Michael Sherratt

2025

Cold-induced fibrosis and metabolic remodeling in the turtle (Trachemys scripta) ventricle

Keen, A. N., McConnell, J. C., Mackrill, J. J., Marrin, J., Holsgrove, A. J., Crossley, J., Henderson, A., Galli, G. L. J., Crossley, D. A., Sherratt, M. J., Gardner, P. & Shiels, H. A., 1 Apr 2025, In: Acta physiologica (Oxford, England). 241, 4, e70026.

Research output: Contribution to journal › Article › peer-review

Open Access

Cold-induced fibrosis and metabolic remodelling in the turtle (Trachemys scripta) ventricle.

Keen, A. N., Mcconnell, J. C., Mackrill, J. J., Marrin, J., Holsgrove, A. J., Crossley, J., Henderson, A., Galli, G. L. J., Crossley II, D. A., Sherratt, M. J., Gardner, P. & Shiels, H. A., 26 Feb 2025, (Accepted/In press) In: Acta Physiologica.

Research output: Contribution to journal › Article › peer-review

Impact of therapeutic X-ray exposure on collagen I and associated proteins

Tuieng, R. J., Disney, C., Cartmell, S. H., Kirwan, C. C., Eckersley, A., Newham, E., Gupta, H. S., Hoyland, J. A., Lee, P. D. & Sherratt, M. J., 8 Mar 2025, (E-pub ahead of print) In: Acta Biomaterialia.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

Acute exposure to ultraviolet radiation targets proteins involved in collagen fibrillogenesis

Platt, C., Stewart-Mcguinness, C., Eckersley, A., Wilkins, L. & Sherratt, M., 15 Mar 2024, In: Frontiers in Physiology. 15, 1352161.

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Open Access

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Prediction, screening and characterization of novel bioactive tetra-peptide matrikines for skin rejuvenation

Jariwala, N., Ozols, M., Eckersley, A., Mambwe, B., Watson, R. E. B., Zeef, L., Gilmore, A., Debelle, L., Bell, M., Bradley, E. J., Doush, Y., Keenan, A., Courage, C., Leroux, R., Peschard, O., Mondon, P., Ringenbach, C., Bernard, L., Pitois, A. & Sherratt, M. J., 22 Apr 2024, In: The British journal of dermatology.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site

Godwin, A., Dajani, R., Zhang, X., Thomson, J., Holmes, D., Adamo, C. S., Sengle, G., Sherratt, M., Roseman, A. & Baldock, C., 1 May 2023, In: Nature Structural and Molecular Biology. 30, p. 608–618

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Defining the Protease and Protease Inhibitor (P/PI) Proteomes of Healthy and Diseased Human Skin by Modified Systematic Review

Stewart-Mcguinness, C., Platt, C. (Corresponding), Ozols, M., Goh, B., Griffiths, T. W. & Sherratt, M., 20 Mar 2022, In: Biomolecules. 12, 3, 475.

Research output: Contribution to journal › Article › peer-review

Open Access

Peptide location fingerprinting identifies species- and tissue-conserved structural remodelling of proteins as a consequence of ageing and disease

Eckersley, A., Ozols, M., Chen, P., Tam, V., Ward, L. J., Hoyland, J. A., Trafford, A., Yuan, X.-M., Schiller, H. B., Chan, D. & Sherratt, M. J., 1 Dec 2022, In: Matrix Biology. 114, p. 108-137 29 p., 114.

Research output: Contribution to journal › Article › peer-review

Open Access

Regional variations in discrete collagen fibre mechanics within intact intervertebral disc resolved using synchrotron computed tomography and digital volume correlation

Disney, C. M., Mo, J., Eckersley, A., Bodey, A. J., Hoyland, J. A., Sherratt, M. J., Pitsillides, A. A., Lee, P. D. & Bay, B. K., Jan 2022, In: Acta Biomaterialia.

Research output: Contribution to journal › Article › peer-review

2021

Peptide location fingerprinting reveals modification-associated biomarker candidates of ageing in human tissue proteomes

Ozols, M., Eckersley, A., Mellody, K. T., Mallikarjun, V., Warwood, S., O'Cualain, R., Knight, D., Watson, R. E. B., Griffiths, C. E. M., Swift, J. & Sherratt, M. J., 20 May 2021, In: Aging cell. 20, 5, e13355.

