Research output per year
Research output per year
Outside of running a successful research group and teaching highly motivated students on the MPharm programme, many of my academic leadership and management roles within the University of Manchester are focused upon the promotion and development of research. Specific contributions are made via the following:
My additional roles focus on equality and diversity and in staff training and development. I chaired the Athena Swan Self Assessment team in Manchester Pharmacy School and was the MPS representative on the previous faculty's Equality and Diversity committee. I am staff training and development lead for Pharmacy and work with colleagues towards developing cases for promotion both within and outwith my division.
Professor Kaye Williams is Leader of the Hypoxia and Therapeutics Group within the Division of Pharmacy and Optometry at the University of Manchester. Kaye joined DPO in November 1996. Following back-to-back Research Associate and Research Fellow positions funded by the MRC, she gained tenure in January 2006, and was promoted to Chair in Experimental Therapeutics and Imaging in August 2012. Her research focuses on the tumour microenvironment, investigating therapeutic targets, vascular biology and molecular interactions that influence tumour response to radiotherapy. Kaye also leads pre-clinical imaging development within the Manchester Cancer Research Centre, and has leadership for preclinical imaging within Imaging@Manchester. Externally, she has had significant roles in the NCRI Clinical and Translational Radiotherapy Research Working Group, in particular through association with the RadCom initiative that aimed to expedite novel drug radiation combinations into clinical trial. She continues to provide leadership in this area via the CRUK Drug-Radiotherapy Working Group. She is part of the team that secured £16.5 million for the University of Manchester towards infrastructure funding in radiation related research via the CRUK RadNET initiative and currently acts as Deputy Director of CRUK RadNET Manchester.
Kaye was awarded the British Association for Cancer Research/AstraZeneca Frank Rose Young Scientist Award in 2005.
Kaye currently leads a multi-disciplinary team who work towards producing proof of concept data to support the translation of novel anti-cancer approaches into patients. She has specific interests in the tumour microenvironment, particularly the condition of hypoxia, and how to therapeutically target this to improve cancer outcomes. Kaye also has a keen interest in the use of molecular targeted and/or biological therapies in combination with radiation treatment. In particular she has investigated the impact of novel agents on the underlying mechanisms that govern radiation response to enable their optimal application in a clinical radiotherapy context. These studies have underpinned ongoing clinical trials within The Christie, Manchester, and nationally that are showing positive patient benefit. Kaye has a lead role in the development of pre-clinical imaging for oncology applications within the Manchester Cancer Research Centre. The focus here is to develop, validate and apply image derived biomarkers to assess changes in tumour biology and therapeutic response.
Patents filed and approved
If you would like to apply for a PhD under the supervision of Professor Williams, please visit this page.
MPharm:
External Teaching and Assessment:
Dr Duncan Forster- Post-doctoral Researcher
Dr Emiy Rowling- Post-doctoral Researcher
Dr Abid Khan- Post-doctoral Researcher
Mrs Lidan Christie- Reserach Technician Preclinical Imaging
Mr Muhammad Babur- Research Technician
Dr Brian Telfer- Experimental Officer
Dr Ben Dickie SEO and Research Fellow, Preclinical MR
Collaborators
Dr Katie Finegan - Lecturer in Cancer Biology and Therapy
Dr Ayse Latif - Lecturer in Cancer Metabolism
Dr Costas Demonacos - Molecular Pharmacology, redox sensitive transcriptional regulation
Professor Caroline Dive - Mechanisms of hypoxia-mediated modification of chemotherapy response
Professor Ian Stratford - Tumour biology
Professor Anne White - Endocrine tumour biology
Dr Adam McMahon - Integration of imaging and proteomic tools; PET radiochemistry
Professor James O’Connor- MR Imaging
Dr Jason Bruce - Pancreatic Cancer
Dr Adam Hurlstone - Lipid Metabolism in Cancer
Professor Tracy Hussell - Cancer and Inflammation
Member of
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Preprint/Working paper › Preprint
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to conference › Abstract › peer-review
Research output: Preprint/Working paper › Preprint
Research output: Contribution to journal › Article › peer-review
Bristow, R. (PI), Burnet, N. (CoI), Choudhury, A. (CoI), Dive, C. (CoI), Faivre-Finn, C. (CoI), Hagan, I. (CoI), Hoskin, P. (CoI), Hussell, T. (CoI), Illidge, T. (CoI), Kirkby, K. (CoI), Kostarelos, K. (CoI), O'Connor, J. (CoI), Peek, N. (CoI), Rattray, M. (CoI), Taylor, S. (CoI), Thornton, D. (CoI), Van Herk, M. (CoI), West, C. (CoI), Whetton, A. (CoI), Williams, K. (CoI) & Yorke, J. (CoI)
1/11/19 → 31/10/24
Project: Research
Finegan, K. (PI), McMahon, A. (CoI) & Williams, K. (CoI)
1/09/19 → 31/08/22
Project: Research
Williams, K. (PI), Clarke, R. (CoI) & Khan, A. (CoI)
1/08/19 → 31/07/22
Project: Research
Finegan, K. (PI), Butterworth, S. (CoI), Houston, J. (CoI) & Williams, K. (CoI)
1/09/18 → 31/10/21
Project: Research
Searle, E. (PI), Illidge, T. (CoI), Metcalf, R. (CoI) & Williams, K. (CoI)
1/09/17 → 28/02/21
Project: Research
Aziz, O. (Recipient), McMahon, A. (Recipient) & Williams, K. (Recipient), 1 Oct 2017
Prize: Prize (including medals and awards)
Stratford, I. (Participant), Williams, K. (Participant), West, C. (Participant), (Participant), (Participant), Eustace, A. (Participant) & (Participant)
Impact: Health impacts
Latif, A. (Contributor), Chadwick, A. (Contributor), Kitson, S. (Contributor), Gregson, H. (Contributor), Sivalingam, V. (Contributor), Bolton, J. (Contributor), McVey, R. J. (Contributor), Roberts, S. (Contributor), Marshall, K. (Contributor), Williams, K. (Contributor), Stratford, I. (Contributor) & Crosbie, E. (Contributor), figshare , 28 Dec 2017
DOI: 10.6084/m9.figshare.c.3963363.v1, https://figshare.com/collections/Monocarboxylate_Transporter_1_MCT1_is_an_independent_prognostic_biomarker_in_endometrial_cancer/3963363/1
Dataset
Heinzmann, K. (Contributor), Honess, D. J. (Contributor), Lewis, D. Y. (Contributor), Smith, D.-M. (Contributor), Cawthorne, C. (Contributor), Keen, H. (Contributor), Heskamp, S. (Contributor), Schelhaas, S. (Contributor), Witney, T. H. (Contributor), Soloviev, D. (Contributor), Williams, K. (Contributor), Jacobs, A. H. (Contributor), Aboagye, E. O. (Contributor), Griffiths, J. R. (Contributor) & Brindle, K. M. (Contributor), figshare , 11 Aug 2016
DOI: 10.6084/m9.figshare.c.3697000.v1, https://figshare.com/collections/The_relationship_between_endogenous_thymidine_concentrations_and_18F_FLT_uptake_in_a_range_of_preclinical_tumour_models/3697000/1
Dataset