Nigel Hooper

2024

Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone

Quinn, J. P., Fisher, K., Corbett, N., Warwood, S., Knight, D., Kellett, K. A. B. & Hooper, N. M., 18 Sept 2024, In: Biochemical Journal. 481, 18, p. 1255-1274 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Zhang, W., Zhao, X., Qi, X., Kimber, S. J., Hooper, N. M. & Wang, T., 8 Jun 2023, (E-pub ahead of print) In: Frontiers in cellular neuroscience. 17, 1195470.

Research output: Contribution to journal › Article › peer-review

Open Access

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Proteolysis of the low-density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteases

Kellett, K. A. B., Fisher, K., Aldworth, H. & Hooper, N. M., 1 Jun 2023, In: FEBS Letters.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

A NEUROVASCULAR 3D CELL MODEL TO INVESTIGATE THE ROLE OF PERICYTES IN DEMENTIA

Polleres, M., Potjewyd, G., Wang, T., Domingos, M. & Hooper, N., 2022, In: Tissue Engineering Part a.

Research output: Contribution to journal › Article

The role of protein aggregation in the pathogenesis of inclusion body myositis

Snedden, A. M., Kellett, K. A. B., Lilleker, J. B., Hooper, N. M. & Chinoy, H., Feb 2022, In: Clinical and Experimental Rheumatology. 40, 2, p. 414-424 11 p.

Research output: Contribution to journal › Review article › peer-review

2021

Impact of type-1 collagen hydrogel density on integrin-linked morphogenic response of SH-SY5Y neuronal cells

Merryweather, D. (Lead), Moxon, S., Capel, A., Hooper, N., Lewis, M. & Roach, P. (Corresponding), 7 Oct 2021, In: RSC Advances. 11, 52, p. 33124-33135 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer's Disease

Hadjidemetriou, M., Rivers-Auty, J., Papafilippou, L., Eales, J., Kellett, K. A. B., Hooper, N. M., Lawrence, C. B. & Kostarelos, K., 27 Apr 2021, In: ACS Nano. 15, 4, p. 7357-7369 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Severe and Regionally Widespread Increases in Tissue Urea in the Human Brain Represent a Novel Finding of Pathogenic Potential in Parkinson's Disease Dementia

Scholefield, M., Church, S. J., Xu, J., Patassini, S., Roncaroli, F., Hooper, N. M., Unwin, R. D. & Cooper, G. J. S., 22 Oct 2021, In: Frontiers in Molecular Neuroscience. 14, 711396.

Research output: Contribution to journal › Article › peer-review

Open Access

Substantively lowered levels of pantothenic acid (vitamin B5) in several regions of the human brain in Parkinson’s disease dementia

Scholefield, M., Church, S., Xu, J., Patassini, S., Hooper, N., Unwin, R. & Cooper, G. J., 23 Aug 2021, (Accepted/In press) In: Metabolites.

Research output: Contribution to journal › Article › peer-review

Widespread Decreases in Cerebral Copper Are Common to Parkinson's Disease Dementia and Alzheimer's Disease Dementia

Scholefield, M., Church, S. J., Xu, J., Patassini, S., Roncaroli, F., Hooper, N. M., Unwin, R. D. & Cooper, G. J. S., 3 Mar 2021, In: Frontiers in aging neuroscience. 13, 641222.

Research output: Contribution to journal › Article › peer-review

Open Access

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2020

A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Poly(ester Urea) Scaffolds

Moxon, S. R., Ferreira, M. J. S., Santos, P. D., Popa, B., Gloria, A., Katsarava, R., Tugushi, D., Serra, A. C., Hooper, N. M., Kimber, S. J., Fonseca, A. C. & Domingos, M. A. N., 30 Jun 2020, In: Polymers. 12, 7, p. 1478

Research output: Contribution to journal › Article › peer-review

Open Access

Effects of Alterations of Post-Mortem Delay and Other Tissue-Collection Variables on Metabolite Levels in Human and Rat Brain

