Research output per year
Research output per year
Personal profile
Overview
I am the Expert Technical Specialist for the Magnetic Measurements technical platform in the Faculty of Science and Engineering. I have over 20 years experience of biomolecular NMR, using it to determine protein structures, dynamics and interactions. My research focus is the mechanism of phosphoryl transfer enzymes, and intrinsically disordered proteins involved in cell signalling and disease. I have recently been developing techniques for NMR-guided directed evolution of single domain antibodies and enzymes
Biography
Bsc (Hons) University of Edinburgh 1995 Biological Sciences (Biochemistry)
PhD. University of Bristol 2000 Dept. of Biochemistry
Researcher University of Bristol 1999-2001 Dept. of Biochemistry
Researcher University College London 2001-2004 Dept. of Biochemistry & Molecular Biology
Researcher University of Sheffield 2004-2012 Mol. Biol. & Biotechnology
Senior Experimental Officer University of Manchester 2012-2021 Manchester Institute of Biotechnology
Senior Technical Specialist University of Manchester 2021-2025 Magnetic Measurements
Expert Technical Specialist University of Manchester 2025- Magnetic Resonance and Related Technology
Areas of expertise
- QD Chemistry
Research Beacons, Institutes and Platforms
- Manchester Institute of Biotechnology
- Biotechnology
- Cancer
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 12 Responsible Consumption and Production
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Microarray screening reveals two non-conventional SUMO-binding modules linked to DNA repair by non-homologous end-joining
Cabello-Lobato, M. J., Jenner, M., Cisneros-Aguirre, M., Brüninghoff, K., Sandy, Z., Da Costa, I. C., Jowitt, T. A., Loch, C. M., Jackson, S. P., Wu, Q., Mootz, H. D., Stark, J. M., Cliff, M. J. & Schmidt, C. K., 6 May 2022, In: Nucleic acids research. 50, 8, p. 4732-4754 23 p.Research output: Contribution to journal › Article › peer-review
Open Access -
An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition
Robertson, A. J., Cruz-Navarrete, F. A., Wood, H. P., Vekaria, N., Hounslow, A. M., Bisson, C., Cliff, M. J., Baxter, N. J. & Waltho, J. P., 4 Mar 2022, In: ACS Catalysis. 12, 5, p. 3149-3164 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Integrated structural dynamics uncover a new B12 photoreceptor activation mode
Rios-Santacruz, R., Poddar, H., Pounot, K., Heyes, D. J., Coquelle, N., Mackintosh, M. J., Johannissen, L. O., Schianchi, S., Jeffreys, L. N., De Zitter, E., Munro, R., Appleby, M., Axford, D., Beale, E., Cliff, M. J., Davila, M., Engilberge, S., Gotthard, G., Hadjidemetriou, K. & Hardman, S. & 28 others, , 4 Feb 2026, In: Nature..Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Downloads (Pure) -
Stereoselective hydrogen isotope exchange on nicotinamide cofactors through flavoenzyme microscopic reversibility
Otun, C. W., Yuen, M., Spacey, H. J., Bawn, C., Cliff, M. J., Falcioni, F., Bragg, R. A., Elmore, C. S., Hay, S. & Rowbotham, J. S., 2026, (Accepted/In press) In: Chemical Science.Research output: Contribution to journal › Article › peer-review
Open Access -
Systematic discovery of UFM1 receptors reveals a regulatory module in DNA repair directing non-homologous end-joining
Wang, Z., Foster, B. M., da Costa, I. C., Wu, Y., Behera, D., Conte, F., Trotter, E. W., Lopezcolorado, F. W., Cabello-Lobato, M. J., Choudhary, S., Wiener, R., Beli, P., Smith, D. L., Banks, W. H., Bagley, S., McKee, S., Minnis, M., Meyer, S., Chaplin, A. K. & Dörner, W. & 7 others, , 15 Jun 2026, In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Open Access
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How enzymes flatten the free energy landscape for inherently slow reactions
Waltho, J. (PI), Almond, A. (CoI) & Cliff, M. (CoI)
1/04/25 → 31/03/28
Project: Research
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Development of a national facility and technical training hub for ‘Biomolecule Engineering’
Heyes, D. (PI), Cliff, M. (CoI), Dunstan, M. (CoI), Hollywood, K. (CoI), Johannissen, L. (CoI) & Levy, C. (CoI)
1/04/24 → 31/03/28
Project: Research
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Defining dynamic protein complexes in DNA repair by non-homologous end-joining (PROJECT)
Schmidt, C. (PI), Cliff, M. (CoI) & Merchant, M. (CoI)
3/07/23 → 2/01/27
Project: Research
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NMR-directed evolution of tight-binding nanobodies
Cliff, M. (PI), Dunstan, M. (CoI), Jowitt, T. (CoI) & Tunnicliffe, R. (CoI)
1/09/24 → 31/08/25
Project: Research
Equipment
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700MHz reaction monitoring spectrometer
Cliff, M. (Core Facility Lead), Adams, R. (Academic lead) & Sakho, A. (Technical Specialist)
Facility/equipment: Equipment
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Biomolecular NMR Facility
Cliff, M. (Core Facility Lead) & Bawn, C. (Technical Specialist)
Manchester Institute of BiotechnologyFacility/equipment: Facility
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Chemistry Building NMR Facility
Cliff, M. (Core Facility Lead), Adams, R. (Academic lead), Bamber, D. (Technician), Bawn, C. (Technical Specialist) & Sakho, A. (Technical Specialist)
FSE ResearchFacility/equipment: Facility
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Core Facility For Magnetic Resonance and Related Technology (MRR)
Cliff, M. (Core Facility Lead)
FSE ResearchFacility/equipment: Platform
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Dynamic Nuclear Polarisation Magic Angle Spinning NMR Facility
Duff, B. (Technical Specialist), Cliff, M. (Core Facility Lead) & Lee, D. (Academic lead)
FSE ResearchFacility/equipment: Facility