Personal profile
Research interests
Research Interest
I joined CCSR at the University of Manchester in January 2012 to work on the fRaill (Frailty, Resilience And Inequality in Later Life) Project. As a geneticist, my role is to investigate genetic influences on later life mental health and wellbeing. I obtained my PhD degree at the University of Manchester in 2011, my thesis examined the genetic vulnerability of depression and related phenotypes.
My research interests include the genetics of mental health phenotypes; gene-environment interactions; and gene-metabolite-phenotype pathways.
Publication list
Mekli K, Payton A, Miyajima F, Platt H, Thomas E, Downey D, Lloyd-Williams K, Chase D, Toth ZG, Elliott R, Ollier WE, Anderson IM, Deakin JF, Bagdy G, Juhasz G. The HTR1A and HTR1B receptor genes influence stress-related information processing. Eur Neuropsychopharmacol. 2011 21:129-39.
Juhasz G, Dunham JS, McKie S, Thomas E, Downey D, Chase D, Lloyd-Williams K, Toth ZG, Platt H, Mekli K, Payton A, Elliott R, Williams SR, Anderson IM, Deakin JF. The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. Biol Psychiatry. 2011 69:762-71.
Molnar E, Lazary J, Benko A, Gonda X, Pap D, Mekli K, Juhasz G, Kovacs G, Kurimay T, Rihmer Z, Bagdy G. Seasonality and winter- type seasonal depression are associated with the rs731779 polymorphism of the serotonin-2A receptor gene. Eur Neuropsychopharmacol. 2010 20:655-62.
Juhasz G, Downey D, Hinvest N, Thomas E, Chase D, Toth ZG, Lloyd-Williams K, Mekli K, Platt H, Payton A, Bagdy G, Elliott R, Deakin JF, Anderson IM. Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders. Neuropsychopharmacology. 2010 35:1109-19.
Juhasz G, Lazary J, Chase D, Pegg E, Downey D, Toth ZG, Stones K, Platt H, Mekli K, Payton A, Anderson IM, Deakin JF, Bagdy G. Variations in the cannabinoid receptor 1 gene predispose to migraine. Neurosci Lett. 2009 461:116-20.
Juhasz G, Chase D, Pegg E, Downey D, Toth ZG, Stones K, Platt H, Mekli K, Payton A, Elliott R, Anderson IM, Deakin JF. CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms. Neuropsychopharmacology. 2009 34:2019-27.
Research Beacons, Institutes and Platforms
- Cathie Marsh Institute
- Manchester Institute for Collaborative Research on Ageing
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 17 Partnerships for the Goals
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Collaborations and top research areas from the last five years
Research output
- 14 Article
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Association between an inflammatory biomarker score and future dementia diagnosis in the population-based UK Biobank cohort of 500,000 people
Mekli, K., Lophatananon, A., Maharani, A., Nazroo, J. & Muir, K., 19 Jul 2023, In: PL o S One. 18, 7, e0288045.Research output: Contribution to journal › Article › peer-review
Open Access -
Exploring the causal role of the immune response to varicella-zoster virus on multiple traits: a phenome-wide Mendelian randomization study
Yu, X., Lophatananon, A., Mekli, K., Muir, K. & Guo, H. (Corresponding), 12 Apr 2023, In: BMC Medicine. 21, 1, 143.Research output: Contribution to journal › Article › peer-review
Open Access -
A suggested shared aetiology of dementia - a colocalization study
Yu, X., Lophatananon, A., Mekli, K., Burns, A., Muir, K. & Guo, H. (Corresponding), 1 Sept 2022, In: Neurobiology of Aging. 117, p. 71-82 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Development and evaluation of polygenic risk scores for prediction of endometrial cancer risk in European women