Scholefield, M., Church, S. J., Xu, J., Robinson, A. C., Gardiner, N. J., Roncaroli, F., Hooper, N. M., Unwin, R. D. & Cooper, G. J. S., 29 Oct 2020, In: Metabolites. 10, 11

Research output: Contribution to journal › Article › peer-review

Open Access

Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location

Scholefield, M., Church, S. J., Xu, J., Kassab, S., Gardiner, N. J., Roncaroli, F., Hooper, N. M., Unwin, R. D. & Cooper, G. J. S., 6 May 2020, In: Metallomics : integrated biometal science.

Research output: Contribution to journal › Article › peer-review

Open Access

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Extracellular Vesicles Isolated from Human Induced Pluripotent Stem Cell-Derived Neurons Contain a Transcriptional Network

Hicks, D. A., Jones, A. C., Corbett, N. J., Fisher, K., Pickering-brown, S. M., Ashe, M. P. & Hooper, N. M., 2 May 2020, (E-pub ahead of print) In: Neurochemical research.

Research output: Contribution to journal › Article › peer-review

Open Access

Gene Ontology Curation of Neuroinflammation Biology Improves the Interpretation of Alzheimer’s Disease Gene Expression Data

Kramarz, B., Huntley, R. P., Rodríguez-lópez, M., Roncaglia, P., Saverimuttu, S. C. C., Parkinson, H., Bandopadhyay, R., Martin, M.-J., Orchard, S., Hooper, N. M., Brough, D. & Lovering, R. C., 13 May 2020, (E-pub ahead of print) In: Journal of Alzheimer's Disease. p. 1-19

Research output: Contribution to journal › Article › peer-review

Open Access

Mild cognitive impairment: the Manchester consensus

Dunne, R., Aarsland, D., O'Brien, J. T., Ballard, C., Banerjee, S., Fox, N. C., Hooper, N., Burns, A., Perry, R. H. J., Isaacs, J. D., Schott, J. M., Kalafatis, C., Jones, R. W., Martin, H., Thomas, A. J., Underwood, B. R., Chan, D., Dening, T., Rasmussen, J. & Schryer, J. & 7 others, Evans, A., Mitchell, S., Jones, A.-M., Pickett, J., Coulthard, E., Alessi, C. & Elton, P., 17 Nov 2020, (E-pub ahead of print) In: Age and Ageing. 9 p., afaa228.

Research output: Contribution to journal › Review article › peer-review

Open Access

The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43

Hicks, D., Jones, A., Pickering-Brown, S. & Hooper, N., 6 Apr 2020, (Accepted/In press) In: Bioscience reports.

Research output: Contribution to journal › Article › peer-review

2019

Blended alginate/collagen hydrogels promote neurogenesis and neuronal maturation

Moxon, S. R., Corbett, N. J., Fisher, K., Potjewyd, G., Domingos, M. & Hooper, N. M., Nov 2019, In: Materials Science and Engineering: C. 104, p. 109904

Research output: Contribution to journal › Article › peer-review

Open Access

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), 2019, In: Nature Genetics. 51, 3, p. 414-430 17 p.

Research output: Contribution to journal › Article › peer-review

Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake

Banerjee, S., Andrew, R. J., Duff, C. J., Fisher, K., Jackson, C. D., Lawrence, C. B., Maeda, N., Greenspan, D. S., Kellett, K. & Hooper, N., 6 Aug 2019, In: Scientific Reports.

Research output: Contribution to journal › Article › peer-review

Open Access

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers

Jarosz-griffiths, H. H., Corbett, N. J., Rowland, H. A., Fisher, K., Jones, A. C., Baron, J., Howell, G. J., Cowley, S. A., Chintawar, S., Cader, M. Z., Kellett, K. A. B. & Hooper, N. M., 2019, In: Journal of Biological Chemistry. 294, 17, p. 7085-7097 13 p.

