Mairead Mcnamara

2023

ABC-12: Exploring the microbiome in patients (pts) with advanced biliary tract cancer (BTC) in a first-line study of durvalumab in combination with cisplatin/gemcitabine (cis/gem)

Mcnamara, M., Timmons, H., Osborne, A., Cox, R., Wasan, H., Corrie, P., Gillmore, R., Sivakumar, S., Ma, Y. T., Faluyi, O., Arora, A., Arif, S., Canham, J., Hurt, C., Hubner, R. A., Bridgewater, J., Adams, R. & Valle, J. W., 2023.

Research output: Contribution to conference › Abstract › peer-review

Advanced extrahepatic cholangiocarcinoma: Post-hoc analysis of the ABC-01, -02 and -03 clinical trials

Lamarca, A., Ross, P. J., Wasan, H. S., Hubner, R., Mcnamara, M., Lopes, A., Palmer, D., Valle, J. & Bridgewater, J. A., 2023.

Research output: Contribution to conference › Abstract › peer-review

Open Access

Basket trials in upper gastrointestinal and hepato-pancreatico-biliary cancers: an emerging entity

Huddar, P., Graham, K., Hubner, R., Valle, J. & Mcnamara, M., 2023.

Research output: Contribution to conference › Abstract › peer-review

Choosing the best systemic treatment sequence for control of tumour growth in gastro-enteropancreatic neuroendocrine tumours (GEP-NETs): what is the recent evidence?

Passhak, M., Mcnamara, M. G., Hubner, R. A., Ben-Aharon, I. & Valle, J. W., 23 Oct 2023, (Accepted/In press) In: Best Practice and Research: Clinical Endocrinology and Metabolism.

Research output: Contribution to journal › Article › peer-review

Current Evidence for Immune Checkpoint Inhibition in Advanced Hepatocellular Carcinoma

Foy, V., Mcnamara, M., Valle, J., Lamarca, A., Edeline, J. & Hubner, R., 21 Sept 2023, In: Current Oncology. 30, 9, p. 8665-8685 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Frequency of dihydropyrimidine dehydrogenase (DPD) deficiency detection and adverse events in patients receiving fluoropyrimidine-based therapy in a pancreatic and biliary tract cancer cohort

Wilson, E., Monaghan, P., Gleeson, J., Lamarca, A., Hubner, R., Valle, J. & Mcnamara, M., 2023.

Research output: Contribution to conference › Abstract › peer-review

Future therapeutic strategies in the treatment of extra-pulmonary neuroendocrine carcinoma: A systematic review

Robinson, M. D., Livesey, D., Hubner, R. A., Valle, J. W. & Mcnamara, M. G., 23 Jan 2023, (Accepted/In press) In: Therapeutic Advances in Medical Oncology.

Research output: Contribution to journal › Review article › peer-review

Influence of cirrhosis on outcomes of patients with advanced intrahepatic cholangiocarcinoma receiving chemotherapy

d'Abrigeon, C., McNamara, M. G., Le Sourd, S., Lamarca, A., Lièvre, A., Bourien, H., Peinoit, A., Uguen, T., Hubner, R. A., Valle, J. W. & Edeline, J., 9 Oct 2023, In: British Journal of Cancer.

Research output: Contribution to journal › Article › peer-review

Open Access

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NET-02: A randomised, non-comparative, phase II trial of nal-IRI/5-FU or docetaxel as second-line therapy in patients with progressive poorly differentiated extra-pulmonary neuroendocrine carcinoma

Mcnamara, M. G., Lamarca, A., Hubner, R. A., Valle, J. W. & al, E., 8 May 2023, (Accepted/In press) In: EClinicalMedicine.

Research output: Contribution to journal › Article › peer-review

NET-02 final results: A randomised, phase II trial of liposomal irinotecan (nal-IRI)/5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line (2L) therapy in patients (pts) with progressive poorly differentiated extrapulmonary neuroendocrine carcinoma (PD-EP-NEC).

Mcnamara, M., Swain, J., Craig, Z., Sharma, R., Faluyi, O., Wadsley, J., Morgan, C., Wall, L. R., Chau, I., Reed, N., Sarker, D., Margetts, J., Krell, D., Cave, J., Sothi, S., Anthoney, A., Patel, A., Lamarca, A., Hubner, R. A. & Valle, J. W., 2023.

