Research output per year
Research output per year
- 1 - 50 out of 94 results
Search results
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2021
Solid state structure of sodium β-1-thiophenyl glucuronate identifies 5-coordinate sodium with three independent glucoronates
Gardiner, J., Whitehead, G., Vitorica-Yrezabal, I. & Alharthi, F., 6 Mar 2021, In: Carbohydrate Research.Research output: Contribution to journal › Article › peer-review
Open AccessFile89 Downloads (Pure) -
2020
Synthesis, Structural Characterization, and Computational Study of New (E)-N'-(3,4-dimethoxybenzylidene)furan-2-carbohydrazide
Mkadmh, A., Morjan, R. Y., Raftery, J., Awadallah, A. M. & Gardiner, J., 25 Jan 2020, In: Arabian Journal of Chemistry. 13, 1, p. 3571-3584 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
C3 and C6 Modification-Specific OYE Biotransformations of Synthetic Carvones and Sequential BVMO Chemoenzymatic Synthesis of Chiral Caprolactones
Issa, I. S., Toogood, H. S., Johannissen, L. O., Raftery, J., Scrutton, N. S. & Gardiner, J. M., 26 Feb 2019, In: Chemistry - A European Journal. 25, 12, p. 2983 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Synthesis of Heparan Sulfate- and Dermatan Sulfate-Related Oligosaccharides via Iterative Chemoselective Glycosylation Exploiting Conformationally Disarmed [2.2.2] l-Iduronic Lactone Thioglycosides
Jeanneret, R. A., Dalton, C. E. & Gardiner, J. M., 6 Dec 2019, In: The Journal of organic chemistry. 84, p. 15063 15 p.Research output: Contribution to journal › Article › peer-review
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2018
Chemoenzymatic Synthesis of the Intermediates in the Peppermint Monoterpenoid Biosynthetic Pathway
Cheallaigh, A. N., Mansell, D. J., Toogood, H. S., Tait, S., Lygidakis, A., Scrutton, N. S. & Gardiner, J. M., 27 Jul 2018, In: Journal of Natural Products. 81, 7, p. 1546-1552 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Engineering the ‘Missing Link’ in Biosynthetic (–)-Menthol Production: Bacterial Isopulegone Isomerase
Currin, A., Dunstan, M., Johannissen, L., Hollywood, K., Vinaixa, M., Jervis, A., Swainston, N., Rattray, N., Gardiner, J., Kell, D., Takano, E., Toogood, H. & Scrutton, N., 24 Jan 2018, In: ACS Catalysis. 8, 3, p. 2012-2020 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Evaluation of neomycin analogues for HIV-1 RRE RNA recognition identifies enhanced activity simplified neamine analogues
Simon, B., Walmsley, C., Jackson, V. J., Garvey, E. P., Slater, M. J., Berrisford, D. J. & Gardiner, J. M., 2018, In: Bioorganic & medicinal chemistry letters.Research output: Contribution to journal › Article › peer-review
Open AccessFile158 Downloads (Pure) -
Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hydroxypropane-1,2,3-tricarboxylate).