Research output: Contribution to journal › Article › peer-review

Quantitative interaction proteomics reveals differences in the interactomes of amyloid precursor protein isoforms

Andrew, R. J., Fisher, K., Heesom, K. J., Kellett, K. A. B. & Hooper, N. M., 21 Jan 2019, In: Journal of neurochemistry. 149, 3, p. 399-412 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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109 Downloads (Pure)

2018

Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer’s Disease Data

Kramarz, B., Roncaglia, P., Meldal, B. H. M., Huntley, R. P., Martin, M. J., Orchard, S., Parkinson, H., Brough, D., Bandopadhyay, R., Hooper, N. & Lovering, R. C., 2018, In: Genes.

Research output: Contribution to journal › Article › peer-review

Open Access

Modelling Sporadic Alzheimer’s Disease using Induced Pluripotent Stem Cells

Rowland, H., Hooper, N. & Kellett, K., 2018, In: Neurochemical research.

Research output: Contribution to journal › Article › peer-review

Open Access

Plasma metals as potential biomarkers in dementia: a case–control study in patients with sporadic Alzheimer’s disease

Xu, J., Church, S. J., Patassini, S., Begley, P., Kellett, K. A. B., Vardy, E. R. L. C., Unwin, R. D., Hooper, N. M. & Cooper, G. J. S., Apr 2018, In: BioMetals. 31, 2, p. 267-276 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Tau proteolysis in the pathogenesis of tauopathies: neurotoxic fragments and novel biomarkers

Quinn, J., Corbett, N., Kellett, K. & Hooper, N., 2018, In: Journal of Alzheimer's Disease. 63, 1, p. 13-33 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective

Potjewyd, G., Moxon, S., Wang, T., Domingos, M. & Hooper, N. M., 6 Feb 2018, In: Trends in Biotechnology.

Research output: Contribution to journal › Article › peer-review

Open Access

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517 Downloads (Pure)

2017

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil

Sellers, K. J., Elliott, C., Jackson, J., Ghosh, A., Ribe, E., Rojo, A. I., Jarosz-Griffiths, H. H., Watson, I. A., Xia, W., Semenov, M., Morin, P., Hooper, N. M., Porter, R., Preston, J., Al-Shawi, R., Baillie, G., Lovestone, S., Cuadrado, A., Harte, M. & Simons, P. & 2 others, Srivastava, D. P. & Killick, R., 19 Oct 2017, In: Alzheimer's & dementia : the journal of the Alzheimer's Association. 14, 3, p. 306-317 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Pathological spread of TAR DNA binding protein 43 (TDP-43) in an induced pluripotent stem cell model of dementia

Hicks, D., Jones, A., Pickering-Brown, S. & Hooper, N., 8 Dec 2017.

Research output: Contribution to conference › Poster

Regulation of amyloid precursor protein and its secretases by TAR DNA binding protein 43 (TDP-43)

Hicks, D., Jones, A. & Hooper, N., 21 May 2017.

Research output: Contribution to conference › Poster

Tau Diagnostics and Clinical Studies

Gozes, I., Höglinger, G., Quinn, J. P., Hooper, N. M. & Höglund, K., 2017, In: Journal of Molecular Neuroscience. 63, 2, p. 123-130 8 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

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The relationship between the amyloid precursor protein and TAR DNA binding protein 43 (TDP-43): links to Alzheimer’s disease

Hicks, D., Jones, A. & Hooper, N., 21 Aug 2017.

Research output: Contribution to conference › Poster

2016

Ablation of prion protein in wild type human amyloid precursor protein (APP) transgenic mice does not alter the proteolysis of APP, levels of amyloid-β or pathologic phenotype

Whitehouse, I. J., Brown, D., Baybutt, H., Diack, A. B., Kellett, K., Piccardo, P., Manson, J. C. & Hooper, N., 22 Jul 2016, In: PLoS ONE. 11, 7, e0159119.

