Karen Kirkby

Search results

• 2023

  Proposing a clinical model for RBE based on proton track-end counts

  Henthorn, N., Gardner, L. L., Aitkenhead, A., Rowland, B., Shin, J., Smith, E., Merchant, M., Mackay, R., Kirkby, K., Chaudhary, P., Prise, K. M., McMahon, S. & Underwood, T., 13 Jan 2023, (E-pub ahead of print) In: International Journal of Radiation: Oncology - Biology - Physics.

  Research output: Contribution to journal › Article › peer-review

  • Biological Product 100%
  • Proton 63%
  • Biological Relative 63%
  • Dose 27%
  • Optimization 27%
• 2022

  A computational approach to quantifying miscounting of radiation-induced double-strand break immunofluorescent foci

  Ingram, S., Warmenhoven, J., Henthorn, N., Chadwick, A., Santina, E., McMahon, S. J., Schuemann, J., Kirkby, N., Mackay, R., Kirkby, K. & Merchant, M., 14 Jun 2022, (Accepted/In press) In: Communications Biology.

  Research output: Contribution to journal › Article › peer-review

  • Radiation 100%
  • Strands 75%
  • Foci 50%
  • Repair 50%
  • Microscopy 50%

• An Update to the Malthus Model for Radiotherapy Utilisation in England

  Heritage, S., Sundaram, S., Kirkby, N. F., Kirkby, K. J., Mee, T. & Jena, R., 11 Jul 2022, (E-pub ahead of print) In: Clinical oncology (Royal College of Radiologists (Great Britain)).

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Radiation Therapy 100%
  • Therapeutic Procedure 20%
  • Diseases 20%
  • Cancer Localization 20%
  • Cancer Incidence 20%

• Estimating the percentage of patients who might benefit from proton beam therapy instead of X-ray radiotherapy

  Burnet, N. G., Mee, T., Gaito, S., Kirkby, N. F., Aitkenhead, A. H., Anandadas, C. N., Aznar, M. C., Barraclough, L. H., Borst, G., Charlwood, F. C., Clarke, M., Colaco, R. J., Crellin, A. M., Defourney, N. N., Hague, C. J., Harris, M., Henthorn, N. T., Hopkins, K. I., Hwang, E., Ingram, S. P., & 25 othersKirkby, K. J., Lee, L. W., Lines, D., Lingard, Z., Lowe, M., Mackay, R. I., McBain, C. A., Merchant, M. J., Noble, D. J., Pan, S., Price, J. M., Radhakrishna, G., Reboredo-Gil, D., Salem, A., Sashidharan, S., Sitch, P., Smith, E., Smith, E. A., Taylor, M. J., Thomson, D. J., Thorp, N. J., Underwood, T. S., Warmenhoven, J. W., Wylie, J. P. & Whitfield, G., 1 May 2022, In: The British journal of radiology. 95, 1133, p. 20211175 A5.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proton Therapy 100%
  • Radiation Therapy 80%
  • Patient 60%
  • Consensus 60%
  • Growth 40%

• The suitability of micronuclei as markers of relative biological effect

  Heaven, C. J., Wanstall, H. C., Henthorn, N. T., Warmenhoven, J-W., Ingram, S. P., Chadwick, A. L., Santina, E., Honeychurch, J., Schmidt, C. K., Kirkby, K. J., Kirkby, N. F., Burnet, N. G. & Merchant, M. J., 2 Apr 2022, In: Mutagenesis. 37, 1, p. 3-12 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cytokinesis 100%
  • Radiation 100%
  • DNA 50%
  • Cytochalasin B 50%
  • Species 50%

• Variable and fixed costs in NHS radiotherapy; consequences for increasing hypo fractionation

  Kirkby, K., 1 Jan 2022, In: Radiotherapy & Oncology.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2021

  Determining the parameter space for effective oxygen depletion for FLASH radiation therapy

  Rothwell, B., Kirkby, N., Merchant, M., Chadwick, A., Lowe, M., Mackay, R., Hendry, J. & Kirkby, K., 25 Feb 2021, In: Physics in Medicine & Biology. 66, 5, 055020.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Parameters 100%
  • Radiation 100%
  • Oxygen 75%
  • Depletion 75%
  • Dose 50%

• FLASH radiotherapy: Considerations for multibeam and hypofractionation dose delivery,

  Mackay, R., Burnet, NG., Matthew, L., Rothwell, B., Kirkby, N., Kirkby, K. & Hendry, J., 14 Oct 2021, In: Radiotherapy & Oncology. 164, p. 122-127 6 p.

