Kaye Williams, BSc PhD

Search results

• 2018

  Oxygen enhanced-{MRI} detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients

  Salem, A., Little, R., Featherstone, A., Babur, M., Mistry, H., Cheung, S., Watson, Y., Tessyman, V., Asselin, M.-C., Jackson, A., Williams, K., Parker, G., Faivre-Finn, C. & O'Connor, J., 1 Jun 2018, ISMRM 2018. 1 p.

  Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

  Open Access

  • Lung Cancer 100%
  • Radiation Therapy 100%
  • Xenograft 100%
  • Hypoxia 100%
  • Magnetic Resonance Imaging 100%
• 2016

  Monitoring pharmacodynamic response to hypoxia-modifying therapy using non-invasive positron emission tomography and magnetic resonance imaging

  Tessyman, V., Duncan, F., Finegan, K., Little, R., Cheung, S., Watson, Y., Babur, M., Asselin, M.-C., O'Connor, J. & Williams, K., Jul 2016, European Journal of Cancer. Supplement 1 ed. Vol. 61. p. S162 2 p. 722

  Research output: Chapter in Book/Conference proceeding › Conference contribution
• 2003

  Angiogenesis Or Apoptosis: The Relationship With iNOS Levels.

  Al-Assah, R., Cowen, R., Chinje, E., Williams, K. & Stratford, I., 2003, Proc. AACR. Vol. 44.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Dual hypoxia and radiation responsive promoters for the delivery of TNFalpha to tumours.

  Chadderton, N., Cowen, R., Williams, K. & Stratford, I., 2003, Molecular Therapy. Vol. 7.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Future opportunities for radiation combined with new modalities

  Stratford, I., Cowen, R., Jaffar, M. & Williams, K., 2003, 2nd Estro Workshop on Biology in Radiation Oncology, The Netherlands 1-3 June 2003. Elsevier BV, Vol. 67(1).

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Genetic regulation of iNOS expression as a potential therapy for cancer.

  Al-Assah, R., Cowen, R., Chinje, E., Williams, K., Telfer, B. & Stratford, I., 2003, Molecular Therapy. Vol. 7.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Hypoxia decreases expression of key Fas death receptor signalling components in human colon carcinoma cells: concomitant reduced response to Fas activating antibody.

  Green, M., Erler, J., Williams, K., Dive, C. & Stratford, I., 2003, Proc. AACR. Vol. 44.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Inhibition of CA-IX modulates toxicity of mitomycin C in anoxic tumour cell lines.

  Parker, C., Jaffar, M., Williams, K., Robertson, N., Harris, A. & Stratford, I., 2003, Proc. AACR. Vol. 44.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• The potential therapeutic application of targeting HIF-1 using gene therapy or small molecule approaches.

  Brown, L., Williams, K., Cowen, R., Melillo, G., Sausville, E. & Stratford, I., 2003, Proc. AACR. Vol. 44.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Uncoupling the contribution of hypoxia and HIF-1 to metastatic disease.

  Lunt, S., Williams, K., Telfer, B. & Stratford, I., 2003, Proc. AACR. Vol. 44.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• ZD6474, a potent inhibitor of VEGF signaling, combined with radiotherapy: schedule-dependent enhancement of anti-tumor activity in a lung tumor xenograft model.

  Williams, K., Telfer, B., Stratford, I. & Wedge, S., 2003, Proc. AACR. Vol. 44.

  Research output: Chapter in Book/Conference proceeding › Conference contribution
• 2002

  Chimeric gene promoters responsive to hypoxia and ionizing radiation for use in cancer gene therapy.

  Greco, O., Marples, B., Dachs, G., Williams, K., Patterson, A. & Scott, S., 2002, host publication.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Chronic anoxia results in downregulation of pro-apoptotic proteins of the Bcl-2 family in a panel of human colon carcinoma cell lines.

  Erler, J., Williams, K., Stratford, I. & Dive, C., 2002, Proc. AACR. Vol. 43.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Differential expression of CA-IX inhuman carcinoma cell lines.

