Research output per year
Research output per year
- 48 results
Search results
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2025
A single centre experience of patients with Rare Cancers referred for Early Phase Clinical Trials
Angelakas, A., Cook, N., Graham, D. A., Krebs, M., Thistlethwaite, F. & Carter, L., 13 Mar 2025, (Accepted/In press) In: BMC Cancer.Research output: Contribution to journal › Article › peer-review
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2024
Ataxia telangiectasia and Rad3-related (ATR) inhibitor camonsertib dose optimization in patients with biomarker-selected advanced solid tumors (TRESR study)
Fontana, E., Rosen, E., Lee, E. K., Højgaard, M., Mettu, N. B., Lheureux, S., Carneiro, B. A., Cote, G. M., Carter, L., Plummer, R., Mahalingam, D., Fretland, A. J., Schonhoft, J. D., Silverman, I. M., Wainszelbaum, M., Xu, Y., Ulanet, D., Koehler, M. & Yap, T. A., 1 Sept 2024, In: Journal of the National Cancer Institute. 116, 9, p. 1439-1449 11 p.Research output: Contribution to journal › Article › peer-review
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Development and validation of a Patient Reported Experience Measure for Experimental Cancer Medicines (PREM-ECM) and their carers (PREM-ECM-Carer): Development & validation of PREM-ECMs
Sawyer, C., Taylor, S., Carter, L., Stanworth, M., Davis, M., Thistlewaite, F., Taylor, J., Eastwood, C. & Yorke, J., 19 Apr 2024, In: BMC Cancer. 24, 500.Research output: Contribution to journal › Article › peer-review
Open Access -
"Oh when's your treatment ending?" "Never!" The unmet needs of cancer patients treated with immunological, biological and precision therapies: A qualitative interview study
Crowe, L., Brown, M. C., Lecouturier, J., Greystoke, A., Bojke, A., Bojke, R., Richardson, J., Wells, M., Ezeala, E., Carter, L., Sharp, L. & Todd, A., Dec 2024, In: European journal of oncology nursing : the official journal of European Oncology Nursing Society. 73, p. 102696Research output: Contribution to journal › Article › peer-review
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Proact 2.0: A new open-source tool to improve patient-doctor communication in clinical trials
Agnelli, L., Villa, A., Butt, F., Duca, M., Guidi, A., Carapezza, M., Addante, M., Lenoci, G., O'Regan, P., Russo, L., Cresta, S., Castano, A., Ebrahem, E., Alfieri, S., Patil, A., Carter, L., Dive, C., De Braud, F. G. & Damian, S., Oct 2024, In: Tumori. 110, 5, p. 304-308 5 p.Research output: Contribution to journal › Article › peer-review
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Results from First-in-Human Phase i Dose-Escalation Study of a Novel Bicycle Toxin Conjugate Targeting EphA2 (BT5528) in Patients with Advanced Solid Tumors
Bashir, B., Wang, J. S., Falchook, G., Fontana, E., Arkenau, H.-T., Carter, L., Galot, R., Basu, B., Greystoke, A., Subbiah, V., Richardson, D. L., Orr, H., Bennett, G., Sharma, R., Xu, H., Paganoni, P., Xu, C., Campbell, C. & McKean, M., 10 Oct 2024, In: Journal of Clinical Oncology. 42, p. 3443-3452Research output: Contribution to journal › Article › peer-review
Open Access -
Sex as a Biological Variable in Early-Phase Oncology Clinical Trials: Enhancing the Path to Personalised Medicine
Sutherland, L. & Carter, L., 30 Jun 2024, In: Heliyon. 10, 12, 13 p., e32597.Research output: Contribution to journal › Article › peer-review
Open Access -
Social determinants of health inequalities in early phase clinical trials in Northern England
Rae, S., Shaya, S., Taylor, E., Hoben, J., Oluwashegun, D., Lowe, H., Haris, N. M., Bashir, S., Oing, C., Krebs, M. G., Thistlethwaite, F. C., Carter, L., Cook, N., Greystoke, A., Graham, D. M. & Plummer, R., 7 Sept 2024, In: British Journal of Cancer. 131, 4, p. 685-691 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer
Kristeleit, R., Plummer, R., Jones, R., Carter, L., Blagden, S., Sarker, D., Arkenau, T., Evans, T. R. J., Danson, S., Symeonides, S. N., Veal, G. J., Klencke, B. J., Kowalski, M. M. & Banerji, U., 27 Jul 2023, In: British Journal of Cancer. 129, 1, p. 38-45 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A Phase I/II Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Low-Dose Gemcitabine in Patients with Advanced Cancer
