Research output per year
Research output per year
Dr
Dr. John Grainger obtained his BSc in Molecular Biology from University College London in 2004. Following this, he undertook his MRes and PhD at the University of Edinburgh on the Wellcome Trust funded Molecular Basis of Disease programme. The focus of his PhD work was exploring mechanisms used by gastrointestinal worms to modulate the host's adaptive immune system in order to improve their own survival. As part of these studies he identified a novel mechanism by which helminths secrete TGF-β homologues to suppress the inflammatory response. After his PhD John moved in 2009 as a visiting research fellow to the Laboratory of Parasitic Diseases at the National Institutes of Health (NIH), USA, where he developed an interest in novel functions of immune cell populations during infection. His recent studies have predominantly focused on understanding innate cell responses towards the commensal microbiota during acute pathogen infection.
The lab is focussed on understanding the mechanisms that regulate myeloid cells, particularly monocytes and macrophages, in health and disease with a view to supporting the development of targeted therapies. We also investigate whether the activation of myeloid cells can be used as a precision medicine tool to identify groups of patients that are responsive to particular treatments.
There are three current research themes in the lab:
Gut and Oral Macrophages - In collaboration with the Konkel Lab, we are investigating how gut and oral macrophages differentiate and their roles in health and inflammation. We are particularly interested in the functions of gut macrophages in allergic-type (type 2) inflammation.
Stroke Immunology - A poorly understood complication of a stroke (when blood stops flowing to a part of your brain) is aberrant activation of the immune system. Working with Prof. Stuart Allan (Brain Inflammation Group), Prof. Craig Smith (Stroke Medicine, Salford Royal Hospital) and the Stroke-IMPaCT network we are trying to understand how interactions between the immune system and brain lead to post-stroke infection and cognitive decline.
Human Immunophenotyping Across Diseases
Rufus Daw - Postdoctoral Researcher
Sabrina Tamburrano - Postdoctoral Researcher
Tom Williams - Postdoctoral Researcher
Natasha Carmichael - MB-PhD Student
Harry Deijnen - PhD Student
Esther Nansubuga - MB-PhD Student
Joana Costa Oliveira - PhD Student
Hayley Bridgeman - Technician
Alexandra Matejcikove - Technician
Mon: 09:15 - 17:00
Tue: 08:30 - 16:30
Wed: 08:30 - 16:30
Thu: 08:30 - 16:30
Fri: 08:30 - 16:30
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Allan, S. (PI), Grainger, J. (CoI) & Smith, C. (CoI)
1/02/18 → 31/01/21
Project: Research