Personal profile
Overview
Professor of Radiotherapy Physics. This is a joint post between the University of Manchester and the Christie. Marcel is responsible for developing a programme of international leading radiotherapy physics research and innovation to deliver direct patient benefits. The main focus is on accuracy of radiotherapy including target volume definition, treatment planning, image guidance and treatment follow-up.
Work Stream 4 for NCRI Clinical and Translational Radiotherapy Research (CTRad) Working Group
Biography
Professor Marcel van Herk joined the University of Manchester on the 1st of April 2015 as new chair in radiotherapy physics. He is currently setting up a research group focussing on improving the accuracy of radiotherapy. As his work heavily involves implementation of research into clinical practice, he has an honorary appointment at the Christie.
He has been active in radiotherapy and worked at the Netherlands Cancer Institute (NKI) since 1982. As a medical physics student he started on the development of a liquid ionization imaging device that later became the Varian PortalVision system for electronic portal imaging. During his PhD at the NKI, the detector was further developed and commercialized and the focus of the work shifted to image processing, correction procedures and margins. Starting during a Postdoc at Harvard Medical School, USA in 1992, his work incorporated 3D image processing, first CT-MR image registration for treatment planning, later measuring organ motion and other uncertainties in radiotherapy such as delineation variability. Much of this work has been integrated in the Elekta Synergy cone-beam CT image guidance system developed jointly in a consortium with Elekta and David Jaffray. For the past 10 years, he also held a part-time teaching role as a Professor at the University of Amsterdam working amongst others at the integration of microscopic optical imaging into radiotherapy treatment planning.
His goal is to do research to improve the clinical practice of radiotherapy in Christie, UK and the world. To achieve this he feels we need to perform first class research, speedy clinical implementation and collaborate with industry to bring our ideas to the market.
Marcel has (co-) authored more than 190 papers in peer reviewed journals.
Research interests
Data mining approach for identifying cancer spread
Image guided radiotherapy for peadiatric patients
MR guided radiotherapy
Radiotherapy response measurement using imaging
Probabilistic treatment planning
Observer varation in contouring of tumor and organs at risk
EPID dosimetry
Image guidance for proton therapy
Image registration for treatment planning
Teaching
ESTRO course on Image Guided Radiotherapy
ICR course "Practical and Theoretical Radiotherapy Physics: radiobiology, accelerator design and quality control, brachytherapy and radiotherapy verification imaging"
My collaborations
Catharine West
Corinne Faivre-Finn
Gillian Whitfield
Ananya Choudhury
Alan McWilliam
Philip Whitehurst
Marianne Aznar
Memberships of committees and professional bodies
Dutch Cancer Foundation
Organisation Committee ICCR 2016
Qualifications
Academic Medical Center, 2004
PhD University of Amsterdam, 1992, Cum Laude
MSc University of Amsterdam, 1985, Cum Laude
BSc University of Amsterdam, 1983
Research Beacons, Institutes and Platforms
- Digital Futures
- Christabel Pankhurst Institute
- Manchester Cancer Research Centre
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
-
SDG 3 Good Health and Well-being
-
SDG 4 Quality Education
-
SDG 9 Industry, Innovation, and Infrastructure
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
The concept of virtual clinical trials: A game changer in radiation oncology research?
