Julian Matthews

2023

First-in-Human Technique Translation of Oxygen-Enhanced MRI to an MR Linac System in Patients with Head and Neck Cancer

Dubec, M. J., Buckley, D. L., Berks, M., Clough, A., Gaffney, J., Datta, A., McHugh, D. J., Porta, N., Little, R. A., Cheung, S., Hague, C., Eccles, C. L., Hoskin, P. J., Bristow, R. G., Matthews, J. C., van Herk, M., Choudhury, A., Jm Parker, G., McPartlin, A. & Pb O'Connor, J., 2 Mar 2023, In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. p. 109592

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Advanced quantitative evaluation of PET systems using the ACR phantom and NiftyPET software

Markiewicz, P. J., da Costa-Luis, C., Dickson, J., Barnes, A., Krokos, G., MacKewn, J., Clark, T., Wimberley, C., MacNaught, G., Yaqub, M. M., Gispert, J. D., Hutton, B. F., Marsden, P., Hammers, A., Reader, A. J., Ourselin, S., Herholz, K., Matthews, J. & Barkhof, F., 1 May 2022, In: Medical Physics. 49, 5, p. 3298-3313 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI

Dickie, B., Tao, J., Wang, P., Hinz, R., Harris, W., Boutin, H., Parker, G. JM., Parkes, L. & Matthews, J., 27 May 2022, (Accepted/In press) In: Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journal › Article › peer-review

2021

Dynamic PET image reconstruction utilizing intrinsic data-driven HYPR4D denoising kernel

Cheng, J-C., Bevington, C., Rahmim, A., Klyuzhin, I., Matthews, J., Boellaard, R. & Sossi, V., 3 Feb 2021, In: Medical Physics. 48, 5, p. 2230-2244 15 p.

Research output: Contribution to journal › Article › peer-review

Optimization of quantitative susceptibility mapping for regional estimation of oxygen extraction fraction in the brain

McFadden, J. J., Matthews, J., Scott, L. A., Parker, G. JM., Lohezic, M. & Parkes, L., 29 Mar 2021, In: Magnetic Resonance in Medicine. 86, 3, p. 1314-1329 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Uncertainty analysis of MR-PET image registration for precision neuro-PET imaging

Markiewicz, P. J., Matthews, J., Ashburner, J., Cash, D. M., Thomas, D. M., De Vita, E., Barnes, A., Cardoso, M. J., Modat, M., Brown, R., Thielemans, K., da Costa-Luis, C., Lopes Alves, I., Domingo Gispert, J., Schmidt, M. E., Marsden, P., Hammers, A., Ourselin, S. & Barkhof, F., 15 May 2021, In: NeuroImage. 232, 117821.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

A highly reproducible method for the measurement of [6‐O‐methyl‐11C]diprenorphine and its radio‐metabolites based on solid‐phase extraction and radio‐high‐pressure liquid chromatography

McMahon, A., Fairclough, M., Jones, A. & Matthews, J., 3 Nov 2020, In: Journal of Labelled Compounds and Radiopharmaceuticals. 10 p., DOI: 10.1002/jlcr.3886.

Research output: Contribution to journal › Article › peer-review

Open Access

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Dopamine and Glutamate in Antipsychotic-Responsive compared to Antipsychotic Non-Responsive Psychosis: A Multicentre Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA)

Egerton, A., Murphy, A., Donocik, J., Anton, A., Barker, G. J., Collier, T., Deakin, J. F. W., Drake, R., Eliasson, E., Emsley, R., Gregory, C., Griffiths, K., Kapur, S., Kassoumeri, L., Knight, L., Lambe, E. J. B., Lawrie, S. M., Lees, J., Lewis, S., Lythgoe, D. J., & 14 othersMatthews, J., McGuire, P. K., McNamee, L., Semple, S. I., Shaw, A. D., Singh, K. D., Stockton-Powdrell, C., Talbot, P., Veronese, M., Wagner, E., Walters, J. T. R., Williams, S. R., MacCabe, J. H. & Howes, O. D., 10 Sept 2020, In: Schizophrenia Bulletin.

