Nicholas Lockyer

2024

Accumulation of Bioactive Lipid Species in LPS-Induced Neuroinflammation Models Analysed with Multi-Modal Mass Spectrometry Imaging

Razo, I. B., Shea, K., Allen, T.-J., Boutin, H., McMahon, A., Lockyer, N. & Hart, P. J., 8 Nov 2024, In: International Journal of Molecular Sciences. 25, 22

Research output: Contribution to journal › Article › peer-review

Reactive Gas Cluster Ion Beams for Enhanced Drug Analysis by Secondary Ion Mass Spectrometry

Lagator, M., Patel, B., Sheraz, S. & Lockyer, N., 13 Sept 2024, In: Analytical Chemistry. 96, 38, p. 15185–15193

Research output: Contribution to journal › Article › peer-review

Open Access

Visualizing active fungicide formulation mobility in tomato leaves with desorption electrospray ionisation mass spectrometry imaging

Ajith, A., Jones, E., Prince, E., Trivedi, D., Johnson, G., Milnes, P. & Lockyer, N., 24 Nov 2024, In: The Analyst. p. 5904-5913 https://doi.org/10.1039/D4AN01309C.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

A High-Resolution Versatile Focused Ion Implantation Platform for Nanoscale Engineering

Adshead, M., Coke, M., Aresta, G., Bellew, A., Lagator, M., Li, K., Cui, Y., Cai, R., Almutawa, A., Haigh, S. J., Moore, K., Lockyer, N., Gourlay, C. M. & Curry, R. J., 1 Nov 2023, In: Advanced Engineering Materials. 25, 22, 2300889.

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Quantitative and qualitative analyses of mass spectra of OEL materials by artificial neural network and interface evaluation: Results from a VAMAS interlaboratory study

Aoyagi, S., Cant, D., Dürr, M., Eyres, A., Fearn, S., Gilmore, I., Iida, S.-I., Ikeda, R., Ishikawa, K., Lagator, M., Lockyer, N., Keller, P., Matsuda, K., Murayama, Y., Okamoto, M., Reed, B., Shard, A., Takano, A., Trindade, G. & Vorng, J.-L., 10 Oct 2023, In: Analytical Chemistry. 95, 40, p. 15078–15085

Research output: Contribution to journal › Article › peer-review

Secondary Ion Mass Spectrometry analysis of metal oxides using 70 keV argon, carbon dioxide and water gas cluster ion beams

Alsaedi, A. H., Walton, A. S. & Lockyer, N. P., 9 Jun 2023, In: Journal of Vacuum Science and Technology B:Nanotechnology and Microelectronics.

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2022

Sensitivity enhancement using chemically reactive gas cluster ion beams in secondary ion mass spectrometry (SIMS)

Lagator, M., Berrueta Razo, I., Royle, T. & Lockyer, N., 10 Jan 2022, In: Surface and Interface Analysis. 54, 4, p. 349-355 6 p.

Research output: Contribution to journal › Article › peer-review

2019

Microdistribution and quantification of the boron neutron capture therapy drug BPA in primary cell cultures of human glioblastoma tumour by NanoSIMS

Aldossari, S., Mcmahon, G., Lockyer, N. & Moore, K., 2019, In: The Analyst.

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2018

The influence of polyatomic primary ion chemistry on matrix effects in secondary ion mass spectrometry analysis

Alnajeebi, A. M., Vickerman, J. & Lockyer, N., 30 Oct 2018, In: Rapid Communications in Mass Spectrometry. 32, 22, p. 1962-1970 8 p.

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2017

Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques

Denbigh, J., Perez-Guaita, D., Vernooij, R., Tobin, M. J., Bambery, K. R., Xu, Y., Southam, A. D., Khanim, F. L., Drayson, M. T., Lockyer, N., Goodacre, R. & Wood, B. R., 2017, In: Scientific Reports. 7

Research output: Contribution to journal › Article › peer-review

Open Access

Quartz crystal microbalance assay of clinical calcinosis samples and their synthetic models differentiates the efficacy of chelation-based treatments

Fei, F., Gallas, A., Chang, Y.-C., Rao, Y., Hunter, A., Winpenny, R., Herrick, A., Lockyer, N. & Blanford, C. F., 28 Jul 2017, In: ACS Applied Materials and Interfaces. 9, 33, p. 27544–27552

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2016

Evaluation of biomolecular distributions in rat brain tissues by means of ToF-SIMS using a continuous beam of Ar clusters

Nakano, S., Yokoyama, Y., Aoyagi, S., Himi, N., Fletcher, J. S., Lockyer, N. P., Henderson, A. & Vickerman, J. C., 8 Jan 2016, In: Biointerphases. 11, p. 02A307 5 p.