Morjan, R. Y., El-Kurdi, S. M., Azarah, J. N., Eleiwa, N. A., Abu-Teim, O. S., Awadallah, A. M., Raftery, J. & Gardiner, J., 2018, In: Acta Crystallographica. Section E: Crystallographic communications.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Excited State Properties of Protochlorophyllide Analogues and Implications for Light Driven Synthesis of Chlorophyll
Heyes, D., Hardman, S., Mansell, D., Ni Cheallaigh, A., Gardiner, J., Johannissen, L., Greetham, G. M., Towrie, M. & Scrutton, N., 2017, In: The Journal of Physical Chemistry Part B.Research output: Contribution to journal › Article › peer-review
Open AccessFile97 Downloads (Pure) -
Metabolism of steroidal lactones by the fungus Corynespora cassiicola CBS 161.60 results in a mechanistically unique intramolecular ring-D cyclization resulting in C-14 spiro-lactones
Hunter, A. C., Oni, Y. I., Dodd, H. T., Raftery, J., Gardiner, J. M. & Uttley, M., Sept 2017, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1862, 9, p. 939-945 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile248 Downloads (Pure) -
Pyrazolobenzothiazine-based carbothioamides as new structural leads for the inhibition of monoamine oxidases: design, synthesis, in vitro bioevaluation and molecular docking studies
Abid, S. M. A., Aslam, S., Zaib, S., Bakht, S. M., Ahmad, M., Athar, M. M., Gardiner, J. & Iqbal, J., 2017, In: MedChemComm.Research output: Contribution to journal › Article › peer-review
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Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1,8-cineole synthase
Karuppiah, V., Ranaghan, K. E., Leferink, N., Johannissen, L., Shanmugam, M., Ni Cheallaigh, A., Bennett, N. J., Takano, E., Gardiner, J., van der Kamp, M. W., Hay, S., Mulholland, A. J., Leys, D. & Scrutton, N., 2017, In: ACS Catalysis.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural insights into the ene-‐reductase synthesis of Profens
Waller, J., Toogood, H., Karuppiah, V., Rattray, N., Mansell, D., Leys, D., Gardiner, J., Fryszkowska, A., Ahmed, S. T., Bandichhor, R., Reddy, G. P. & Scrutton, N., 2017, In: Organic and Biomolecular Chemistry.Research output: Contribution to journal › Article › peer-review
Open Access -
2016
An updated synthesis of the diazo-transfer reagent imidazole- 1-sulfonyl azide hydrogen sulfate
Potter, G., Jayson, G., Miller, G. & Gardiner, J., 21 Mar 2016, (Accepted/In press) In: Journal of Organic Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile843 Downloads (Pure) -
Pinpointing a mechanistic switch between ketoreduction and ‘ene’-reduction in short chain dehydrogenases/reductases
Lygidakis, A., Karuppiah, V., Hoeven, R., Ni Cheallaigh, A., Leys, D., Gardiner, J., Toogood, H. & Scrutton, N., 8 Aug 2016, In: Angewandte Chemie. 55, 33, p. 9596-9600 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Preparation of Methyl 1,2,3,4-tetra-O-acetyl-β-Dglucopyranuronate
Ni Cheallaigh, A., Potter, G. T., Gardiner, J. & Miller, G., 2016, In: Organic Syntheses. 93, p. 200-209Research output: Contribution to journal › Article › peer-review
Open AccessFile751 Downloads (Pure) -
Single-molecule Fluorescence Detection of a Synthetic Heparan Sulfate Disaccharide
Dalton, C. E., Quinn, S. D., Rafferty, A., Morten, M. J., Gardiner, J. & Magennis, S., 2016, In: ChemPhysChem.Research output: Contribution to journal › Article › peer-review
Open AccessFile89 Downloads (Pure) -
Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo.
Avizienyte, E., Cole, C., Rushton, G., Miller, G., Bugatti, A., Presta, M., Gardiner, J. & Jayson, G., 4 Aug 2016, In: PLoS ONE. 11, 8, e0159739.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides
Miller, G., Broberg, K., Rudd, C., Helliwell, M., Jayson, G. & Gardiner, J., 9 Sept 2015, In: Organic & biomolecular chemistry. 13, 46, p. 11208-11219Research output: Contribution to journal › Article › peer-review
Open Access -
Amyl nitrite-mediated conversion of aromatic and heteroaromatic primary amides to carboxylic acids
Potter, G., Miller, G., Jayson, G. & Gardiner, J. M., May 2015, In: Tetrahedron Letters. p. 5153-5156 3 p.Research output: Contribution to journal › Article › peer-review
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Enzymatic Menthol Production: One-pot Approach Using Engineered Escherichia coli.