Research output: Contribution to journal › Article › peer-review

Open Access

A Greek Tragedy: the Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

Andrew, R. J., Kellett, K., Thinakaran, G. & Hooper, N., 9 Sept 2016, In: Journal of Biological Chemistry. 291, p. 19235-19244 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

121 Downloads (Pure)

A step-by-step translation of evidence into a psychosocial intervention for everyday activities in dementia: a focus group study

Giebel, C., Challis, D., Hooper, N. & Ferris, S., 2016, In: Aging and Mental Health.

Research output: Contribution to journal › Article › peer-review

Open Access

File

30 Downloads (Pure)

Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia

Xu, J., Begley, P., Church, S., Patassini, S., Mcharg, S., Kureishy, N., Hollywood, K., Waldvogel, H. J., Liu, H., Zhang, S., Lin, W., Herholz, K., Turner, C., Synek, B. J., Curtis, M. A., Rivers-Auty, J., Lawrence, C., Kellett, K., Hooper, N. & Vardy, E. R. L. C. & 5 others, Wu, D., Unwin, R., Faull, R. L. M., Dowsey, A. & Cooper, G., 9 Jun 2016, In: Scientific Reports. 6, 12 p., 27524.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Downloads (Pure)

2015

A novel Alzheimer disease locus located near the gene encoding tau protein.

