Personal profile
Biography
2017 - present, Senior Lecturer, Faculty of Biology, Medicine and Health, University of Manchester, UK.
2016 - 2017, Lecturer, Faculty of Biology, Medicine and Health, University of Manchester, UK.
2012 - 2016, Lecturer, Faculty of Life Sciences, University of Manchester, UK.
2007 – 2012, Healing Foundation Fellow, Faculty of Life Sciences, University of Manchester, UK.
2003 – 2007, Ruth L. Kirschstein NIH Postdoctoral Fellow, Department of Surgery, University of California San Francisco, USA. Supervisors: David Young/Nancy Boudreau.
1997 – 2003, PhD, Division of Biology, Section on Cell and Developmental Biology, University of California San Diego, USA. Supervisor: William McGinnis.
1996 – 1997, Research Associate, Department of Biology, University of Nevada Las Vegas, USA. Supervisor: Deborah Hoshizaki.
1992 – 1996, BSc, Department of Biology, University of Nevada, Las Vegas, USA.
1986 – 1991, BFA, Drama, School of Theatre, University of Southern California, Los Angeles, California, USA.
Research interests
Regulation of adult stem cell recruitment, engraftment, and differentiation during tissue repair and regeneration
Tissue repair and regeneration are ancient responses to physical damage shared by all metazoans requiring coordinated cell movements and changes in gene expression. My lab is interested in the regulation of transcription in response to injury, and the underlying molecular mechanisms that promote wound repair and regeneration, as well as limit it. Current studies are focused on skin repair and regeneration, and in particular, the role of myeloid cells in this process, using the mouse as a model system.
Myeloid cells differentiate from progenitors in the bone marrow and are recruited to injured tissue where they can promote or inhibit the repair and regeneration process depending on context.The balance of different myeloid cell types present in the injured tissue can profoundly affect the repair and regeneration process. Currently our focus is on the identification of different subset of myeloid cells recruited to the wound at different times, experimental manipulation of these populations in vitro and in vivo, and the analysis of myeloid cell differentiation at the site of injury.
Research Beacons, Institutes and Platforms
- Manchester Regenerative Medicine Network
- Lydia Becker Institute
- Christabel Pankhurst Institute
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Intrinsic changes in cell differentiation and identity drive impaired wound healing in aged female murine skin
Dube, C., Oguz, G., Ong, Y. H. B., Sudhagar, S., Prabhakar, S., Ronshaugen, M., Ramasamy, A. (Lead), Lim, C. Y. (Lead) & Mace, K. (Lead), 1 Nov 2025, In: Biogerontology.Research output: Contribution to journal › Article › peer-review
Open Access -
Electrical stimulation for wound healing - More than skin deep
Verdes, M., Mace, K., Margetts, L. & Cartmell, S., Jul 2023, In: Tissue Engineering Part a. 29, 13-14, 1 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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Understanding the Mechanisms of Action of Collagen- Based Dressings to Promote Healing
Verdolino, D., Thomason, H., Mace, K., Warde, D., Mann, E., Willis, R. & Cartmell, S., 1 Jun 2023, In: Tissue Engineering Part a. 29, 11-12, p. 1541-1542 2 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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Understanding The Mechanisms Of Action Of Collagen-Based Wound Dressings To Promote Healing
Verdolino, D. V., Thomason, H., Warde, D., Willis, R., Mace, K. & Cartmell, S., Jul 2023, In: Tissue Engineering Part a. 29, 13-14, 2 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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Age-related alterations in macrophage distribution and function are associated with delayed cutaneous wound healing
Dube, C., Binn Ong, Y. H., Wemyss, K., Krishnan, S., Ju Tan, T., Janela, B., Grainger, J., Ronshaugen, M., Mace, K. & Lim, C. Y., 8 Jul 2022, In: Frontiers in Immunology.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Supplementary Data for PhD Thesis: Myeloid cell ageing and wound healing: analysing ageing-related changes to myeloid cells and their impact on cutaneous wound healing
Dube, C. (Creator), Ronshaugen, M. (Creator) & Mace, K. A. (Creator), University of Manchester Figshare, 14 Dec 2022
DOI: 10.48420/21701534, https://figshare.manchester.ac.uk/articles/dataset/Myeloid_cell_ageing_and_wound_healing_analysing_ageing-related_changes_to_myeloid_cells_and_their_impact_on_cutaneous_wound_healing_PhD_Thesis/21701534
Dataset