Toogood, H., Ni Cheallaigh, A., Tait, S., Mansell, D. J., Jervis, A., Lygidakis, A., Humphreys, L. D., Takano, E., Gardiner, J. & Scrutton, N. S., 27 May 2015, In: A C S Synthetic Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Making the longest sugars: a chemical synthesis of heparin-related [4]n oligosaccharides from 16-mer to 40-mer
Hansen, S. U., Miller, G. J., Cliff, M. J., Jaysonc, G. C. & Gardiner, J. M., 24 Jul 2015, In: Chemical Science. 6, 11, p. 6158-6164 6 p.Research output: Contribution to journal › Article › peer-review
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Modular synthesis of heparin-related tetra-, hexa- and octasaccharides with differential O-6 protections: programming for regio-defined 6 Omodifications
Baráth, M., Hansen, S. U., Dalton, C. E., Jayson, G. C., Miller, G. J. & Gardiner, J. M., 2015, In: Molecules. 20, 4, p. 6167-6180 13 p.Research output: Contribution to journal › Article › peer-review
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Molecular docking and anti-viral screening of N-substituted benzyl/phenyl-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl)acetamides
Ahmad, M., Aslam, S., Rizvi, S. U., Muddassar, M., Ashfaq, U. A., Montero, C., Ollinger, O., Detorio, M., Gardiner, J. & Schinazi, R. F., 2015, In: Bioorganic & medicinal chemistry letters. p. 1348-1351 3 p.Research output: Contribution to journal › Article › peer-review
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Synthesis, antibacterial, and QSAR evaluation of 5- oxo and 5-thio derivatives of 1,4-disubstituted tetrazoles
Morjan, R. Y., El-Attar, N., Abu-Tiem, O., Ulrich, M., Awadallah, A. M., Mkadmh, A. M., Elmanama, A. A., Raftery, J., Abu-Awwad, F. M., Yaseen, Z. J., Elqidra, A. F. & Gardiner, J. M., 2015, In: Bioorganic & medicinal chemistry letters.Research output: Contribution to journal › Article › peer-review
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Synthesis of L‐iduronic acid derivatives via [3.2.1] and [2.2.2] L‐iduronic lactones from bulk glucose-derived cyanohydrin hydrolysis: A reversible conformationally-switched superdisarmed/rearmed lactone route to heparin disaccharides
Hansen, S. U., Dalton, C. E., Baráth, M., Kwan, G., Raftery, J., Jayson, G. C., Miller, G. J. & Gardiner, J. M., 2015, In: The Journal of organic chemistry. 80, p. 3777-3789 12 p.Research output: Contribution to journal › Article › peer-review
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Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology
Jayson, G. C., Hansen, S. U., Miller, G. J., Cole, C. L., Rushton, G., Avizienyte, E. & Gardiner, J. M., 18 Sept 2015, In: Chemical Communications. 51, 72, p. 13846-9 4 p.Research output: Contribution to journal › Article › peer-review
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The influence of few-layer graphene on the gas permeability of the high-free-volume polymer PIM-1
Althumayri, K., Harrison, W. J., Shin, Y., Gardiner, J. M., Casiraghi, C., Budd, P., Bernardo, P., Clarizia, G. & Jansen, J. C., 2015, In: Royal Society of London. Philosophical Transactions A. Mathematical, Physical and Engineering Sciences.Research output: Contribution to journal › Article › peer-review
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2014
Antibacterial activities of novel synthetic N-acylhydrazones of nicotinic acid hydrazide and their conversion into N-acetyl-1,3,4-oxadiazoles
Morjan, R. Y., Mkadmh, A. M., Beadham, I., Elmanama, A. A., Mattar, M. R., Raftery, J., Pritchard, R. G., Adel M. Awadallah, A. M. & Gardiner, J. M., 2014, In: Bioorganic & medicinal chemistry letters.Research output: Contribution to journal › Article › peer-review
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Inhibition of quorum sensing and biofilm formation in Vibrio harveyi by 4-fluoro-DPD; A novel potent inhibitor of AI-2 signalling
Kadirvel, M., Fanimarvasti, F., Forbes, S., McBain, A., Gardiner, J. M., Brown, G. D. & Freeman, S., 21 May 2014, In: Chemical Communications. 50, 39, p. 5000-5002 2 p.Research output: Contribution to journal › Article › peer-review
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Novel structural hybrids of pyrazolobenzothiazines with benzimidazoles as cholinesterase inhibitors
Aslam, S., Zaib, S., Ahmad, M., Gardiner, J. M., Ahmad, A., Hameed, A., Furtmann, N., Gütschow, M., Bajorath, J. & Iqbal, J., 6 May 2014, In: European Journal of Medicinal Chemistry. 78, p. 106-117 11 p.Research output: Contribution to journal › Article › peer-review
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Reaction of Nitrilimines with 2-Aminopicoline, 3-Amino-1,2,4-triazole, 5-Aminotetrazole and 2-Aminopyrimidine
Morjan, R. Y., Qesta, B. S., Al-Shayyah, H. T., Gardiner, J. M., Thaher, B. A. A. & Awadallah, A. M., 2014, In: International Journal of Organic Chemistry. 4, p. 201-207 6 p.Research output: Contribution to journal › Article › peer-review
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Synthesis of a heparin-related GlcN–IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy.
