Kaye Williams

2023

Abstract 625: PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven adaptive resistance

Wong, C. W., Evangelou, C., Sefton, K. N., Leshem, R., Sergiou, K., Carro, M. L. F., Uzuner, E., Mole, H., Telfer, B. A., Wilcock, D. J., Smith, M. P., Kunii, K., Perl, N. R., Lorigan, P., Williams, K. J., Rao, P. E., Nagaraju, R. T., Niepel, M. & Hurlstone, A. F., 1 Apr 2023. 1 p.

Research output: Contribution to conference › Abstract › peer-review

PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFN_ϒ-drive acquired resistance in preclinical cancer models

Wong, C. W., Evangelou, C., Sefton, K. N., Leshem, R., Zhang, W., Gopalan, V., Chattrakarn, S., Fernandez Carro, M. L., Uzuner, E., Mole, H., Wilcock, D. J., Smith, M. P., Sergiou, K., Telfer, B. A., Isaac, D. T., Liu, C., Perl, N. R., Marie, K., Lorigan, P. & Williams, K. J. & 4 others, Rao, P. E., Nagaraju, R. T., Niepel, M. & Hurlstone, A. F. L., 18 Sept 2023, (Accepted/In press) In: Nature Communications.

Research output: Contribution to journal › Article › peer-review

2022

Invasion and secondary site colonization as a function of in vitro primary tumor matrix stiffness: breast to bone metastasis

Shah, L., Latif, A., Williams, K., Mancuso, E. & Tirella, A., 17 Oct 2022, (Accepted/In press) In: Advanced Healthcare Materials.

Research output: Contribution to journal › Article › peer-review

Role of stiffness and physico-chemical properties of tumour microenvironment on breast cancer cell stemness

Shah, L., Latif, A., Williams, K. & Tirella, A., 30 Aug 2022, (Accepted/In press) In: Acta Biomaterialia.

Research output: Contribution to journal › Article › peer-review

The characterization of molecular weight distribution and aggregation by asymmetrical flow field-flow fractionation of unmodified and oxidized alginate

Zhao, C., Latif, A., Williams, K. J. & Tirella, A., 1 Jun 2022, In: Reactive and Functional Polymers. 175, 105292.

Research output: Contribution to journal › Article › peer-review

Open Access

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2021

A Novel Mechanism of Ataxia Telangiectasia Mutated Mediated Regulation of Chromatin Remodeling in Hypoxic Conditions

Likhatcheva, M., Gieling, R. G., Brown, J. A. L., Demonacos, C. & Williams, K. J., 21 Sept 2021, In: Frontiers in cell and developmental biology. 9, 11 p., 720194.

Research output: Contribution to journal › Article › peer-review

Open Access

Immunomodulation by radiotherapy in tumour control and normal tissue toxicity

Cytlak, U. M., Dyer, D. P., Honeychurch, J., Williams, K. J., Travis, M. A. & Illidge, T. M., 1 Jul 2021, In: Nature Reviews Immunology.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer

Bibby, B. A. S., Thiruthaneeswaran, N., Yang, L., Pereira, R. R., More, E., McArt, D. G., O'Reilly, P., Bristow, R. G., Williams, K. J., Choudhury, A. & West, C. M. L., 1 Jul 2021, In: BMC urology. 21, 1, 96.

Research output: Contribution to journal › Article › peer-review

Open Access

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2020

3D DESI-MS lipid imaging in a xenograft model of glioblastoma: a proof of principle

Henderson, F., Jones, E., Denbigh, J., Christie, L., Chapman, R., Hoyes, E., Claude, E., Williams, K., Roncaroli, F. & McMahon, A., 5 Oct 2020, In: Scientific Reports. 10, 16512 (2020).