Research output: Contribution to journal › Article › peer-review

Open Access

SIRF: Synergistic Image Reconstruction Framework

Ovtchinnikov, E., Brown, R., Kolbitsch, C., Pasca, E., da Costa-Luis, C., Gillman, A. G., Thomas, B. A., Efthimiou, N., Mayer, J., Wadhwa, P., Ehrhardt, M. J., Ellis, S., Jorgensen, J., Matthews, J., Prieto, C., Reader, A. J., Tsoumpas, C., Turner, M., Atkinson, D. & Thielemans, K., 2020, In: Computer Physics Communications.

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Open Access

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2019

[18F]fluorothymidine and [18F]fluorodeoxyglucose PET Imaging Demonstrates Uptake and Differentiates Growth in Neurofibromatosis 2 Related Vestibular Schwannoma

Anton-rodriguez, J. M., Lewis, D., Djoukhadar, I., Russell, D., Julyan, P., Coope, D., King, A. T., Lloyd, S. K. L., Evans, D. G., Jackson, A. & Matthews, J. C., 2019, In: Otology and Neurotology. p. 1

Research output: Contribution to journal › Article › peer-review

Open Access

Comparison of a standard resolution PET-CT scanner with an HRRT brain scanner for imaging small tumours within the head

Anton-Rodriguez, J., Julyan, P., Djoukhadar, I., Russell, D., Evans, D. G., Jackson, A. & Matthews, J., 2019, In: IEEE Transactions on Radiation and Plasma Medical Sciences .

Research output: Contribution to journal › Article › peer-review

Open Access

Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non-small Cell Lung Cancer

Salem, A., Little, R. A., Latif, A., Featherstone, A. K., Babur, M., Peset, I., Cheung, S., Watson, Y., Tessyman, V., Mistry, H., Ashton, G., Behan, C., Matthews, J. C., Asselin, M-C., Bristow, R. G., Jackson, A., Parker, G. J. M., Faivre-Finn, C., Williams, K. J. & O'Connor, J. P. B., 1 Jul 2019, In: Clinical Cancer Research. 25, 13, p. 3818-3829 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Acute and chronic changes in brain activity with deep brain stimulation for refractory depression

Conen, S., Matthews, J., Anton-Rodriguez, J., Patel, N. & Talbot, P., 2018, In: Journal of Psychopharmacology. 32, 4, p. 430– 440

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Open Access

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Data-driven mapping of hypoxia-related tumor heterogeneity using DCE-MRI and OE-MRI

Featherstone, A. K., O'Connor, J. P. B., Little, R. A., Watson, Y., Cheung, S., Babur, M., Williams, K. J., Matthews, J. C. & Parker, G. J. M., 1 Apr 2018, In: Magnetic Resonance in Medicine. 79, 4, p. 2236-2245 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Elevated translocator protein in anterior cingulate in major depression and a role for inflammation in suicidal thinking: a positron emission tomography study

Holmes, S., Hinz, R., Conen, S., Gregory, C., Matthews, J., Anton-Rodriguez, J., Gerhard, D. A. & Talbot, P., 1 Jan 2018, In: Biological Psychiatry. 83, 1, p. 61-69 8 p.

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Experimental validation of estimated spatially variant radioisotope-specific point spread functions using published positron range simulations and fluorine-18 measurements

Anton-Rodriguez, J. M., Krokos, G., Kotasidis, F., Asselin, M. C., Morris, O., Julyan, P., Archer, A. & Matthews, J. C., 7 Dec 2018, In: Physics in Medicine and Biology. 63, 24, 24NT01.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Incorporating HYPR de-noising within iterative PET reconstruction (HYPR-OSEM)

Cheng, J-C., Matthews, J., Sossi, V., Anton-Rodriguez, J., Salomon, A. & Boellaard, R., 2017, In: Physics in Medicine and Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

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2016

Deep brain stimulation of the periaqueductal gray releases endogenous opioids in humans

Sims - Williams, H., Matthews, J., Talbot, P., Love-Jones, S., CW Brooks, J., K. Patel, N. & E. Pickering, A., 2016, In: NeuroImage. 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

In-vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [¹¹C](R)-PK11195 positron emission tomography study

Holmes, S., Hinz, R., Drake, R., Gregory, C., Conen, S., Matthews, J., Anton-Rodriguez, J., Gerhard, D. A. & Talbot, P., Dec 2016, In: Molecular psychiatry. 21, 12, p. 1672-1679

Research output: Contribution to journal › Article › peer-review

Open Access

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2015

Assessment of bootstrap resampling performance for PET data

Markiewicz, P. J., Reader, A. J. & Matthews, J. C., 2015, In: Physics in Medicine and Biology. 60, 1

Research output: Contribution to journal › Article › peer-review

Open Access

Full field spatially-variant image-based resolution modelling reconstruction for the HRRT.

