I am a Professor of Rheumatology and Director of Experimental Medicine at the Centre for Musculoskeletal Research, University of Manchester. I am a NIHR Senior Investigator and at the NIHR Manchester Biomedical Research Centre, lead the ‘Advanced Diagnostics & Therapeutics Catalyst’ cluster and within this, theme co-lead for ‘Next Generation Therapeutics’. 

My clinical and experimental research programme comprises the following research themes: (i) PRECISion medicinE across the disease continuum to prevent and treat Rheumatoid Arthritis (PRECISE-RA); with a focus on personalised therapeutics in early vs Difficult-to-Treat-Refractory disease (ii) CARDIOvascular pathology in Immune-Mediated Inflammatory Diseases (CARDIO-IMID) to identify patients at risk of cardiovacsular disease (CVD), optimal detection methods and shared mechanisms of IMID-CVD (iii) Improving therapeutics and cardiovascular outcomes in Systemic Sclerosis. In addition to clinical trials, I undertake complex observational studies and linked experimental investigation to identify prognostic, mechanistic and predictive biomarkers. 

I am Chief Investigator of the Medical Research Council (MRC)-British Heart Foundation (BHF) UK CARDIO(vascular)-IMID partnership, bringing together 30 centres to deliver experimental studies in IMID-CVD and co-lead of the NIHR-BHF cardiovascular Partnership 'Cardio-Immune' theme.  I am also national lead of NIHR Bioresource rare disease ‘systemic sclerosis’. I have informed multiple national/European guidelines in RA and SSc.