Research output: Contribution to journal › Article › peer-review

Open Access

Actinomycin D Downregulates Sox2 and Improves Survival in Preclinical Models of Recurrent Glioblastoma

Taylor, J. T., Ellison, S., Pandele, A., Wood, S., Nathan, E., Forte, G., Parker, H., Zindy, E., Elvin, M., Dickson, A., Williams, K. J., Karabatsou, K., McCabe, M., McBain, C. & Bigger, B. W., 30 Mar 2020, In: Neuro-Oncology. 22, 9, p. 1289-1301 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart

Ghita, M., Gill, E. K., Walls, G. M., Edgar, K. S., McMahon, S. J., Osorio, E. V., Bergom, C., Grieve, D. J., Watson, C. J., McWilliam, A., Aznar, M., van Herk, M., Williams, K. J. & Butterworth, K. T., 11 Jul 2020, (E-pub ahead of print) In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Research output: Contribution to journal › Article › peer-review

Open Access

Diffusion model comparison identifies distinct tumor sub-regions and tracks treatment response

McHugh, D. J., Lipowska-Bhalla, G., Babur, M., Watson, Y., Peset, I., Mistry, H. B., Hubbard Cristinacce, P. L., Naish, J. H., Honeychurch, J., Williams, K. J., O'Connor, J. P. B. & Parker, G. J. M., 2020, In: Magnetic Resonance in Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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Meeting report on ICRR2019, the 16th International Congress on Radiation Research

Williams, K. J., Hammond, E. M., West, C., Anderson, R. M., Badie, C. & Jeggo, P. A., 1 Feb 2020, In: International Journal of Radiation Biology.

Research output: Contribution to journal › Article

Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer

Green, D., Eyre, H., Singh, A., Taylor, J., Chu, J., Jeys, L., Sumathi, V. P., Coonar, A., Rassl, D., Babur, M., Forster, D., Alzabin, S., Ponthan, F., McMahon, A., Bigger, B., Reekie, T., Kassiou, M., Williams, K., Dalmay, T. & Fraser, W. D. & 1 others, Finegan, K., 13 Jul 2020, In: Oncogene. 39, p. 5553–5569

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Enhanced fatty acid scavenging and glycerophospholipid metabolism accompanies melanocyte neoplasia progression in zebrafish

Henderson, F., Johnston, H., Badrock, A., Jones, E., Forster, D., Nagaraju, R., Evangelou, C., Kamarashev, J., Green, M., Fairclough, M., Barinaga-Rementeria, I., He, S., Jagalska, E. S., Hollywood, K., Dunn, W., Spaink, H. P., Smith, M., Lorigan, P., Claude, E. & Williams, K. & 2 others, Mcmahon, A. & Hurlstone, A., 12 Mar 2019, In: Cancer Research. 79, 9, p. 2136-2151 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Evaluating the Efficiency of Hyaluronic Acid for Tumor Targeting via CD44

Spadea, A., Rios De La Rosa, J. M., Tirella, A., Ashford, M. B., Williams, K. J., Stratford, I. J., Tirelli, N. & Mehibel, M., 23 Apr 2019, In: Molecular Pharmaceutics. 16, 6, p. 2481–2493

Research output: Contribution to journal › Article › peer-review

Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours

Youshani, A. S., Rowlston, S., O'Leary, C., Forte, G., Parker, H., Liao, A., Telfer, B., Williams, K., Kamaly-Asl, I. D. & Bigger, B. W., 2019, In: Journal of Neuroinflammation. 16, 1, 25.

Research output: Contribution to journal › Article › peer-review

Open Access

Novel phase I trial design to evaluate the addition of cediranib orselumetinib to preoperative chemoradiotherapy for locally advanced rectal cancer:the DREAMtherapy trial

Marti Marti, F., Jayson, G., Manoharan, P., O'Connor, J., Renehan, A., Backen, A., Mistry, H., Ortega, F., Simpson, K., Misra, V., Williams, K., Stratford, I., Jackson, A., Dive, C., Li, K.-L. & Saunders, M., 21 Jun 2019, In: European journal of cancer (Oxford, England : 1990). 117, p. 48-59 11 p.

