Research output per year
Research output per year
Personal profile
Research interests
I work with Prof. Cliona Kirwan on her research into the symbiotic relationship between cancer and clotting. Whilst cancer seems to promote clotting, the clotting system helps cancer grow and spread. This therefore provides the potential to treat cancer through targeting the clotting system.
I am based at the Manchester Cancer Research Centre where I study systemic and tissue biomarkers of hypercoagulability and cancer, as well as cancer stem cells and the tumour microenvironment. My work focuses on breast and colorectal cancer through the studies WiSDen, CHAMPion, T-POETIC and TuFClot as well as the currently recruiting TIP Trial.
My collaborations
Prof. Cliona Kirwan (Supervisor)
Prof. Robert Clarke
Prof. Caroline Dive
Fellow Team Members:
Dr. Emma Blower
Ms. Urvashi Singh
Dr. Sophie Greenhalgh
Dr. Adam Rees
Dr. Hudhaifah Shaker
Dr. Hamish Clouston
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Beacons, Institutes and Platforms
- Cancer
- Manchester Cancer Research Centre
Keywords
- Cancer
- Coagulation
- Breast Biology, Breast Cancer Stem Cells, Endocrine Resistance, Breast Cancer Prevention
- Colorectal
Fingerprint
Dive into the research topics where John Castle is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
-
Breast cancer stromal clotting activation (Tissue Factor and thrombin): A pre-invasive phenomena that is prognostic in invasion. a pre-invasive phenomena that is prognostic in invasion
Castle, J. & Kirwan, C., 21 Jan 2020, In: Cancer Medicine.Research output: Contribution to journal › Article › peer-review
Open Access -
Circulating tumour cells and hypercoagulability: a lethal relationship in metastatic breast cancer
Kirwan, C. C., Descamps, T. & Castle, J., 31 Aug 2019, In: Clinical and Translational Oncology.Research output: Contribution to journal › Article › peer-review
Open Access -
Challenges in enumeration of CTCs in breast cancer using techniques independent of cytokeratin expression
Castle, J., Morris, K., Pritchard, S. A. & Kirwan, C. C., 19 Apr 2017, In: PLoS ONE. 12, 4, e0175647.Research output: Contribution to journal › Article › peer-review
Open Access -
The significance of circulating tumour cells in breast cancer: A review
Castle, J., Shaker, H., Morris, K., Tugwood, J. D. & Kirwan, C. C., Oct 2014, In: The Breast. 23, 5, p. 552-60 9 p.Research output: Contribution to journal › Review article › peer-review
Datasets
-
Raw Data for 'The effects of coagulation factors and their inhibitors on proliferation and migration in colorectal cancer'.
Rees, P. A. (Creator), Castle, J. (Creator), Clouston, H. (Creator), Singh, U. (Creator), Duff, S. (Creator) & Kirwan, C. (Creator), University of Manchester Figshare, 12 May 2023
DOI: 10.48420/22787444, https://figshare.manchester.ac.uk/articles/dataset/Raw_Data_for_The_effects_of_coagulation_factors_and_their_inhibitors_on_proliferation_and_migration_in_colorectal_cancer_/22787444 and one more link, https://figshare.manchester.ac.uk/articles/dataset/Raw_Data_for_The_effects_of_coagulation_factors_and_their_inhibitors_on_proliferation_and_migration_in_colorectal_cancer_/22787444/1 (show fewer)
Dataset
-
TuFClot Study Raw Data 04JUL2019
Castle, J. (Contributor), Kirwan, C. (Contributor) & Descamps, T. (Contributor), Mendeley Data, 11 Jul 2019
DOI: 10.17632/742ftgfg54.2, https://data.mendeley.com/datasets/742ftgfg54
Dataset