Jun, G., Ibrahim-Verbaas, C. A., Vronskaya, M., Lambert, J.-C., Chung, J., Naj, A. C., Kunkle, B. W., Wang, L.-S., Bis, J. C., Bellenguez, C., Harold, D., Lunetta, K. L., Destefano, A. L., Grenier-Boley, B., Sims, R., Beecham, G. W., Smith, A. V., Chouraki, V., Hamilton-Nelson, K. L. & Ikram, M. A. & 406 others, Fievet, N., Denning, N., Martin, E. R., Schmidt, H., Kamatani, Y., Dunstan, M. L., Valladares, O., Laza, A. R., Zelenika, D., Ramirez, A., Foroud, T. M., Choi, S.-H., Boland, A., Becker, T., Kukull, W. A., van der Lee, S. J., Pasquier, F., Cruchaga, C., Beekly, D., Fitzpatrick, A. L., Hanon, O., Gill, M., Barber, R., Gudnason, V., Campion, D., Love, S., Bennett, D. A., Amin, N., Berr, C., Tsolaki, M., Buxbaum, J. D., Lopez, O. L., Deramecourt, V., Fox, N. C., Cantwell, L. B., Tárraga, L., Dufouil, C., Hardy, J., Crane, P. K., Eiriksdottir, G., Hannequin, D., Clarke, R., Evans, D., Mosley, T. H., Letenneur, L., Brayne, C., Maier, W., De Jager, P., Emilsson, V., Dartigues, J.-F., Hampel, H., Kamboh, M. I., de Bruijn, R. F. A. G., Tzourio, C., Pastor, P., Larson, E. B., Rotter, J. I., O'Donovan, M. C., Montine, T. J., Nalls, M. A., Mead, S., Reiman, E. M., Jonsson, P. V., Holmes, C., St George-Hyslop, P. H., Boada, M., Passmore, P., Wendland, J. R., Schmidt, R., Morgan, K., Winslow, A. R., Powell, J. F., Carasquillo, M., Younkin, S. G., Jakobsdóttir, J., Kauwe, J. S. K., Wilhelmsen, K. C., Rujescu, D., Nöthen, M. M., Hofman, A., Jones, L., Haines, J. L., Psaty, B. M., Van Broeckhoven, C., Holmans, P., Launer, L. J., Mayeux, R., Lathrop, M., Goate, A. M., Escott-Price, V., Seshadri, S., Pericak-Vance, M. A., Amouyel, P., Williams, J., van Duijn, C. M., Schellenberg, G. D., Farrer, L. A., Adams, P. M. (Collaborator), Albert, M. S. (Collaborator), Albin, R. L. (Collaborator), Apostolova, L. G. (Collaborator), Arnold, S. E. (Collaborator), Asthana, S. (Collaborator), Atwood, C. S. (Collaborator), Baldwin, C. T. (Collaborator), Barmada, M. M. (Collaborator), Barnes, L. L. (Collaborator), Beach, T. G. (Collaborator), Becker, J. T. (Collaborator), Bigio, E. H. (Collaborator), Bird, T. D. (Collaborator), Blacker, D. (Collaborator), Boeve, B. F. (Collaborator), Bowen, J. D. (Collaborator), Boxer, A. (Collaborator), Burke, J. R. (Collaborator), Cairns, N. J. (Collaborator), Cao, C. (Collaborator), Carlson, C. S. (Collaborator), Carlsson, C. M. (Collaborator), Carney, R. M. (Collaborator), Carrasquillo, M. M. (Collaborator), Carroll, S. L. (Collaborator), Chui, H. C. (Collaborator), Clark, D. G. (Collaborator), Corneveaux, J. (Collaborator), Cribbs, D. H. (Collaborator), Crocco, E. A. (Collaborator), Cruchaga, C. (Collaborator), De Jager, P. L. (Collaborator), DeCarli, C. (Collaborator), DeKosky, S. T. (Collaborator), Demirci, F. Y. (Collaborator), Dick, M. (Collaborator), Dickson, D. W. (Collaborator), Doody, R. S. (Collaborator), Duara, R. (Collaborator), Ertekin-Taner, N. (Collaborator), Faber, K. M. (Collaborator), Fairchild, T. J. (Collaborator), Fallon, K. B. (Collaborator), Farlow, M. R. (Collaborator), Ferris, S. (Collaborator), Frosch, M. P. (Collaborator), Galasko, D. R. (Collaborator), Gearing, M. (Collaborator), Geschwind, D. H. (Collaborator), Ghetti, B. (Collaborator), Gilbert, J. R. (Collaborator), Glass, J. D. (Collaborator), Graff-Radford, N. R. (Collaborator), Green, R. C. (Collaborator), Growdon, J. H. (Collaborator), Hakonarson, H. (Collaborator), Hamilton, R. L. (Collaborator), Hardy, J. (Collaborator), Harrell, L. E. (Collaborator), Head, E. (Collaborator), Honig, L. S. (Collaborator), Huebinger, R. M. (Collaborator), Huentelman, M. J. (Collaborator), Hulette, C. M. (Collaborator), Hyman, B. T. (Collaborator), Jarvik, G. P. (Collaborator), Jicha, G. A. (Collaborator), Jin, L.