Research output: Contribution to journal › Article › peer-review

Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non-small Cell Lung Cancer

Salem, A., Little, R. A., Latif, A., Featherstone, A. K., Babur, M., Peset, I., Cheung, S., Watson, Y., Tessyman, V., Mistry, H., Ashton, G., Behan, C., Matthews, J. C., Asselin, M.-C., Bristow, R. G., Jackson, A., Parker, G. J. M., Faivre-Finn, C., Williams, K. J. & O'Connor, J. P. B., 1 Jul 2019, In: Clinical Cancer Research. 25, 13, p. 3818-3829 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Preclinical dosimetry: exploring the use of small animal phantoms

Biglin, E. R., Price, G. J., Chadwick, A. L., Aitkenhead, A. H., Williams, K. J. & Kirkby, K. J., 2019, In: Radiation Oncology. 14, 1

Research output: Contribution to journal › Article › peer-review

Open Access

2018

A new method for the high-precision assessment of tumor changes in response to treatment

Tar, P., Thacker, N., Babur, M., Watson, Y., Cheung, S., Little, R., Gieling, R., Williams, K. & O'Connor, J., 14 Mar 2018, In: Bioinformatics. 34, 15, p. 2625-2633 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Clinical Development of Novel Drug-Radiotherapy Combinations

Ahmad, S. S., Crittenden, M. R., Tran, P. T., Kluetz, P. G., Blumenthal, G. M., Bulbeck, H., Baird, R. D., Williams, K. J., Illidge, T., Hahn, S. M., Lawrence, T. S., Spears, P. A., Walker, A. J. & Sharma, R. A., 29 Nov 2018, (E-pub ahead of print) In: Clinical cancer research : an official journal of the American Association for Cancer Research.

Research output: Contribution to journal › Article › peer-review

Data-driven mapping of hypoxia-related tumor heterogeneity using DCE-MRI and OE-MRI

Featherstone, A. K., O'Connor, J. P. B., Little, R. A., Watson, Y., Cheung, S., Babur, M., Williams, K. J., Matthews, J. C. & Parker, G. J. M., 1 Apr 2018, In: Magnetic Resonance in Medicine. 79, 4, p. 2236-2245 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma

Yu, K. K. H., Taylor, J. T., Pathmanaban, O. N., Youshani, A. S., Beyit, D., Dutko-Gwozdz, J., Benson, R., Griffiths, G., Peers, I., Cueppens, P., Telfer, B. A., Williams, K. J., McBain, C., Kamaly-Asl, I. D. & Bigger, B. W., 2 Mar 2018, In: PLoS ONE. 13, 3, e0193694.

Research output: Contribution to journal › Article › peer-review

Open Access

Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry

Henderson, F., Hart, P. J., Pradillo, J. M., Kassiou, M., Christie, L., Williams, K. J., Boutin, H. & McMahon, A., 14 Apr 2018, In: Rapid Communications in Mass Spectrometry. 32, 9, p. 721-729 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Multi-modality imaging to interrogate lipidome changes during melanoma progression in zebrafish

Henderson, F., Johnston, H., Jones, E., Foster, D., Nagaraju, R. T., Green, M., Fairclough, M., Ramirez, I.B.-R., He, S., Snaar-Jagalska, B. E., Hollywood, K. A., Dunn, W., Spaink, H. P., Lorigan, P., Claude, E., Williams, K., Hurlstone, A. & McMahon, A., Jul 2018, In: Cancer Research. 78, 13

Research output: Contribution to journal › Meeting Abstract › peer-review

Oxygen enhanced-{MRI} detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients

Salem, A., Little, R., Featherstone, A., Babur, M., Mistry, H., Cheung, S., Watson, Y., Tessyman, V., Asselin, M.-C., Jackson, A., Williams, K., Parker, G., Faivre-Finn, C. & O'Connor, J., 1 Jun 2018, ISMRM 2018. 1 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Open Access

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

Mehibel, M., Ortiz-martinez, F., Voelxen, N., Boyers, A., Chadwick, A., Telfer, B. A., Mueller-klieser, W., West, C. M., Critchlow, S. E., Williams, K. J. & Stratford, I. J., 1 Dec 2018, In: Scientific Reports. 8, 1, 16804.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Akt inhibition improves long-term tumour control following radiotherapy by altering the microenvironment

Searle, E., Telfer, B., Mukherjee, D., Forster, D., Davies, B. R., Williams, K., Stratford, I. & Illidge, T., 30 Oct 2017, In: EMBO Molecular Medicine . 9, 12, p. 1646-1659