Research output: Contribution to conference › Abstract › peer-review

Patients Undergoing Systemic Anti-Cancer Therapy Who Require Surgical Intervention: What Surgeons Need to Know

Robinson, M., Mcnamara, M. G., Clouston, H. W., Sutton, P. A., Hubner, R. A. & Valle, J. W., 26 Jul 2023, (E-pub ahead of print) In: Cancers. 15, 15, 3781.

Research output: Contribution to journal › Article › peer-review

Open Access

Plain language summary of the TOPAZ-1 study: durvalumab and chemotherapy for advanced biliary tract cancer

Mcnamara, M., Valle, J. W. & et al., 11 Aug 2023, (Accepted/In press) In: Future Oncology.

Research output: Contribution to journal › Article › peer-review

Prognosis discussion and referral to community palliative care services in patients with advanced pancreatic cancer treated in a tertiary cancer centre

Clelland, S., Nuttall, C. L., Stott, H. E., Cope, J., Barratt, N. L., Farrell, K., Eyong, M., Gleeson, J. P., Lamarca, A., Hubner, R. A., Valle, J. W. & Mcnamara, M. G., 16 Oct 2023, (Accepted/In press) In: Healthcare.

Research output: Contribution to journal › Article › peer-review

Prospective Observational Study of Prevalence, Assessment and Treatment of Pancreatic Exocrine Insufficiency in Patients with Inoperable Pancreatic Malignancy (PANcreatic Cancer Dietary Assessment—PanDA)

Carnie, L. E., Shah, D., Vaughan, K., Kapacee, Z. A., McCallum, L., Abraham, M., Backen, A., Mcnamara, M. G., Hubner, R. A., Barriuso, J., Gillespie, L., Lamarca, A. & Valle, J. W., 13 Apr 2023, In: Cancers. 15, 8, 2277.

Research output: Contribution to journal › Article › peer-review

Open Access

Relevant Study: Patient and Clinician Perspectives on Clinically-Meaningful Outcomes in Advanced Pancreatic Cancer

Pihlak, R., Frizziero, M., Mak, S. Y. G., Nuttall, C., Lamarca, A., Hubner, R. A., Valle, J. W. & Mcnamara, M. G., 25 Jan 2023, In: Cancers. 15, 3, p. 738

Research output: Contribution to journal › Article › peer-review

Open Access

Resistance mechanism to fibroblast growth factor receptor (FGFR) inhibitors in cholangiocarcinoma

Lamarca, A., Ostios, L., Mcnamara, M. G., Garzon, C., Gleeson, J. P., Edeline, J., Herrero, A., Hubner, R. A., Moreno, V. & Valle, J. W., 16 Sept 2023, (E-pub ahead of print) In: Cancer Treatment Reviews. 102627.

Research output: Contribution to journal › Article › peer-review

Open Access

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Selection of Chemotherapy in Advanced Poorly Differentiated Extra-Pulmonary Neuroendocrine Carcinoma

Weaver, J. M. J., Hubner, R., Valle, J. & Mcnamara, M., 11 Oct 2023, In: Cancers. 15, 20, 4951.

Research output: Contribution to journal › Article › peer-review

Open Access

Targeting PD-1/PD-L1 in biliary tract cancer; role and available data

Mahmood, R. D., Graham, K., Gleeson, J., Hubner, R. A., Valle, J. W. & Mcnamara, M. G., 1 May 2023, In: Immunotherapy. 15, 7, p. 517-530 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Third-Line Palliative Systemic Therapy for Advanced Biliary Tract Cancer: Multicentre Review of Patterns of Care and Outcomes

Gray, S., Letissier, O., D’abrigeon, C., Shah, D., Wardell, S., Faluyi, O., Lamarca, A., Hubner, R. A., Edeline, J., Valle, J. W. & Mcnamara, M. G., 3 Jun 2023, In: Cancers. 15, 11, 3047.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

ALBI grade predicts suitability for further systemic therapy following sorafenib in patients with advanced hepatocellular carcinoma.

Fakih, O., Haddad, S. S., Walker, S., Edeline, J., Estrade, F., Wang, X., Lamarca, A., Mcnamara, M. G., Valle, J. W. & Hubner, R. A., 5 Aug 2022, (Accepted/In press) In: Liver Cancer International.