  Research output: Contribution to journal › Article › peer-review

• Mechanistic Modelling of Slow and Fast NHEJ DNA Repair Pathways Following Radiation for G0/G1 Normal Tissue Cells

  Qi, Y., Warmenhoven, J., Henthorn, N., Ingram, S., XG, X., Kirkby, K. & Merchant, M., 3 May 2021, In: Cancers. 13, 9, 2202.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Radiation 100%
  • Protein 50%
  • Surgery 50%
  • Non-Homologous End Joining 50%
  • Cell Line 16%

• Oxygen depletion in proton spot scanning: a tool for exploring the conditions needed for FLASH

  Rothwell, B., Lowe, M., Kirkby, N., Merchant, M., Chadwick, A., Mackay, R., Hendry, J. & Kirkby, K., 22 Nov 2021, In: Radiation. 1, 4, p. 290-304 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oxygen 100%
  • Proton 50%
  • Depletion 50%
  • Protons 50%
  • Obstetric Delivery 33%

• Towards harmonizing clinical linear energy transfer (LET) reporting in proton radiotherapy: A European multi-centric study

  Hahn, C., Dasu, A., Vestergaard, A., Fulsang Jensen, M., Sokol, O., Pardi, C., Bourhaleb, F., Leite, A., de Marzi, L., Smith, E., Aitkenhead, A., Rose, C., Merchant, M., Kirkby, K., Grzanka, L., Pawelke, J. & Luhr, A., 22 Oct 2021, In: Acta Oncologica . p. 1-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Linear Energy Transfer 100%
  • Proton 53%
  • Relative Biologic Effectiveness 46%
  • Biological Product 46%
  • Dose 40%
  6 Downloads (Pure)

• Variations in demand across England for the MR-linac technology, simulated utilising local-level demographic and cancer data in the Malthus Project

  Mee, T., Vickers, A., Jena, R., Kirkby, K., Choudhury, A. & Kirkby, N., 23 Feb 2021, (Accepted/In press) In: Clinical Oncology.

  Research output: Contribution to journal › Article › peer-review

  • Linear Accelerator 100%
  • Malignant Neoplasm 71%
  • Radiotherapy 71%
  • Radiation Therapy 71%
  • Obstetric Delivery 42%
• 2020

  An open source heterogeneous 3D printed mouse phantom utilising a novel bone representative thermoplastic

  Price, G. J., Biglin, E. R., Collins, S., Aitkenhead, A. H., Subiel, A., Chadwick, A. L., Cullen, D. M., Kirkby, K. J., Schettino, G., Tipping, J. & Robinson, A., 2020, In: Physics in Medicine and Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phantom 100%
  • Device Material 83%
  • Enalapril Maleate 66%
  • Standard 50%
  • Procedures 33%
  215 Downloads (Pure)

• Characterization of a pixelated silicon microdosimeter in micro-beams of light ions

  Pola, A., Bortot, D., Mazzucconi, D., Fazzi, A., Galer, S., Kirkby, K. J., Merchant, M. J., Palmans, H. & Agosteo, S., Apr 2020, In: Radiation Measurements. 133, 106296.

  Research output: Contribution to journal › Article › peer-review

  • Silicon 100%
  • Region 100%
  • Diameters 100%
  • Tissue 66%
  • Events 66%

• Characterizing local dose perturbations due to gas cavities in Magnetic Resonance guided Radiotherapy

  Shortall, J., Vasquez Osorio, E., Chuter, R., Green, A., Mcwilliam, A., Kirkby, K., Mackay, R. & Van Herk, M., 6 Mar 2020, (E-pub ahead of print) In: Medical Physics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Error 100%
  • Radiotherapy 81%
  • Nuclear Magnetic Resonance 81%
  • Radiation Therapy 81%
  • Dose 72%
  14 Downloads (Pure)

