Research output per year
Research output per year
Personal profile
Overview
I am a Professor of Rheumatology and Director of Experimental Medicine at the Centre for Musculoskeletal Research, University of Manchester. I am a NIHR Senior Investigator and at the NIHR Manchester Biomedical Research Centre, lead the ‘Disease complexity and multimorbidity’ cluster and within this, theme lead for ‘Next Generation Therapeutics’.
My clinical and experimental research programme comprises the following research themes: (i) PRECISion medicinE across the disease continuum to prevent and treat Rheumatoid Arthritis (PRECISE-RA); with a focus on personalised therapeutics in early RA and Difficult-to-Treat-Refractory disease (ii) CARDIOvascular pathology in Immune-Mediated Inflammatory Diseases (CARDIO-IMID) to identify patients at risk of CVD, optimal detection methods and shared mechanisms of CV-IMID comorbidity (iii) Improving therapeutics and cardiovascular outcomes in Systemic Sclerosis. In addition to clinical trials, I undertake complex observational studies and linked experimental investigation to identify prognostic, mechanistic and predictive biomarkers.
I am Chair of the NIHR-Versus Arthritis UK Musculoskeletal Translational Research Collaboration, which aims to support and innovate the experimental research landscape and deliver meaningful, multi-centre trials in the UK. I lead the Medical Research Council (MRC)-British Heart Foundation (BHF) UK CARDIO(vascular)-IMID (immune mediated inflammatory diseases partnership, bringing together 29 centres to deliver experimental studies in IMID-CVD and I am national lead of NIHR Bioresource rare disease ‘systemic sclerosis’. I have also informed multiple national/European guidelines in RA and SSc.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
National lead, MRC-BHF UK CARDIO-IMID Partnership
Jun 2023 → …
Chair , NIHR-Versus Arthritis UK Musculoskeletal Translational Research Collaboration
2020 → …
Visiting Professor of Rheumatology, University of Leeds
1 Oct 2019 → …
Co-lead Cardio-Immune work stream, NIHR-BHF Cardiovascular partnership
2019 → …
NIHR Bioresource Systemic Sclerosis national lead
2018 → …
Areas of expertise
- RZ Other systems of medicine
- Rheumatology
- Scleroderma
- Immune mediated inflammatory disease
- Cardiovascular
- RM Therapeutics. Pharmacology
- Targeted therapies
- Precision Medicine
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A pragmatic randomised controlled trial of Very early Etanercept and MTX versus MTX with Delayed Etanercept in RA – the VEDERA trial
Emery, P., Horton, S., Dumitru, R. B., Naraghi, K., Heijde, D. V. D., Wakefield, R., Hensor, E. M. A. & Buch, M., 2020, In: Annals of the rheumatic diseases. 79, 4, p. 464-471Research output: Contribution to journal › Article › peer-review
Open Access -
Defining refractory rheumatoid arthritis
Buch, M. H., Jul 2018, In: Annals of the rheumatic diseases. 77, 7, p. 966-969 4 p.Research output: Contribution to journal › Review article › peer-review
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Synovial Tissue Heterogeneity in Rheumatoid Arthritis and Changes With Biologic and Targeted Synthetic Therapies to Inform Stratified Therapy
Ouboussad, L., Burska, A. N., Melville, A. & Buch, M. H., 19 Mar 2019, In: Frontiers in Medicine. 6, p. 45Research output: Contribution to journal › Review article › peer-review
Open Access -
First cardiovascular MRI study in individuals at risk of rheumatoid arthritis detects abnormal aortic stiffness suggesting an anti-citrullinated peptide antibody-mediated role for accelerated atherosclerosis
Fent, G., Mankia, K., Erhayiem, B., Hunt, L., Nam, J. L., Bissell, L-A., Foley, J. R., Chew, P. G., Brown, L. E., Greenwood, J. P., Emery, P., Plein, S. & Buch, M. H., Aug 2019, In: Annals of the rheumatic diseases. 78, 8, p. 1138-1140 3 p.Research output: Contribution to journal › Letter › peer-review
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EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update
Smolen, JS., Landewe, RBM., Bergstra, SA., Kerschbaumer, A., Sepriano, A., Aletaha, D., Caporali, R., Edwards, CJ., Hyrich, KL., Pope, JE., de Souza, S., Stamm, TA., Takeuchi, T., Verschueren, P., Winthrop, KL., Balsa, A., Bathon, JM., Buch, MH., Burmester, GR., Buttgereit, F., & 28 others, Jan 2023, In: Annals of the rheumatic diseases. 82, 1, p. 3-18 16 p.Research output: Contribution to journal › Article › peer-review
Projects
- 1 Active
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NIHR Manchester Biomedical Research Centre
Bruce, I., Lord, G., Lennon, R., Black, G., Wedge, D., Morris, A., Hussell, T., Sharrocks, A., Stivaros, S., Buch, M., Gough, J., Kostarelos, K., Thistlethwaite, F., Kadler, K., Barton, A., Hyrich, K., Mcbeth, J., O'Neill, T., Vestbo, J., Simpson, A., Singh, S., Smith, J., Felton, T., Murray, C., Griffiths, C., Cullum, N., Rhodes, L., Warren, R., Paus, R., Dumville, J., Viros Usandizaga, A., Keavney, B., Tomaszewski, M., Allan, S., Body, R., Cartwright, E., Heagerty, A., Kalra, P., Miller, C., Rutter, M., Smith, C., Trafford, A., Evans, D., Crosbie, E., Crosbie, P., Harvie, M., Howell, S., Renehan, A., Dive, C., Blackhall, F., Landers, D., Krebs, M., Cook, N., Clarke, R., Taylor, S., Jorgensen, C., Lorigan, P., Jayson, G., Valle, J., Mccabe, M., Armstrong, A., Freitas, A., Illidge, T., Choudhury, A., Hoskin, P., West, C., Van Herk, M., Faivre-Finn, C., Bristow, R., Kirkby, K., Birtle, A., Mackay, R., Radford, J., Linton, K., Higham, C., Munro, K., Plack, C., Arden Armitage, C., Bruce, I., Moore, D., Saunders, G., Stone, M., Haddock, G., Lewis, S., Elliott, R., Green, J., Lovell, K., Morrison, A., Shaw, J., Bucci, S., Ainsworth, J., Webb, R., Newman, W., Banka, S., Clayton-Smith, J., Payne, K., Moldovan, R., Wynn, R. & Jones, S.
1/12/22 → 30/11/27
Project: Research