-W. (Collaborator), Karydas, A. (Collaborator), Kauwe, J. S. (Collaborator), Kaye, J. A. (Collaborator), Kim, R. (Collaborator), Koo, E. H. (Collaborator), Kowall, N. W. (Collaborator), Kramer, J. H. (Collaborator), LaFerla, F. M. (Collaborator), Lah, J. J. (Collaborator), Leverenz, J. B. (Collaborator), Levey, A. I. (Collaborator), Li, G. (Collaborator), Lieberman, A. P. (Collaborator), Lin, C.-F. (Collaborator), Lopez, O. L. (Collaborator), Lyketsos, C. G. (Collaborator), Mack, W. J. (Collaborator), Marson, D. C. (Collaborator), Martiniuk, F. (Collaborator), Mash, D. C. (Collaborator), Masliah, E. (Collaborator), McCormick, W. C. (Collaborator), McCurry, S. M. (Collaborator), McDavid, A. N. (Collaborator), McKee, A. C. (Collaborator), Mesulam, M. (Collaborator), Miller, B. L. (Collaborator), Miller, C. A. (Collaborator), Miller, J. W. (Collaborator), Morris, J. C. (Collaborator), Mukherjee, S. (Collaborator), Murrell, J. R. (Collaborator), Myers, A. J. (Collaborator), O'Bryant, S. (Collaborator), Olichney, J. M. (Collaborator), Pankratz, V. S. (Collaborator), Parisi, J. E. (Collaborator), Partch, A. (Collaborator), Paulson, H. L. (Collaborator), Perry, W. (Collaborator), Peskind, E. (Collaborator), Petersen, R. C. (Collaborator), Pierce, A. (Collaborator), Poon, W. W. (Collaborator), Potter, H. (Collaborator), Quinn, J. F. (Collaborator), Raj, A. (Collaborator), Raskind, M. (Collaborator), Reisberg, B. (Collaborator), Reisch, J. S. (Collaborator), Reitz, C. (Collaborator), Ringman, J. M. (Collaborator), Roberson, E. D. (Collaborator), Rogaeva, E. (Collaborator), Rosen, H. J. (Collaborator), Rosenberg, R. N. (Collaborator), Royall, D. R. (Collaborator), Sager, M. A. (Collaborator), Sano, M. (Collaborator), Saykin, A. J. (Collaborator), Schneider, J. A. (Collaborator), Schneider, L. S. (Collaborator), Seeley, W. W. (Collaborator), Smith, A. G. (Collaborator), Sonnen, J. A. (Collaborator), Spina, S. (Collaborator), Stern, R. A. (Collaborator), Tanzi, R. E. (Collaborator), Thornton-Wells, T. A. (Collaborator), Trojanowski, J. Q. (Collaborator), Troncoso, J. C. (Collaborator), Tsuang, D. W. (Collaborator), Van Deerlin, V. M. (Collaborator), Van Eldik, L. J. (Collaborator), Vardarajan, B. N. (Collaborator), Vinters, H. V. (Collaborator), Vonsattel, J. P. (Collaborator), Weintraub, S. (Collaborator), Welsh-Bohmer, K. A. (Collaborator), Williamson, J. (Collaborator), Wishnek, S. (Collaborator), Woltjer, R. L. (Collaborator), Wright, C. B. (Collaborator), Wu, C.-K. (Collaborator), Yu, C.-E. (Collaborator), Yu, L. (Collaborator), Au, R. (Collaborator), Wolf, P. A. (Collaborator), Beiser, A. (Collaborator), Satizabal, C. (Collaborator), Uitterlinden, A. G. (Collaborator), Rivadeneira, F. (Collaborator), Koudstaal, P. J. (Collaborator), Longstreth Jr, W. T. (Collaborator), Kuller, L. H. (Collaborator), Lumley, T. (Collaborator), Rice, K. (Collaborator), Harris, T. B. (Collaborator), Nalls, M. (Collaborator), Marksteiner, J. J. M. (Collaborator), Dal-Bianco, P. (Collaborator), Töglhofer, A. M. (Collaborator), Freudenberger, P. (Collaborator), Ransmayr, G. (Collaborator), Benke, T. (Collaborator), Toeglhofer, A. M. (Collaborator), Boerwinkle, E. (Collaborator), Bressler, J. (Collaborator), Fornage, M. (Collaborator), Morón, F. J. (Collaborator), Hernández, I. (Collaborator), Roca, M. R. (Collaborator), Mauleón, A. (Collaborator), Alegret, M. (Collaborator), Ramírez-Lorca, R. (Collaborator), González-Perez, A. (Collaborator), Alpérovitch, A. (Collaborator), Alvarez, V. (Collaborator), Barberger-Gateau, P. (Collaborator), Bettens, K. (Collaborator), Bossù, P. (Collaborator), Brice, A. (Collaborator), Bullido, M. (Collaborator), Caffara, P. (Collaborator), Clarimon, J. (Collaborator), Combarros, O. (Collaborator), Coto, E. (Collaborator), Zampo, M. D. (Collaborator), Delepine, M. (Collaborator), Deniz