Research output: Contribution to journal › Article › peer-review

Clinical challenges associated with utility of neoadjuvant treatment in patients with pancreatic ductal adenocarcinoma

Gray, S., de Liguori-Carino, N., Radhakrishna, G., Lamarca, A., Hubner, R. A., Valle, J. W. & Mcnamara, M. G., 10 Feb 2022, (Accepted/In press) In: European Journal of Surgical Oncology.

Research output: Contribution to journal › Article › peer-review

Development of a Quality of Life Questionnaire for Patients with Pancreatic Neuroendocrine Tumours (the PANNET module)

Ramage, J. K., Friend, E., Randell, J., King, B., Fernandez Ortega, P., Mcnamara, M. G., Kaltsas, G., Falconi, M., Cwikla, J., Capdevila, J., Grozinsky‐glasberg, S., Mandair, D., Gamper, E., Srirajaskanthan, R., Weickert, M. & Gray, D., 30 Jan 2022, In: Journal of Neuroendocrinology.

Research output: Contribution to journal › Article › peer-review

Open Access

Durvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer

Mcnamara, M. G. & et al., 15 Apr 2022, (Accepted/In press) In: NEJM Evidence.

Research output: Contribution to journal › Article › peer-review

Endoscopic surveillance alone is feasible and safe in type I gastric neuroendocrine neoplasms less than 10mm in diameter

Exarchou, K., Hu, H., Stephens, N. A., Moore, R. A., Kelly, M., Lamarca, A., Mansoor, W., Hubner, R., Mcnamara, M. G., Smart, H., Howes, N. R., Valle, J. W. & Pritchard, D. M., 9 Jul 2022, (Accepted/In press) In: Endocrine.

Research output: Contribution to journal › Article › peer-review

Expanding therapeutic opportunities for Extra-Pulmonary Neuroendocrine Carcinoma

Frizziero, M., Kilgour, E., Simpson, K. L., Rothwell, D. G., Moore, D. A., Frese, K. K., Galvin, M., Lamarca, A., Hubner, R. A., Valle, J. W., Mcnamara, M. G. & Dive, C., 28 Jan 2022, In: Clinical Cancer Research.

Research output: Contribution to journal › Article › peer-review

Open Access

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Influence of cirrhosis on outcomes of patients with advanced intrahepatic cholangiocarcinoma receiving chemotherapy

D'abrigeon, C., Mcnamara, M., LeSourd, S., Lamarca, A., Lievre, A., Hubner, R., Valle, J. & Edeline, J., 2022.

Research output: Contribution to conference › Abstract › peer-review

Intrahepatic cholangiocarcinoma hidden within cancer of unknown primary

Conway, A-M., Morris, G. C., Smith, S., Vekeria, M., Manoharan, P., Mitchell, C., Backen, A., Oliveira, P., Hubner, R., Lamarca, A., Mcnamara, M., Valle, J. & Cook, N., 29 Mar 2022, (Accepted/In press) In: British Journal of Cancer..

Research output: Contribution to journal › Article › peer-review

Management and outcomes of patients with extra-pulmonary neuroendocrine neoplasms and brain metastases

Kapacee, Z. A., Allison, J., Dawod, M., Frizziero, M., Chakrabarty, B., Manoharan, P., McBain, C., Mansoor, W., Lamarca, A., Hubner, R., Valle, J. & Mcnamara, M. G., 13 Jul 2022, (Accepted/In press) In: Current Oncology.

Research output: Contribution to journal › Article › peer-review

Markers of tumour inflammation as prognostic factors for overall survival in patients with advanced pancreatic cancer receiving first line FOLFIRINOX chemotherapy

Kamposioras, K., Papaxoinis, G., Dawood, M., Appleyard, J., Collinson, F., Lamarca, A., Ahmad, U., Hubner, R. A., Wright, F., Pihlak, R., Damyanova, I., Razzaq, B., Valle, J., Mcnamara, M. & Anthoney, A., 11 Mar 2022, (Accepted/In press) In: Acta Oncologica .

Research output: Contribution to journal › Article › peer-review

Molecular Profiling of Well-Differentiated Neuroendocrine Tumours: The role of ctDNA in Real World Practice

Lamarca, A., Friziero, M., Barriuso, J., Kapacee, Z. A., Mansoor, W., Mcnamara, M., Hubner, R. A. & Valle, J., 17 Feb 2022, In: Cancers.

