John Castle

John Castle

Mr

 https://orcid.org/0000-0001-8213-9775
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Personal profile

Research interests

I work with Prof. Cliona Kirwan on her research into the symbiotic relationship between cancer and clotting. Whilst cancer seems to promote clotting, the clotting system helps cancer grow and spread. This therefore provides the potential to treat cancer through targeting the clotting system.

I am based at the Manchester Cancer Research Centre where I study systemic and tissue biomarkers of hypercoagulability and cancer, as well as cancer stem cells and the tumour microenvironment. My work focuses on breast and colorectal cancer through the studies WiSDen, CHAMPion, T-POETIC and TuFClot as well as the currently recruiting TIP Trial.

My collaborations

Prof. Cliona Kirwan (Supervisor)

 

Prof. Robert Clarke
Prof. Caroline Dive

 

 

Fellow Team Members:

Dr. Emma Blower

Ms. Urvashi Singh

Dr. Sophie Greenhalgh

Dr. Adam Rees

Dr. Hudhaifah Shaker

Dr. Hamish Clouston

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Beacons, Institutes and Platforms

  • Cancer
  • Manchester Cancer Research Centre

Keywords

  • Cancer
  • Coagulation
  • Breast Biology, Breast Cancer Stem Cells, Endocrine Resistance, Breast Cancer Prevention
  • Colorectal

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