Naranjo, M. C. (Collaborator), Epelbaum, J. (Collaborator), Fratiglioni, L. (Collaborator), Galimberti, D. (Collaborator), Graff, C. (Collaborator), Hiltunen, M. (Collaborator), Ingelsson, M. (Collaborator), Keller, L. (Collaborator), Lannfelt, L. (Collaborator), Llèo, A. (Collaborator), Mancuso, M. (Collaborator), Mateo, I. (Collaborator), Mecocci, P. (Collaborator), Nacmias, B. (Collaborator), Panza, F. (Collaborator), Pilotto, A. (Collaborator), Garcia, F. S. (Collaborator), Scarpini, E. (Collaborator), Seripa, D. (Collaborator), Sleegers, K. (Collaborator), Soininen, H. (Collaborator), Sorbi, S. (Collaborator), Spalletta, G. (Collaborator), Wallon, D. (Collaborator), Thomas, C. (Collaborator), Gerrish, A. (Collaborator), Chapman, J. (Collaborator), Stretton, A. (Collaborator), Morgan, A. (Collaborator), Oldham, H. (Collaborator), Owen, M. J. (Collaborator), Kehoe, P. G. (Collaborator), Medway, C. (Collaborator), Brown, K. (Collaborator), Lord, J. (Collaborator), Turton, J. (Collaborator), Hooper, N. M. (Collaborator), Vardy, E. (Collaborator), Warren, J. D. (Collaborator), Schott, J. M. (Collaborator), Uphill, J. (Collaborator), Hollingworth, P. (Collaborator), Psy, D. (Collaborator), Ryan, N. (Collaborator), Rossor, M. (Collaborator), Collinge, J. (Collaborator), Ben-Shlomo, Y. (Collaborator), Makrina, D. (Collaborator), Gkatzima, O. (Collaborator), Lupton, M. (Collaborator), Koutroumani, M. (Collaborator), Avramidou, D. (Collaborator), Germanou, A. (Collaborator), Jessen, F. (Collaborator), Riedel-Heller, S. (Collaborator), Dichgans, M. (Collaborator), Heun, R. (Collaborator), Kölsch, H. (Collaborator), Schürmann, B. (Collaborator), Herold, C. (Collaborator), Lacour, A. (Collaborator), Drichel, D. (Collaborator), Hoffmann, P. (Collaborator), Kornhuber, J. (Collaborator), Gu, W. (Collaborator), Feulner, T. (Collaborator), Mayhaus, M. (Collaborator), Pichler, S. (Collaborator), Riemenschneider, M. (Collaborator), Bussche, H. V. D. (Collaborator), Lawlor, B. (Collaborator), Lynch, A. (Collaborator), Mann, D. (Collaborator), Smith, A. D. (Collaborator), Warden, D. (Collaborator), Wilcock, G. (Collaborator), Heuser, I. (Collaborator), Wiltfang, J. (Collaborator), Frölich, L. (Collaborator), Hüll, M. (Collaborator), Mayo, K. (Collaborator), Livingston, G. (Collaborator), Bass, N. J. (Collaborator), Gurling, H. (Collaborator), McQuillin, A. (Collaborator), Gwilliam, R. (Collaborator), Deloukas, P. (Collaborator), Al-Chalabi, A. (Collaborator), Shaw, C. E. (Collaborator), Singleton, A. B. (Collaborator), Guerreiro, R. (Collaborator), Russo, G. (Collaborator), Jöckel, K.-H. (Collaborator), Moebus, S. (Collaborator), Klopp, N. (Collaborator), Wichmann, H.-E. (Collaborator), Ma, L. (Collaborator), Bisceglio, G. (Collaborator), Fisher, E. (Collaborator), Warner, N. (Collaborator), Pickering-Brown, S. (Collaborator), Craig, D. (Collaborator), Johnston, J. A. (Collaborator), McGuinness, B. (Collaborator), Todd, S. (Collaborator), Rubinsztein, D. C. (Collaborator), Lovestone, S. (Collaborator), Bayer, A. (Collaborator), Gallacher, J. (Collaborator), Proitsi, P. (Collaborator) & Ortega-Cubero, S. (Collaborator), 17 Mar 2015, In: Molecular psychiatry.