Angelis, G. I., Kotasidis, F. A., Matthews, J. C., Markiewicz, P. J., Lionheart, W. R. & Reader, A. J., Mar 2015, In: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB). 31, 2, p. 137-145 9 p.

Research output: Contribution to journal › Article › peer-review

Striatal opioid receptor availability is related to acute and chronic pain perception in arthritis: Does opioid adaptation increase resilience to chronic pain?

Brown, C., Matthews, J., Fairclough, M., Mcmahon, A., Barnett, E., Al-Kaysi, A., El-Deredy, W. & Jones, A., 3 Nov 2015, In: Pain. 156, 11, p. 2267-2275 8 p.

Research output: Contribution to journal › Article › peer-review

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The assessment of time-of-flight on image quality and quantification with reduced administered activity and scan times in F-18-FDG PET

Armstrong, I. S., James, J. M., Williams, H. A., Kelly, M. D. & Matthews, J. C., 2015, In: Nuclear Medicine Communications. 36, 7, p. 728-737 10 p.

Research output: Contribution to journal › Article › peer-review

2014

Image-based spatially variant and count rate dependent point spread function on the HRRT

Kotasidis, F. A., Angelis, G. I., Anton-Rodriguez, J., Markiewicz, P., Lionheart, W. R., Reader, A. J. & Matthews, J. C., 2014, In: Ieee Transactions on Nuclear Science. 61, 3, p. 1192-1202 10 p., 6825942.

Research output: Contribution to journal › Article › peer-review

Isotope specific resolution recovery image reconstruction in high resolution PET imaging

Kotasidis, F. A., Angelis, G. I., Anton-Rodriguez, J., Matthews, J. C., Reader, A. J. & Zaidi, H., 2014, In: Medical Physics. 41, 5, 052503.

Research output: Contribution to journal › Article › peer-review

The effect of 18F-florbetapir dose reduction on region-based classification of cortical amyloid deposition

Herholz, K., Evans, R., Anton-Rodriguez, J., Hinz, R. & Matthews, J. C., 8 Jul 2014, In: European Journal of Nuclear Medicine and Molecular Imaging. 41, 11, p. 2144-2149 6 p.

Research output: Contribution to journal › Article › peer-review

2013

Acceleration of image-based resolution modelling reconstruction using an expectation maximization nested algorithm.

Angelis, G. I., Reader, A. J., Markiewicz, P. J., Kotasidis, F. A., Lionheart, W. R. & Matthews, J. C., 7 Aug 2013, In: Physics in Medicine and Biology. 58, 15, p. 5061-5083 22 p.

Research output: Contribution to journal › Article › peer-review

P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study

Feldmann, M., Asselin, M. C., Liu, J., Wang, S., McMahon, A., Anton-Rodriguez, J., Walker, M., Symms, M., Brown, G., Hinz, R., Matthews, J., Bauer, M., Langer, O., Thom, M., Jones, T., Vollmar, C., Duncan, J. S., Sisodiya, S. M. & Koepp, M. J., 18 Jun 2013, In: The Lancet Neurology. 12, 8, p. 777-785 8 p.

Research output: Contribution to journal › Article › peer-review

2012

A Comparison of Gray Matter Density in Restless Legs Syndrome Patients and Matched Controls Using Voxel-Based Morphometry

Comley, R. A., Cervenka, S., Palhagen, S. E., Panagiotidis, G., Matthews, J. C., Lai, R. Y., Halldin, C., Farde, L., Nichols, T. E. & Whitcher, B. J., Jan 2012, In: Journal of Neuroimaging. 22, 1, p. 28-32 4 p.

Research output: Contribution to journal › Article › peer-review

Optimization of methods for quantification of rCBF using high-resolution [ 15O]H 2O PET images

Walker, D., Matthews, C., Anton-Rodriguez, M., Koepp, J., Asselin, M-C., Walker, M. D., Feldmann, M., Matthews, J. C., Anton-Rodriguez, J. M., Wang, S., Koepp, M. J. & Asselin, M. C., 21 Apr 2012, In: Physics in Medicine and Biology. 57, 8, p. 2251-2271 20 p.

