Research output per year
Research output per year
Personal profile
Overview
I am the Senior Technical Specialist for the Magnetic Measurements technical platform in the Faculty of Science and Engineering. I have over 20 years experience of biomolecular NMR, using it to determine protein structures, dynamics and interactions. My research focus is the mechanism of phosphoryl transfer enzymes, and intrinsically disordered proteins involved in cell signalling and disease.
Biography
Bsc (Hons) University of Edinburgh 1995 Biological Sciences (Biochemistry)
PhD. University of Bristol 2000 Dept. of Biochemistry
Researcher University of Bristol 1999-2001 Dept. of Biochemistry
Researcher University College London 2001-2004 Dept. of Biochemistry & Molecular Biology
Researcher University of Sheffield 2004-2012 Mol. Biol. & Biotechnology
Senior Experimental Officer University of Manchester 2012-2021 Manchester Institute of Biotechnology
Senior Technical Specialist University of Manchester 2021- Magnetic Measurements
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Areas of expertise
- QD Chemistry
Research Beacons, Institutes and Platforms
- Manchester Institute of Biotechnology
- Biotechnology
- Cancer
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Microarray screening reveals two non-conventional SUMO-binding modules linked to DNA repair by non-homologous end-joining
Cabello-Lobato, M. J., Jenner, M., Cisneros-Aguirre, M., Brüninghoff, K., Sandy, Z., Da Costa, I. C., Jowitt, T. A., Loch, C. M., Jackson, S. P., Wu, Q., Mootz, H. D., Stark, J. M., Cliff, M. J. & Schmidt, C. K., 6 May 2022, In: Nucleic acids research. 50, 8, p. 4732-4754 23 p.Research output: Contribution to journal › Article › peer-review
Open Access -
An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition
Robertson, A. J., Cruz-Navarrete, F. A., Wood, H. P., Vekaria, N., Hounslow, A. M., Bisson, C., Cliff, M. J., Baxter, N. J. & Waltho, J. P., 4 Mar 2022, In: ACS Catalysis. 12, 5, p. 3149-3164 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Backbone 1H, 13C and 15N resonance assignment of the ubiquitin specific protease 7 catalytic domain (residues 208–554) in complex with a small molecule ligand
Pandya, M., Augustyniak, W., Cliff, M., Lindner, I., Stinn, A., Kahmann, J., Temmerman, K., Dannatt, H., Waltho, J. & Watson, M., 1 Jun 2024, In: Biomolecular NMR Assignments. 18, 1, p. 33-44 12 p.Research output: Contribution to journal › Article › peer-review
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Metal fluorides: Multi-functional tools for the study of phosphoryl transfer enzymes
Pellegrini, E., Juyoux, P., Velsen, J. V., Baxter, N. J., Dannatt, H. R. W., Yi, J., Cliff, M. J., Waltho, J. P. & Bowler, M. W., 27 Mar 2024, In: bioRxiv.Research output: Contribution to journal › Article
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Metal fluorides—multi-functional tools for the study of phosphoryl transfer enzymes, a practical guide
Pellegrini, E., Juyoux, P., von Velsen, J., Baxter, N. J., Dannatt, H. R. W., Jin, Y., Cliff, M. J., Waltho, J. P. & Bowler, M. W., 2024, (Accepted/In press) In: Structure.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Mapping hidden residual structure within the Myc bHLH-LZ domain using chemical denaturant titration. Panova et al
Cliff, M. (Creator), Mendeley Data, 22 Aug 2019
DOI: 10.17632/xhdwd26fdc.1, https://data.mendeley.com/datasets/xhdwd26fdc
Dataset
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1H,13C,15N backbone resonance assignment for 1-164 construct of XRCC4
Cabello Lobato, M. J. (Creator), Schmidt, C. (Creator) & Cliff, M. (Creator), Biological Magnetic Resonance Data Bank, 28 Jun 2021
Dataset
Equipment
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700MHz reaction monitoring spectrometer
Matthew Cliff (Platform Lead), Ralph Adams (Academic lead) & Aminata Sakho (Technical Specialist)
Facility/equipment: Equipment
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Biomolecular NMR Facility
Cliff, M. (Platform Lead)
Manchester Institute of BiotechnologyFacility/equipment: Facility
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Chemistry Building NMR Facility
Matthew Cliff (Platform Lead), Ralph Adams (Academic lead), Daryl Bamber (Technician), Carlo Bawn (Technical Specialist) & Aminata Sakho (Technical Specialist)
Manchester Institute of BiotechnologyFacility/equipment: Facility
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EPSRC National Research Facility for Electron Paramagnetic Resonance
Cliff, M. (Platform Lead), Collison, D. (Academic lead), Mcinnes, E. (Academic lead), Tuna, F. (Academic lead), Bowen, A. (Academic lead), Shanmugam, M. (Senior Technical Specialist) & Brookfield, A. (Technical Specialist)
FSE ResearchFacility/equipment: Facility
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Magnetic Resonance and Related Technology (MRR)
Matthew Cliff (Platform Lead)
FSE ResearchFacility/equipment: Platform