Faivre-Finn, C., Baker, C., Dempsey, C., Fisher, J., Frangi, A. F., Gosling, A., Hiley, C., Lowe, M., Marchant, T., McWilliam, A., Price, G., Rieu, R., van Herk, M., Vasquez Osorio, E., Woolf, D. & Aznar, M., Jan 2026, In: Radiotherapy and Oncology. 214, 111264.Research output: Contribution to journal › Letter › peer-review
Open Access -
A case report of continuous glucose monitoring for a radiographer working in a 1.5T MR Linac
Dobby, B., Nelder, C., Tallon, J., McDaid, L., van Herk, M., Daly, M. & Eccles, C. L., 1 Dec 2025, In: Journal of Medical Imaging and Radiation Sciences. 56, 6, 6 p., 102063.Research output: Contribution to journal › Article › peer-review
-
Cone-beam computed tomography reconstruction for a commercial proton beam therapy system
Lindsay, J., Meara, S., Clarke, M., Lowe, M., Lines, D., Aznar, M. & Van Herk, M., 13 Mar 2025, (E-pub ahead of print) In: Physics and Imaging in Radiation Oncology. 100745.Research output: Contribution to journal › Article › peer-review
Open Access -
Individualised dose mapping uncertainty estimation in the reirradiation setting
Thiong'o, C. M., Van Herk, M., Banfill, K., Banfill, K., Harris, C., Lowe, M., Marchant, T., Mohamed, I., Motamedi-Ghahfarokhi, G., Thomson, D., Appelt, A. L. & Vasquez Osorio, E., 28 Nov 2025, (Accepted/In press) In: Physics and Imaging in Radiation Oncology.Research output: Contribution to journal › Article › peer-review
-
Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy
Bouzaki, A., Vasquez Osorio, E., Kerns, S., Van Herk, M., Morris, A., Shortall, J., Azria, D., Farcy-Jacquet, M. P., Chang-Claude, J., Choudhury, A., Dunning, A., Lambrecht, M., Avuzzi, B., de Ruysscher, D., Seibold, P., Sperk, E., Talbot, C., Vega, A., Veldeman, L. & Webb, A. & 5 others, , 17 Oct 2025, In: Clinical Cancer Research. p. OF1-OF9Research output: Contribution to journal › Article › peer-review
Open Access
-
NIHR Manchester Biomedical Research Centre
Bruce, I. (PI), Lord, G. (CoI), Lennon, R. (CoI), Black, G. (CoI), Wedge, D. (CoI), Morris, A. (CoI), Hussell, T. (CoI), Sharrocks, A. (CoI), Stivaros, S. (CoI), Buch, M. (CoI), Gough, J. (CoI), Kostarelos, K. (CoI), Thistlethwaite, F. (CoI), Kadler, K. (CoI), Barton, A. (CoI), Hyrich, K. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI), Vestbo, J. (CoI), Simpson, A. (CoI), Singh, S. (CoI), Smith, J. (CoI), Felton, T. (CoI), Murray, C. (CoI), Griffiths, C. (CoI), Cullum, N. (CoI), Rhodes, L. (CoI), Warren, R. (CoI), Paus, R. (CoI), Dumville, J. (CoI), Viros Usandizaga, A. (CoI), Keavney, B. (CoI), Tomaszewski, M. (CoI), Allan, S. (CoI), Body, R. (CoI), Cartwright, E. (CoI), Heagerty, A. (CoI), Kalra, P. (CoI), Miller, C. (CoI), Rutter, M. (CoI), Smith, C. (CoI), Trafford, A. (CoI), Evans, D. (CoI), Davidson, E. (CoI), Crosbie, P. (CoI), Harvie, M. (CoI), Howell, S. (CoI), Renehan, A. (CoI), Dive, C. (CoI), Blackhall, F. (CoI), Landers, D. (CoI), Krebs, M. (CoI), Cook, N. (CoI), Clarke, R. (CoI), Taylor, S. (CoI), Jorgensen, C. (CoI), Lorigan, P. (CoI), Jayson, G. (CoI), Valle, J. (CoI), Mccabe, M. (CoI), Armstrong, A. (CoI), Freitas, A. (CoI), Illidge, T. (CoI), Choudhury, A. (CoI), Hoskin, P. (CoI), West, C. (CoI), Van Herk, M. (CoI), Faivre-Finn, C. (CoI), Bristow, R. (CoI), Kirkby, K. (CoI), Birtle, A. (CoI), Mackay, R. (CoI), Radford, J. (CoI), Linton, K. (CoI), Higham, C. (CoI), Munro, K. (CoI), Plack, C. (CoI), Arden Armitage, C. (CoI), Bruce, I. (CoI), Moore, D. (CoI), Saunders, G. (CoI), Stone, M. (CoI), Haddock, G. (CoI), Lewis, S. (CoI), Elliott, R. (CoI), Green, J. (CoI), Lovell, K. (CoI), Morrison, A. (CoI), Shaw, J. (CoI), Bucci, S. (CoI), Ainsworth, J. (CoI), Webb, R. (CoI), Newman, W. (CoI), Banka, S. (CoI), Clayton-Smith, J. (CoI), Payne, K. (CoI), Moldovan, R. (CoI), Wynn, R. (CoI) & Jones, S. (CoI)
1/12/22 → 30/11/27
Project: Research
-
MAnchester RESearch Transforming Radiation Oncology (MAESTRO) Programme as Part of CRUK RadNet.