Research output: Contribution to journal › Article › peer-review

Fossilization of melanosomes via sulfurization

Mcnamara, M. E., van Dongen, B. E., Lockyer, N. P., Bull, I. D. & Orr, P. J., 1 May 2016, In: Palaeontology. 59, 3, p. 337-350 14 p.

Research output: Contribution to journal › Article › peer-review

Matrix Effects in Biological SIMS using Cluster Ion Beams of Different Chemical Composition

Alnajeebi, A., Vickerman, J. C. & Lockyer, N. P., 2016, In: Biointerphases. 11, 2

Research output: Contribution to journal › Article › peer-review

Open Access

Peptide Fragmentation and Surface Structural Analysis by Means of ToF-SIMS Using Large Cluster Ion Sources

Yokoyama, Y., Aoyagi, S., Fujii, M., Matsuo, J., Fletcher, J. S., Lockyer, N. P., Vickerman, J. C., Passarelli, M. K., Havelund, R. & Seah, M. P., 19 Apr 2016, In: Analytical Chemistry. 88, 7, p. 3592-3597 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Enhancing Ion Yields in TOF-SIMS: A Comparative Study of Argon and Water Cluster Primary Beams

Sheraz, S., Razo, I. B., Kohn, T., Lockyer, N. P. & Vickerman, J. C., 14 Jan 2015, In: Analytical Chemistry. 87, 4, p. 2367–2374

Research output: Contribution to journal › Article › peer-review

Mass spectrometric imaging of brain tissue by time-of-flight secondary ion mass spectrometry – How do polyatomic primary beams C60+, Ar2000+, water-doped Ar2000+ and (H2O)6000+ compare?

Berrueta Razo, I., Sheraz (nee Rabbani), S., Henderson, A., Lockyer, N. P. & Vickerman, J. C., Oct 2015, In: Rapid Communications in Mass Spectrometry. 29, 20, p. 1851-1862 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2014

Comparing C60+ and (H2O)n+ clusters for mouse brain tissue analysis

Berrueta Razo, I., Sheraz, S., Henderson, A., Lockyer, N. P. & Vickerman, J. C., Nov 2014, In: Surface and Interface Analysis. 46, S1, p. 136–139 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Quantitative Surface Analysis of a Binary Drug Mixture Suppression Effects in the Detection of Sputtered Ions and Post-Ionized Neutrals

Karras, G. & Lockyer, N. P., May 2014, In: American Society for Mass Spectrometry. Journal. 25, 5, p. 832-840 8 p.

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Spatiotemporal lipid profiling during early embryo development of Xenopus laevis using dynamic Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) Imaging

Tian, H., Fletcher, J. S., Thuret, R., Henderson, A., Papalopulu, N., Vickerman, J. C. & Lockyer, N. P., Sept 2014, In: Journal of Lipid Research (Print). 55, 9, p. 1970-1980

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Spatiotemporal lipid profiling during early embryo development of Xenopus laevis using dynamic ToF-SIMS imaging

Tian, H., Fletcher, J. S., Thuret, R., Henderson, A., Papalopulu, N., Vickerman, J. C. & Lockyer, N. P., 2014, In: Journal of Lipid Research. 55, 9, p. 1970-1980 10 p.

Research output: Contribution to journal › Article › peer-review

2013

Enhancing secondary ion yields in time of flight-secondary ion mass spectrometry using water cluster primary beams

Sheraz Née Rabbani, S., Barber, A., Fletcher, J. S., Lockyer, N. P. & Vickerman, J. C., 18 Jun 2013, In: Analytical Chemistry. 85, 12, p. 5654-5658 4 p.

Research output: Contribution to journal › Article › peer-review

Imaging of metabolites using secondary ion mass spectrometry

Armitage, E. G., Kotze, H. L. & Lockyer, N. P., 2013, In: Metabolomics. 9, 1, p. 102-109 7 p.

