Research output per year
Research output per year
Personal profile
Research interests
My interests lie in understanding the mechanistic links between the circadian clock and inflammation. My previous work has demonstrated that immune cells possess internal timers which dictate their amplitude of response to inflammatory stimuli. These cellular timers can be critical in restraining inflammation and allowing resolution. By mapping the connections between the circadian clock and inflammatory pathways we will gain a greater understanding of clock control of inflammation, and identify potential new therapeutic targets.
Methodological knowledge
My expertise includes in the use of animal models of inflammatory disease and the development of transgenic mice lacking clocks in various immune cells. The use of these tools allows me to explore the role of biological timers within the immune system in regulating the dynamics of inflammatory disease.
Qualifications
PhD Neuroscience, King's College London
BSc (Hons) Neuroscience, University of Manchester (2:1)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Beacons, Institutes and Platforms
- Lydia Becker Institute
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis
Downton, P., Dickson, S. H., Ray, D. W., Bechtold, D. A. & Gibbs, J. E., 10 Jul 2024, In: Open Biology. 14, 7, 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Airway inflammation and hyperresponsiveness in asthma is regulated by the circadian clock through REV-ERBα
Chakraborty, A., Cain, J., Maidstone, R., Krakowiak, K., Deugi, V., Begley, N., Gibbs, J. & Durrington, H., 2023, In: European Respiratory Journal. 62, OA4208.Research output: Contribution to journal › Conference article › peer-review
Open Access -
ClinCirc identifies alterations of the circadian peripheral oscillator in critical care patients
Cunningham, P., Kitchen, G., Jackson, C., Papachristos, S., Springthorpe, T., Van Dellen, D., Gibbs, J., Felton, T., Wilson, A., Bannard-Smith, J., Rutter, M. K., House, T., Dark, P., Augustine, T., Akman, O., Hazel, A. & Blaikley, J., 15 Feb 2023, In: The Journal of clinical investigation. 133, 4, e162775.Research output: Contribution to journal › Article › peer-review
Open Access -
The associations of chronotype and shift work with rheumatoid arthritis
Butler, T., Maidstone, R., Rutter, M. K., Mclaughlin, J., Ray, D. & Gibbs, J., 11 May 2023, (Accepted/In press) In: Journal of Biological Rhythms.Research output: Contribution to journal › Article › peer-review
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Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism
Downton, P., Sanna, F., Maidstone, R., Poolman, T., Hayter, E., Dickson, S., Early, J., Adamson, A., Spiller, D., Simpkins, D., Baxter, M., Fischer, R., Rattray, M., Loudon, A., Gibbs, J., Bechtold, D. & Ray, D., 3 May 2022, In: PNAS. 2112781119.Research output: Contribution to journal › Article › peer-review
Open Access
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Inflammatory arthritis - time to reveal the bigger picture
Gibbs, J. (PI)
4/10/21 → 3/10/26
Project: Research
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Centre for Biological Timing
Lucas, R. (PI), Bechtold, D. (PI), Fustin, J.-M. (PI), Ashe, H. (PI), Brown, T. (PI), Blaikley, J. (PI), Brass, A. (PI), Chandola, T. (PI), Durrington, H. (PI), Else, K. (PI), Hepworth, M. (PI), Hunter, L. (PI), Kadler, K. (PI), Kitchen, G. (PI), Loudon, A. (PI), Macdonald, A. (PI), Mcbeth, J. (PI), Milosavljevic, N. (PI), Rattray, M. (PI), Rutter, M. (PI), Sharrocks, A. (PI), Spiller, D. (PI), Storchi, R. (PI), Belle, M. (PI), Meng, Q.-J. (PI), Allen, A. (PI), Dixon, W. (PI), Gibbs, J. (PI), Hazel, A. (PI), Papalopulu, N. (PI), Ray, D. (PI), White, M. (PI) & Chang, J. (PI)
Project: Research
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Timing of Ventilation, is it Circadian?
Blaikley, J. (PI), Gibbs, J. (CoI) & Kitchen, G. (CoI)
1/08/19 → 31/01/21
Project: Research
Activities
- 1 Organising a conference, workshop, exhibition, performance, inquiry, course etc
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Centre for Biological Timing Summer Showcase Seminars 2020
Fustin, J.-M. (Organiser) & Gibbs, J. (Organiser)
28 Jun 2020 → 30 Jun 2020Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc › Research
Press/Media
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Aches in the morning? Gene discovery may loosen you up
9/08/16
1 item of Media coverage
Press/Media: Research