Research output: Contribution to journal › Article › peer-review

2011

A custom-built PET phantom design for quantitative imaging of printed distributions.

Markiewicz, P. J., Angelis, G. I., Kotasidis, F., Green, M., Lionheart, W. R., Reader, A. J. & Matthews, J. C., 7 Nov 2011, In: Physics in Medicine and Biology. 56, 21, p. N247-N261

Research output: Contribution to journal › Article › peer-review

Bias in iterative reconstruction of low-statistics PET data: Benefits of a resolution model

Walker, M. D., Asselin, M. C., Julyan, P. J., Feldmann, M., Talbot, P. S., Jones, T. & Matthews, J. C., 21 Feb 2011, In: Physics in Medicine and Biology. 56, 4, p. 931-949 18 p.

Research output: Contribution to journal › Article › peer-review

Molecular Imaging and Pharmacokinetic Analysis of Carbon-11 Labeled Antisense Oligonucleotide LY2181308 in Cancer Patients.

Saleem, A., Matthews, J. C., Ranson, M., Callies, S., André, V., Lahn, M., Dickinson, C., Prenant, C., Brown, G., McMahon, A., Talbot, D. C., Jones, T. & Price, P. M., 2011, In: Theranostics. 1, p. 290-301 12 p.

Research output: Contribution to journal › Article › peer-review

Optimized data preprocessing for multivariate analysis applied to 99mTc-ECD SPECT data sets of Alzheimer's patients and asymptomatic controls

Merhof, D., Markiewicz, P. J., Platsch, G., Declerck, J., Weih, M., Kornhuber, J., Kuwert, T., Matthews, J. C. & Herholz, K., Jan 2011, In: Journal of Cerebral Blood Flow and Metabolism. 31, 1, p. 371-383 12 p.

Research output: Contribution to journal › Article › peer-review

Robustness of correlations between PCA of FDG-PET scans and biological variables in healthy and demented subjects

Markiewicz, P. J., Matthews, J. C., Declerck, J. & Herholz, K., 15 May 2011, In: NeuroImage. 56, 2, p. 782-787 5 p.

Research output: Contribution to journal › Article › peer-review

Single scan parameterization of space-variant point spread functions in image space via a printed array: The impact for two PET/CT scanners

Kotasidis, F. A., Matthews, J. C., Angelis, G. I., Noonan, P. J., Jackson, A., Price, P., Lionheart, W. R. & Reader, A. J., 21 May 2011, In: Physics in Medicine and Biology. 56, 10, p. 2917-2942 25 p.

Research output: Contribution to journal › Article › peer-review

The performance of monotonic and new non-monotonic gradient ascent reconstruction algorithms for high-resolution neuroreceptor PET imaging

Angelis, G. I., Reader, A. J., Kotasidis, F. A., Lionheart, W. R. & Matthews, J. C., 7 Jul 2011, In: Physics in Medicine and Biology. 56, 13, p. 3895-3917 22 p.

Research output: Contribution to journal › Article › peer-review

Verification of predicted robustness and accuracy of multivariate analysis

Markiewicz, P. J., Matthews, J. C., Declerck, J. & Herholz, K., 1 Jun 2011, In: NeuroImage. 56, 3, p. 1382-1385 3 p.

Research output: Contribution to journal › Article › peer-review

2010

A Multi-Center Randomized Proof-of-Concept Clinical Trial Applying [18F]FDG-PET for Evaluation of Metabolic Therapy with Rosiglitazone XR in Mild to Moderate Alzheimer's Disease

Matthews, J., Tzimopoulou, S., Cunningham, V. J., Nichols, T. E., Searle, G., Bird, N. P., Mistry, P., Dixon, I. J., Hallett, W. A., Whitcher, B., Brown, A. P., Zvartau-Hind, M., Lotay, N., Lai, R. Y., Castiglia, M., Jeter, B., Matthews, J. C., Chen, K., Bandy, D., Reiman, E. M., & 3 othersGold, M., Rabiner, E. A. & Matthews, P. M., 2010, In: Journal of Alzheimer's Disease. 22, 4, p. 1241-1256

Research output: Contribution to journal › Article › peer-review

Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: A PET study using 11C-DASB in healthy humans

Talbot, P. S., Bradley, S., Clarke, C. P., Babalola, K. O., Philipp, A. W., Brown, G., McMahon, A. W. & Matthews, J. C., Feb 2010, In: Neuropsychopharmacology. 35, 3, p. 741-751 10 p.

