Research output per year
Research output per year
Personal profile
Biography
Judi Allen has a B.Sc. from Bates College, Maine and following several years in the Biotech industry, obtained her PhD from University of California, Berkeley in 1991. She went to Imperial College, London for her postdoc and subsequently moved to Edinburgh, where she established her own group with an MRC Senior Fellowship in 1997. In 2005, Judi became Professor of Immunobiology and in 2016 joined the Faculty of Life Sciences at the University of Manchester. She is also a Fellow of the Royal Society of Edinburgh, a Fellow of the Royal Society of Biology, a Fellow of the Academy of Medical Sciences and a member of EMBO. Judi was elected a Fellow of the Royal Society in 2023.
Research interests
The Allen laboratory investigates the host immune response to parasite infection with a particular focus on type 2 immunity, the response mammals characteristically make to large multicellular parasites (helminths). A major research theme of the lab has been to investigate the function of macrophages activated by type 2 cytokines and their role in anti-helminth immunity. Prof Allen’s research interests include the relationship of anti-helminth immunity to wound repair pathways, and understanding the challenges faced by the immune system during co-infection with both micro and macroparasites.
My group
Lab Members (start date):
Brian Chan (May 2016)
James Parkinson (Mar 2017)
Pedro Papotto (Oct 2019)
Georgia Baldwin (Oct 2020)
Lili Zhang (Jan 2022)
Becky Dodd (w/ Tara Sutherland & Tony Day)
Hannah Tompkins (w/ Tara Sutherland)
Mariana Suárez (Feb 2023) from Alvaro Diaz lab, Uruguay
Recent Lab Alumni:
Stella Pearson (2017 - 2022)
Hannah Smith (2021 - 2022)
Jesuthas Ajendra (2016 - 2021)
Conor Finlay (2017 - 2021)
Alistair Chenery (2016 - 2020)
Lab Associates:
Overview
The Allen laboratory studies the interaction between helminth parasites and their hosts. We aim to understand the function of the ‘type 2’ immune response typically induced in response to helminths. We are particularly interested in macrophages activated in the ‘type 2’ environment. We are funded by the Medical Research Council and the Wellcome Trust.
Please see recent key papers:
Finlay, Parkinson, Zhang et al. Immunity. T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity
Sutherland, Dyer, Allen. Science. The extracellular matrix and the immune system: A mutually dependent relationship.
Allen. Annual Review of Immunology. IL-4 and IL-13: Regulators and Effectors of Wound Repair.
Donlan et al. JCI Insight. IL-13 is a driver of COVID-19 severity
Ajendra et al. Mucosal Immunology. IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Honorary Professor, University of Edinburgh
15 Feb 2016 → …
Research Beacons, Institutes and Platforms
- Lydia Becker Institute
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species
Han, J., Gallerand, A., Erlich, E. C., Helmink, B. A., Mair, I., Li, X., Eckhouse, S. R., Dimou, F. M., Shakhsheer, B. A., Phelps, H. M., Chan, M. M., Mintz, R. L., Lee, D. D., Schilling, J. D., Finlay, C. M., Allen, J. E., Jakubzick, C. V., Else, K. J., Onufer, E. J. & Zhang, N. & 1 others, , 1 Jan 2024, In: Nature Immunology. 25, 1, p. 155-165 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile74 Downloads (Pure) -
Pulmonary Function and Survival 1 Year After Dupilumab Treatment of Acute Moderate to Severe Coronavirus Disease 2019: A Follow-up Study From a Phase 2a Trial
Hendrick, J., Ma, J. Z., Haughey, H. M., Coleman, R., Nayak, U., Kadl, A., Sturek, J. M., Jackson, P., Young, M. K., Allen, J. E. & Petri, W. A., 1 Feb 2024, In: Open Forum Infectious Diseases. 11, 2, fad630.Research output: Contribution to journal › Article › peer-review
Open Access -
The genome of Litomosoides sigmodontis illuminates the origins of Y chromosomes in filarial nematodes
Stevens, L., Kieninger, M., Chan, B., Wood, J. M. D., de la Rosa, P. G., Allen, J. & Blaxter, M., 16 Jan 2024, In: PLoS Genetics. 20, 1, e1011116.Research output: Contribution to journal › Article › peer-review
Open Access -
IL-4 and IL-13: Regulators and Effectors of Wound Repair
Allen, J. E., 26 Apr 2023, In: Annual Review of Immunology. 41, 1Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Downloads (Pure) -
Immunology of a unique biological structure: the Echinococcus laminated layer
Díaz, Á., Barrios, A. A., Grezzi, L., Mouhape, C., Jenkins, S. J., Allen, J. E. & Casaravilla, C., 16 Mar 2023, In: Protein & cell. 14, 2, p. 87-104 18 p.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 2 Finished
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Advanced human pluripotent stem cell kidney organoid model for understanding development and disease.
Kimber, S. (PI), Allen, J. (CoI), Domingos, M. (CoI) & Woolf, A. (CoI)
1/02/23 → 30/11/24
Project: Research
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Defining Functional Impacts of Macrophages in the Formation of Surgical Adhesions.
Herrick, S. (PI), Allen, J. (CoI), Ruckerl, D. (CoI) & Woolf, A. (CoI)
1/09/19 → 20/07/23
Project: Research
Prizes
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Fellow of the Academy of Medical Sciences
Allen, Judi (Recipient), 2016
Prize: Election to learned society
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Fellow of the Royal Society of Edinburgh
Allen, Judi (Recipient), 2014
Prize: Election to learned society
Activities
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the Myeloid Network
Allen, J. (Speaker)
9 Dec 2021Activity: Talk or presentation › Invited talk › Research
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Global ImmunoTalks
Judi Allen (Plenary speaker)
29 Sept 2021Activity: Talk or presentation › Invited talk › Research
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Oxford Immunology Symposium
Allen, J. (Keynote speaker)
20 Apr 2021Activity: Talk or presentation › Invited talk › Research
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IMM-PACT Programme for Clinical Scientists - University of Freiburg
Judi Allen (Keynote speaker)
30 Mar 2021Activity: Talk or presentation › Invited talk › Research
Datasets
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Whole Lung Proteome in N. brasiliensis Infection in IL-13 deficient mice.
Allen, J. (Creator), PRoteomics IDEntifications Database, 2021
https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD021853
Dataset
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The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p
Czimmerer, Z. (Contributor), Varga, T. (Contributor), Kiss, M. (Contributor), Vázquez, C. O. (Contributor), Doan-Xuan, Q. M. (Contributor), Ruckerl, D. (Contributor), Tattikota, S. G. (Contributor), Yan, X. (Contributor), Nagy, Z. S. (Contributor), Daniel, B. (Contributor), Poliska, S. (Contributor), Horvath, A. (Contributor), Nagy, Z. S. (Contributor), Varallyay, E. (Contributor), Poy, M. N. (Contributor), Allen, J. (Contributor), Bacso, Z. (Contributor), Abreu-Goodger, C. (Contributor) & Nagy, Z. S. (Contributor), figshare , 31 May 2016
DOI: 10.6084/m9.figshare.c.3643313.v1, https://figshare.com/collections/The_IL-4_STAT6_signaling_axis_establishes_a_conserved_microRNA_signature_in_human_and_mouse_macrophages_regulating_cell_survival_via_miR-342-3p/3643313/1
Dataset
Press/Media
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NATURE: The pros and cons of mentoring by Skype
23/07/18
1 item of Media coverage
Press/Media: Expert comment