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Personal profile

Overview

  • Martin is Professor of Cardiometabolic Medicine at the University of Manchester and Honorary Consultant Physician at the Diabetes, Endocrinology and Metabolism Centre, Manchester Royal Infirmary. His main research interest is the pathogenesis of cardiometabolic diseases such as heart disease, obesity and diabetes. He has several roles with Diabetes UK including: Chair, Professional Conference Organising Committee; member, Science and Research Advisory Committee (2018 onwards); and Chair, Diabetes Research Steering Group 6 (diabetes-related complications). He is the clinical lead physician for the islet cell transplantation service and co-lead for the diabetes-renal service at Manchester University NHS Foundation Trust.

Biography

  • Martin received his undergraduate education at Edinburgh University Medical School. He was trained in Diabetes and Endocrinology in Newcastle-upon-Tyne, UK, where he received a Doctorate of Medicine degree for research work in the cardiovascular complications of diabetes. Between 2000 and 2002 was a Research Fellow in Cardiology and Endocrinology at the Lahey Clinic, MA, USA where he worked with the Framingham Heart Study team. He was a Consultant Physician in General Medicine, Diabetes and Endocrinology in Chester, UK, between 2002 and 2006; and then moved to Manchester Royal Infirmary from 2006 until 2009, where he was a Consultant Physician in General Medicine and Diabetes.
  • He is currently Professor of Cardiometabolic Medicine at the University of Manchester. Prior to this, he held a HEFCE-funded Clinical Senior Lecturer post at the University of Manchester from 2009. His research is focussed on the pathogenesis of cardiometabolic disease and covers a range of areas including: sleep/chronotype; vascular stiffness; cardiovascular disease in diabetes; diabetes and malignancy; islet and pancreas transplantation and endocrine aspects of frailty. He has current research funding from National Institute for Health Research (NIHR), Innovate UK, MRC, Diabetes UK and NIHR Manchester Biomedical Research Centre.
  • Martin has publications in leading journals focusing on the pathogenesis of cardiometabolic disease including several with the Framingham Heart Study and more recently with teams working with UK Biobank data. He leads several research collaborations with groups in the UK, Europe and the USA. He served as an Associate Editor for Diabetic Medicine between 2004 and 2010 (cardiovascular manuscripts), for Diabetologia between 2014 and Dec 2017 (cardiovascular manuscripts), and for Current Cardiovascular Risk Reports between 2012 and 2016. He served on the Advisory Board for Diabetologia 2017-2021.

Qualifications

  • MB ChB, 1985, Edinburgh University Medical School
  • DGM, 1991, Royal College of Physicians, Glasgow
  • MRCP (UK) 1991, Royal College of Physicians, UK
  • Dip Med Sci, 1994, University of Newcastle upon Tyne
  • MD, 2003, University of Newcastle upon Tyne
  • FRCP, 2005, Royal College of Physicians, Edinburgh
  • FHEA, 2013, The Higher Education Academy, UK

Research interests

  • Metabolic predictors of cardiometabolic disease: his work largely focuses on understanding mechanisms of disease using data from UK Biobank, the Clinical Practice Research Datalink (CPRD), the European Male Ageing Study (EMAS), islet and pancreas transplant registries and locally generated data.
  • Sleep/chronotype: he leads a group exploring causal relationships between sleep/chronotype and cardiometabolic and chronic inflammatory diseases using UK Biobank data. He is a member of the UK Biobank Sleep working group (focussing on the use of actigraphy data). He is co-I on a University-funded grant supporting studies in biological timing.
  • Vascular stiffness: he leads a group exploring the pathogenesis of vascular stiffness using UK Biobank data. He is co-lead of a UK Biobank Cardiometabolic Peripheral Arterial Disease (PAD) working group. These studies links to the Molecules and Pathways in Cardiovascular Disease (MAP-CVD) Study that he leads.
  • UK Biobank Cardiometabolic Consortium: He is a member of CHD, Diabetes and Obesity working groups and is co-lead for the PAD working group
  • Cardiovascular disease in diabetes: he leads several projects investigating the links between diabetes and cardiovascular disease and in a particular the impact of medical therapies on cardiovascular risk. These projects use data from CPRD and the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial.
  • Frailty: he co-leads a project focusing on the endocrine predictors of frailty using data from the European Male Ageing Study (EMAS) and an MRC-funded project in collaboration with a team at Manchester Metropolitan University.
  • Identification and Management of Psoriasis Associated Co-morbidity (IMPACT) study: he is a co-investigator in this NIHR-funded 5-year Programme of work and leads study focusing on arterial stiffness.
  • Manchester Centre for Biological Timing: he was a co-applicant on a University-funded grant supporting studies in biological timing and now serves on the steering committee. His focus is on the relevance of circadian rhythms to metabolic disease/diabetes.
  • Islet cell and pancreas transplantation: he leads and co-leads several projects focusing on the role of insulin therapy in transplantation and the cardiovascular and microvascular benefits of transplantation.

My collaborations

Manchester

  • Sleep/chronotype - Manchester Centre for Biological Timing: Prof David Ray, Prof David Bechtold, Prof Rob Lucas and Prof Andrew Loudon.
  • Diabetes and cardiovascular risk: Prof Darren Ashcroft, Dr Alison Wright, Dr Matthew Carr, Prof Evan Kontapantelis.
  • Vascular stiffness and MAP-CVD studies (UK Biobank; aortic tissue integrative genomics): Prof Bernard Keavney, Dr Hui Guo, Prof Carlo Berzuini, Prof Tony Heagerty, Dr David Gerrard, Dr Adam Stevens, Dr Richard Unwin, Prof Daniel Keenan, Mr Eddie McLaughlin, Mr Ragheb Hasan, Prof Roy Goodacre and Prof Brian Derby.
  • Islet and pancreas transplantation: Mr David van Dellen, Mr Iestyn Shapey, Mr Petros Yiannoullou.
  • Psoriasis and cardiovascular disease: Prof Chris Griffiths, Prof Darren Ashcroft (see http://www.impactpsoriasis.org.uk).
  • MRC-funded frailty study: Dr Jamie McPhee, Dr Mat Piasecki and Dr Alex Ireland

Other UK

  • Sleep/chronotype: Prof Debbie Lawlor, Dr Jack Bowden, Dr Simon Kyle
  • Vascular stiffness: Dr Ioanna Tzoulaki, Prof Nilesh Samani, Prof Phil Chowienczyk, Prof Ian Wilkinson, Dr Jack Bowden, Prof Naveed Sattar, Prof Seamus Harrison, Dr Chris Nelson, and Dr Florence Lai.
  • Islet cell transplantation: Prof Jim Shaw, Prof Paul Johnson, Prof Stephanie Amiel, Mr John Casey, Dr Miranda Rosenthal, Prof Jane Speight and Prof Pratik Choudhary

Europe

  • Sleep/chronotype: Dr Kai Spiegelhalder.
  • MAP-CVD study: Prof Gerard Pasterkamp (Netherlands); Prof Anders Hamsten and Prof Per Eriksson (Sweden).
  • The European Male Ageing Study: several PIs: http://www.emas.man.ac.uk

USA

  • Sleep/chronotype: Dr Richa Saxena, Dr Jackie Lane, Prof Susan Redline, Dr Sara Mariani, Dr Hassan Dashti and Prof Frank Scheer (Harvard Medical School), Dr Celine Vetter (University of Colorado at Boulder)
  • Vascular stiffness: Prof Vasan Ramachandran (Framingham Heart Study) and Dr Gary Mitchell (Cardiovascular engineering inc)

Methodological knowledge

  • Epidemiology and statistics
  • Vascular biology
  • Integtative genomics

Memberships of committees and professional bodies

  • Diabetes UK: Chair, Professional Conference Organising Committee; member, Science and Research Advisory Committee (2018 onwards); Chair, Diabetes Research Steering Group 6 (diabetes-related complications)
  • European Association for the Study of Diabetes
  • American Heart Association
  • Advisory Committee on Clinical Excellence Awards, regional sub-committee member (2018 onwards)

Teaching

  • Undergraduate: he leads a clinical teaching firm and teaches 3rd-year medical students on a weekly basis.
  • Postgraduate: he is regularly invited to lecture on aspects of diabetes including CVD risk and islet cell transplantation. 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Beacons, Institutes and Platforms

  • Digital Futures

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