Research output: Contribution to journal › Article › peer-review

Open Access

NET-02: A multicenter, randomized, phase II trial of liposomal irinotecan (nal-IRI) and 5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line therapy in patients (pts) with progressive poorly differentiated extra-pulmonary neuroendocrine carcinoma (PD-EP-NEC).

Mcnamara, M., Swain, J., Craig, Z., Sharma, R., Faluyi, O., Wadsley, J., Morgan, C., Wall, L. R., Chau, I., Reed, N., Sarker, D., Margetts, J., Krell, D., Cave, J., Sharmila, S., Anthoney, A., Patel, A., Lamarca, A., Hubner, R. A. & Valle, J., 2022.

Research output: Contribution to conference › Abstract › peer-review

Prognosis discussion and referral to community palliative care services (CPCS) in patients with advanced pancreas cancer (APC)

Clelland, S., Nuttall, C., Stott, H., Cope, J., Barratt, N., Farrell, K., Eyong, M., Lamarca, A., Hubner, R., Valle, J. & Mcnamara, M., 2022, p. 120–124. 5 p.

Research output: Contribution to conference › Abstract › peer-review

Prognostic and predictive factors for locoregional and systemic therapies in hepatocellular carcinoma

Gray, S., Lamarca, A., Mcnamara, M. G., Edeline, J., Piper Hanley, K., Valle, J. & Hubner, R., 30 Aug 2022, (Accepted/In press) In: Liver Cancer International.

Research output: Contribution to journal › Article › peer-review

Randomized, Phase II Study of Selumetinib, an oral inhibitor of MEK, in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer.

Doherty, M. K., Tam, V. C., Mcnamara, M. G., Jang, R., Hedley, D., Chen, E., Dhani, N., Tang, P., Sim, H-W., O'Kane, G. M., De Luca, S., Wang, L., Pedutem, T. & Knox, J. J., 28 Jun 2022, (Accepted/In press) In: British Journal of Cancer.

Research output: Contribution to journal › Article › peer-review

Regional subgroup analysis of the phase 3 TOPAZ-1 study of durvalumab (D) plus gemcitabine and cisplatin (GC) in advanced biliary tract cancer (BTC).

Vogel, A., Chen, L-T., He, A. R., Kim, J. W., Chen, M-H., Mcnamara, M., Shimizu, S., Gillmore, R., Ray, F., Kim, H., Xiong, J., Makowsky, M., Rokutanda, N., Cohen, G. & Oh, D-Y., 2022.

Research output: Contribution to conference › Abstract › peer-review

Targeted Therapies for Perihilar Cholangiocarcinoma

Gray, S., Lamarca, A., Edeline, J., Klümpen, H., Hubner, R. A., Mcnamara, M. G. & Valle, J. W., 1 Apr 2022, In: Cancers. 14, 7, p. 1789 1789.

Research output: Contribution to journal › Article › peer-review

Open Access

The microbiome as a potential diagnostic biomarker for pancreatic ductal adenocarcinoma (PDAC)

Wheatley, R. C., Valle, J. W. & Mcnamara, M. G., Oct 2022, In: Hepatobiliary Surgery and Nutrition. p. 0-0

Research output: Contribution to journal › Editorial › peer-review

Open Access

Use of the Rockwood Clinical Frailty Scale in patients with advanced hepatopancreaticobiliary malignancies

Shah, D., Kapacee, Z. A., Lamarca, A., Hubner, R. A., Valle, J. W. & Mcnamara, M. G., 6 Jul 2022, In: Expert Review of Anticancer Therapy. 22, 9, p. 1009-1015 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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What is the gender representation in authorship in later phase systemic clinical trials in biliary tract cancer (BTC)?: a retrospective review of the published literature

Mcnamara, M. G., Bridgewater, J., Goyal, L., Jacobs, T., Wagner, A. D., Goldstein, D., Shroff, R. T., Moehler, M., Lowery, M., Bekaii-Saab, T., Kelley, R. K., Furuse, J., Rimassa, L., Morizane, C., Lamarca, A., Hubner, R., Knox, J. J. & Valle, J. W., 22 Sept 2022, (Accepted/In press) In: BMJ Open.