• Evaluation of GATE‐RTion (GATE/Geant4) Monte Carlo simulation settings for proton pencil beam scanning quality assurance

  Winterhalter, C., Taylor, M., Boersma, D., Elia, A., Guatelli, S., Mackay, R., Kirkby, K., Maigne, L., Ivanchenko, V., Resch, A. F., Sarrut, D., Sitch, P., Vidal, M., Grevillot, L. & Aitkenhead, A., 23 Sep 2020, (E-pub ahead of print) In: Medical Physics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient 100%
  • Time 62%
  • Proton 62%
  • Computer Assisted Tomography 62%
  • Quality Control 50%

• Experimental verification the Electron Return Effect around spherical air cavities for the MR Linac using Monte Carlo calculation

  Shortall, J., Vasquez Osorio, E., Mackay, R., Aitkenhead, A., Kirkby, K., Budgell, G., Agnew, J., Mcwilliam, A., Chuter, R. & Van Herk, M., 7 Mar 2020, (E-pub ahead of print) In: Medical Physics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phantom 100%
  • Dose 42%
  • Treatment Planning Software 42%
  • Poly(methyl Methacrylate) 42%
  • Analysis 28%
  27 Downloads (Pure)

• Heavy charged particle beam therapy and related new radiotherapy technologies: The clinical potential, physics and technical developments required to deliver benefit for patients with cancer

  Kirkby, K., Kirkby, N., Burnet, N., Owen, H., Mackay, R., Crellin, A. & Green, S., 2 Sep 2020, (Accepted/In press) In: British Journal of Radiology .

  Research output: Contribution to journal › Article › peer-review

  • Radiation Therapy 100%
  • Radiotherapy 100%
  • Proton 50%
  • Electric Potential 50%
  • Patient 50%

• Hi-C implementation of genome structure for in silico models of radiation-induced DNA damage

  Ingram, S. P., Henthorn, N. T., Warmenhoven, J. W., Kirkby, N. F., Mackay, R. I., Kirkby, K. J. & Merchant, M. J., 16 Dec 2020, In: PLoS computational biology. 16, 12, e1008476.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Damage 100%
  • Radiation 75%
  • Chromosome 50%
  • Radiosensitivity 50%
  • Conformation 50%
  54 Downloads (Pure)

• Insights into the Non-Homologous End Joining Pathway and Double Strand Break End Mobility Provided by Mechanistic In Silico Modelling

  Warmenhoven, J., Henthorn, N., Ingram, S., Chadwick, A., Sotiropoulos, M., Korabel, M., Fedotov, S., Mackay, R., Kirkby, K. & Merchant, M., Jan 2020, In: DNA Repair.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Behavior (Neuroscience) 100%
  • Behavior 100%
  • Introspection 66%
  • Time 66%
  • Computer Model 66%

• Inter- and intra-fractional stability of rectal gas in pelvic cancer patients during MRIgRT

  Shortall, J., Vasquez Osorio, E., Mackay, R., Song, Y. P., Kirkby, K., Cree, A., Dubec, M., Chuter, R., Mcwilliam, A., Price, G. & Van Herk, M., 9 Nov 2020, (E-pub ahead of print) In: Medical Physics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gas 100%
  • Patient 52%
  • Rectum 38%
  • Magnetic Resonance Imaging 33%
  • Volume 19%
  42 Downloads (Pure)

• Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project

  Henthorn, N., Kirkby, K., Merchant, M. & Warmenhoven, J., 6 Oct 2020, In: Frontiers in Physics. 8, 565055.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Infrastructure 100%
  • Proton 100%
  • Protons 100%
  • Research 75%
  • Particle 75%

• Proton Beam Therapy – perspectives on the National Health Service England clinical service and research programme

  Burnet, N., Mackay, R., Smith, E. R., Chadwick, A., Whitfield, G., Thomson, D., Lowe, M., Kirkby, N., Crellin, A. M. & Kirkby, K., 1 Mar 2020, In: British Journal of Radiology. 93, 1107, p. 20190873 1 p., 20190873.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Proton Therapy 100%
  • Therapeutic Procedure 28%
  • Evaluation Study 28%
  • Patient 14%
  • Tissues 14%
  36 Downloads (Pure)