Research output: Contribution to journal › Article › peer-review

Peak picking as a pre-processing technique for imaging time of flight secondary ion mass spectrometry

Moore, J. D., Henderson, A., Fletcher, J. S., Lockyer, N. P. & Vickerman, J. C., Jan 2013, In: Surface and Interface Analysis. 45, 1, p. 461-465 5 p.

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Peptide structural analysis using continuous Ar cluster and C60 ion beams

Aoyagi, S., Fletcher, J. S., Sheraz, S., Kawashima, T., Berrueta Razo, I., Henderson, A., Lockyer, N. P. & Vickerman, J. C., Aug 2013, In: Analytical and bioanalytical chemistry. 405, 21, p. 6621-6628 7 p.

Research output: Contribution to journal › Article › peer-review

Time-of-flight SIMS as a novel approach to unlocking the hypoxic properties of cancer

Armitage, E. G., Kotze, H. L., Fletcher, J. S., Henderson, A., Williams, K. J., Lockyer, N. P. & Vickerman, J. C., Jan 2013, In: Surface and Interface Analysis. 45, 1, p. 282-285 3 p.

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ToF-SIMS as a tool for metabolic profiling small biomolecules in cancer systems

Kotze, H. L., Armitage, E. G., Fletcher, J. S., Henderson, A., Williams, K. J., Lockyer, N. P. & Vickerman, J. C., Jan 2013, In: Surface and Interface Analysis. 45, 1, p. 277-281 4 p.

Research output: Contribution to journal › Article › peer-review

34 Downloads (Pure)

2011

Developments in molecular SIMS depth profiling and 3D imaging of biological systems using polyatomic primary ions

Fletcher, J. S., Lockyer, N. P. & Vickerman, J. C., Jan 2011, In: Mass spectrometry reviews. 30, 1, p. 142-174 32 p.

Research output: Contribution to journal › Article › peer-review

Exploring subcellular imaging on the buncher-ToF J105 3D chemical imager

Rabbani, S., Fletcher, J. S., Lockyer, N. P. & Vickerman, J. C., Jan 2011, In: Surface and Interface Analysis. 43, 1-2, p. 380-384 4 p.

Research output: Contribution to journal › Article › peer-review

Investigating the effect of temperature on depth profiles of biological material using ToF-SIMS

Piwowar, A., Fletcher, J., Lockyer, N. & Vickerman, J., Jan 2011, In: Surface and Interface Analysis. 43, 1-2, p. 207-210 3 p.

Research output: Contribution to journal › Article › peer-review

Synchrotron FTIR analysis of drug treated ovarian A2780 cells: An ability to differentiate cell response to different drugs?

Flower, K. R., Khalifa, I., Bassan, P., Démoulin, D., Jackson, E., Lockyer, N. P., McGown, A. T., Miles, P., Vaccari, L. & Gardner, P., 7 Feb 2011, In: Analyst. 136, 3, p. 498-507 9 p.

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Three-dimensional mass spectral imaging of HeLa-M cells - Sample preparation, data interpretation and visualisation

Fletcher, J. S., Rabbani, S., Henderson, A., Lockyer, N. P. & Vickerman, J. C., Apr 2011, In: Rapid communications in mass spectrometry : RCM. 25, 7, p. 925-932 7 p.

Research output: Contribution to journal › Article › peer-review

2010

C60+ secondary ion microscopy using a delay line detector

Klerk, L. A., Lockyer, N. P., Kharchenko, A., MacAleese, L., Dankers, P. Y. W., Vickerman, J. C. & Heeren, R. M. A., 1 Feb 2010, In: Analytical Chemistry. 82, 3, p. 801-807 6 p.

Research output: Contribution to journal › Article › peer-review

Effects of cryogenic sample analysis on molecular depth profiles with TOF-secondary ion mass spectrometry

Piwowar, A. M., Fletcher, J. S., Kordys, J., Lockyer, N. P., Winograd, N. & Vickerman, J. C., 1 Oct 2010, In: Analytical Chemistry. 82, 19, p. 8291-8299 8 p.

Research output: Contribution to journal › Article › peer-review

Influence of omega-6 PUFA arachidonic acid and bone marrow adipocytes on metastatic spread from prostate cancer

Brown, M. D., Hart, C., Gazi, E., Gardner, P., Lockyer, N. & Clarke, N., Jan 2010, In: British Journal of Cancer. 102, 2, p. 403-413 10 p.