Jones, R., Plummer, R., Moreno, V., Carter, L., Roda, D., Garralda, E., Kristeleit, R., Sarker, D., Arkenau, T., Roxburgh, P., Walter, H. S., Blagden, S., Anthoney, A., Klencke, B. J., Kowalski, M. M. & Banerji, U., 17 Jan 2023, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 29, 2, p. 331-340 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results
Yap, T. A., Fontana, E., Lee, E. K., Spigel, D. R., Højgaard, M., Lheureux, S., Mettu, N. B., Carneiro, B. A., Carter, L., Plummer, R., Cote, G. M., Meric-Bernstam, F., O’Connell, J., Schonhoft, J. D., Wainszelbaum, M., Fretland, A. J., Manley, P., Xu, Y., Ulanet, D. & Rimkunas, V. & 5 others, , 5 Jun 2023, In: Nature Medicine. 29, 6, p. 1400-1411 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Epic: an evaluation of the psychological impact of early-phase clinical trials in cancer patients
Jittla, P., Graham, D. M., Zhou, C., Halliwell, J., O'Reilly, S., Aruketty, S., Azizi, A., Germetaki, T., Lowe, J., Little, M., Punnett, G., McMahon, P., Benson, L., Carter, L., Krebs, M. G., Thistlethwaite, F. C., Darlington, E., Yorke, J. & Cook, N., 1 Oct 2022, In: ESMO Open. 7, 5, 100550.Research output: Contribution to journal › Article › peer-review
Open Access -
Patient attrition in Molecular Tumour Boards: a systematic review
Frost, H., Graham, D. M., Carter, L., O’Regan, P., Landers, D. & Freitas, A., 8 Aug 2022, In: British Journal of Cancer. 127, 8, p. 1557-1564 8 p.Research output: Contribution to journal › Article › peer-review
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The UpSMART Accelerator: driving digital innovation to change the conduct of early phase cancer medicine trials
Fouziah, B., Laura, S., Luca, A., Xenia, V., Rachel, C., Filippo, D., Silvia, D., Rodrigo, D., Elisabetta, F., Elena, G., Donna, G., Andrew, G., Dónal, L., Paul, O., Akshita, P., Aoife, R., Jennifer, R., Julie, S., Alison, W. & Caroline, D. & 2 others, , Jan 2022, In: Digital Medicine. 8, 1, p. 7Research output: Contribution to journal › Article › peer-review
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2021
Discovery and Evaluation of Protein Biomarkers as a Signature of Wellness in Late-Stage Cancer Patients in Early Phase Clinical Trials
Geary, B., Peat, E., Dransfield, S., Cook, N., Thistlethwaite, F., Graham, D., Carter, L., Hughes, A., Krebs, M. G. & Whetton, A. D., 18 May 2021, In: Cancers. 13, 10, 2443.Research output: Contribution to journal › Article › peer-review
Open Access -
Enrolment of older adults with cancer in early phase clinical trials—an observational study on the experience in the north west of England
Gomes, F., Descamps, T., Lowe, J., Little, M., Lauste, R., Krebs, M., Graham, D., Thistlethwaite, F., Carter, L. & Cook, N., 9 Jun 2021, In: Age and Ageing. 50Research output: Contribution to journal › Article › peer-review
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Enrolment of older cancer patients in early phase clinical trials – an observational study on the experience in the north west of England
Gomes, F., Descamps, T., Lowe, J., Little, M., Lauste, R., Krebs, M., Graham, D., Thistlethwaite, F., Carter, L. & Cook, N., 5 Mar 2021, (Accepted/In press) In: Age and Ageing.Research output: Contribution to journal › Article › peer-review
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Oncology patients' experiences in experimental medicine cancer trials: a qualitative study
Sawyer, C., Preston, L., Taylor, S., Davies, M., Carter, L., Krebs, M., Cook, N., Graham, D., Thistlethwaite, F. & Yorke, J., 5 Oct 2021, In: BMJ Open. 11, 10, 047813.Research output: Contribution to journal › Article › peer-review
Open Access -
Patient attrition in Molecular Tumour Boards: A Review
Frost, H., Graham, D. M., Carter, L., O’Regan, P., Landers, D. & Freitas, A., 7 Oct 2021, In: medRxiv.Research output: Contribution to journal › Article › peer-review
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2020