Research output: Contribution to journal › Article › peer-review

Open Access

Comparison of lipid imaging in a zebrafish melanoma model by positron emission tomography (PET) and desorption electrospray ionization-mass spectrometry (DESI-MS)

Jones, E., Henderson, F., Midey, A., Hurlstone, A., Forster, D., Johnston, H., Williams, K., Batey, M. A., McMahon, A. & Claude, E., 1 Jan 2017, In: Drug Metabolism and Pharmacokinetics. 32, 1, S, p. S42-S43

Research output: Contribution to journal › Article › peer-review

High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrina

Piras, M., Testa, A., Fleming, I., Dall'Angelo, S., Andriu, A., Menta, S., Mori, M., Brown, G., Forster, D., Williams, K. & Zanda, M., 2017, In: ChemMedChem.

Research output: Contribution to journal › Article › peer-review

Open Access

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In vivo characterisation of a therapeutically relevant self-assembling ¹⁸F-labelled β-sheet forming peptide and its hydrogel using positron emission tomography

Morris, O., Elsawy, M., Fairclough, M., Williams, K., Mcmahon, A., Grigg, J., Forster, D., Miller, A. F., Saiani, A. & Prenant, C., Aug 2017, In: Journal of Labelled Compounds and Radiopharmaceuticals. 60, 10, p. 481-488 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Measuring and Modifying Temozolomide Delivery in Brain TUmours

Djoukhadar, I., Asselin, M.-C., Williams, K. & Jackson, A., Jan 2017, p. 128. 1 p.

Research output: Contribution to conference › Abstract › peer-review

Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer

Latif, A., Chadwick, A. L., Kitson, S. J., Gregson, H. J., Sivalingam, V. N., Bolton, J., McVey, R. J., Roberts, S. A., Marshall, K. M., Williams, K. J., Stratford, I. J. & Crosbie, E. J., 28 Dec 2017, In: BMC Clinical Pathology. 17, p. 27

Research output: Contribution to journal › Article › peer-review

Open Access

Novel carbonic anhydrase IX-targeted therapy enhances the anti-tumour effects of cisplatin in small cell lung cancer

Bryant, J., Gieling, R., Meredith, S., Allen, T.-J., Walker, L., Telfer, B., Supuran, C. T., Williams, K. & White, A., 7 Nov 2017, In: International Journal of Cancer. 142, 1, p. 191-201 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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N-tert-Prenylation of indole ring improves the cytotoxicity of a short antagonist G analogue against Small Cell Lung Cancer

Offerman, S., Kadirvel, M., Abusara, O., Bryant, J., Telfer, B., Brown, G., Freeman, S., White, A., Williams, K. & Aojula, H., 2017, In: MedChemComm.

Research output: Contribution to journal › Article › peer-review

Open Access

Oxygen enhanced optoacoustic tomography (OE-OT) reveals vascular dynamics in murine models of prostate cancer

Tomaszewski, M., Quiros Gonzalez, I., O'Connor, J., Abeyakoon, O., Parker, G., Williams, K., Gilbert, F. J. & Bohndiek, S. E., 8 Jul 2017, In: Theranostics. 7, 11, p. 2900-2913

Research output: Contribution to journal › Article › peer-review

Open Access

Tubulin-binding dibenz[c,e]oxepines: Part 2. Structural variation and biological evaluation as tumour vasculature disrupting agents

Rossington, S., Hadfield, J., Shnyder, S. D., Wallace, T. & Williams, K., 1 Mar 2017, In: Bioorganic and Medicinal Chemistry. 25, 5, p. 1630-1642 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2016

Evaluating the impact of a final year project on health promotion and public engagement on students perceived confidence for demonstrating skills in practice

Parmar, H., Hughes, J., Tavares, V., Ledder, R., Mcbain, A., Penny, J., Rhodes, M., Silkstone, V. & Williams, K., 2016.

Research output: Contribution to conference › Abstract › peer-review

Irradiation Decreases the Neuroendocrine Biomarker Pro-Opiomelanocortin in Small Cell Lung Cancer Cells In Vitro and In Vivo.