• Μulti-institutional dosimetric delivery assessment of intracranial stereotactic radiosurgery on different treatment platforms

  Dimitriadis, A., Tsang, Y. M., Thomas, R., Palmer, A., Eaton, D., Lee, J., Patel, R., Silvestre Patallo, I., Gouldstone, C., Snaith, J., Kirkby, K., Nisbet, A. & Clark, C., 20 May 2020, In: Radiotherapy & Oncology. 147, p. 153-161

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Obstetric Delivery 100%
  • Alanine 100%
  • Measurement 66%
  • Dose 66%
  • Linear Accelerator 66%
  116 Downloads (Pure)
• 2019

  A New Method to Reconstruct in 3D the Emission Position of the Prompt Gamma Rays following Proton Beam Irradiation

  Panaino, C., Mackay, R., Kirkby, K. & Taylor, M., 2019, In: Scientific Reports. 9, 18820.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tylenol 100%
  • Proton Beams 100%
  • Spectrometer 75%
  • Proton 75%
  • Procedures 50%

• A new Standard DNA Damage (SDD) data format

  Warmenhoven, J., Henthorn, N., Kirkby, K., Merchant, M., Ingram, S. & et al., 2019, In: Radiation Research. 191, 1, p. 76-93

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA 100%
  • Radiation 80%
  • DNA Damage 80%
  • Standards 80%
  • Comprehension 40%

• Assessing localised dosimetric effects due to unplanned gas cavities during pelvic MR‐guided Radiotherapy using Monte Carlo simulations

  Shortall, J., Vasquez Osorio, E., Chuter, R., Mcwilliam, A., Choudhury, A., Kirkby, K., Mackay, R. & Van Herk, M., 2019, In: Medical Physics.

  Research output: Contribution to journal › Article › peer-review

  • Radiotherapy 100%
  • Phantom 100%
  • Radiation Therapy 100%
  • Dose 75%
  • Pelvis 75%

• A Systematic Review of Health Economic Evaluations of proton Beam therapy for adult cancer: Appraising Methodology and Quality

  Jones, D. A., Smith, J., Mei, X. W., Hawkins, M. A., Maughan, T., van den Heuvel, F., Kirkby, K., Mee, T., Kirkby, N. & Gray, A., 29 Oct 2019, (Accepted/In press) In: Clinical and Translational Oncology.

  Research output: Contribution to journal › Article › peer-review

• Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons

  Henthorn, N., Warmenhoven, J., Sotiropoulos, M., Aitkenhead, A., Smith, E., Ingram, S., Kirkby, N., Chadwick, A., Burnet, N., Mackay, R., Kirkby, K. & Merchant, M., 2019, In: RSC Advances.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biological Relative 100%
  • Complexity 80%
  • Protons 80%
  • DNA Damage 80%
  • Photons 60%

• Full 3D Position Reconstruction of a Radioactive Source Based on a Novel Hyperbolic Geometrical Algorithm

  Panaino, C., Mackay, R., Sotiropoulos, M., Kirkby, K. & Taylor, M., 26 Dec 2019, In: Computer Physics Communications. 252, 107131.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Algorithms 100%
  • Algorithm 100%
  • Value 50%
  • Arrays 50%
  • Procedures 50%

• In Silico Models of DNA Damage and Repair in Proton Treatment Planning: A Proof of Concept

  Smith, E., Henthorn, N., Warmenhoven, J., Ingram, S., Aitkenhead, A., Richardson, J., Chadwick, A., Underwood, T., Merchant, M., Burnet, N., Kirkby, N., Kirkby, K. & Mackay, R., 27 Dec 2019, In: Scientific Reports.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Relative Biologic Effectiveness 100%
  • Treatment 33%
  • Therapeutic Procedure 22%
  • Proton 22%
  • DNA Repair 22%

• Mechanistic modelling supports entwined rather than exclusively competitive DNA double-strand break repair pathway

  Ingram, S., Warmenhoven, J., Henthorn, N., Smith, E., Burnet, N., Mackay, R., Kirkby, N., Kirkby, K. & Merchant, M., 23 Apr 2019, In: Scientific Reports. 9, 1, p. 6359 6359.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Non-Homologous End Joining 100%
  • Homologous Recombination 100%
  • Protein 75%
  • DNA 50%
  • DNA Damage 25%

