Research output per year
Research output per year
- 31 results
Search results
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2022
eEF2K activity is required for the phenotypes of the Rpl24 mouse
Knight, J. R. P., Proud, C. G., Mallucci, G., Haar, T. V. D., Smales, C. M., Willis, A. E. & Sansom, O. J., 15 Jul 2022, In: Journal of Investigative Dermatology.Research output: Contribution to journal › Letter › peer-review
Open Access -
2021
MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression
Knight, J. R. P., Alexandrou, C., Skalka, G. L., Vlahov, N., Pennel, K., Officer, L., Teodosio, A., Kanellos, G., Gay, D. M., May-Wilson, S., Smith, E. M., Najumudeen, A. K., Gilroy, K., Ridgway, R. A., Flanagan, D. J., Smith, R. C. L., McDonald, L., MacKay, C., Cheasty, A. & McArthur, K. & 19 others, , 1 May 2021, In: Cancer discovery. 11, 5, p. 1228-1247 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
Knight, J. R. P., Vlahov, N., Gay, D. M., Ridgway, R. A., Faller, W. J., Proud, C. G., Mallucci, G. R., Haar, T. V. D., Smales, C. M., Willis, A. E. & Sansom, O. J., 5 May 2021, bioRxiv, p. 1-57, 57 p. (COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv).Research output: Preprint/Working paper › Preprint
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Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
Knight, J. R. P., Vlahov, N., Gay, D. M., Ridgway, R. A., Faller, W. J., Proud, C., Mallucci, G. R., von der Haar, T., Smales, C. M., Willis, A. E. & Sansom, O. J., Dec 2021, In: eLife. 10, e69729.Research output: Contribution to journal › Article › peer-review
Open Access -
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer
CRUK Rosetta Grand Challenge Consortium, 7 Jan 2021, In: Nature Genetics. 53, 1, p. 16-26 11 p.Research output: Contribution to journal › Article › peer-review
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Translation initiation in cancer at a glance
Smith, R. C. L., Kanellos, G., Vlahov, N., Alexandrou, C., Willis, A. E., Knight, J. R. P. & Sansom, O. J., 13 Jan 2021, In: Journal of Cell Science. 134, 1, jcs248476.Research output: Contribution to journal › Article › peer-review
Open Access -
Tuning protein synthesis for cancer therapy
Knight, J. R. P. & Sansom, O. J., 4 Mar 2021, In: Molecular & cellular oncology.Research output: Contribution to journal › Review article › peer-review
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2020
BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration
Loveridge, C. J., Slater, S., Campbell, K. J., Nam, N. A., Knight, J., Ahmad, I., Hedley, A., Lilla, S., Repiscak, P., Patel, R., Salji, M., Fleming, J., Mitchell, L., Nixon, C., Strathdee, D., Neilson, M., Ntala, C., Bryson, S., Zanivan, S. & Edwards, J. & 4 others, , 20 Feb 2020, In: Oncogene. 39, 8, p. 1797-1806 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Control of translation elongation in health and disease
Knight, J., Garland, G., Pöyry, T., Mead, E., Vlahov, N., Sfakianos, A., Grosso, S., De-Lima-Hedayioglu, F., Mallucci, G., von der Haar, T., Smales, C. M., Sansom, O. J. & Willis, A. E., 1 Mar 2020, In: Disease Models & Mechanisms. 13, 3Research output: Contribution to journal › Review article › peer-review
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2019
A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer
Schmidt, S., Gay, D., Uthe, F. W., Denk, S., Paauwe, M., Matthes, N., Diefenbacher, M. E., Bryson, S., Warrander, F. C., Erhard, F., Ade, C. P., Baluapuri, A., Walz, S., Jackstadt, R., Ford, C., Vlachogiannis, G., Valeri, N., Otto, C., Schülein-Völk, C. & Maurus, K. & 10 others, , 1 Nov 2019, In: Nature Cell Biology. 21, 11, p. 1413-1424 12 p.Research output: Contribution to journal › Article › peer-review
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Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas
Liko, D., Mitchell, L., Campbell, K. J., Ridgway, R. A., Jones, C., Dudek, K., King, A., Bryson, S., Stevenson, D. A., Blyth, K., Strathdee, D., Morton, J. P., Bird, T. G., Knight, J. R. P., Willis, A. E. & Sansom, O. J., 1 Dec 2019, In: Cell Death and Differentiation. 26, 12, p. 2535-2550 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling
Kugeratski, F. G., Atkinson, S. J., Neilson, L. J., Lilla, S., Knight, J. R. P., Serneels, J., Juin, A., Ismail, S., Bryant, D. M., Markert, E. K., Machesky, L. M., Mazzone, M., Sansom, O. J. & Zanivan, S., 5 Feb 2019, In: Science Signaling. 12, 567, eaan8247.Research output: Contribution to journal › Article › peer-review
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2018
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
Novo, D., Heath, N., Mitchell, L., Caligiuri, G., MacFarlane, A., Reijmer, D., Charlton, L., Knight, J., Calka, M., McGhee, E., Dornier, E., Sumpton, D., Mason, S., Echard, A., Klinkert, K., Secklehner, J., Kruiswijk, F., Vousden, K., Macpherson, I. R. & Blyth, K. & 6 others, , 1 Dec 2018, In: Nature Communications. 9, 1, 5069.Research output: Contribution to journal › Article › peer-review
Open Access -
TAp73 contributes to the oxidative stress response by regulating protein synthesis
Marini, A., Rotblat, B., Sbarrato, T., Niklison-Chirou, M. V., Knight, J. R. P., Dudek, K., Jones, C., Bushell, M., Knight, R. A., Amelio, I., Willis, A. E. & Melino, G., 12 Jun 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 24, p. 6219-6224 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3
