Research output per year
Research output per year
Personal profile
Research interests
My interests lie in understanding the mechanistic links between the circadian clock and inflammation. My previous work has demonstrated that immune cells possess internal timers which dictate their amplitude of response to inflammatory stimuli. These cellular timers can be critical in restraining inflammation and allowing resolution. By mapping the connections between the circadian clock and inflammatory pathways we will gain a greater understanding of clock control of inflammation, and identify potential new therapeutic targets.
Methodological knowledge
My expertise includes in the use of animal models of inflammatory disease and the development of transgenic mice lacking clocks in various immune cells. The use of these tools allows me to explore the role of biological timers within the immune system in regulating the dynamics of inflammatory disease.
Qualifications
PhD Neuroscience, King's College London
BSc (Hons) Neuroscience, University of Manchester (2:1)
Research Highlights, Institutes and Platforms
- Lydia Becker Institute
Accepting PhD students
- Accepting PhD students
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The club cell circadian clock regulates temporal patterns in leukocyte trafficking in chronic allergic airways disease
Cain, J., Chakraborty, A., Deugi, V., Krakowiak, K., Bechtold, D., Gibbs, J. E. & Durrington, H. J., 14 Jul 2026, (Accepted/In press) In: Mucosal Immunology. 41 p.Research output: Contribution to journal › Article › peer-review
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The importance of meal timing for maintenance of daily rhythms in the gut transcriptome and microbiota.
Hunter, F., Downton, P., Luengas Martinez, A., Dickson, S., Cain, J., Else, K., Hepworth, M. & Gibbs, J., 22 Jun 2026, In: npj Biological Timing and Sleep. 3, 29.Research output: Contribution to journal › Article › peer-review
Open Access -
Ablation of Bronchiolar Epithelial Cell Clock Gene, Rev-erbα, Disrupts Circadian Rhythmicity in Airway Hyperresponsiveness by Introducing Transcriptomic Changes
Chakraborty, A., Cain, J., Maidstone, R., Deugi, V., Bechtold, D., Gibbs, J. & Durrington, H., May 2025, In: American Journal of Respiratory and Critical Care Medicine. 211, 2 p.Research output: Contribution to journal › Meeting Abstract › peer-review
Open Access -
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Parkinson, J. E., Tompkins, H. E., Chakraborty, A., Burgess, M. O., Dodd, R. J., Adamson, A. D., MacDonald, A. S., Gibbs, J. E., Durrington, H. J., Allen, J. E. & Sutherland, T. E., 19 Sept 2025, In: Science Immunology. 10, 111, eadk6707.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Downloads (Pure) -
Colonic inflammation modulates the intestinal circadian landscape
Butler, T., Downton, P., Dickson, S., Luengas Martinez, A., Simpkins, D., Khoo, I., Veal, S., West, A., Adamson, A., Bechtold, D., Mclaughlin, J. & Gibbs, J., 15 Aug 2025, In: iScience. 28, 8, 113183.Research output: Contribution to journal › Article › peer-review
Open Access
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Inflammatory arthritis - time to reveal the bigger picture
Gibbs, J. (PI)
4/10/21 → 3/10/26
Project: Research
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Centre for Biological Timing
Lucas, R. (PI), Bechtold, D. (PI), Fustin, J.-M. (PI), Ashe, H. (PI), Brown, T. (PI), Blaikley, J. (PI), Brass, A. (PI), Chandola, T. (PI), Durrington, H. (PI), Else, K. (PI), Hepworth, M. (PI), Hunter, L. (PI), Kadler, K. (PI), Kitchen, G. (PI), Loudon, A. (PI), Macdonald, A. (PI), Mcbeth, J. (PI), Milosavljevic, N. (PI), Rattray, M. (PI), Rutter, M. (PI), Sharrocks, A. (PI), Spiller, D. (PI), Storchi, R. (PI), Belle, M. (PI), Meng, Q.-J. (PI), Allen, A. (PI), Dixon, W. (PI), Gibbs, J. (PI), Hazel, A. (PI), Papalopulu, N. (PI), Ray, D. (PI), White, M. (PI), Chang, J. (PI), Bano Otalora, B. (CoI), Zavala, E. (PI), Orlowska-Feuer, P. (PI) & Didikoglu, A. (PI)
Project: Research
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FluidFM: Next Generation Single Cell Genetic Manipulation and Analysis
Adamson, A. (PI), Allen, J. (CoI), Banka, S. (CoI), Birket, M. (CoI), Brough, D. (CoI), Couper, K. (CoI), Eyre, S. (CoI), Fustin, J.-M. (CoI), Gibbs, J. (CoI), Greenhalgh, A. (CoI), Hepworth, M. (CoI), Kimber, S. (CoI), Lennon, R. (CoI), Lopez-Castejon, G. (CoI), Lowe, M. (CoI), Papalopulu, N. (CoI), Piper Hanley, K. (CoI), Richardson, S. (CoI), Sharrocks, A. (CoI), Smith, M. (CoI), Travis, M. (CoI), Warren, R. (CoI) & Wong, F. K. (CoI)
1/08/23 → 29/02/24
Project: Research
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Metabolic and behavioural phenotyping system
Bechtold, D. (PI), Brown, T. (CoI), Cruickshank, S. (CoI), D'Agostino, G. (CoI), Else, K. (CoI), Fustin, J.-M. (CoI), Gibbs, J. (CoI), Grencis, R. (CoI), Hepworth, M. (CoI), Loudon, A. (CoI), Lucas, R. (CoI), Luckman, S. (CoI), Mclaughlin, J. (PI) & Rutter, M. (PI)
1/08/21 → 31/07/22
Project: Research
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Timing of Ventilation, is it Circadian?
Blaikley, J. (PI), Gibbs, J. (CoI) & Kitchen, G. (CoI)
1/08/19 → 31/01/21
Project: Research
Activities
- 1 Organising a conference, workshop, exhibition, performance, inquiry, course etc
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Centre for Biological Timing Summer Showcase Seminars 2020
Fustin, J.-M. (Chair) & Gibbs, J. (Co-Chair)
28 Jun 2020 → 30 Jun 2020Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc › Research
Press/Media
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Aches in the morning? Gene discovery may loosen you up
9/08/16
1 item of Media coverage
Press/Media: Research