• Preclinical dosimetry: exploring the use of small animal phantoms

  Biglin, E. R., Price, G. J., Chadwick, A. L., Aitkenhead, A. H., Williams, K. J. & Kirkby, K. J., 2019, In: Radiation Oncology. 14, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Development 100%
  • Animal 100%
  • Radiation Therapy 75%
  • Dosimetry 75%
  • Tissues 50%

• The targeting of RNA polymerase I transcription using CX-5461 in combination with radiation enhances tumour cell killing effects in human solid cancers

  Ismael, M., Webb, R., Ajaz, M., Kirkby, K. & Coley, H., 13 Sep 2019, (Accepted/In press) In: Cancers.

  Research output: Contribution to journal › Article › peer-review
• 2018

  Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit

  Mcnamara, A. L., Ramos-méndez, J., Perl, J., Held, K., Dominguez, N., Moreno, E., Henthorn, N. T., Kirkby, K. J., Meylan, S., Villagrasa, C., Incerti, S., Faddegon, B., Paganetti, H. & Schuemann, J., 6 Sep 2018, In: Physics in Medicine and Biology. 63, 17, 175018.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Simulation 100%
  • Tool 62%
  • Particle 50%
  • Radiation 37%
  • Geometry 37%
  219 Downloads (Pure)

• In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density

  Henthorn, N., Warmenhoven, J., Sotiropoulos, M., Mackay, R., Kirkby, N., Kirkby, K. & Merchant, M., 8 Feb 2018, In: Scientific Reports. 8, 1, p. 2654 2654.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Density 100%
  • Non-Homologous End Joining 66%
  • Ion Therapy 66%
  • Linear Energy Transfer 66%
  • Dose 66%

• Mathematical Modelling for Patient Selection in Proton Therapy

  Mee, T., Kirkby, N. & Kirkby, K., 14 Feb 2018, In: Clinical Oncology. 30, 5, p. 299-306 8 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Proton Therapy 100%
  • Statistical Modeling 50%
  • Patient 25%
  • Tissues 25%
  • Life 25%
  299 Downloads (Pure)

• Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit

  National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Proton Beam Clinical Trial Strategy Group & Kirkby, K., May 2018, In: Clinical oncology (Royal College of Radiologists (Great Britain)). 30, 5, p. 280-284 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Proton Therapy 100%
  • Radiation Therapy 75%
  • Radiotherapy 75%
  • Obstetric Delivery 50%
• 2017

  Automated microbeam observation environment for biological analysis—Custom portable environmental control applied to a vertical microbeam system

  England, M. J., Bigelow, A. W., Merchant, M. J., Velliou, E., Welch, D., Brenner, D. J. & Kirkby, K. J., 1 Feb 2017, In: Sensors and Actuators, B: Chemical. 239, p. 1134-1143 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Environment 100%
  • Observation 83%
  • Biological Analysis 50%
  • Time 33%
  • Control System 33%

• Coupling Monte Carlo simulations with thermal analysis for correcting microdosimetric spectra from a novel micro-calorimeter

  Fathi, K., Galer, S., Kirkby, K., Palmans, H. & Nisbet, A., 2017, In: Radiation Physics and Chemistry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Particle 100%
  • Optical Spectrum 80%
  • Tissue 60%
  • Therapy 60%
  • Simulation 60%
  923 Downloads (Pure)

• Modelling direct DNA damage for gold nanoparticle enhanced proton therapy

  Sotiropoulos, M., Henthorn, N., Warmenhoven, J., Mackay, R., Kirkby, K. & Merchant, M., 2017, In: Nanoscale.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gold Nanoparticle 100%
  • Radiosensitization 83%
  • DNA 66%
  • Proton 66%
  • DNA Damage 66%

• Monte Carlo simulation of a TEPC for microdosimetry of carbon ions

  Galer, S., Shipley, D. R., Palmans, H., Kirkby, K. J. & Nisbet, A., 1 Nov 2017, In: Radiation Physics and Chemistry. 140, p. 412-418 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Simulation 100%
  • Optical Spectrum 100%
  • Biological Product 100%
  • Carbon 100%
  • Tissue 66%

