Personal profile
Research interests
Our research interests span synthetic biology, biosensors, cellular transport, and metabolic control. We are currently exploring a number of applied research areas including; i) the development and application of genetically encoded biosensors, for sensing, control and communication within and between engineered microbial strains, ii) development of consolidated bioprocesses and use of alternative non-energy crop feedstocks for bioproduction, and the iii) use of mobile genetic elements with catabolic payloads for bioremediation of xenobiotics.
The driver of these applied research areas is the development of biological and process engineering approaches to help harness the power of biological systems to i) support sustainable development and the transition towards circular low carbon-based production-consumption-disposal models, and ii) remediate contaminated environments polluted wiht xenobiotics.
For further information: https://dixonlab.org/research/
Biography
Neil Dixon received a 1st class Hons degree in Medicinal Chemistry from the University of Leeds (UK) in 2000 and then undertook in his PhD in Bioorganic Chemistry also at Leeds on “Probing the inhibition of the vacuolar (H⁺)-ATPase: targeting osteoporosis” (2004). After an extended period travel in Latin America he then pursued post-doctoral research in Chemical Biology at the University of Manchester (UK) on the topic re-engineering the molecular recognition properties of regulatory RNAs termed riboswitches, using rational design, high-throughput screening, directed evolution, along with structural and and biophysical characterization (2006-2010).
Neil Dixon previously held a BBSRC David Phillips Fellowship and a BBSRC Enterprise fellow based at the Manchester Institute of Biotechnology(MIB). His research group is focused on developing engineering tools and technologies to enhance the capacity and introduce new capability into biological hosts for biotech and biomed applications. His group currently comprising of 3 post doctoral scientists, 5 PhD students and 2 Research Techniciasn is supported from BBSRC, EPSRC, Innovate UK, Wellcome Trust, Brazilian and Indonesian Governments.
Areas of expertise
- Q Science (General)
Research Beacons, Institutes and Platforms
- Biotechnology
- Sustainable Futures
- Manchester Institute of Biotechnology
- Manchester Environmental Research Institute
Keywords
- Synthetic Biology
- Metabolic Engineering
- Biosensors
- Sustainable Development
- Bioprocesss Engineering
- Engineering Biology
- Bioremediation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 7 Affordable and Clean Energy
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SDG 8 Decent Work and Economic Growth
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SDG 9 Industry, Innovation, and Infrastructure
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SDG 11 Sustainable Cities and Communities
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SDG 12 Responsible Consumption and Production
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SDG 13 Climate Action
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SDG 14 Life Below Water
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SDG 15 Life on Land
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SDG 17 Partnerships for the Goals
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Collaborations and top research areas from the last five years
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Genetically encoded biosensor enabled mining, characterisation and engineering of aromatic acid MFS transporters
Le Roy, P., Chacon, M. & Dixon, N., 30 Sept 2025, (Accepted/In press) In: Journal of Biological Engineering.Research output: Contribution to journal › Article › peer-review
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Genetic bioaugmentation-mediated bioremediation of terephthalate in soil microcosms using an engineered environmental plasmid
Marquiegui Alvaro, A., Kottara, A., Chacon, M., Cliffe, L., Brockhurst, M. & Dixon, N., 13 Jan 2025, In: Microbial Biotechnology. 18, 1, e70071.Research output: Contribution to journal › Article › peer-review
Open Access -
Complex waste stream valorisation through combined enzymatic hydrolysis and catabolic assimilation by Pseudomonas putida
Chacόn, M., Alvarez Gonzalez, G., Gosalvitr, P., Berepiki, A., Fisher, K., Cuellar Franca, R. & Dixon, N., 4 Dec 2024, (E-pub ahead of print) In: Trends in Biotechnology.Research output: Contribution to journal › Article › peer-review
Open Access -
Engineered co-culture for consolidated production of phenylpropanoids directly from aromatic-rich biomass
Chacon, M., Percival, E., Bugg, T. D. H. & Dixon, N., 1 Jan 2024, In: Bioresource Technology. 391, 129935.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhanced 4-hydroxybutyrate incorporation into the PHA terpolymer of Haloferax mediterranei by heterologous expression of 4-hydroxybutyrate-CoA transferases/synthetases
Zheng, X., Chacόn, M., Allers, T., Dixon, N. & Winterburn, J., 16 Sept 2024, (E-pub ahead of print) In: Biochemical Engineering Journal.Research output: Contribution to journal › Article › peer-review
Open Access
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Deuterose: enabling frontier life sciences and diagnostics with low cost deuterated sugars
Rowbotham, J. (PI) & Dixon, N. (CoI)
1/10/25 → 30/09/28
Project: Research
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How does plasmid-chromosome crosstalk influence the spread of genes through complex microbial communities?
Dixon, N. (PI) & Brockhurst, M. (CoI)
1/05/25 → 30/04/28
Project: Research
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Rules of life in CO2-driven microbial communities: Microbiome engineering for a Net Zero future
Nixon, S. (PI), Breitling, R. (CoI), Brockhurst, M. (CoI), Cameron, D. (CoI), Coyte, K. (CoI), Cuellar Franca, R. (CoI), Hollywood, K. (CoI), Johnson, D. (CoI), Pitt, A. (CoI), Quince, C. (CoI), Takano, E. (CoI) & Dixon, N. (PI)
1/01/25 → 31/12/29
Project: Research
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Sustainable biocatalytic approaches to pyridine and piperidine heterocycles
Dixon, N. (PI), Leys, D. (CoI) & Turner, N. (CoI)
1/06/24 → 31/05/27
Project: Research
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SuCCEED: SuCCEED: Sustainable Commodity Chemicals through Enzyme Engineering & Design
Leys, D. (PI), Cuellar Franca, R. (CoI), Dixon, N. (CoI), Esteban Serrano, J. (CoI), Green, A. (CoI), Scrutton, N. (CoI), Spallina, V. (CoI), Turner, M. (CoI) & Winterburn, J. (CoI)
15/11/23 → 14/11/28
Project: Research