Lydia Tabernero

2024

Impact of diesel exhaust particles on infections with Mycobacterium bovis BCG in in vitro human macrophages and an in vivo Galleria mellonella model

Rodríguez-Fernández, P., Romero-Andrada, I., Molina-Moya, B., Latorre, I., Lacoma, A., Prat-Aymerich, C., Tabernero, L. & Domínguez, J., 15 Jan 2024, In: Environmental Pollution. 341, 122597.

Research output: Contribution to journal › Article › peer-review

Open Access

MptpB Inhibitor Improves the Action of Antibiotics against Mycobacterium tuberculosis and Nontuberculous Mycobacterium avium Infections

Rodríguez-Fernández, P., Botella, L., Cavet, J. S., Domínguez, J., Gutierrez, M. G., Suckling, C. J., Scott, F. J. & Tabernero, L., 12 Jan 2024, In: ACS Infectious Diseases. 10, 1, p. 170-183 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

VSpipe-GUI, an Interactive Graphical User Interface for Virtual Screening and Hit Selection

Hussain, R., Hackett, A. S., Álvarez-Carretero, S. & Tabernero, L., 7 Feb 2024, In: International Journal of Molecular Sciences. 25, 4, 2024.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness

Issler, N., Afonso, S., Weissman, I., Jordan, K., Cebrian-Serrano, A., Meindl, K., Dahlke, E., Tziridis, K., Yan, G., Robles-López, J. M., Tabernero, L., Patel, V., Kesselheim, A., Klootwijk, E. D., Stanescu, H. C., Dumitriu, S., Iancu, D., Tekman, M., Mozere, M. & Jaureguiberry, G. & 30 others, Outtandy, P., Russell, C., Forst, A.-L., Sterner, C., Heinl, E.-S., Othmen, H., Tegtmeier, I., Reichold, M., Schiessl, I. M., Limm, K., Oefner, P., Witzgall, R., Fu, L., Theilig, F., Schilling, A., Shuster Biton, E., Kalfon, L., Fedida, A., Arnon-Sheleg, E., Ben Izhak, O., Magen, D., Anikster, Y., Schulze, H., Ziegler, C., Lowe, M., Davies, B., Böckenhauer, D., Kleta, R., Falik Zaccai, T. C. & Warth, R., 31 Mar 2022, In: Journal of the American Society of Nephrology : JASN.

Research output: Contribution to journal › Article › peer-review

2021

A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis

Adams, J., Thornton, B. & Tabernero, L., 6 Nov 2021, (Accepted/In press) In: International Journal of Molecular Sciences.

Research output: Contribution to journal › Article › peer-review

Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis.

Fernandez Soto, P., Casulli, J., Solano-Castro, D., Rodriguez Fernandez, P., Jowitt, T., Travis, M., Cavet, J. & Tabernero, L., 2021, In: Scientific Reports.

Research output: Contribution to journal › Article › peer-review

Spin Labeling of Surface Cysteines Using a Bromoacrylaldehyde Spin Label

Heaven, G., Hollas, M. A., Tabernero, L. & Fielding, A. J., 2021, In: Applied Magnetic Resonance. 52, 8, p. 959-970 12 p.

Research output: Contribution to journal › Article › peer-review

2020

Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme

Egbe, E., Levy, C. W. & Tabernero, L., 2020, In: PLoS ONE. 15, 6, p. e0235133

Research output: Contribution to journal › Article › peer-review

Open Access

Expression and purification of soluble recombinant SapM from Mycobacterium tuberculosis

Fernandez-soto, P., Cavet, J. S. & Tabernero, L., 2020, In: Protein Expression and Purification. p. 105663

Research output: Contribution to journal › Article › peer-review

Targeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence

Scott, J., Sueiro Olivares, M., Thornton, B., Owens, R. A., Muhamadali, H., Fortune-Grant, R., Thomson, D., Thomas, R., Hollywood, K., Doyle, S., Goodacre, R., Tabernero, L., Bignell, E. & Amich Elias, J., 13 Oct 2020, In: mBio. 11, 5, p. 1-23 23 p., e01985-20.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Characteristics of the first protein tyrosine phosphatase with phytase activity from a soil metagenome

Villamizar, G. A. C., Nacke, H., Griese, L., Tabernero, L., Funkner, K. & Daniel, R., 2019, In: Genes. 10, 2, 101.

Research output: Contribution to journal › Article › peer-review

Open Access

Characterization of the atypical Ppz/Hal3 phosphatase system from the pathogenic fungus Cryptococcus neoformans

Zhang, C., García-Rodas, R., Molero, C., de Oliveira, H. C., Tabernero, L., Reverter, D., Zaragoza, O. & Ariño, J., 9 Apr 2019, In: Molecular Microbiology. 111, 4, p. 898-917 20 p.

Research output: Contribution to journal › Article › peer-review

Identification of Functional and Druggable Sites in Aspergillus fumigatus Essential Phosphatases by Virtual Screening

Thornton, B. P., Johns, A., Al-shidhani, R., Álvarez-carretero, S., Storer, I. S. R., Bromley, M. J. & Tabernero, L., 19 Sept 2019, (E-pub ahead of print) In: International Journal of Molecular Sciences. 20, 18, p. 4636

Research output: Contribution to journal › Article › peer-review

Open Access

Kinetic modeling of DUSP regulation in Herceptin-resistant HER2-positive breast cancer

Buiga, P., Elson, A., Tabernero, L. & Schwartz, J.-M., 26 Jul 2019, In: Genes. 10, 568.

Research output: Contribution to journal › Article › peer-review

Open Access

Mechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs

Fernandez-Soto, P., Bruce, A. J. E., Fielding, A. J., Cavet, J. S. & Tabernero, L., 16 Jul 2019, In: Scientific Reports. 9, 1, p. 10315

Research output: Contribution to journal › Article › peer-review

Open Access

Modelling the role of dual specificity phosphatases in herceptin resistant breast cancer cell lines

Buiga, P., Elson, A., Tabernero, L. & Schwartz, J. M. (Corresponding), 1 Jun 2019, In: Computational Biology and Chemistry. 80, p. 138-146 9 p.

Research output: Contribution to journal › Article › peer-review

2018

Dissecting the role of His Domain Protein Tyrosine Phosphatase/PTPN23 and ESCRTs in sorting activated epidermal growth factor receptor to the multivesicular body

Woodman, P. & Tabernero, L., Oct 2018, In: Biochemical Society Transactions. 46, 5, p. 1037-1046

Research output: Contribution to journal › Article › peer-review

Open Access

Identification and functional analysis of a novel oculocerebrorenal syndrome of Lowe (OCRL) gene variant in two pedigrees with varying phenotypes including isolated congenital cataract

Shalaby, A. K., Emery-Billcliff, P., Baralle, D., Dabir, T., Begum, S., Waller, S., Tabernero, L., Lowe, M. & Self, J., 2018, In: Molecular vision.

Research output: Contribution to journal › Article › peer-review

Open Access

File

70 Downloads (Pure)

Regulation of dual specificity phosphatases in breast cancer during initial treatment with Herceptin: a Boolean model analysis

Buiga, P., Elson, A., Tabernero, L. & Schwartz, J.-M. (Corresponding), 2018, In: BMC Systems Biology. 12, Suppl 1, 11.

Research output: Contribution to journal › Article › peer-review

Open Access

Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo

Vickers, C. F., Silva, A. P. G., Chakraborty, A., Fernandez, P., Kurepina, N., Saville, C., Naranjo, Y., Pons, M., Schnettger, L. S., Gutierrez, M. G., Park, S., Kreiswith, B. N., Perlin, D. S., Thomas, E. J., Cavet, J. S. & Tabernero, L., 27 Sept 2018, In: Journal of Medicinal Chemistry. 61, 18, p. 8337-8352 16 p.

Research output: Contribution to journal › Article › peer-review

VSpipe, an Integrated Resource for Virtual Screening and Hit Selection: Applications to Protein Tyrosine Phospahatase Inhibition

Alvarez Carretero, S., Pavlopoulou , N., Adams, J., Gilsenan, J. & Tabernero, L., 7 Feb 2018, In: Molecules. 23, 2

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Structural basis for specific interaction of TGFβ signalling regulators SARA/endofin with HD-PTP

Gahloth, D., Levy, C., Walker, L., Wunderley, L., Mould, A., Taylor, S., Woodman, P. & Tabernero, L., 2017, In: Structure.

Research output: Contribution to journal › Article › peer-review

Open Access

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

Gahloth, D., Heaven, G., Jowitt, T., Mould, A., Bella, J., Baldock, C., Woodman, P. & Tabernero, L., 2017, In: Scientific Reports. 7

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Structural basis for selective interaction between the ESCRT regulator HD-PTP and UBAP1

Gahloth, D., Levy, C., Heaven, G., Stefani, F., Wunderley, L., Mould, A., Cliff, M., Bella, J., Fielding, A., Woodman, P. & Tabernero, L., 10 Nov 2016, In: Structure. 24, 12, p. 0

Research output: Contribution to journal › Article › peer-review

Open Access

File

206 Downloads (Pure)

2015

Cadherin flexibility provides a key difference between desmosomes and adherens junctions

Tariq, H., Bella, J., Jowitt, T. A., Holmes, D. F., Rouhi, M., Nie, Z., Baldock, C., Garrod, D. & Tabernero, L., 28 Apr 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 17, p. 5395-5400 5 p.

Research output: Contribution to journal › Article › peer-review

File

98 Downloads (Pure)

2014

Dual-specificity phosphatases as molecular targets for inhibition in human disease.

Ríos, P., Nunes-Xavier, C. E., Tabernero, L., Köhn, M. & Pulido, R., 10 May 2014, In: Antioxidants & redox signaling. 20, 14

Research output: Contribution to journal › Article › peer-review

Hyper-adhesion: a unique property of desmosomes.

Garrod, D. & Tabernero, L., Oct 2014, In: Cell communication & adhesion. 21, 5

Research output: Contribution to journal › Article › peer-review

The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex.

Wunderley, L., Brownhill, K., Stefani, F., Tabernero, L. & Woodman, P., 1 Feb 2014, In: Journal of Cell Science. 127, Pt 3

Research output: Contribution to journal › Article › peer-review

2013

Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.

Böhmer, F., Szedlacsek, S., Tabernero, L., Ostman, A. & den Hertog, J., Jan 2013, In: The FEBS Journal. 280, 2

Research output: Contribution to journal › Article › peer-review

2011

Dual-specificity MAP kinase phosphatases as targets of cancer treatment

Nunes-Xavier, C., Romá-Mateo, C., Ríos, P., Tárrega, C., Cejudo-Marín, R., Tabernero, L. & Pulido, R., 2011, In: Anti-Cancer Agents in Medicinal Chemistry. 11, 1, p. 109-132 23 p.

Research output: Contribution to journal › Article › peer-review

Membrane-impermeable cross-linking provides evidence for homophilic, isoform-specific binding of desmosomal cadherins in epithelial cells

Nie, Z., Merritt, A., Rouhi-Parkouhi, M., Tabernero, L. & Garrod, D., 21 Jan 2011, In: Journal of Biological Chemistry. 286, 3, p. 2143-2154 11 p.

Research output: Contribution to journal › Article › peer-review

Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms

Romá-Mateo, C., Sacristán-Reviriego, A., Beresford, N. J., Caparrós-Martín, J. A., Culiáñez-Macià, F. A., Martín, H., Molina, M., Tabernero, L. & Pulido, R., Apr 2011, In: Molecular Genetics and Genomics. 285, 4, p. 341-354 13 p.

Research output: Contribution to journal › Article › peer-review

2010

2009

Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages

Beresford, N. J., Mulhearn, D., Szczepankiewicz, B., Liu, G., Johnson, M. E., Fordham-Skelton, A., Abad-Zapatero, C., Cavet, J. S. & Tabernero, L., 2009, In: Journal of Antimicrobial Chemotherapy. 63, 5, p. 928-936 8 p.

Research output: Contribution to journal › Article › peer-review

2008

Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125

Chu, M. L. H., Chavas, L. M. G., Douglas, K. T., Eyers, P. A. & Tabernero, L., 1 Aug 2008, In: Journal of Biological Chemistry. 283, 31, p. 21495-21500 5 p.

Research output: Contribution to journal › Article › peer-review

Protein tyrosine phosphatases: Structure-function relationships

Tabernero, L., Aricescu, A. R., Jones, E. Y. & Szedlacsek, S. E., Mar 2008, In: FEBS Journal. 275, 5, p. 867-882 15 p.

Research output: Contribution to journal › Article › peer-review

2007

A Novel Phosphatase Family, Structurally Related to Dual-specificity Phosphatases, that Displays Unique Amino Acid Sequence and Substrate Specificity

Romá-Mateo, C., Ríos, P., Tabernero, L., Attwood, T. K. & Pulido, R., 7 Dec 2007, In: Journal of molecular biology. 374, 4, p. 899-909 10 p.

Research output: Contribution to journal › Article › peer-review

2006

2005

Constructing ontology-driven protein family databases

Wolstencroft, K., McEntire, R., Stevens, R., Tabernero, L. & Brass, A., 15 Apr 2005, In: Bioinformatics. 21, 8, p. 1685-1692 7 p.

Research output: Contribution to journal › Article › peer-review

ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1

Tárrega, C., Ríos, P., Cejudo-Marín, R., Blanco-Aparicio, C., Van Den Berk, L., Schepens, J., Hendriks, W., Tabernero, L. & Pulido, R., 11 Nov 2005, In: Journal of Biological Chemistry. 280, 45, p. 37885-37894 9 p.

Research output: Contribution to journal › Article › peer-review

Hyper-adhesion in desmosomes: Its regulation in wound healing and possible relationship to cadherin crystal structure

Garrod, D. R., Berika, M. Y., Bardsley, W. F., Holmes, D. & Tabernero, L., 15 Dec 2005, In: Journal of Cell Science. 118, 24, p. 5743-5754 11 p.

Research output: Contribution to journal › Article › peer-review

PhosphaBase: An ontology-driven database resource for protein phosphatases

Wolstencroft, K. J., Stevens, R., Tabernero, L. & Brass, A., 1 Feb 2005, In: Proteins: Structure, Function and Bioinformatics. 58, 2, p. 290-294 4 p.

Research output: Contribution to journal › Article › peer-review

2004

Class II 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductases?

Hedl, M., Tabernero, L., Stauffacher, C. V. & Rodwell, V. W., Apr 2004, In: Journal of Bacteriology. 186, 7, p. 1927-1932 5 p.

Research output: Contribution to journal › Article › peer-review

Lydia Tabernero, BSc, BSc, PhD

Research output

Search results