• Nanodosimetric simulation of direct ion induced DNA damage using different chromatin geometry models

  Henthorn, N., Warmenhoven, J., Sotiropoulos, M., Mackay, R. I., Kirkby, K. & Merchant, M., Dec 2017, In: Radiation Research. 188, 6, p. 690-703 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Model 100%
  • Chromatin 87%
  • DNA 87%
  • Simulation 62%
  • Fibers 62%
• 2015

  An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells

  Powell, J. J., Thomas-McKay, E., Thoree, V., Robertson, J., Hewitt, R. E., Skepper, J. N., Brown, A., Hernandez-Garrido, J. C., Midgley, P. A., Gomez-Morilla, I., Grime, G. W., Kirkby, K. J., Mabbott, N. A., Donaldson, D. S., Williams, I. R., Rios, D., Girardin, S. E., Haas, C. T., Bruggraber, S. F. A., Laman, J. D., & 5 othersTanriver, Y., Lombardi, G., Lechler, R., Thompson, R. P. H. & Pele, L. C., 9 Mar 2015, In: Nature Nanotechnology. 10, 4, p. 361-369

  Research output: Contribution to journal › Article › peer-review

• Automatic cell detection in bright-field microscopy for microbeam irradiation studies

  Georgantzoglou, A., Merchant, M. J., Jeynes, J. C. G., Wéra, A-C., Kirkby, K. J., Kirkby, N. & Jena, R., 21 Aug 2015, In: Physics in Medicine and Biology. 60, 16, p. 6289-6303 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Radiation Effect 100%
  • Detection 40%
  • Microscopy 30%
  • Corners 30%
  • Substrates 20%

• Current status of cranial stereotactic raDiosurgery in the UK

  Dimitriadis, A., Kirkby, K. J., Nisbet, A. & Clark, C. H., 2015, In: British Journal of Radiology. 89, 1058, 20150452.

  Research output: Contribution to journal › Article › peer-review

  • Stereotactic Radiosurgery 100%
  • Patient 22%
  • Radiation Therapy 22%
  • Obstetric Delivery 11%
  • Water 11%

• Investigating the Intrinsic Noise Limit of Dayem Bridge NanoSQUIDs

  Patel, T., Li, B., Gallop, J., Cox, D. & Kirkby, K., Jun 2015, In: I E E E Transactions on Applied Superconductivity. 25, 3

  Research output: Contribution to journal › Article › peer-review

  • Preamplifier 100%
  • Arrays 75%
  • Weak Link 75%
  • Noise 75%
  • Thin Films 50%
• 2014

  Influence of the nucleus area distribution on the survival fraction after charged particles broad beam irradiation.

  Wéra, A-C., Barazzuol, L., Jeynes, J. C. G., Merchant, M. J., Suzuki, M., Kirkby, K. J. & W??ra, AC., 7 Aug 2014, In: Physics in Medicine and Biology. 59, 15, p. 4197-4211 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Area 100%
  • Survival 83%
  • Fractions 66%
  • Irradiation 66%
  • Variations 50%

• Investigation of gold nanoparticle radiosensitization mechanisms using a free radical scavenger and protons of different energies

  Jeynes, J. C. G., Merchant, M. J., Spindler, A., Wera, A. C. & Kirkby, K. J., 1 Sep 2014, In: Physics in Medicine and Biology. 59, 21, p. 6431-6443 13 p., 6431.

  Research output: Contribution to journal › Article › peer-review

  • Proton 100%
  • Gold Nanoparticle 85%
  • Free Radicals 71%
  • Protons 57%
  • Cells 42%

• Radiosensitisation of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays

  Barazzuol, L., Jeynes, JC., Merchant, MJ., Wera, AC., Barry, M., Kirkby, K. J. & Suzuki, M., 1 Jul 2014, In: International Journal of Radiation Biology. 91, 1

  Research output: Contribution to journal › Article › peer-review

  • Cells 100%
  • Carbon 100%
  • X-Ray 100%
  • Vorinostat 100%
  • Therapeutic Procedure 66%