  Parker, C., Jaffar, M., Williams, K., Harris, A. & Stratford, I., 2002, BJC. Vol. 86.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• DT-diaphorase and cytochrome p450 reductase overexpression sensitise human breast cancer cell lines to mitomycin C treatment both in vitro and in vivo

  Williams, K., Patterson, A., Telfer, B., Cowen, R., Jaffar, M. & Stratford, I., 2002, BJC.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Hypoxia driven gene therapy to target radiation resistant tumours

  Cowen, R., Chadderton, N., Williams, K., Patterson, A., Telfer, B. & Stratford, I., 2002, Molecular Therapy, the Journal of the American Society of Gene Therapy, Abstracts from the Fifth Annual Meeting of the American Society of Gene Therapy, June 5-9. Vol. 5(5).

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Novel promoter-enhancer for hypoxia-selective gene therapy

  Chadderton, N., Cowen, R., Williams, K., Ratcliffe, P., Harris, A. & Stratford, I., 2002, British Cancer Research Meeting, Glasgow. s1 ed. Vol. 86.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Over-expression of DT-diaphoprase and cytochrome p450 reductase sensitizes human breast cancer cell lines to mitomycin treatment in both vitro and in vivo

  Williams, K., Patterson, A., Telfer, B., Cowen, R., Jaffar, M. & Stratford, I., 2002, Proc. AACR. Vol. 43.

  Research output: Chapter in Book/Conference proceeding › Conference contribution
• 2001

  Combination of ZD1839 ("Iressa"), an EGFR-TKI, and radiotherapy increases anti-tumour efficacy in a human colon cancer xenograft model

  Williams, K., Telfer, B., Stratford, I. & Wedge, S., 2001, Proc. AACR.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Identifying those patients most at risk from treatment failure. What can be done to help?

  Stratford, I., Williams, K., Cowen, R., Jaffar, M., Airley, R. & West, C., 2001, British Pharmaceutical Conference, Glasgow.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Integrating the transcriptional response to hypoxia and ionizing radiation applications for gene therapy

  Robinson, S., Patterson, A. V., Chadderton, N., Williams, K. & Cowen, R., 2001, British Journal Of Cancer. Churchill Livingstone, Vol. 85, S1.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Rational design and synthesis of thymidine phosphorylase inhibitors.

  McNally, V., Williams, K., Bryce, R., Stratford, I., Jaffar, M. & Freeman, S., 2001, Proc. EORTC Int. Conference: Molecular Targets and Cancer Therapeutics.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Tumour radiosensitisation using TBI-361, an inhibitor of poly (ADP-reibose)polymerase (PARP).

  Williams, K., Wang, L., Telfer, B., Curtin, N., Newell, D., Hostomski, Z. & Stratford, I., 2001, Proc. EORTC Int. Conference: Molecular Targets and Cancer Therapeutics.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• ZD1839 ("Iressa"), an EGFR-TKI, enhances the antitumour effect of radiotherapy in a human colorectal carcinoma xenograft model

  Williams, K., Telfer, B., Stratford, I. & Wedge, S., 2001, Proc. AACR. Vol. 85.

  Research output: Chapter in Book/Conference proceeding › Conference contribution
• 1999

  Contribution of tumour physiology to radiation response in HIF-1Beta deficient tumour xenografts.

  Williams, K., Telfer, B., Dachs, G., Honess, D., Peters, H., Van Der Kogel, A. & Stratford, I., 1999, British Journal of Radiology.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Potentiation of radiosensitivity in tumours lacking HIF-1Beta

  Williams, K., Telfer, B., Dachs, G., Honess, D., Peters, H., Van Der Kogel, A. & Stratford, I., 1999, Radiation Research Volume 1 : Abstracts 11th ICRR. Vol. 232.

  Research output: Chapter in Book/Conference proceeding › Conference contribution
• 1998

  Difference in response to low oxygen and low glucose in HIF-1B/ARNT deficient cells compared to parental cells.

  Williams, K. & Stratford, I., 1998, Proceedings of Int. Conference on Chemical Modifiers of Cancer Treatment, Jan 28-31, Clearwater, USA.

  Research output: Chapter in Book/Conference proceeding › Conference contribution

• Increased sensitivity to glucose deprivation in HIF-1B/ARNT deficient cells compared to parental cells - a contributing factor to ereduced xenograft growth?

  Williams, K., Harris, A. L., Ratcliffe, P. J. & Stratford, I., 1998, Proceedings of the American Assocaition for Cancer Research. Vol. 39.

  Research output: Chapter in Book/Conference proceeding › Conference contribution