A biobank of small cell lung cancer CDX models elucidates inter- and intratumoral phenotypic heterogeneity
Simpson, K. L., Stoney, R., Frese, K. K., Simms, N., Rowe, W., Pearce, S. P., Humphrey, S., Booth, L., Morgan, D., Dynowski, M., Trapani, F., Catozzi, A., Revill, M., Helps, T., Galvin, M., Girard, L., Nonaka, D., Carter, L., Krebs, M. G. & Cook, N. & 6 others, , 2020, In: Nature Cancer. 1, 4, p. 437-451 15 p.Research output: Contribution to journal › Article › peer-review
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Brief report on the clinical characteristics of patients whose samples generate small cell lung cancer circulating tumour cell derived explants
Vickers, A. J., Frese, K., Galvin, M., Carter, M., Franklin, L., Morris, K., Pierce, J., Descamps, T., Blackhall, F., Dive, C. & Carter, L., 5 Nov 2020, (E-pub ahead of print) In: Lung Cancer. 150, p. 216-220 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile64 Downloads (Pure) -
Liquid Biopsy in Small Cell Lung Cancer—A Route to Improved Clinical Care?
Church, M., Carter, L. & Blackhall, F., 3 Dec 2020, In: Cells. 9, 12, p. 2586Research output: Contribution to journal › Article › peer-review
Open Access -
Supportive Care: An Indispensable Component of Modern Oncology
Berman, R., Davies, A., Cooksley, T., Gralla, R., Carter, L., Darlington, E., Scotté, F. & Higham, C., 16 Aug 2020, In: Clinical Oncology. 32, 11, p. 781-788 8 p.Research output: Contribution to journal › Article › peer-review
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2019
Cumulative Antibiotic Use Significantly Decreases Efficacy of Checkpoint Inhibitors in Patients with Advanced Cancer
Tinsley, N., Zhou, C., Tan, G., Rack, S., Lorigan, P., Blackhall, F., Krebs, M., Carter, L., Thistlethwaite, F., Graham, D. & Cook, N., 2019, In: The oncologist.Research output: Contribution to journal › Article › peer-review
Open AccessFile59 Downloads (Pure) -
Utility of ctDNA to support patient selection for early phase clinical trials: The TARGET Study
Rothwell, D., Ayub, M., Cook, N., Thistlethwaite, F., Carter, L., Dean, E., Smith, N., Villa, S., Dransfield, J., Clipson, A., White, D., Nessa, K., Ferdous, S., Howell, M., Gupta, A., Kilerci, B., Mohan, S., Frese, K., Gulati, S. & Miller, C. & 22 others, , 22 Apr 2019, In: Nature Medicine. 25, 5, p. 738-743 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile730 Downloads (Pure) -
2018
Impact of tumour profiling on clinical trials in salivary gland cancer
Rack, S., Rahman, R., Carter, L., Mckay, C. & Metcalf, R., 2018, In: Clinical Otolaryngology.Research output: Contribution to journal › Article › peer-review
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2017
1588PEnhanced supportive care in early phase clinical trials
Carter, L., 2017, In: Annals of Oncology.Research output: Contribution to journal › Article
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1628ODevelopment of the Manchester Cancer Research Centre Molecular Tumour Board for matching patients to clinical trials based on tumour and ctDNA genetic profiling
Carter, L., 2017, In: Annals of Oncology.Research output: Contribution to journal › Article
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41 Solstice: sancuso in supportive and palliative care; a feasibility study in patients with cancer and refractory nausea and vomiting
Villa, S., Berman, R., Dean, E. & Carter, L., Sept 2017, In: BMJ Supportive & Palliative Care.. 7, 3, p. A362-A363 2 p.Research output: Contribution to journal › Article
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A Phase 1 first-in-human trial to evaluate the safety and tolerability of CCT3833, an oral panRAF inhibitor, in patients with advanced solid tumours, including metastatic melanoma
Dean, E. J., Banerji, U., Girotti, R., Niculescu-Duvaz, I., Lopes, F., Davies, L., Niculescu-Duvaz, D., Dhomen, N., Ellis, S., Ali, Z., O'Carrigan, B., Carter, L., Chisolm, L., Dive, C., Lane, H. A., Lorigan, P., Gore, M. E., Larkin, J., Marais, R. & Springer, C., 20 May 2017, In: Journal of Clinical Oncology. 34, 15Research output: Contribution to journal › Article › peer-review