Research output: Contribution to journal › Article › peer-review

Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event

Lewis, V., Johanssen, V. A., Crouch, P. J., Klug, G. M., Hooper, N. M. & Collins, S. J., 2015, In: Cell Mol Life Sci.

Research output: Contribution to journal › Article › peer-review

The effects of the cellular and infectious prion protein on the neuronal adaptor protein X11alpha

O'Sullivan, J., Comerford, E., Rachidi, W., Scott, M., Hooper, N. M. & McMahon, H. E., 2015, In: Biochimica et biophysica acta. 1850, 11, p. 2213-21 2191 p.

Research output: Contribution to journal › Article › peer-review

The Role of Tissue Non-specific Alkaline Phosphatase (TNAP) in Neurodegenerative Diseases: Alzheimer's Disease in the Focus

Kellett, K. A. & Hooper, N. M., 2015, In: Subcell Biochem. 76, p. 363-74 288 p.

Research output: Contribution to journal › Article › peer-review

2014

A label-free electrical impedimetric biosensor for the specific detection of Alzheimer's amyloid-beta oligomers

Rushworth, J. V., Ahmed, A., Griffiths, H. H., Pollock, N. M., Hooper, N. M. & Millner, P. A., 15 Jun 2014, In: Biosensors and Bioelectronics. 56, p. 83-90 7 p.

Research output: Contribution to journal › Article › peer-review

Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421

Lambert, D. W., Lambert, L. A., Clarke, N. E., Hooper, N. M., Porter, K. E. & Turner, A. J., 2014, In: Clinical Science. 127, 4, p. 243-249 6 p.

Research output: Contribution to journal › Article › peer-review

Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease.

Sassi, C., Guerreiro, R., Gibbs, R., Ding, J., Lupton, M. K., Troakes, C., Lunnon, K., Al-Sarraj, S., Medway, C., Lord, J., Turton, J., Mann, D., Snowden, J., Neary, D., Harris, J., Bras, J., Powell, J. F., Singleton, A., Hardy, J. & Passmore, P. (Collaborator) & 18 others, Craig, D. (Collaborator), Johnston, J. (Collaborator), McGuinness, B. (Collaborator), Todd, S. (Collaborator), Heun, R. (Collaborator), Kölsch, H. (Collaborator), Kehoe, P. G. (Collaborator), Hooper, N. M. (Collaborator), Vardy, E. R. L. C. (Collaborator), Mann, D. (Collaborator), Pickering-Brown, S. (Collaborator), Brown, K. (Collaborator), Lowe, J. (Collaborator), Morgan, K. (Collaborator), Smith, A. D. (Collaborator), Wilcock, G. (Collaborator), Warden, D. (Collaborator) & Holmes, C. (Collaborator), Oct 2014, In: Neurobiology of Aging. 35, 10, p. 2422e13-e16

Research output: Contribution to journal › Article › peer-review

Heme oxygenase-1 protects against Alzheimer's amyloid-beta(1-42)-induced toxicity via carbon monoxide production

Hettiarachchi, N., Dallas, M., Al-Owais, M., Griffiths, H., Hooper, N., Scragg, J., Boyle, J. & Peers, C., 11 Dec 2014, In: Cell Death Dis. 5, p. 0 e1569.

Research output: Contribution to journal › Article › peer-review

Lipid rafts: linking prion protein to zinc transport and amyloid-beta toxicity in Alzheimer's disease

Watt, N. T., Griffiths, H. H. & Hooper, N. M., 2014, In: Front Cell Dev Biol. 2

Research output: Contribution to journal › Article › peer-review

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.

Cruchaga, C., Karch, C. M., Jin, S. C., Benitez, B. A., Cai, Y., Guerreiro, R., Harari, O., Norton, J., Budde, J., