Personal profile
Overview
My research focuses on understanding how tissue-infiltrating B cells interact with the surrounding microenvironment and promote inflammation in chronic respiratory diseases and autoimmunity. I have recently been awarded a UKRI Future Leaders Fellowship to further develop my independent research programme. Prior to this, I completed my postdoctoral studies at Harvard Medical School, Boston (with Prof Vijay Kuchroo and Dr Brian Hafler), identifying inflammatory pathways contributing to age-related macular degeneration. I also trained as a postdoc at University College London (with Prof Claudia Mauri), investigating the role of intestinal barrier dysfunction in the pathogenesis of rheumatoid arthritis. I obtained my PhD in Immunology from University College London in 2015 unravelling the crosstalk between B cells and plasmacytoid dendritic cells in systemic lupus erythematosus.
My group
Holly Sedgwick - PhD student
Peter West - Postdoctoral Researcher
Maana Layeghi - PhD student
Rebecca Rowan - PhD student
Areas of expertise
- QR180 Immunology
Research Beacons, Institutes and Platforms
- Lydia Becker Institute
Keywords
- B cells
- COPD
- Lung disease
- Autoimmunity
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Lymphocyte alterations and elevated complement signaling are key features of refractory myasthenia gravis
Dodd, K. C., Baillie, K., Holt, J. K. L., Leite, M. I., Lin, L., West, P. W., Miller, J. A. L., Spillane, J., Viegas, S., Zelek, W. M., Sussman, J. & Menon, M., 6 Feb 2026, (E-pub ahead of print) In: Med. 100987.Research output: Contribution to journal › Article › peer-review
Open Access -
Autoantibodies Neutralizing Type III Interferons Are Uncommon in Patients with Severe Coronavirus Disease 2019 Pneumonia
Vanker, M., Särekannu, K., Fekkar, A., Jørgensen, S. E., Haljasmägi, L., Kallaste, A., Kisand, K., Lember, M., Peterson, P., Menon, M., Hussell, T., Knight, S., Moore-Stanley, J., Bastard, P., Zhang, S.-Y., Mogensen, T. H., Philippot, Q., Zhang, Q., Puel, A. & Casanova, J.-L. & 1 others, , 15 Sept 2023, In: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 43, 9, p. 379-393 15 p.Research output: Contribution to journal › Article › peer-review
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Inactive disease in patients with lupus is linked to autoantibodies to type I interferons that normalize blood IFNα and B cell subsets.
Bradford, H., Haljasmägi, L., Menon, M., McDonnell, T., Särekannu, K., Vanker, M., Peterson, P., Wincup, C., Abida, R., Gonzalez, R., Bondet, V., Duffy, D., Isenberg, D., Kisand, K. & Mauri, C., 17 Jan 2023, In: Cell reports. Medicine. 4, 1, 100894.Research output: Contribution to journal › Article › peer-review
Open Access -
Monocyte migration profiles define disease severity in acute COVID-19 and unique features of long COVID
CIRCO, Scott, N. A., Pearmain, L., Knight, S. B., Brand, O., Morgan, D. J., Jagger, C., Harbach, S., Khan, S., Shuwa, H. A., Franklin, M., Kästele, V., Williams, T., Prise, I., McClure, F. A., Hackney, P., Smith, L., Menon, M., Konkel, J. E. & Lawless, C. & 18 others, , 11 May 2023, (E-pub ahead of print) In: The European respiratory journal. 61, 5, 20 p., 2202226.Research output: Contribution to journal › Article › peer-review
Open Access -
Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19
CIRCO Collaborative Group, 21 Jan 2022, In: iScience. 25, 1, p. 103672 103672.Research output: Contribution to journal › Article › peer-review
Open Access
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Cellular dynamics in chronic lung disease: the neglected B cell axis
Menon, M. (PI)
1/01/25 → 31/12/28
Project: Research
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Laser capture dissection for spatially-resolved -omics analysis
Swift, J. (PI), Caswell, P. (CoI), Chang, J. (CoI), Clarke, R. (CoI), Couper, K. (CoI), Dyer, D. (CoI), Eckersley, A. (CoI), Gilmore, A. (CoI), Hadjidemetriou, M. (CoI), Hayes, A. (CoI), Hepworth, M. (CoI), Hussell, T. (CoI), Knight, D. (CoI), Kostarelos, K. (CoI), Lennon, R. (CoI), March, P. (CoI), Meng, Q.-J. (CoI), Menon, M. (CoI), Piper Hanley, K. (CoI), Reid, A. (CoI), Sharrocks, A. (CoI), Sherratt, M. (CoI), Thornton, D. (CoI), Unwin, R. (CoI), Wong, J. (CoI) & Woolner, S. (CoI)
1/07/24 → 28/02/25
Project: Research
Press/Media
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MANCHESTER EVENING NEWS: How Manchester's top scientists are racing to pinpoint who coronavirus will hit hardest
Hussell, T., Mann, E. & Menon, M.
5/04/20
1 item of Media coverage
Press/Media: Research