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Molecular analysis of single circulating tumour cells following long-term storage of clinical samples
Mesquita, B., Rothwell, D., Burt, D., Chemi, F., Fernandez-Gutierrez, F., Slane-Tan, D., Antonello, J., Carter, M., Carter, L., Parry, M., Franklin, L., Marais, R., Blackhall, F., Dive, C. & Brady, G., 1 Dec 2017, In: Molecular Oncology. 11, 12, p. 1687-1697 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Molecular profiling of recurrent and metastatic salivary gland cancer to personalise cancer therapy
Rack, S., Darlington, E., Odedra, S., Owens, R., Dransfield, J., Shah, B., Cook, N., Thistlethwaite, F., Carter, L., Hughes, A., Homer, J., Slevin, N., Krebs, M. & Metcalf, R., Oct 2017, In: Annals of Oncology. 28, Suppl. 7, 2 p., 58.Research output: Contribution to journal › Article › peer-review
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Novel Early Phase Clinical Trial Design in Oncology
O’Brien, C., Carter, L., Cook, N. & Dean, E., 1 Oct 2017, In: Pharmaceutical Medicine. 31, 5, p. 297-307 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile76 Downloads (Pure) -
2016
Clinical evaluation of a novel microfluidic device for epitope-independent enrichment of circulating tumour cells in patients with small cell lung cancer.
Chudziak, J., Burt, D., Mohan, S., Rothwell, D., Mesquita, B., Antonello, J., Dalby, S., Ayub, M., Priest, L., Carter, L., Krebs, M., Blackhall, F., Dive, C. & Brady, G., 1 Jan 2016, In: The Analyst.Research output: Contribution to journal › Article › peer-review
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Investigating chemoresistance in small cell lung cancer through the molecular profiling of single circulating tumour cells
Carter, L. R., Rothwell, D. G., Leong, H., Li, Y., Burt, D. J., Antonello, J., Hodgkinson, C., Morris, K., Franklin, L., Miller, C. J., Blackhall, F., Dive, C. & Brady, G., Jul 2016, In: Cancer Research. 76Research output: Contribution to journal › Article › peer-review
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Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer
Carter, L., Rothwell, D., Mesquita, B., Smowton, C., Leong, H. S., Fernandez-Gutierrez, F., Li, Y., Burt, D. J., Antonello, J., Morrow, C. J., Hodgkinson, C., Morris, K., Priest, L., Carter, M., Miller, C., Hughes, A., Blackhall, F., Dive, C. & Brady, G., 21 Nov 2016, In: Nature Medicine. 23, p. 114–119Research output: Contribution to journal › Article › peer-review
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Phase I modular study of AZD6738, a novel oral, potent and selective ataxia telangiectasia Rad3-related (ATR) inhibitor in combination (combo) with carboplatin, olaparib or durvalumab in patients (pts) with advanced cancers
Carter, L., 2016, In: European Journal of Cancer.Research output: Contribution to journal › Article
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Selumetinib in the treatment of non-small-cell lung cancer
Bernabe, R., Patrao, A., Carter, L., Blackhall, F. & Dean, E., 2016, In: Future Oncology.Research output: Contribution to journal › Article › peer-review
Open AccessFile246 Downloads (Pure) -
The TARGET trial: Molecular profiling of circulating tumour DNA to stratify patients to early phase clinical trials
Carter, L., 2016, In: European Journal of Surgical Oncology.Research output: Contribution to journal › Article
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Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study
Morrow, C., Trapani, F., Metcalf, R., Bertolini, G., Hodgkinson, C., Khandelwal, G., Kelly, P., Galvin, M., Carter, L., Simpson, K., Williamson, S., Wirth, C., Simms, N., Franklin, L., Frese, K., Rothwell, D., Nonaka, D., Miller, C., Brady, G. & Blackhall, F. & 1 others, , 24 Mar 2016, In: Annals of Oncology.Research output: Contribution to journal › Article › peer-review
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2015
Development of a circulating miRNA assay to monitor tumor burden: From mouse to man.
