Research output per year
Research output per year
Personal profile
Overview
- Professor and Head of Neuroscience Research at the Wolfson Molecular Imaging Centre
- Honorary neurological consultant at Salford Royal Hospital
- Honorary consultant at the Nuclear Medicine Department, Central Manchester Foundation Trust
Biography
- Graduation as medical doctor at the University of Erlangen, Germany, in 1980
- After basic general clinical training, clinical research fellow at the Max-Planck-Institute for Neurological Research in Cologne, Germany, since 1982
- Clinical specialist training in neurology at municipal and university hospitals, Cologne, Germany, from 1982 to 1990
- Since 1994 professor of neurology at the University of Cologne
- Since 2005, after moving to the University of Manchester, UK, professor in clinical neuroscience and head of the neuroscience imaging programme at the Wolfson Molecular Imaging Centre (WMIC)
- WMIC director from April 2006 to July 2010
Research interests
- Neuroimaging studies (PET and MRI) of
- dementia (early diagnosis of dementia in patients with mild cognitive deficits, multicentre studies, impairment of specific transmitter systems and their relevance for cognitive symptoms and distinction of dementing disorders, monitoring of progression, clinical trials in collaboration with pharmaceutical companies)
- brain tumors (grading of metabolic activity, detection of progression to higher grade of malignancy, interference with and plasticity of normal brain function, monitoring of therapy, 3D visualization for planning of neurosurgical intervention)
- Coordination of National and International Multicentre PET Studies
- Early Diagnosis of Neurodegenerative Diseases within the EU-funded Networks on Diagnostic Molecular Imaging (www.dimi.eu), Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND), the Medical Informatics Framework on Alzheimer's Disease (EMIF-AD) and the MRC-funded DPUK partnership on MR-PET imaging
- Chief investigator of the EU-funded "Network for Efficiency and Standardisation of Dementia Diagnosis" (NEST-DD) with a comprehensive clinical and neuroimaging digital database of more than 1000 subjects
- Collaboration with the NIH-funded Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Memberships of committees and professional bodies
- Royal College of Physicians, fellow
- Royal Society of Medicine, fellow
- Association of British Neurologists
- British Neuro-Oncology Society
- Deutsche Gesellschaft für Neurologie
- Society of Cerebral Blood Flow and Metabolism
- Manchester Medical Society
- British Medical Association
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Society of Nuclear Medicine
- Brain Imaging Council, President (2010/2011)
Methodological knowledge
- Functional neuroimaging, especially using positron emission tomography (PET)
- Accredited expert in radiation protection (ARSAC)
Qualifications
- Doctor of medicine (Dr.med.), University of Erlangen, Germany
- Specialist board examination in neurology, Duesseldorf, Germany
- Habilitation and Venia legendi in neurology, University of Cologne, Germany
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Beacons, Institutes and Platforms
- Dementia@Manchester
- Digital Futures
- Manchester Institute for Collaborative Research on Ageing
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Structural and metabolic correlates of neuropsychological profiles in multiple system atrophy and Parkinson's disease
Kübler, D., Kobylecki, C., McDonald, K. R., Anton-Rodriguez, J. M., Herholz, K., Carter, S. F., Hinz, R., Thompson, J. C., Al-Fatly, B. & Gerhard, A., Feb 2023, In: Parkinsonism & Related Disorders.Research output: Contribution to journal › Article › peer-review
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Advanced quantitative evaluation of PET systems using the ACR phantom and NiftyPET software
Markiewicz, P. J., da Costa-Luis, C., Dickson, J., Barnes, A., Krokos, G., MacKewn, J., Clark, T., Wimberley, C., MacNaught, G., Yaqub, M. M., Gispert, J. D., Hutton, B. F., Marsden, P., Hammers, A., Reader, A. J., Ourselin, S., Herholz, K., Matthews, J. & Barkhof, F., 1 May 2022, In: Medical Physics. 49, 5, p. 3298-3313 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Evaluation of in vivo staging of amyloid deposition in cognitively unimpaired elderly aged 78–94
Michalowska, M. M., Herholz, K., Hinz, R., Amadi, C., Mcinnes, L., Anton-rodriguez, J. M., Karikari, T. K., Blennow, K., Zetterberg, H., Ashton, N. J., Pendleton, N. & Carter, S. F., 20 Jul 2022, In: Molecular psychiatry.Research output: Contribution to journal › Article › peer-review
Open Access -
Measurement of Protein Synthesis Rate in Rat by [11C]Leucine PET Imaging: Application to the TgF344-AD Model of Alzheimer’s Disease
Bochicchio, D., Christie, L., Lawrence, C. B., Herholz, K., Parker, C. A., Hinz, R. & Boutin, H., 20 Dec 2022, (E-pub ahead of print) In: Molecular Imaging and Biology. 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Amyloid-PET Positive Patient with bvFTD: Wrong Diagnosis, False Positive Scan, or Co-pathology?
Langheinrich, T., Kobylecki, C., Jones, M., Thompson, J. C., Snowden, J. S., Hinz, R., Pickering-Brown, S., Mann, D., Roncaroli, F., Herholz, K. & Gerhard, A., 25 Jan 2021, In: Neurology: Clinical Practice. 11, 6, p. e952-e955Research output: Contribution to journal › Article › peer-review
Open AccessFile71 Downloads (Pure)
Projects
- 3 Finished
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Quantification of Vascular and Neuronal Pathology in Dementia Using PET and MRI.
Parker, G., Asselin, M., Boutin, H., Burns, A., Herholz, K., Matthews, J., Parkes, L. & Williams, S.
1/01/15 → 28/02/19
Project: Research
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CRUK Imaging Centres.
Jackson, A., Asselin, M., Coope, D., Dive, C., Faivre-Finn, C., Herholz, K., Hinz, R., Illidge, T., Manoharan, P., Marais, R., Matthews, J., McMahon, A., O'Connor, J., Parker, G., Stivaros, S., Thacker, N., Williams, K. & Withers, P.
1/12/13 → 30/11/19
Project: Research
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EURIPIDES: European research initiative to develop imaging probes for early in-vivo diagnosis and evaluation of response to therapeutic substances (EURIPIDES)
Asselin, M., Brown, G., Herholz, K., Jackson, A., Matthews, J., McMahon, A. & Talbot, P.
1/02/08 → 31/07/12
Project: Research
Prizes
Datasets
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Supplementary Material for: Performance of FDG PET for Detection of Alzheimer’s Disease in Two Independent Multicentre Samples (NEST-DD and ADNI)
Haense, C. (Contributor), Herholz, K. (Contributor), Jagust, W. J. (Contributor) & Heiss, W. D. (Contributor), figshare , 25 Sep 2009
DOI: 10.6084/m9.figshare.5120839.v1, https://figshare.com/articles/Supplementary_Material_for_Performance_of_FDG_PET_for_Detection_of_Alzheimer_s_Disease_in_Two_Independent_Multicentre_Samples_NEST-DD_and_ADNI_/5120839/1 and one more link, https://ndownloader.figshare.com/files/8705161 (show fewer)
Dataset