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RMieS-EMSC correction for infrared spectra of biological cells: Extension using full Mie theory and GPU computing

Bassan, P., Kohler, A., Martens, H., Lee, J., Jackson, E., Lockyer, N., Dumas, P., Brown, M., Clarke, N. & Gardner, P., 2010, In: Journal of biophotonics. 3, 8-9, p. 609-620 11 p.

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2009

A cancer research UK pharmacokinetic study of BPA-mannitol in patients with high grade glioma to optimise uptake parameters for clinical trials of BNCT

Cruickshank, G. S., Ngoga, D., Detta, A., Green, S., James, N. D., Wojnecki, C., Doran, J., Hardie, J., Chester, M., Graham, N., Ghani, Z., Halbert, G., Elliot, M., Ford, S., Braithwaite, R., Sheehan, T. M. T., Vickerman, J., Lockyer, N., Steinfeldt, H. & Croswell, G. & 3 others, Chopra, A., Sugar, R. & Boddy, A., Jul 2009, In: Applied Radiation and Isotopes. 67, 7-8, p. S31-S33

Research output: Contribution to journal › Article › peer-review

A FTIR microspectroscopic study of the uptake and metabolism of isotopically labelled fatty acids by metastatic prostate cancer

Gazi, E., Harvey, T. J., Brown, M. D., Lockyer, N. P., Gardner, P. & Clarke, N. W., 26 May 2009, In: Vibrational Spectroscopy. 50, 1, p. 99-105 6 p.

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Explanatory multivariate analysis of ToF-SIMS spectra for the discrimination of bacterial isolates

Vaidyanathan, S., Fletcher, J. S., Jarvis, R. M., Henderson, A., Lockyer, N. P., Goodacre, R. & Vickerman, J. C., 2009, In: Analyst. 134, 11, p. 2352-2360 8 p.

Research output: Contribution to journal › Article › peer-review

2008

A new dynamic in mass spectral imaging of single biological cells

Fletcher, J. S., Rabbani, S., Henderson, A., Blenkinsopp, P., Thompson, S. P., Lockyer, N. P. & Vickerman, J. C., 1 Dec 2008, In: Analytical Chemistry. 80, 23, p. 9058-9064 6 p.

Research output: Contribution to journal › Article › peer-review

Discrimination of prostate cancer cells and non-malignant cells using secondary ion mass spectrometry

Baker, M. J., Brown, M. D., Gazi, E., Clarke, N. W., Vickerman, J. C. & Lockyer, N. P., 2008, In: Analyst. 133, 2, p. 175-179 4 p.

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Uncovering new challenges in bio-analysis with ToF-SIMS

Fletcher, J. S., Henderson, A., Biddulph, G. X., Vaidyanathan, S., Lockyer, N. P. & Vickerman, J. C., 15 Dec 2008, In: Applied Surface Science. 255, 4, p. 1264-1270 6 p.

Research output: Contribution to journal › Article › peer-review

2007

Biomolecular profiling of metastatic prostate cancer cells in bone marrow tissue using FTIR microspectroscopy: A pilot study

Gazi, E., Dwyer, J., Lockyer, N. P., Gardner, P., Shanks, J. H., Roulson, J., Hart, C. A., Clarke, N. W. & Brown, M. D., Mar 2007, In: Analytical and bioanalytical chemistry. 387, 5, p. 1621-1631 10 p.

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Direct evidence of lipid translocation between adipocytes and prostate cancer cells with imaging FTIR microspectroscopy

Gazi, E., Gardner, P., Lockyer, N. P., Hart, C. A., Brown, M. D. & Clarke, N. W., Aug 2007, In: Journal of Lipid Research. 48, 8, p. 1846-1856 10 p.

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2006

A Correlation of FTIR Spectra Derived from Prostate Cancer Biopsies with Gleason Grade and Tumour Stage

Gazi, E., Baker, M., Dwyer, J., Lockyer, N. P., Gardner, P., Shanks, J. H., Reeve, R. S., Hart, C. A., Clarke, N. W. & Brown, M. D., Oct 2006, In: European Urology. 50, 4, p. 750-761 11 p.

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Nicholas Lockyer, BSc PhD CChem FRSC

Research output

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