Miller, G. J., Hansen, S. U., Baráth, M., Johannessen, C., Blanch, E. W., Jayson, G. C. & Gardiner, J. M., 2014, In: Carbohydrate Research. 400, p. 44-53 9 p.Research output: Contribution to journal › Article › peer-review
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The development of anti-angiogenic heparan sulfate oligosaccharides
Jayson, G., Miller, G. J., Hansen, S. U., Barath, M., Gardiner, J. & Avizienyte, E., 1 Dec 2014, In: Biochemical Society. Transactions. 42, 6, p. 1596-1600Research output: Contribution to journal › Article › peer-review
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2013
(Z)-1-Chloro-1-[2-(2-nitrphenyl)hydrazinylidene]propan-2-one
Morjan, R. Y., Abu Thaher, B. A., Schollmeyer, D., Awadallah, A. M. & Gardiner, J. M., 1 Jan 2013, In: Acta Crystallographica Section E: Structure Reports Online. 69, 1Research output: Contribution to journal › Article › peer-review
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Biocatalytic asymmetric alkene reduction: Crystal structure and characterization of a double bond reductase from Nicotiana tabacum
Mansell, D. J., Toogood, H. S., Waller, J., Hughes, J. M. X., Levy, C. W., Gardiner, J. M. & Scrutton, N. S., 2013, In: ACS Catalysis. 3, 3, p. 370-379 9 p.Research output: Contribution to journal › Article › peer-review
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Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2- and VEGF165-mediated endothelial cell functions
Miller, G. J., Hansen, S. U., Avizienyte, E., Rushton, G., Cole, C., Jayson, G. C., Gardiner, J. M. & Mcdonald, E., Aug 2013, In: Chemical Science. 4, 8, p. 3218-3222 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Downloads (Pure) -
First gram-scale synthesis of a heparin-related dodecasaccharide
Hansen, S. U., Miller, G. J., Jayson, G. C. & Gardiner, J. M., 4 Jan 2013, In: Organic Letters. 15, 1, p. 88-91 3 p.Research output: Contribution to journal › Article › peer-review
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Small-molecule-induced clustering of heparan sulfate promotes cell adhesion
Takemoto, N., Suehara, T., Frisco, H. L., Sato, S. I., Sezaki, T., Kusamori, K., Kawazoe, Y., Park, S. M., Yamazoe, S., Mizuhata, Y., Inoue, R., Miller, G. J., Hansen, S. U., Jayson, G. C., Gardiner, J. M., Kanaya, T., Tokitoh, N., Ueda, K., Takakura, Y. & Kioka, N. & 2 others, , 31 Jul 2013, In: Journal of the American Chemical Society. 135, 30, p. 11032-11039 7 p.Research output: Contribution to journal › Article › peer-review
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Synthesis, structural characterization, and computational study of novel (E)-N′-(1-p-tolylethylidene)furan-2-carbohydrazide
Morjan, R. Y., Mkadmh, A. M., Abu-Awwad, F. M., Helliwell, M., Awadallah, A. M. & Gardiner, J. M., 2013, In: Journal of Molecular Structure. 1051, p. 345-353 8 p.Research output: Contribution to journal › Article › peer-review
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Synthesis and antioxidant studies of novel N-substituted benzyl/phenyl-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H) -yl)acetamides
Ahmad, M., Siddiqui, H. L., Gardiner, J. M., Parvez, M. & Aslam, S., Feb 2013, In: Medicinal Chemistry Research. 22, 2, p. 794-805 11 p.Research output: Contribution to journal › Article › peer-review
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Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies
Hansen, S. U., Miller, G. J., Cole, C., Rushton, G., Avizienyte, E., Jayson, G. C., Gardiner, J. M. & Mcdonald, E., 2013, In: Nature Communications. 4, 3016.Research output: Contribution to journal › Article › peer-review
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2012
A surprising observation that oxygen can affect the product enantiopurity of an enzyme-catalysed reaction
Fryszkowska, A., Toogood, H. S., Mansell, D., Stephens, G., Gardiner, J. M. & Scrutton, N. S., Nov 2012, In: FEBS Journal. 279, 22, p. 4160-4171 11 p.Research output: Contribution to journal › Article › peer-review
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Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor
Ferreras, C., Rushton, G., Cole, C. L., Babur, M., Telfer, B. A., Van Kuppevelt, T. H., Gardiner, J. M., Williams, K. J., Jayson, G. C. & McDonald, E., 19 Oct 2012, In: Journal of Biological Chemistry. 287, 43, p. 36132-36146 14 p.Research output: Contribution to journal › Article › peer-review
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Mechanistic Reappraisal of Early Stage Photochemistry in the Light-Driven Enzyme Protochlorophyllide Oxidoreductase
Heyes, D. J., Hardman, S. J. O., Mansell, D., Gardiner, J. M. & Scrutton, N. S., 26 Sept 2012, In: PLoS ONE. 7, 9, e45642.Research output: Contribution to journal › Article › peer-review
Open Access -
Synthesis and scalable conversion of L-iduronamides to heparin-related Di- and tetrasaccharides
Hansen, S. U., Miller, G. J., Baráth, M., Broberg, K. R., Avizienyte, E., Helliwell, M., Raftery, J., Jayson, G. C., Gardiner, J. M. & Mcdonald, E., 21 Sept 2012, In: Journal of Organic Chemistry. 77, 18, p. 7823-7843 20 p.Research output: Contribution to journal › Article › peer-review
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2011
Active site modifications in pentaerythritol tetranitrate reductase can lead to improved product enantiopurity, decreased by-product formation and altered stereochemical outcome in reactions with α,β-unsaturated nitroolefins
Fryszkowska, A., Toogood, H., Sakuma, M., Stephens, G. M., Gardiner, J. M. & Scrutton, N. S., Sept 2011, In: Catalysis Science and Technology. 1, 6, p. 948-957 9 p.Research output: Contribution to journal › Article › peer-review
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A Site-Saturated Mutagenesis Study of Pentaerythritol Tetranitrate Reductase Reveals that Residues 181 and 184 Influence Ligand Binding, Stereochemistry and Reactivity
Toogood, H. S., Fryszkowska, A., Hulley, M., Sakuma, M., Mansell, D., Stephens, G. M., Gardiner, J. M. & Scrutton, N. S., 21 Mar 2011, In: ChemBioChem: a European journal of chemical biology . 12, 5, p. 738-749 11 p.Research output: Contribution to journal › Article › peer-review
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A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation
Miller, G. J. & Gardiner, J. M., 22 Jun 2011, In: Tetrahedron Letters. 52, 25, p. 3216-3218 2 p.Research output: Contribution to journal › Article › peer-review
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2010
Adaptable synthesis of C-glycosidic multivalent carbohydrates and succinamide-linked derivatization
Miller, G. J. & Gardiner, J. M., 19 Nov 2010, In: Organic Letters. 12, 22, p. 5262-5265 3 p.Research output: Contribution to journal › Article › peer-review