Kimberly Mace
  • Michael Smith Building, Oxford Road

    M13 9PT Manchester

    United Kingdom

Personal profile

Biography

2017 - present, Senior Lecturer, Faculty of Biology, Medicine and Health, University of Manchester, UK.

2016 - 2017, Lecturer, Faculty of Biology, Medicine and Health, University of Manchester, UK.

2012 - 2016, Lecturer, Faculty of Life Sciences, University of Manchester, UK.

2007 – 2012, Healing Foundation Fellow, Faculty of Life Sciences, University of Manchester, UK.

2003 – 2007, Ruth L. Kirschstein NIH Postdoctoral Fellow, Department of Surgery, University of California San Francisco, USA. Supervisors: David Young/Nancy Boudreau.

1997 – 2003, PhD, Division of Biology, Section on Cell and Developmental Biology, University of California San Diego, USA. Supervisor: William McGinnis.

1996 – 1997, Research Associate, Department of Biology, University of Nevada Las Vegas, USA. Supervisor: Deborah Hoshizaki.

1992 – 1996, BSc, Department of Biology, University of Nevada, Las Vegas, USA.

1986 – 1991, BFA, Drama, School of Theatre, University of Southern California, Los Angeles, California, USA.

Research interests

Regulation of adult stem cell recruitment, engraftment, and differentiation during tissue repair and regeneration

Tissue repair and regeneration are ancient responses to physical damage shared by all metazoans requiring coordinated cell movements and changes in gene expression. My lab is interested in the regulation of transcription in response to injury, and the underlying molecular mechanisms that promote wound repair and regeneration, as well as limit it. Current studies are focused on skin repair and regeneration, and in particular, the role of myeloid cells in this process, using the mouse as a model system.

Myeloid cells differentiate from progenitors in the bone marrow and are recruited to injured tissue where they can promote or inhibit the repair and regeneration process depending on context.The balance of different myeloid cell types present in the injured tissue can profoundly affect the repair and regeneration process. Currently our focus is on the identification of different subset of myeloid cells recruited to the wound at different times, experimental manipulation of these populations in vitro and in vivo, and the analysis of myeloid cell differentiation at the site of injury.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Beacons, Institutes and Platforms

  • Manchester Regenerative Medicine Network
  • Lydia Becker Institute
  • Christabel Pankhurst Institute

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