Bristow, R. (PI), Burnet, N. (CoI), Choudhury, A. (CoI), Dive, C. (CoI), Faivre-Finn, C. (CoI), Hagan, I. (CoI), Hoskin, P. (CoI), Hussell, T. (CoI), Illidge, T. (CoI), Kirkby, K. (CoI), Kostarelos, K. (CoI), O'Connor, J. (CoI), Peek, N. (CoI), Rattray, M. (CoI), Taylor, S. (CoI), Thornton, D. (CoI), Van Herk, M. (CoI), West, C. (CoI), Whetton, A. (CoI), Williams, K. (CoI) & Yorke, J. (CoI)
1/11/19 → 31/10/24
Project: Research
-
NIHR Biomedical Research Centre: Cancer Advanced Radiotherapy Theme.
West, C. (PI), Bristow, R. (CoI), Bruce, I. (CoI), Burnet, N. (CoI), Choudhury, A. (CoI), Evans, D. (CoI), Faivre-Finn, C. (CoI), Hoskin, P. (CoI), Illidge, T. (CoI), Kirkby, K. (CoI), Kirkby, N. (CoI), O'Connor, J. (CoI) & Van Herk, M. (CoI)
1/04/17 → 31/03/19
Project: Research
-
A Tool for Predicting an Individual Prostate Cancer Patient's Risk of Metastasis and Need for Lymph Node Irradiation.
Choudhury, A. (PI), Kirkby, N. (CoI), Mcwilliam, A. (CoI), Van Herk, M. (CoI) & West, C. (CoI)
1/03/17 → 28/06/20
Project: Research
-
Advanced Radiotherapies Technologies Network (ART-NET)
Faivre-Finn, C. (PI), Illidge, T. (CoI), Kirkby, K. (CoI) & Van Herk, M. (CoI)
1/09/16 → 31/08/21
Project: Research
Prizes
Activities
-
Beyond Quantec
Van Herk, M. (Chair)
24 Feb 2020 → 25 Feb 2020Activity: Participating in or organising event(s) › Participating in a conference, workshop, exhibition, performance, inquiry, course etc › Research
-
AERO Academy Conference
Van Herk, M. (Chair)
7 Feb 2020 → 8 Feb 2020Activity: Participating in or organising event(s) › Participating in a conference, workshop, exhibition, performance, inquiry, course etc › Research
-
Data mining for adaptive radiotherapy
Van Herk, M. (Invited speaker)
17 Jan 2020Activity: Talk or presentation › Invited talk › Research
-
4D Treatment Workshop for Particle Therapy 2019
Van Herk, M. (Chair)
23 Nov 2019Activity: Participating in or organising event(s) › Participating in a conference, workshop, exhibition, performance, inquiry, course etc › Research
-
George Edelstyn Lecture
Van Herk, M. (Speaker)
4 Oct 2019Activity: Talk or presentation › Invited talk › Research
Datasets
-
Considerable interobserver variation in delineation of pancreatic cancer on 3DCT and 4DCT: a multi-institutional study
Versteijne, E. (Contributor), Gurney-Champion, O. J. (Contributor), van der Horst, A. (Contributor), Lens, E. (Contributor), Kolff, M. W. (Contributor), Buijsen, J. (Contributor), Ebrahimi, G. (Contributor), Neelis, K. J. (Contributor), Rasch, C. R. N. (Contributor), Stoker, J. (Contributor), Van Herk, M. (Contributor), Bel, A. (Contributor) & van Tienhoven, G. (Contributor), figshare , 23 Mar 2017
DOI: 10.6084/m9.figshare.c.3725035.v1, https://figshare.com/collections/Considerable_interobserver_variation_in_delineation_of_pancreatic_cancer_on_3DCT_and_4DCT_a_multi-institutional_study/3725035/1
Dataset
-
Prospective evaluation of relationships between radiotherapy dose to masticatory apparatus and trismus
Hague, C. (Creator), Beasley, W. (Creator), Garcez, K. (Creator), Lee, L. W. (Creator), Mcpartlin, A. (Creator), Mcwilliam, A. (Creator), Ryder, D. (Creator), Sykes, A. J. (Creator), Thomson, D. (Creator), Van Herk, M. (Creator), West, C. (Creator) & Slevin, N. (Creator), figshare , 9 Apr 2018
DOI: 10.6084/m9.figshare.6116009
Dataset