Research output per year
Research output per year
Personal profile
Overview
My research retains a strong modelling theme - spanning developmental biology, cancer biology and computational biology. My multidisciplinary approach explores embryonic melanocyte progenitor programs of the neural crest lineage to shed new light on embryonic lineage cell states that are re-acquired during melanoma metastasis.
Biography
Kerrie completed her PhD at the MRC Human Genetics Unit, Edinburgh, supported by the University of Edinburgh in 2013. her PhD work focussed on developmental models of embryonic melanocyte development and regeneration in the zebrafish model, with a view to uncovering novel pathways that are regulated in development but dysregulated in disease. Her work was centred around chemical-genetics techniques, drug screening and timelapse confocal imaging of the melanocytic lineage. From these studies Kerrie became fascinated with how melanocyte lineage pathways are dysregulated in melanoma progression. From here she moved to the National Cancer Institute at the National Institutes of Health in 2014 to develop my expertise in mouse models of melanoma metastasis and therapy resistance. Kerrie's postdoctoral work centred on mouse experimental metastases models, models of Immune Checkpoint Blockade (ICB) resistance, 'Omics analyses of melanoblast development and melanoma disease progression, fundamental molecular biology of Endoplasmic Reticulum (ER) stress biology, single-cell technologies and computational analysis.
In 2022 Kerrie moved to the multidisciplinary environment of the University of Manchester as a Wellcome Trust ISSF Fellow, later being awarded with a prestigious University of Manchester Dean's Prize award. Kerrie's lab focuses on understanding cell fate decisions in the embryonic melanocyte precursors of the neural crest and using these insights to shed new light on embryonic lineage cell states that are re-acquired during melanoma metastasis.
Opportunities
I am accepting applications from all excellent candidates for the below fully-funded, multidisciplinary position:
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Beacons, Institutes and Platforms
- Cancer
Keywords
- Melanoma
- Metastasis
- Melanoblast
- Melanocyte
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Comprehensive single-cell transcriptomic analysis of embryonic melanoblasts uncovers lineage-specific mechanisms of melanoma metastasis and therapy resistance
Gopalan, V., Day, C.-P., Pérez-Guijarro, E., Chin, S., Ebersole, J., Smith, C., Simpson, M., Sassano, A., Constantino, M. A., Wu, E., Yang, H. H., Lee, M. P., Hannenhalli, S., Merlino, G. & Marie, K. L., 17 Oct 2022, In: bioRxiv.Research output: Contribution to journal › Article
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Melanoma models for the next generation of therapies
Patton, E. E., Mueller, K. L., Adams, D. J., Anandasabapathy, N., Aplin, A. E., Bertolotto, C., Bosenberg, M., Ceol, C. J., Burd, C. E., Chi, P., Herlyn, M., Holmen, S. L., Karreth, F. A., Kaufman, C. K., Khan, S., Kobold, S., Leucci, E., Levy, C., Lombard, D. B. & Lund, A. W. & 16 others, , 10 May 2021, In: Cancer Cell. 39, 5, p. 610-631 22 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Profiles of expressed mutations in single cells reveal subclonal expansion patterns and therapeutic impact of intratumor heterogeneity
Marie, K. L., 28 Mar 2021Research output: Other contribution
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PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation
Johansson, J. A., Marie, K. L., Lu, Y., Brombin, A., Santoriello, C., Zeng, Z., Zich, J., Gautier, P., von Kriegsheim, A., Brunsdon, H., Wheeler, A. P., Dreger, M., Houston, D. R., Dooley, C. M., Sims, A. H., Busch-Nentwich, E. M., Zon, L. I., Illingworth, R. S. & Patton, E. E., 10 Aug 2020, In: Developmental cell. 54, 3, p. 317-332.E9 26 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis
Marie, K., Sassano, A., Yang, H. H., Michalowski, A. M., Michael, H. T., Guo, T., Tsai, Y. C., Weissman, A. M., Lee, M. P., Jenkins, L. M., Zaidi, M. R., Pérez-Guijarro, E., Day, C.-P., Ylaya, K., Hewitt, S. M., Patel, N. L., Arnheiter, H., Davis, S., Meltzer, P. S. & Merlino, G. & 1 others, , 16 Jan 2020, In: Nature Communications. 11, p. 1-18 18 p., 333.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
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Cellular Dynamics and Compartmentalisation
Allan, V. (Researcher), Byron, A. (Researcher), Chang, J. (Researcher), Das, R. (Researcher), Davies, A. (Researcher), Francavilla, C. (Researcher), Herbert, S. (Researcher), Lowe, M. (Researcher), Marie, K. (Researcher), Prokop, A. (Researcher), Turner, S. (Researcher) & Woodman, P. (Researcher)
Project: Research
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Gene Expression and Cellular Programming
Ashe, H. (Researcher), Byron, A. (Researcher), Day, A. (Researcher), Grzechnik, P. (Researcher), Kim, M. (Researcher), Sharrocks, A. (Researcher), Marie, K. (Researcher), Nagarajan, S. (Researcher), Poulin, G. (Researcher) & White, M. (Researcher)
Project: Research