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Open Access

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Peptide location fingerprinting reveals tissue region‐specific differences in protein structures in an ageing human organ

Eckersley, A., Ozols, M., Chen, P., Tam, V., Hoyland, J. A., Trafford, A., Chan, D. & Sherratt, M. J., 27 Sept 2021, In: International Journal of Molecular Sciences. 22, 19, 10408.

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Open Access

Predicting Proteolysis in Complex Proteomes Using Deep Learning

Ozols, M., Eckersley, A., Platt, C. I., Stewart-McGuinness, C., Hibbert, S. A., Revote, J., Li, F., Griffiths, C. E. M., Watson, R. E. B., Song, J., Bell, M. & Sherratt, M. J., 17 Mar 2021, In: International Journal of Molecular Sciences. 22, 6, p. 1-20 20 p., 3071.

Research output: Contribution to journal › Article › peer-review

Open Access

The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins

Tuieng, R. J., Cartmell, S. H., Kirwan, C. C. & Sherratt, M. J., 5 Nov 2021, In: Cells.

Research output: Contribution to journal › Article › peer-review

2020

Heterogeneity of fibrillin-rich microfibrils extracted from human skin of diverse ethnicity

Langton, A., Hann, M., Costello, P., Halai, P., Cesar, S. S. A., Chien, A.L.-L., Kang, S., Griffiths, C., Sherratt, M. & Watson, R., 2020, In: Journal of Anatomy.

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Investigation of fibrillin microfibrils in the canine cruciate ligament in dogs with different predispositions to ligament rupture

Cox, T., Comerford, E. J., Wegg, M., Mills, A., Barrett, S. D., Smith, K. D., Sherratt, M. J. & Akhtar, R., 1 Dec 2020, In: Research in Veterinary Science. 133, p. 53-58 6 p.

Research output: Contribution to journal › Article › peer-review

Loss of PKCα increases arterial medial calcification in a uremic mouse model of chronic kidney disease

Borland, S. J., Facchi, C., Behnsen, J., Adamson, A., Humphreys, N. E., Withers, P. J., Sherratt, M. J., Francis, S. E., Brennan, K., Ashton, N. & Canfield, A. E., 21 May 2020, In: bioRxiv.

Research output: Contribution to journal › Article › peer-review

Predicting and validating protein degradation in proteomes using deep learning

Ozols, M., Eckersley, A., Platt, C. I., Mcguinness, C. S., Hibbert, S. A., Revote, J., Li, F., Griffiths, C. E. M., Watson, R. E. B., Song, J., Bell, M., Sherratt, M. J., Building, S. & Rd, O., 2020, In: bioRxiv. p. 2020.11.29.402446

Research output: Contribution to journal › Article

Proteomic fingerprints of damage in extracellular matrix assemblies

Eckersley, A., Ozols, M., O'Cualain, R., Keevill, E.-J., Foster, A. R., Pilkington, S., Knight, D., Griffiths, C., Watson, R. & Sherratt, M., 2020, In: Matrix Biology Plus.

Research output: Contribution to journal › Article › peer-review

Open Access

Remodelling of fibrillin-rich microfibrils by solar-simulated radiation: Impact of skin ethnicity

Langton, A., Hann, M., Costello, P., Halai, P., Griffiths, C., Sherratt, M. & Watson, R., 27 Jun 2020, (Accepted/In press) In: Photochemical and Photobiological Sciences.

Research output: Contribution to journal › Article › peer-review

The systemic influence of chronic smoking on skin structure and mechanical function

Langton, A., Tsoureli-Nikita, E., Merrick, H., Zhao, X., Antoniou, C., Stratigos, A., Akhtar, R., Derby, B., Sherratt, M., Watson, R. & Griffiths, C., 1 Aug 2020, In: Journal of Pathology. 251, 4, p. 420-428

Research output: Contribution to journal › Article › peer-review

Open Access

X-ray micro computed tomography: an emerging technology to analyze vascular calcification in animal models

Borland, S., Behnsen, J., Ashton, N., Francis, S. E., Brennan, K., Sherratt, M., Withers, P. & Canfield, A., 19 Jun 2020, (Accepted/In press) In: International Journal of Molecular Sciences.

Research output: Contribution to journal › Article › peer-review

2019

How stiff is skin?

