., Blaikley, J. F., Fowler, S. J., Singh, D., Simpson, A. & Ray, D. W., 15 Dec 2018, In: American Journal of Respiratory and Critical Care Medicine . 198, 12, p. 1578-1581 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sputum 100%
  • Asthma 80%
  • Eosinophil Granulocyte 80%
  • Severe Asthma 80%
  • Eosinophil 80%
  39 Downloads (Pure)
• 2017

  Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing

  Hoyle, N. P., Seinkmane, E., Putker, M., Feeney, K. A., Krogager, T. P., Chesham, J. E., Bray, L. K., Thomas, J. M., Dunn, K., Blaikley, J. & O'Neill, J. S., 8 Nov 2017, In: Science Translational Medicine. 9, 415, eaal2774.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Wound Healing 100%
  • Fibroblast 100%
  • Actin 80%
  • Dynamics 40%
  • Rhythm 40%
  236 Downloads (Pure)

• 'In a dark place we find ourselves ': Light Intensity in Critical Care Units

  Durrington, H., Clark, R., Greer, R., Martial, F. P., Blaikley, J., Dark, P., Lucas, R. & Ray, D., 7 Feb 2017, In: Intensive Care Medicine Experimental. 5, 9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient 100%
  • Clinical Outcome 33%
  • Time 33%
  • Biological Product 33%
  • Mask 33%

• Persistent air leak after pulmonary transplantation

  Pearmain, L., Krysiak, P., Blaikley, J. & Alaloul, M., 27 Jul 2017, In: BMJ Case Reports. 2017

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Tissues 66%
  • Bronchoscopy 66%
  • Chest 66%
  • Emphysema 66%
• 2016

  A matter of time: study of circadian clocks and their role in inflammation.

  Carter, S. J., Durrington, H., Gibbs, J., Blaikley, J., Loudon, A., Ray, D. & Sabroe, I., Apr 2016, In: Journal of leukocyte biology|J Leukoc Biol. 99, 4, p. 549-560 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Circadian Rhythm 100%
  • Inflammation 60%
  • Immunity 40%
  • Comprehension 20%
  • Regulatory Mechanism 20%
• 2015

  Clinical outcome of patients transplanted with marginal donor lungs via EVLP compared to standard lung transplantation

  Fildes, J. E., Archer, L. D., Blaikley, J., Ball, A., Stone, J., Sjoberg, T., Steen, S. & Yonan, N., May 2015, In: Transplantation. 99, 5, p. 1078–1083 PMID: 25757211.

  Research output: Contribution to journal › Article › peer-review

  • Lung 100%
  • Ex Vivo 50%
  • Transplantation 50%
  • Perfusion 50%
  • Patient 40%
• 2013

  British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE.

  Du Rand, I. A., Blaikley, J., Booton, R., Chaudhuri, N., Gupta, V., Khalid, S., Mandal, S., Martin, J., Mills, J., Navani, N., Rahman, N. M., Wrightson, J. M. & Munavvar, M., Aug 2013, In: Thorax. 68, Supplement 1, p. i1-i44

  Research output: Contribution to journal › Article › peer-review

• Evaluation of Glucocorticoid Receptor Function in COPD Lung Macrophages Using Beclomethasone-17-Monopropionate

  Plumb, J., Robinson, L., Lea, S., Banyard, A., Blaikley, J., Ray, D., Bizzi, A., Volpi, G., Facchinetti, F. & Singh, D., 21 May 2013, In: PLoS ONE. 8, 5, e64257.

  Research output: Contribution to journal › Article › peer-review

  • Lung 100%
  • Glucocorticoid Receptor 100%
  • Macrophage 85%
  • Alveolar Macrophage 85%
  • Patient 42%

• Optimized chemical probes for REV-ERBα

  Trump, R. P., Bresciani, S., Cooper, A. W. J., Tellam, J. P., Wojno, J., Blaikley, J., Orband-Miller, L. A., Kashatus, J. A., Boudjelal, M., Dawson, H. C., Loudon, A., Ray, D., Grant, D., Farrow, S. N., Willson, T. M. & Tomkinson, N. C. O., 13 Jun 2013, In: Journal of Medicinal Chemistry. 56, 11, p. 4729-4737 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Bioavailability 100%
  • Agonist 100%

• Summary of the British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults.

  Du Rand, I. A., Blaikley, J., Booton, R., Chaudhuri, N., Gupta, V., Khalid, S., Mandal, S., Martin, J., Mills, J., Navani, N., Rahman, N. M., Wrightson, J. M. & Munavvar, M., Aug 2013, In: Thorax. 68, 8, p. 786-787 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Bronchoscopy 100%
  • Diagnosis 66%
  • Adult 33%
  • Respiratory Medicine 33%
• 2012

  The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

  Gibbs, J. E., Blaikley, J., Beesley, S., Matthews, L., Simpson, K. D., Boyce, S. H., Farrow, S. N., Else, K. J., Singh, D., Ray, D. W. & Loudon, A. S. I., 10 Jan 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 2, p. 582-587 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Macrophage 100%
  • Circadian Rhythm 37%
  • Mouse 25%
  • Cells 25%
  • Regulatory Mechanism 25%
• 2011

  Management of peripheral lymph node tuberculosis in routine practice: An unselected 10-year cohort

  Blaikley, J. F., Khalid, S. & Ormerod, L. P., Mar 2011, In: International Journal of Tuberculosis and Lung Disease. 15, 3, p. 375-378 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Tuberculosis 83%
  • Tuberculous Lymphadenitis 83%
  • Chemotherapy 66%
  • Therapeutic Procedure 50%
• 2010

  Familial glucocorticoid resistance caused by a novel frameshift glucocorticoid receptor mutation

  Trebble, P., Matthews, L., Blaikley, J., Wayte, A. W. O., Black, G. C. M., Wilton, A. & Ray, D. W., Dec 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 12, p. E490-E499

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucocorticoid Receptor 100%
  • Mutation 45%
  • Glucocorticoid 36%
  • Mutant 27%
  • Ligand 27%
  119 Downloads (Pure)

• Increased airway T regulatory cells in asthmatic subjects

  Smyth, L. J. C., Eustace, A., Kolsum, U., Blaikely, J., Singh, D. & Blaikley, J., 1 Oct 2010, In: Chest. 138, 4, p. 905-912 7 p.

  Research output: Contribution to journal › Article › peer-review

  • CD4 100%
  • Severe Asthma 90%
  • Asthma 63%
  • Regulatory T Cell 63%
  • Cells 45%
• 2007

  Severe community-acquired pneumonia on the intensive care unit

  Blaikley, J. & Woodhead, M., 2007, In: British Journal of Intensive Care. 17, 4, p. 127-132

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Community Acquired Pneumonia 50%
  • Therapeutic Procedure 25%
  • Assessment 25%
  • Mortality Rate 25%
• 2003

  Cutaneous T-cell lymphoma with adrenal insufficiency

  Blaikley, J. F., Atkinson, P. & Almond, M. K., Oct 2003, In: Journal of the Royal Society of Medicine. 96, 10, p. 503-504 1 p.

  Research output: Contribution to journal › Article › peer-review

• Tubular proteinuria and enzymuria following open heart surgery

  Blaikley, J., Sutton, P., Walter, M., Lapsley, M., Norden, A., Pugsley, W. & Unwin, R., 1 Aug 2003, In: Intensive care medicine. 29, 8, p. 1364-1367 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Neprilysin 50%
  • Marker 37%
  • Heart Surgery 37%
  • Measurement 25%