Research output per year
Research output per year
- 21 results
Search results
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2021
A plasmid toolset for CRISPR-mediated genome editing and CRISPRi gene regulation in Escherichia coli
Jervis, A., Hanko, E., Dunstan, M., Robinson, C., Takano, E. & Scrutton, N., 12 Mar 2021, In: Microbial Biotechnology.Research output: Contribution to journal › Article › peer-review
Open Access -
Prototyping of microbial chassis for the biomanufacturing of high-value chemical targets
Robinson, C. J., Tellechea-luzardo, J., Carbonell, P., Jervis, A. J., Yan, C., Hollywood, K. A., Dunstan, M. S., Currin, A., Takano, E. & Scrutton, N. S., 8 Jun 2021, In: Biochemical Society Transactions.Research output: Contribution to journal › Article › peer-review
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2020
Engineering Escherichia coli towards de novo production of gatekeeper (2S)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol.
Dunstan, M., Robinson, C., Jervis, A., Yan, C., Carbonell, P., Hollywood, K., Currin, A., Swainston, N., Le Feuvre, R., Micklefield, J., Faulon, J.-L., Breitling, R., Turner, N., Takano, E. & Scrutton, N., 6 Aug 2020, In: Synthetic Biology . 5, 1, ysaa012.Research output: Contribution to journal › Article › peer-review
Open Access -
Ribosomal Protein L11 Selectively Stabilizes a Tertiary Structure of the GTPase Center rRNA Domain
Welty, R., Rau, M., Pabit, S., Dunstan, M. S., Conn, G. L., Pollack, L. & Hall, K. B., 14 Feb 2020, In: Journal of molecular biology. 432, 4, p. 991-1007 17 p.Research output: Contribution to journal › Article › peer-review
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2019
Design and evolution of an enzyme with a non-canonical organocatalytic mechanism
Burke, A. J., Lovelock, S. L., Frese, A., Crawshaw, R., Ortmayer, M., Dunstan, M., Levy, C. & Green, A. P., 27 May 2019, In: Nature. 570, p. 219-223Research output: Contribution to journal › Article › peer-review
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Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries
Currin, A., Swainston, N., Dunstan, M., Jervis, A., Mulherin, P., Robinson, C., Taylor, S., Carbonell, P., Hollywood, K., Yan, C., Takano, E., Scrutton, N. & Breitling, R., 29 Oct 2019, In: Synthetic Biology .Research output: Contribution to journal › Article › peer-review
Open Access -
Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli
Jervis, A. J., Carbonell, P., Vinaixa, M., Dunstan, M. S., Hollywood, K. A., Robinson, C. J., Rattray, N. J. W., Yan, C., Swainston, N., Currin, A., Sung, R., Toogood, H., Taylor, S., Faulon, J.-L., Breitling, R., Takano, E. & Scrutton, N. S., 18 Jan 2019, In: ACS Synthetic Biology. 8, 1, p. 127-136 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
SelProm: A Queryable and Predictive Expression Vector Selection Tool for Escherichia coli
Jervis, A. J., Carbonell, P., Taylor, S., Sung, R., Dunstan, M. S., Robinson, C. J., Breitling, R., Takano, E. & Scrutton, N. S., 2019, In: ACS Synthetic Biology.Research output: Contribution to journal › Article › peer-review
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2018
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals
Carbonell, P., Jervis, A., Robinson, C., Yan, C., Dunstan, M., Swainston, N., Vinaixa, M., Hollywood, K., Currin, A., Rattray, N., Taylor, S., Spiess, R., Sung, R., Williams, A. R., Fellows, D., Stanford, N., Mulherin, P., Le Feuvre, R., Barran, P. & Goodacre, R. & 9 others, , 2018, In: Communications Biology. 1, 66.Research output: Contribution to journal › Article › peer-review
Open Access -
Engineering the ‘Missing Link’ in Biosynthetic (–)-Menthol Production: Bacterial Isopulegone Isomerase
Currin, A., Dunstan, M., Johannissen, L., Hollywood, K., Vinaixa, M., Jervis, A., Swainston, N., Rattray, N., Gardiner, J., Kell, D., Takano, E., Toogood, H. & Scrutton, N., 24 Jan 2018, In: ACS Catalysis. 8, 3, p. 2012-2020 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