Graham, H., McConnell, J., Limbert, G. & Sherratt, M., Feb 2019, In: Experimental Dermatology. 28, S1

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Lysyl oxidase-like 2 (LOXL2)-mediated cross-linking of tropoelastin

Schmelzer, C. E. H., Heinz, A., Troilo, H., Lockhart, M., Jowitt, T., Marchland, M. F., Bidault, L., Bignon, M., Hedtke, T., Barret, A., Mcconnell, J., Sherratt, M., Germain, S., Hulmes, D. J. S., Baldock, C. & Muller, L., 1 Apr 2019, In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 4, p. 5468-5481 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Mass spectrometry-based proteomics reveals the distinct nature of the skin proteomes of photoaged compared to intrinsically aged skin

Newton, V. L., Riba-Garcia, I., Griffiths, C. E. M., Rawlings, A. V., Voegeli, R., Unwin, R. D., Sherratt, M. J. & Watson, R. E. B., 20 Jan 2019, In: International Journal of Cosmetic Science.

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Selective proteolysis by matrix metalloproteinases of photo-oxidised dermal extracellular matrix proteins

Hibbert, S., Watson, R., Griffiths, C., Gibbs, N. & Sherratt, M., 1 Feb 2019, In: Cell. Signal.. 54, p. 191-199

Research output: Contribution to journal › Article › peer-review

Open Access

2018

A Review of Techniques for Visualising Soft Tissue Microstructure Deformation and Quantifying Strain Ex Vivo

Disney, C., Lee, P., Hoyland, J., Sherratt, M. & Bay, B. K., 2018, In: Journal of Microscopy.

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Open Access

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Defining tissue proteomes by systematic literature review

Hibbert, S. A., Ozols, M., Griffiths, C. E. M., Watson, R. E. B., Bell, M. & Sherratt, M. J., 11 Jan 2018, In: Scientific Reports. 8, 1, 546.

Research output: Contribution to journal › Article › peer-review

Open Access

Extracellular matrix fragmentation in young, healthy cartilaginous tissues

Craddock, R., Hodson, N., Ozols, M., Shearer, T., Hoyland, J. & Sherratt, M., 2018, In: European Cells & Materials . 35, p. 34-53

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Open Access

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Macro- and micro-mechanical remodelling in the fish atrium is associated with regulation of collagen 1 alpha 3 chain expression.

Keen, A. N., Fenna, A. J., Mcconnell, J., Sherratt, M., Gardner, P. & Shiels, H., 2018, In: Pflügers Archiv European Journal of Physiology.

Research output: Contribution to journal › Article › peer-review

Open Access

MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome

López-Guimet, J., Peña-Pérez, L., Bradley, R. S., García-Canadilla, P., Disney, C., Geng, H., Bodey, A. J., Withers, P., Bijnens, B., Sherratt, M. & Egea, G., 2018, In: Theranostics. 8, 21, p. 6038-6052 15 p.

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Open Access

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Multiscale Imaging Reveals the Hierarchical Organization of Fibrillin Microfibrils

Godwin, A., Starborg, T., Smith, D., Sherratt, M., Roseman, A. & Baldock, C., 19 Oct 2018, In: Journal of molecular biology. 430, 21, p. 4142-4155 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Structural and compositional diversity of fibrillin microfibrils in human tissues

Eckersley, A., Mellody, K. T., Pilkington, S. M., Griffiths, C. E., Watson, R. E. B., O'Cualain, R., Baldock, C., Knight, D. & Sherratt, M. J., 6 Apr 2018, In: The Journal of biological chemistry. 293, 14, p. 5117-5133 17 p.

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Open Access

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The Impact of Ultraviolet Radiation on Barrier Function in Human Skin: Molecular Mechanisms and Topical Therapeutics

Alhasaniah, A., Sherratt, M. J. & O'Neill, C. A., 20 Nov 2018, In: Current Medicinal Chemistry. 25, 40, p. 5503-5511 9 p.