Bafligil, C., Thompson, D. J., Lophatananon, A., Ryan, N., Smith, M. J., Dennis, J., Mekli, K., O'Mara, T. A., Evans, D. G. & Crosbie, E., 2 Sept 2022, In: Genetics in Medicine.Research output: Contribution to journal › Article › peer-review
Open Access -
Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank
Mekli, K., Lophatananon, A., Cant, R., Burns, A., Dobson, C. B., Itzhaki, R. F. & Muir, K. R., 2022, In: PLoS ONE. 17, 10, p. e0274872Research output: Contribution to journal › Article › peer-review
Open Access
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EPHG: Epidemiology and Public Health Group
Jones, A. (PI), Voros, E. (Support team), George-Davidson, A. (Support team), Hammond, A. (Researcher), Povey, A. (Researcher), Spencer, A. (Researcher), Sahu, A. (Researcher), Clayson, A. (Researcher), Harrison, A. (Researcher), Edwards, A. (PI), Verma, A. (PI), Lophatananon, A. (Researcher), Doyle, C. (Support team), Wasiuk, C. (Researcher), Greenhalgh, C. (Researcher), Huish, C. (Researcher), Nash, D. (Researcher), Mcelvenny, D. (Researcher), Payne, D. (Researcher), Cairns, D. (Researcher), Cowley, E. (PI), Dalgarno, E. (Researcher), Evans, E. (Researcher), Morgans, E. (Researcher), Borocin, F. (Researcher), Clough, G. (Researcher), Williams, G. (Researcher), Mohamed, H. (Researcher), Waterson, H. (Researcher), Wei, H. (Researcher), Basinas, I. (Researcher), Iskandar, I. (Researcher), Gemmell, I. (Researcher), Lamb, J. (Researcher), Stocks, J. (Researcher), Owen, J. (Researcher), Chadwick, J. (Support team), Walsh, K. (Researcher), Winstanley, K. (Researcher), Muir, K. (PI), Fowler, K. (Researcher), Mekli, K. (Researcher), Blake, L. (Researcher), Byrne, L. (Support team), Hasler, L. (Researcher), White, L. (Support team), Kennedy, L. (Researcher), Van Tongeren, M. (PI), Regan, M. (Researcher), Carder, M. (Researcher), Brook, N. (Support team), Gartland, N. (Researcher), Bouamra, O. (Researcher), Whittaker, P. (Support team), Hammond, P. (Researcher), Bentley, R. (Researcher), Addam, R. (Researcher), Harrison, R. (Researcher), Zubaite, R. (Researcher), Mason, S. (Support team), Jones, S. (Support team), Jahr, S. (Support team), Mitchell, S. (Researcher), Senior, S. (Researcher), Taylor, S. (Support team), Walsh, S. (Researcher), Farragher, T. (Researcher), Zagrodnik, V. (Researcher), Alam, W. (Support team), Mangan, D. (Technical team), Davidson, H. (Researcher), Mcconnell, J. (Researcher), Lewis, C. (Researcher), Tilley, C. (Support team), Clarke, D. (Support team), Yu, X. (Researcher), Seed, M. (Researcher), Weston, R. (Support team), Sugden, S. (Technical team) & Ahmed, S. (Researcher)
Project: Research
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Lifelong Health
Price, D. (PI), Haarmans, M. (PI), Chandola, T. (PI), Higgins, V. (PI), Smith, N. (PI), Hannemann, T. (PI), Doran, P. (PI), Prattley, J. (PI), Taylor, H. (PI), Williams, B. (PI), Webber, R. (PI), Phillipson, C. (PI), Nazroo, J. (PI), Yarker, S. (PI), Shryane, N. (PI), Buffel, T. (PI), Cotterell, N. (PI), James, H. (PI), Pendleton, N. (PI), Mekli, K. (PI), Chatzi, G. (PI), Rémillard-Boilard, S. (PI), Pashazadeh, F. (PI), Li, Y. (PI), Matthews, K. (PI), Tampubolon, G. (PI), Kapadia, D. (PI), Gosling, Z. (Support team) & Zhang, N. (PI)
1/08/19 → 30/09/22
Project: Research
Thesis
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Investigation of serotonergic receptors and transporter genes in vulnerability to depression, anxiety and neuroticism: A human population study
Mekli, K. (Author), 7 Jan 2011Student thesis: Phd
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