PartsGenie: an integrated tool for optimizing and sharing synthetic biology parts
Swainston, N., Dunstan, M., Jervis, A. J., Robinson, C. J., Carbonell, P., Williams, A. R., Faulon, J.-L., Scrutton, N. S. & Kell, D. B., 1 Jul 2018, In: Bioinformatics. 34, 12Research output: Contribution to journal › Article › peer-review
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Structure and Biocatalytic Scope of Coclaurine N-Methyltransferase
Bennett, M., Thompson, M., Levy, C., Menon, B., Cronin, V., Smith, D., Herbert, A., Dunstan, M., Shepherd, S. & Micklefield, J., 13 Aug 2018, In: Angewandte Chemie - International Edition. 57, 33, p. 10600-10604 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides
Wood, A., Weise, N., Frampton, J. D., Dunstan, M., Hollas, M., Derrington, S., Lloyd, R. C., Quaglia, D., Parmeggiani, F., Leys, D., Turner, N. & Flitsch, S., 13 Nov 2017, In: Angewandte Chemie. 56, 46, p. 14498-14501 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile56 Downloads (Pure) -
biochem4j: integrated and extensible biochemical knowledge through graph databases
Swainston, N., Batista-Navarro, R. T., Carbonell, P., Dobson, P., Dunstan, M., Jervis, A., Vinaixa, M., Williams, A., Ananiadou, S., Faulon, J.-L., Pedrosa Mendes, P., Kell, D., Scrutton, N. & Breitling, R., 2017, In: PLoS ONE. 12, 7, e0179130.Research output: Contribution to journal › Article › peer-review
Open Access -
Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis
Gahloth, D., Dunstan, M. S., Quaglia, D., Klumbys, E., Lockhart-Cairns, M. P., Hill, A., Derrington, S. R., Scrutton, N. S., Turner, N. J. & Leys, D., 2017, In: Nature chemical biology. 13, p. 975-981 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile201 Downloads (Pure) -
Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes
Weise, N. J., Ahmed, S. T., Parmeggiani, F., Galman, J. L., Dunstan, M. S., Charnock, S. J., Leys, D. & Turner, N. J., 2017, In: Scientific Reports. 7, 1, 13691.Research output: Contribution to journal › Article › peer-review
Open Access -
2016
Single-Biocatalyst Synthesis of Enantiopure D-Arylalanines Exploiting an Engineered D-Amino Acid Dehydrogenase
Parmeggiani, F., Ahmed, S., Thompson, M., Weise, N., Galman, J., Gahloth, D., Leys, D., Turner, N. & Dunstan, M., 13 Oct 2016, In: Advanced synthesis & catalysis.Research output: Contribution to journal › Article › peer-review
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Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes
Menon, B., Latham, J., Dunstan, M., Brandenburger, E., Klemstein, U., Leys, D., Karthikeyan, C. V., Greaney, M., Shepherd, S. & Micklefield, J., 6 Sept 2016, In: Organic and Biomolecular Chemistry. 14, p. 9354-9361Research output: Contribution to journal › Article › peer-review
Open Access -
SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.
Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N. J. W., Robinson, C. J., Swainston, N., Vinaixa, M., Williams, A., Yan, C., Barran, P., Breitling, R., Chen, G.G.-Q., Faulon, J.-L., Goble, C., Goodacre, R., Kell, D. B., Feuvre, R. L. & Micklefield, J. & 4 others, , 15 Jun 2016, In: Biochemical Society Transactions. 44, 3, p. 675-7Research output: Contribution to journal › Article › peer-review
Open Access -
SYNBIOCHEM Synthetic Biology Research Centre, Manchester - A UK foundry for fine and speciality chemicals production
Le, F. R., Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N., Robinson, C., Swainston, N., Vinaixa, M., Williams, A., Yan, C., Barran, P., Breitling, R., Chen, G., Faulon, J., Goble, C., Goodacre, R., Kell, D. & Micklefield, J. & 4 others, , 2016, In: Synthetic and Systems Biotechnology.Research output: Contribution to journal › Article › peer-review
Open Access -
2014
Modular Riboswitch Toolsets for Synthetic Genetic Control in Diverse Bacterial Species.
Robinson, C., Vincent, H., Wu, M.-C., Lowe, P., Dunstan, M., Leys, D. & Micklefield, J., 30 Dec 2014, In: J. Am. Chem. Soc.. 136, p. 10615–10624Research output: Contribution to journal › Article › peer-review
Open Access