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Krisztina Mekli


Personal profile

Research interests

Research Interest

I joined CCSR at the University of Manchester in January 2012 to work on the fRaill (Frailty, Resilience And Inequality in Later Life) Project. As a geneticist, my role is to investigate genetic influences on later life mental health and wellbeing. I obtained my PhD degree at the University of Manchester in 2011, my thesis examined the genetic vulnerability of depression and related phenotypes.
 My research interests include the genetics of mental health phenotypes; gene-environment interactions; and gene-metabolite-phenotype pathways.

Publication list
Mekli K, Payton A, Miyajima F, Platt H, Thomas E, Downey D, Lloyd-Williams K, Chase D, Toth ZG, Elliott R, Ollier WE, Anderson IM, Deakin JF, Bagdy G, Juhasz G. The HTR1A and HTR1B receptor genes influence stress-related information processing. Eur Neuropsychopharmacol. 2011 21:129-39.

Juhasz G, Dunham JS, McKie S, Thomas E, Downey D, Chase D, Lloyd-Williams K, Toth ZG, Platt H, Mekli K, Payton A, Elliott R, Williams SR, Anderson IM, Deakin JF. The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. Biol Psychiatry. 2011 69:762-71.

Molnar E, Lazary J, Benko A, Gonda X, Pap D, Mekli K, Juhasz G, Kovacs G, Kurimay T, Rihmer Z, Bagdy G. Seasonality and winter- type seasonal depression are associated with the rs731779 polymorphism of the serotonin-2A receptor gene. Eur Neuropsychopharmacol. 2010 20:655-62.

Juhasz G, Downey D, Hinvest N, Thomas E, Chase D, Toth ZG, Lloyd-Williams K, Mekli K, Platt H, Payton A, Bagdy G, Elliott R, Deakin JF, Anderson IM. Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders. Neuropsychopharmacology. 2010 35:1109-19.

Juhasz G, Lazary J, Chase D, Pegg E, Downey D, Toth ZG, Stones K, Platt H, Mekli K, Payton A, Anderson IM, Deakin JF, Bagdy G. Variations in the cannabinoid receptor 1 gene predispose to migraine. Neurosci Lett. 2009 461:116-20.

Juhasz G, Chase D, Pegg E, Downey D, Toth ZG, Stones K, Platt H, Mekli K, Payton A, Elliott R, Anderson IM, Deakin JF. CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms. Neuropsychopharmacology. 2009 34:2019-27.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Beacons, Institutes and Platforms

  • Cathie Marsh Institute
  • Manchester Institute for Collaborative Research on Ageing


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Collaborations and top research areas from the last five years

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