Research output: Contribution to journal › Article › peer-review

Development and validation of a variance model for dynamic PET: Uses in fitting kinetic data and optimizing the injected activity

Julyan, P., Walker, M. D., Matthews, J. C., Asselin, M. C., Watson, C. C., Saleem, A., Dickinson, C., Charnley, N., Julyan, P. J., Price, P. M. & Jones, T., 21 Nov 2010, In: Physics in Medicine and Biology. 55, 22, p. 6655-6672 17 p.

Research output: Contribution to journal › Article › peer-review

The Benefits and Risks of Using Positron Emission Tomography in Clinical Drug Development

Matthews, J. C., 2010, In: Drug Development. 5, p. 37-42

Research output: Contribution to journal › Article › peer-review

Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: A proof-of-concept, first-in-human dose study

Talbot, D. C., Ranson, M., Davies, J., Lahn, M., Callies, S., André, V., Kadam, S., Burgess, M., Slapak, C., Olsen, A. L., McHugh, P. J., De Bono, J. S., Matthews, J., Saleem, A. & Price, P., 15 Dec 2010, In: Clinical Cancer Research. 16, 24, p. 6150-6158 8 p.

Research output: Contribution to journal › Article › peer-review

2009

Microdosing imaging pharmacokinetic (PK) study of the antisense oligonucleotide (ASO) to survivin (LY2181308) using positron emission tomography (PET): A novel paradigm in clinical drug development. A novel paradigm in clinical drug development

Saleem, A., Ranson, M., Callies, S., Lahn, M., Prenant, C., Brown, G., Matthews, J. C., Dence, C. S., McMahon, A. & Price, P., 20 May 2009, In: Journal of Clinical Oncology. 27, 15_Suppl., p. 3578-3578 1 p.

Research output: Contribution to journal › Article › peer-review

Optimization of the injected activity in dynamic 3D PET: A generalized approach using patient-specific NECs as demonstrated by a series of 15O-H2O scans

Walker, M. D., Matthews, J. C., Asselin, M. C., Saleem, A., Dickinson, C., Charnley, N., Julyan, P. J., Price, P. M. & Jones, T., 1 Sept 2009, In: Journal Of Nuclear Medicine. 50, 9, p. 1409-1417 8 p.

Research output: Contribution to journal › Article › peer-review

Robustness of multivariate image analysis assessed by resampling techniques and applied to FDG-PET scans of patients with Alzheimer's disease

Markiewicz, P. J., Matthews, J. C., Declerck, J. & Herholz, K., Jun 2009, In: NeuroImage. 46, 2, p. 472-485 13 p.

Research output: Contribution to journal › Article › peer-review

Testing the performance of iterative reconstruction at low statistics via listmode sub-sampling in high resolution brain PET

Walker, MD., Julyan, PJ., Talbot, PS. & Matthews, JC., 2009, In: Journal of Cerebral Blood Flow & Metabolism. 29, p. S334

Research output: Contribution to journal › Article › peer-review

2008

No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma

Charnley, N., Airley, R., Du Plessis, D., West, C., Brock, C., Barnett, C., Matthews, J., Symonds, K., Bottomly, M., Swindell, R. & Price, P., Sept 2008, In: Oncology Reports. 20, 3, p. 537-542 6 p.

Research output: Contribution to journal › Article › peer-review

Plasma pharmacokinetic evaluation of cytotoxic agents radiolabelled with positron emitting radioisotopes.

Saleem, A., Aboagye, EO., Matthews, J. & Price, PM., Apr 2008, In: Cancer Chemother Pharmacol. 61, 5, p. 865-873 8 p.

Research output: Contribution to journal › Article › peer-review

Synthesis and Evaluation of [11C]SB207145 as the First In vivo Serotonin 5-HT4 Receptor Radioligand for PET Imaging in Man

Gee, AD., Martarello, L., Passchier, J., Wishart, M., Parker, C., Matthews, J., Comley, R., Hopper, R. & Gunn, R., 2008, In: Current Radiopharmaceuticals. 1, p. 110-114 5 p.

Research output: Contribution to journal › Article › peer-review

Julian Matthews, Ph.D.

Research output

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