Meredith, S., Bryant, J., Babur, M., Riddell, P. W., Behrouzi, R., Williams, K. & White, A., 5 Feb 2016, In: P L o S One. 11, 2, e0148404 .

Research output: Contribution to journal › Article › peer-review

Open Access

Monitoring pharmacodynamic response to hypoxia-modifying therapy using non-invasive positron emission tomography and magnetic resonance imaging

Tessyman, V., Duncan, F., Finegan, K., Little, R., Cheung, S., Watson, Y., Babur, M., Asselin, M.-C., O'Connor, J. & Williams, K., Jul 2016, European Journal of Cancer. Supplement 1 ed. Vol. 61. p. S162 2 p. 722

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models

O'Connor, J., Boult, J. K. R., Jamin, Y., Babur, M., Finegan, K., Williams, K., Little, R., Jackson, A., Parker, G., Reynolds, A. R., Waterton, J. & Robinson, S. P., 15 Feb 2016, In: Cancer Research. 76, 4, p. 787-795 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas

Burrows, N., Williams, J., Telfer, B., Resch, J., Valentine, H., Fitzmaurice, R., Eustace, A., Irlam, J., Rowling, E., Hoang-Vu, C., West, C., Brabant, G. & Williams, K., 4 Aug 2016, In: Oncotarget. 7, 39, p. 63106-63123

Research output: Contribution to journal › Article › peer-review

Open Access

Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase

Mehibel, M., Singh, S., Cowen, R. L., Williams, K. & Stratford, I., 13 Jan 2016, In: Oncology Reports. 35, 4, p. 1925-1932 7 p., PMID: 26782976.

Research output: Contribution to journal › Article › peer-review

The novel Akt inhibitor AZD5363 following radiotherapy improves tumor control in mouse models of head and neck cancer

Searle, E., Telfer, B., Forster, D., Davies, B. R., Stratford, I., Illidge, T. & Williams, K., 22 Jul 2016, In: Cancer Research. 76, 14, p. 3042

Research output: Contribution to journal › Meeting Abstract › peer-review

Open Access

The relationship between endogenous thymidine concentrations and [¹⁸F]FLT uptake in a range of preclinical tumour models

Heinzmann, K., Honess, D. J., Lewis, D. Y., Smith, D. M., Cawthorne, C., Keen, H., Heskamp, S., Schelhaas, S., Witney, T. H., Soloviev, D., Williams, K. J., Jacobs, A. H., Aboagye, E. O., Griffiths, J. R. & Brindle, K. M., 11 Aug 2016, In: EJNMMI Research. 6, 1, 63.

Research output: Contribution to journal › Article › peer-review

Open Access

The sulfamate small molecule CAIX inhibitor 1 S4 modulates 2 doxorubicin efficacy

van Kuijk, S. J. A., Gieling, R., Niemans , R., Lieuwes , N., Biemans, R., Telfer, B., Haenen, G. R. M. M., Yaromina, A., Lambin, P., Dubois, L. J. & Williams, K., 11 Aug 2016, In: PLoS One..

Research output: Contribution to journal › Article › peer-review

Open Access

Treatment with the novel Akt inhibitor AZD5363 following radiotherapy improves tumour control in mouse models of head and neck cancer

Searle, E., Telfer, B., Forster, D., Davies, B. R., Stratford, I., Illidge, T. & Williams, K., 2016, In: European Journal of Cancer. 61, Supplement 1, p. S162

Research output: Contribution to journal › Meeting Abstract › peer-review

Open Access

2015

Binary behaviour of an oxidation-responsive MRI nano contrast agent

Jeanmaire, D., Timco, G. A., Gennari, A., Sproules, S., Williams, K. J., Winpenny, R. E. P. & Tirelli, N., 2015, In: Chemical Communications. 51, 6, p. 1074-1076 3 p.

Research output: Contribution to journal › Article › peer-review

Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells

Armitage, E. G., Kotze, H. L., Allwood, J. W., Dunn, W. B., Goodacre, R. & Williams, K., Oct 2015, In: Scientific Reports. 5, p. 1-12 11 p., 15649 .

Research output: Contribution to journal › Article › peer-review

Open Access

Kaye Williams, BSc PhD

Research output

Search results