Research output per year
Research output per year
Personal profile
Overview
My fellowship focuses on the role that peripheral infection plays in stroke pathophysiology, specifically stroke in young adults.
Using mouse models of acute respiratory infection and ischaemic stroke, combined with pre-clinical MR imaging, I am investigating pre-stroke changes to cerebral bloodflow and inflammtory processes in the brain in response to localised infection in the lungs.
In other projects I am developing a novel thrombolytic for the treatment of ischaemic stroke and identifying new therapeutic targets to resolve thrombo-inflammation during stroke.
Biography
Kieron completed his PhD in Biochemistry at the University of Essex, investigating the molecular basis of rhodopsin activation during visual transduction.
He then changed fields, joining the haemostasis and thrombosis research group at Imperial College London under Prof. David Lane's mentorship.
To pursue his interest in stroke research he went on to join Prof. Stuart Allan's group at the University of Manchester where he was recently awarded a Medical Research Foundation mid-career Fellowship.
Qualifications
2012 - PhD in Biochemistry, University of Essex
2007 - BSc in Biochemistry and Molecular Medicine, University of Essex
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Enhanced activity of an ADAMTS-13 variant (R568K/F592Y/R660K/Y661F/Y665F) against platelet agglutination in vitro and in a murine model of acute ischemic stroke
South, K., Denorme, F., Salles-crawley, I. I., De Meyer, S. F. & Lane, D. A., Nov 2018, In: Journal of Thrombosis and Haemostasis. 16, 11, p. 2289-2299 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
ADAMTS-13 and von Willebrand factor: a dynamic duo
South, K. & Lane, D. A., 1 Jan 2018, In: Journal of thrombosis and haemostasis : JTH. 16, 1, p. 6-18 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Conformational activation of ADAMTS13
South, K., Luken, B. M., Crawley, J. T. B., Thomas, M., Collins, R. F., Deforche, L., Vanhoorelbeke, K. & Lane, D. A., 30 Dec 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 52, p. 18578-18583 6 p.Research output: Contribution to journal › Article › peer-review
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The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension
Newnham, M., South, K., Bleda, M., Auger, W. R., Barberà, J. A., Bogaard, H., Bunclark, K., Cannon, J. E., Delcroix, M., Hadinnapola, C., Howard, L. S., Jenkins, D., Mayer, E., Ng, C., Rhodes, C. J., Screaton, N., Sheares, K., Simpson, M. A., Southwood, M. & Su, L. & 12 others, , 2019, In: The European respiratory journal. 53, 3Research output: Contribution to journal › Article › peer-review
Open Access -
Highly conserved tyrosine stabilizes the active state of rhodopsin
Goncalves, J. A., South, K., Ahuja, S., Zaitseva, E., Opefi, C. A., Eilers, M., Vogel, R., Reeves, P. J. & Smith, S. O., 16 Nov 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 46, p. 19861-19866 6 p.Research output: Contribution to journal › Article › peer-review
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Brain disorders
Allan, S. (Researcher), Baines, R. (Researcher), Bromley, R. (Researcher), Brough, D. (Researcher), Burns, A. (Researcher), Doig, A. (Researcher), Gigg, J. (Researcher), Green, J. (Researcher), Hooper, N. (Researcher), Kasher, P. (Researcher), Lawrence, C. (Researcher), Milosavljevic, N. (Researcher), Miyan, J. (Researcher), Pinteaux, E. (Researcher), Roncaroli, F. (Researcher), Rothwell, N. (Researcher), Schiessl, I. (Researcher), South, K. (Researcher), Verkhratsky, A. (Researcher), Wykes, R. (Researcher) & Ryan, S. (Researcher)
Project: Research
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Neuroinflammation
Allan, S. (Researcher), Brough, D. (Researcher), Green, J. (Researcher), Kasher, P. (Researcher), Lawrence, C. (Researcher), Ryan, S. (Researcher), Pinteaux, E. (Researcher), Rothwell, N. (Researcher), Schiessl, I. (Researcher), South, K. (Researcher) & Youshani, A. (Researcher)
Project: Research
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ICF State-of-the art preclinical MRI for imaging brain physiology
Dickie, B. (PI), Allan, S. (CoI), Asselin, M.-C. (CoI), Aznar, M. (CoI), Butterworth, S. (CoI), Couper, K. (CoI), Dunne, R. (CoI), Frangi, A. F. (CoI), Greenstein, A. (CoI), Kamper, M. (CoI), Kostarelos, K. (CoI), Lawrence, C. (CoI), Ogden, D. (CoI), Ohene, Y. (CoI), Parkes, L. (CoI), Pritchard, H. (CoI), Rowbotham, J. (CoI), South, K. (CoI), Stivaros, S. (CoI), Williams, K. (CoI) & Wykes, R. (CoI)
1/12/25 → 31/03/26
Project: Research
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The Influence of Thromboinflammatory Changes During S. pneumoniae Infection on Stroke Pathophysiology in Young Adults.
South, K. (PI), Allan, S. (CoI) & Smith, C. (CoI)
1/05/19 → 30/04/22
Project: Research