Research output per year
Research output per year
Personal profile
Biography
Prof Valle was appointed as a Consultant in Medical Oncology at The Christie having completed his training in Medical Oncology in Manchester in 2010. He works within the gastrointestinal disease group and has developed a specialist interest in HPB and NETs.
Major achievements include international recognition for research in the field of biliary tract cancers, particularly through establishing the reference treatment for patients with advanced disease [ABC-02 study, published in the prestigious New Engl J Med in 2010]. This has provided a platform for follow-on studies as well as studies in earlier stages of the disease. He has also been involved in practice changing studies in NETs [also published in New Engl J Med in 2011] and pancreatic cancer [see publication list].
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Beacons, Institutes and Platforms
- Manchester Cancer Research Centre
Keywords
- pancreatic cancer
- cancer
- cancer sciences
- Christie Hospital
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Advanced intrahepatic cholangiocarcinoma with extrahepatic metastasis and high tumour mutation burden: A case report of complete pathological response to cisplatin/gemcitabine and pembrolizumab
Robinson, M., Wheatley, R., Foster, L., Jamdar, S., Siriwardena, A. K., Lamarca, A., Hubner, R., Valle, J. & Mcnamara, M., 21 Feb 2024, (Accepted/In press) In: JCO Precision Oncology.Research output: Contribution to journal › Article › peer-review
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British Society of Gastroenterology Guidelines for the Diagnosis and Management of Cholangiocarcinoma
Rushbrook, S., Kendall, T. J., Zen, Y., Albazaz, R., Manoharan, P., Pereira, S. P., Sturgess, R., Davidson, B., Malik, H., Manas, D., Heaton, N., Prasad, R., Bridgewater, J., Valle, J. W., Goody, R., Hawkins, M., Prentice, W., Morement, H., Walmsley , M. & Khan , S. A., 1 Jan 2024, In: Gut. 73, 1Research output: Contribution to journal › Article › peer-review
Open Access -
The clinical utility of plasma cell-free DNA (cfDNA) in NET-02: Randomised, phase II trial of liposomal irinotecan (nal-IRI)/5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line (2L) therapy in patients (pts) with progressive poorly differentiated extra-pulmonary neuroendocrine carcinoma (PD-EP-NEC).
Mcnamara, M., Pearce, S., Swain, J., Halford, M. A., Sharma, R., Faluyi, O. O., Wadsley, J., Morgan, C., Wall, L. R., Chau, I., Reed, N., Sarker, D., Margetts, J., Anthoney, A., Oughton, J. B., Lamarca, A., Hubner, R., Rothwell, D. G., Valle, J. W. & Clipson, A., 2024.Research output: Contribution to conference › Abstract › peer-review
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Updated overall survival and outcomes of long-term survivors from the randomised phase 3 TOPAZ-1 study of durvalumab or placebo plus gemcitabine and cisplatin in advanced biliary tract cancer
Mcnamara, M. G., Valle, J. W. & al, E., 22 Mar 2024, (Accepted/In press) In: The Lancet Gastroenterology and Hepatology.Research output: Contribution to journal › Article › peer-review
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ABC-12: Exploring the microbiome in patients (pts) with advanced biliary tract cancer (BTC) in a first-line study of durvalumab in combination with cisplatin/gemcitabine (cis/gem)
Mcnamara, M., Timmons, H., Osborne, A., Cox, R., Wasan, H., Corrie, P., Gillmore, R., Sivakumar, S., Ma, Y. T., Faluyi, O., Arora, A., Arif, S., Canham, J., Hurt, C., Hubner, R. A., Bridgewater, J., Adams, R. & Valle, J. W., 2023.Research output: Contribution to conference › Abstract › peer-review
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NIHR Manchester Biomedical Research Centre
Bruce, I. (PI), Lord, G. (CoI), Lennon, R. (CoI), Black, G. (CoI), Wedge, D. (CoI), Morris, A. (CoI), Hussell, T. (CoI), Sharrocks, A. (CoI), Stivaros, S. (CoI), Buch, M. (CoI), Gough, J. (CoI), Kostarelos, K. (CoI), Thistlethwaite, F. (CoI), Kadler, K. (CoI), Barton, A. (CoI), Hyrich, K. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI), Vestbo, J. (CoI), Simpson, A. (CoI), Singh, S. (CoI), Smith, J. (CoI), Felton, T. (CoI), Murray, C. (CoI), Griffiths, C. (CoI), Cullum, N. (CoI), Rhodes, L. (CoI), Warren, R. (CoI), Paus, R. (CoI), Dumville, J. (CoI), Viros Usandizaga, A. (CoI), Keavney, B. (CoI), Tomaszewski, M. (CoI), Allan, S. (CoI), Body, R. (CoI), Cartwright, E. (CoI), Heagerty, A. (CoI), Kalra, P. (CoI), Miller, C. (CoI), Rutter, M. (CoI), Smith, C. (CoI), Trafford, A. (CoI), Evans, D. (CoI), Crosbie, E. (CoI), Crosbie, P. (CoI), Harvie, M. (CoI), Howell, S. (CoI), Renehan, A. (CoI), Dive, C. (CoI), Blackhall, F. (CoI), Landers, D. (CoI), Krebs, M. (CoI), Cook, N. (CoI), Clarke, R. (CoI), Taylor, S. (CoI), Jorgensen, C. (CoI), Lorigan, P. (CoI), Jayson, G. (CoI), Valle, J. (CoI), Mccabe, M. (CoI), Armstrong, A. (CoI), Freitas, A. (CoI), Illidge, T. (CoI), Choudhury, A. (CoI), Hoskin, P. (CoI), West, C. (CoI), Van Herk, M. (CoI), Faivre-Finn, C. (CoI), Bristow, R. (CoI), Kirkby, K. (CoI), Birtle, A. (CoI), Mackay, R. (CoI), Radford, J. (CoI), Linton, K. (CoI), Higham, C. (CoI), Munro, K. (CoI), Plack, C. (CoI), Arden Armitage, C. (CoI), Bruce, I. (CoI), Moore, D. (CoI), Saunders, G. (CoI), Stone, M. (CoI), Haddock, G. (CoI), Lewis, S. (CoI), Elliott, R. (CoI), Green, J. (CoI), Lovell, K. (CoI), Morrison, A. (CoI), Shaw, J. (CoI), Bucci, S. (CoI), Ainsworth, J. (CoI), Webb, R. (CoI), Newman, W. (CoI), Banka, S. (CoI), Clayton-Smith, J. (CoI), Payne, K. (CoI), Moldovan, R. (CoI), Wynn, R. (CoI) & Jones, S. (CoI)
1/12/22 → 30/11/27
Project: Research
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A Study to Assess the Feasibility of Evaluating BRCAness in Plasma and Tumour Samples from Patients with Advanced Pancreatic Adenocarcinoma.
Mcnamara, M. (PI) & Valle, J. (CoI)
4/09/18 → 3/09/20
Project: Research
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Development of an Alternative 'Precision Medicine' Platform for Identifying and Testing Novel Therapeutic Strategies for Advanced Extra-Pulmonary (EP), Poorly Differentiated (PD), Neuroendocrine Carcinoma (NEC).
Mcnamara, M. (PI), Dive, C. (CoI) & Valle, J. (CoI)
1/07/18 → 30/06/19
Project: Research
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Collins Pancreatic Cancer UK Scholarship.
Valle, J. (PI) & Mcnamara, M. (CoI)
1/04/16 → 30/09/19
Project: Research
Impacts
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Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer (ABC-02). N Engl J Med 362(14): 1273-81
Juan Valle (Corresponding participant)
Impact: Health impacts, Societal impacts
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Defining immunotherapy in combination with chemotherapy as first-line treatment of patients with advanced biliary tract cancer (durvalumab)
Valle, J. (Corresponding participant) & Mcnamara, M. (Participant)
Impact: Health and wellbeing
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Defining the role of second-line chemotherapy for patients with advanced / inoperable biliary tract cancer (FOLFOX (oxaliplatin/5FU))
Juan Valle (Corresponding participant)
Impact: Health and wellbeing
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Establishing a standard of care treatment for biliary tract cancer patients following surgery (capecitabine)
Valle, J. (Corresponding participant)
Impact: Health and wellbeing
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Improved treatment option for patients with previously treated IDH-1 mutated cholangiocarcinoma (bile duct cancer) (Ivosidenib)
Juan Valle (Corresponding participant)
Impact: Health and wellbeing
Datasets
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Supplementary Material for: 68Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management
Lamarca, A. (Contributor), Pritchard, D. M. (Contributor), Westwood, T. (Contributor), Papaxoinis, G. (Contributor), Nonaka, D. (Contributor), Vinjamuri, S. (Contributor), Valle, J. (Contributor), Manoharan, P. (Contributor) & Mansoor, W. (Contributor), figshare , 16 May 2017
DOI: 10.6084/m9.figshare.5008877.v1, https://figshare.com/articles/Supplementary_Material_for_68Gallium_DOTANOC-PET_Imaging_in_Lung_Carcinoids_Impact_on_Patients_Management/5008877/1 and one more link, https://ndownloader.figshare.com/files/8439359 (show fewer)
Dataset
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Supplementary Material for: Everolimus in Neuroendocrine Tumors of the Gastrointestinal Tract and Unknown Primary
Singh, S. (Creator), Carnaghi, C. (Creator), Buzzoni, R. (Creator), Pommier, R. F. (Creator), Raderer, M. (Creator), Tomasek, J. (Creator), Lahner, H. (Creator), Valle, J. (Creator), Voi, M. (Creator), Bubuteishvili-Pacaud, L. (Creator), Lincy, J. (Creator), Wolin, E. (Creator), Okita, N. (Creator), Libutti, S. K. (Creator), Oh, D.-Y. (Creator), Kulke, M. (Creator), Strosberg, J. (Creator), Yao, J. C. (Creator), Pavel, M. E. (Creator) & Fazio, N. (Creator), figshare , 18 Jul 2017
DOI: 10.6084/m9.figshare.5217421
Dataset