Greystoke, A., Ayub, M., Rothwell, D. G., Morris, D., Burt, D., Hodgkinson, C. L., Morrow, C. J., Smith, N., Aung, K., Valle, J., Carter, L., Blackhall, F., Dive, C. & Brady, G., 28 Oct 2015, In: Molecular Oncology.Research output: Contribution to journal › Article › peer-review
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Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample.
Rothwell, D. G., Smith, N., Morris, D., Leong, H. S., Li, Y., Hollebecque, A., Ayub, M., Carter, L., Antonello, J., Franklin, L., Miller, C., Blackhall, F., Dive, C., Brady, G. & Brady, G., 19 Nov 2015, In: Molecular Oncology.Research output: Contribution to journal › Article › peer-review
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Molecular Characterisation of SCLC Using Both Circulating Tumour DNA and Circulating Tumour Cells Isolated from the Same preserved whole blood sample
Rothwell, D. G., Smith, N., Morris, D., Leong, H. S., Li, Y., Carter, L., Blackhall, F., Miller, C., Dive, C. & Brady, G., Sept 2015, In: Molecular Oncology. 10, p. S344-S344Research output: Contribution to journal › Article › peer-review
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2014
Evaluation and validation of a robust single cell RNA-amplification protocol through transcriptional profiling of enriched lung cancer initiating cells
Rothwell, D. G., Li, Y., Ayub, M., Tate, C., Newton, G., Hey, Y., Carter, L., Faulkner, S., Moro, M., Pepper, S., Miller, C., Blackhall, F., Bertolini, G., Roz, L., Dive, C. & Brady, G., 2014, In: BMC Genomics. 15, 1, p. 1129-1129Research output: Contribution to journal › Article › peer-review
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Molecular analysis of circulating tumour cells—biology and biomarkers
Krebs, M. G., Metcalf, R. L., Carter, L., Brady, G., Blackhall, F. H. & Dive, C., Mar 2014, In: Nature Reviews Clinical Oncology. 11, 3, p. 129-144 15 p.Research output: Contribution to journal › Article › peer-review
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Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer
Hodgkinson, C., Morrow, C., Li, Y., Metcalf, R., Rothwell, D. G., Trapani, F., Polanski, R., Burt, D. J., Simpson, K. L., Morris, K., Pepper, S. D., Nonaka, D., Greystoke, A., Kelly, P., Bola, B., Krebs, M. G., Antonello, J., Ayub, M., Faulkner, S. & Priest, L. & 6 others, , Aug 2014, In: Nature Medicine. 20, 8, p. 897-903 6 p.Research output: Contribution to journal › Article › peer-review
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2012
32 Circulating Tumour Cells, Utility Beyond Prognosis?
Carter, L., 2012, In: European Journal of Cancer.Research output: Contribution to journal › Article
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2010
Smoking in teenagers
Carter, L., Chow, S., Scott, D., Hartshorn, G. S., Califano, R. & Blackhall, F. H., 2010, In: Lung Cancer. 67, Supplement 1, p. s39 1 p.Research output: Contribution to journal › Article