Research output: Contribution to journal › Article › peer-review

2021

Assessing the management of bone metastases in patients diagnosed with neuroendocrine neoplasms: Re-audit of clinical practice

Garcia-Torralba, E., Lim, KHJ., Barriuso, J., Mcnamara, M., Hubner, R., Mansoor, W., Valle, J. & Lamarca, A., 2021.

Research output: Contribution to conference › Abstract › peer-review

Chemotherapy for Advanced Gallbladder Cancer (GBC): A Systematic Review and Meta-Analysis

Azizi, A. A., Lamarca, A., Mcnamara, M. & Valle, J., 26 Mar 2021, (Accepted/In press) In: Critical Reviews in Oncology/Hematology.

Research output: Contribution to journal › Article › peer-review

Distal migration of a partially covered duodenal stent requiring emergency surgical extraction

Campana, L. G., Fish, R., Dickinson, O. T., Mcnamara, M., O'Dwyer, S. T. & Laasch, H-U., 21 Oct 2021, (Accepted/In press) In: International Journal of Gastrointestinal Intervention .

Research output: Contribution to journal › Article › peer-review

Druggable molecular alterations in bile duct cancer: potential and current therapeutic applications in clinical trials

Bourien, H., Lamarca, A., Mcnamara, M., Hubner, R. A., Valle, J. & Edeline, J., 2021, In: Expert Opinion on Investigational Drugs.

Research output: Contribution to journal › Article › peer-review

Editorial comment on: development and external validation of a model to predict overall survival in patients with resected gallbladder cancer

Mcnamara, M. G., 31 Dec 2021, In: Hepatobiliary Surgery and Nutrition.

Research output: Contribution to journal › Editorial › peer-review

Open Access

Everolimus-induced pneumonitis in patients with neuroendocrine neoplasms: real-world study on risk factors and outcomes

Taboada, R. G., Riechelmann, R. P., Mauro, C., Barros, M., Hubner, R., Mcnamara, M., Lamarca, A. & Valle, J., 29 Sept 2021, (Accepted/In press) In: The oncologist.

Research output: Contribution to journal › Article › peer-review

Gender representation in authorship in later-phase systemic clinical trials in biliary tract cancer (BTC).

Mcnamara, M., Bridgewater, J., Goyal, L., Goldstein, D., Shroff, R. T., Moehler, M. H., Lowery, M. A., Bekaii-Saab, T. S., Kelley, R. K., Furuse, J., Rimassa, L., Morizane, C., Lamarca, A., Hubner, R., Knox, J. J. & Valle, J., 2021.

Research output: Contribution to conference › Abstract › peer-review

Generation of a Circulating Tumour Cell (CTC)-Derived eXplant of a NeuroEndocrine Carcinoma of unknown origin

Frizziero, M., Kilgour, E., Simpson, K., Frese, K., Valle, J., Mcnamara, M. & Dive, C., 2021.

Research output: Contribution to conference › Abstract › peer-review

Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis

Lee, B. Y., Hogg, E. K. J., Below, C. R., Kononov, A., Blanco-gomez, A., Heider, F., Xu, J., Hutton, C., Zhang, X., Scheidt, T., Beattie, K., Lamarca, A., Mcnamara, M., Valle, J. W. & Jørgensen, C., 17 Dec 2021, In: Nature Communications. 12, 1, 7336.

Research output: Contribution to journal › Article › peer-review

Open Access

Incidence of brain metastases (BMs) and outcomes in patients (pts) with extrapulmonary neuroendocrine neoplasms (EP-NENs).

Kapacee, Z., Dawod, M., Allison, J., Frizziero, M., Chakrabarty, B., Manoharan, P., McBain, C., Mansoor, W., Lamarca, A., Hubner, R., Valle, J. & Mcnamara, M., 2021.

Research output: Contribution to conference › Abstract › peer-review

Intrahepatic cholangiocarcinoma (iCCA) hidden amongst the unknown: A retrospective analysis of cancer of unknown primary (CUP) cases from a tertiary cancer centre

Conway, A., Morris, G., Smith, S., Manoharan, P., Mitchell, CL., Backen, A., Oliveira, P., Hubner, R., Lamarca, A., Mcnamara, M., Valle, J. & Cook, N., 2021.

Research output: Contribution to conference › Abstract › peer-review

Mairead Mcnamara, MB, BCh, BAO, B Med Sci, BSc, PhD, MRCP UK

Research output

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