Research output: Contribution to journal › Article › peer-review

2017

A new in vitro assay to test UVR protection of dermal extracellular matrix components by a flat spectrum sunscreen

Hibbert, S., Costello, P., O'Connor, C., Bell, M., Griffiths, C., Watson, R. & Sherratt, M., Oct 2017, In: Journal of Photochemistry and Photobiology, B: Biology. 175, p. 58-64 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Defining the hierarchical organisation of collagen VI microfibrils at nanometre to micrometre length scales

Godwin, A., Starborg, T., Sherratt, M., Roseman, A. & Baldock, C., 1 Apr 2017, In: Acta Biomaterialia. 52, p. 21-32 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Implication of free fatty acids in thrombin generation and fibrinolysis in vascular inflammation in Zucker rats and evolution with aging

Lagrange, J., Didelot, M., Mohamadi, A., Walton, L. A., Bloemen, S., de Laat, B., Louis, H., Thornton, S. N., Derby, B., Sherratt, M. J., Fève, B., Challande, P., Akhtar, R., Cruickshank, J. K., Lacolley, P. & Regnault, V., 22 Nov 2017, In: Frontiers in Physiology. 8, NOV, 949.

Research output: Contribution to journal › Article › peer-review

Open Access

Organisation of the dermal matrix impacts the biomechanical properties of skin

Langton, A. K., Graham, H., McConnell, J. C., Sherratt, M. J., Griffiths, C. E. M. & Watson, R. E. B., 2017, In: British Journal of Dermatology. 177, 3, p. 818-827

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Open Access

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Visualising the 3D microstructure of stained and native intervertebral discs using X-ray microtomography

Disney, C., Madi, K., A.J., B., Lee, P., Hoyland, J. & Sherratt, M., 2017, In: Scientific Reports. 7, 16279.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Combined MSC and GLP-1 therapy modulates collagen remodeling and apoptosis following myocardial infarction

Wright, E., Hodson, N., Sherratt, M., Kassem, M., Lewis, A. L., Wallrapp, C., Malik, N. & Holt, C., 19 Oct 2016, In: Stem cells international. 2016, 12 p., 7357096.

Research output: Contribution to journal › Article › peer-review

Open Access

Frequency-modulated atomic force microscopy localises viscoelastic remodelling in the ageing sheep aorta

Akhtar, R., Graham, H., Derby, B., Sherratt, M., Trafford, A., Chadwick, R. & Gavara, N., Dec 2016, In: Journal of the Mechanical Behaviour of Materials. 64, p. 10-17 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Increased peri-ductal collagen micro-organization may contribute to raised mammographic density

Mcconnell, J., O'Connell, O. V., Brennan, K., Weiping, L., Howe, M., Joseph, L., Knight, D., O'Cualain, R., Lim, Y., Leek, A., Waddington, R., Rogan, J., Gandhi, A., Astley, S., Gandhi, A., Kirwan, C., Streuli, C., Sherratt, M. & Streuli, C., 8 Jan 2016, In: Breast Cancer Research. 18, 5.

Research output: Contribution to journal › Article › peer-review

Open Access

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Novel approaches to characterize age-related remodelling of the dermal-epidermal junction in 2D, 3D and in vivo

Newton, V. L., Bradley, R. S., Seroul, P., Cherel, M., Griffiths, C. E. M., Rawlings, A. V., Voegeli, R., Watson, R. E. B. & Sherratt, M. J., 9 Aug 2016, In: Skin Research and Technology.

Research output: Contribution to journal › Article › peer-review

Open Access

Raised mammographic density: Causative mechanisms and biological consequences

Sherratt, M. J., McConnell, J. C. & Streuli, C. H., 3 May 2016, In: Breast Cancer Research. 18, 1, 45.

Research output: Contribution to journal › Article › peer-review

Open Access

The impact of intrinsic ageing on the protein composition of the dermal-epidermal junction.

Langton, A., Halai, P., Griffiths, C., Sherratt, M. J. & Watson, R. E., 21 Mar 2016, In: Mechanisms of ageing and development|Mech Ageing Dev. 156, p. 14-16

Research output: Contribution to journal › Article › peer-review

Open Access

2015

A novel ex vivo model of compressive immature rib fractures at pathophysiological rates of loading

Beadle, N., Burnett, T., Hoyland, J., Sherratt, M. & Freemont, A. J., Nov 2015, In: Journal of the mechanical behavior of biomedical materials. 51, p. 154-162 8 p.

Research output: Contribution to journal › Article › peer-review

A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues

Hibbert, S., Watson, R., Gibbs, N., Costello, P., Baldock, C., Weiss, A. S., Griffiths, C. & Sherratt, M. J., 11 Apr 2015, In: Redox biology. 5, p. 101-113 12 p.

Research output: Contribution to journal › Article › peer-review