Bastide, A., Peretti, D., Knight, J. R. P., Grosso, S., Spriggs, R. V., Pichon, X., Sbarrato, T., Roobol, A., Roobol, J., Vito, D., Bushell, M., von der Haar, T., Smales, C. M., Mallucci, G. R. & Willis, A. E., 6 Mar 2017, In: Current Biology. 27, 5, p. 638-650 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells
Tan, T. C. J., Knight, J., Sbarrato, T., Dudek, K., Willis, A. E. & Zamoyska, R., 25 Jul 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. E6117-E6126 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2016
Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis
Knight, J. R. P., Bastide, A., Peretti, D., Roobol, A., Roobol, J., Mallucci, G. R., Smales, C. M. & Willis, A. E., Apr 2016, In: RNA. 22, 4, p. 623-635 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Ribosomes and Stress - Linked from Birth to Death
Knight, J. R. P., Sbarrato, T., Stoneley, M. & Willis, A. E., 2016, Functional Cell Biology. Elsevier BV, Vol. 3. p. 270-280 11 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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2015
A common polymorphism in the 5’ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy
Somers, J., Wilson, L. A., Kilday, J. P., Horvilleur, E., Cannell, I. G., Pöyry, T. A. A., Cobbold, L. C., Kondrashov, A., Knight, J. R. P., Puget, S., Grill, J., Grundy, R. G., Bushell, M. & Willis, A. E., 15 Sept 2015, In: Genes and development. 29, 18, p. 1891-1896 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Control of translation in the cold: Implications for therapeutic hypothermia
Knight, J. R. P. & Willis, A. E., 1 Jun 2015, In: Biochemical Society Transactions. 43, p. 333-337 5 p.Research output: Contribution to journal › Review article › peer-review
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Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation
Knight, J. R. P., Bastide, A., Roobol, A., Roobol, J., Jackson, T. J., Utami, W., Barrett, D. A., Smales, C. M. & Willis, A. E., 15 Jan 2015, In: Biochemical Journal. 465, p. 227-238 12 p.Research output: Contribution to journal › Article › peer-review
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MTORC1-mediated translational elongation limits intestinal tumour initiation and growth
Faller, W. J., Jackson, T. J., Knight, J. R. P., Ridgway, R. A., Jamieson, T., Karim, S. A., Jones, C., Radulescu, S., Huels, D. J., Myant, K. B., Dudek, K. M., Casey, H. A., Scopelliti, A., Cordero, J. B., Vidal, M., Pende, M., Ryazanov, A. G., Sonenberg, N., Meyuhas, O. & Hall, M. N. & 3 others, , 22 Jan 2015, In: Nature . 517, 7535, p. 497-500 4 p.Research output: Contribution to journal › Article › peer-review
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P58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity
Roobol, A., Roobol, J., Bastide, A., Knight, J. R. P., Willis, A. E. & Smales, C. M., 15 Jan 2015, In: Biochemical Journal. 465, p. 213-225 13 p.Research output: Contribution to journal › Article › peer-review
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Transient association of MCM complex proteins with the nuclear matrix during initiation of mammalian DNA replication
Hesketh, E. L., Knight, J. R. P., Wilson, R. H. C., Chong, J. P. J. & Coverley, D., 1 Feb 2015, In: Cell Cycle. 14, 3, p. 333-341 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2014
Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways
Allison, S. J., Knight, J. R. P., Granchi, C., Rani, R., Minutolo, F., Milner, J. & Phillips, R. M., 12 May 2014, In: Oncogenesis. 3, e102.Research output: Contribution to journal › Article › peer-review
Open Access -
The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: B, i and h
Roobol, A., Roobol, J., Carden, M. J., Smith, M. E., Hershey, J. W. B., Bastide, A., Knight, J. R. P., Willis, A. E. & Smales, C. M., 1 Mar 2014, In: Biochemical Journal. 458, 2, p. 213-224 12 p.Research output: Contribution to journal › Article › peer-review
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2013
Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity
Knight, J. R. P., Allison, S. J. & Milner, J., 20 Nov 2013, In: Open Biology. 3, NOV, 130130.Research output: Contribution to journal › Article › peer-review
Open Access -
Active regulator of SIRT1 is required for ribosome biogenesis and function
Knight, J. R. P., Willis, A. E. & Milner, J., Apr 2013, In: Nucleic acids research. 41, 7, p. 4185-4197 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2012
A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes
Shah, Z. H., Ahmed, S. U., Ford, J. R., Allison, S. J., Knight, J. R. P. & Milner, J., Feb 2012, In: Molecular and Cellular Biology. 32, 3, p. 704-716 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
SIRT1, metabolism and cancer.
Knight, J. R. P. & Milner, J., Jan 2012, In: Current opinion in oncology. 24, 1, p. 68-75 8 p.Research output: Contribution to journal › Review article › peer-review
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2011
Cyclin e is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells
Munkley, J., Copeland, N. A., Moignard, V., Knight, J. R. P., Greaves, E., Ramsbottom, S. A., Pownall, M. E., Southgate, J., Ainscough, J. F. X. & Coverley, D., Apr 2011, In: Nucleic acids research. 39, 7, p. 2671-2677 7 p.Research output: Contribution to journal › Article › peer-review
Open Access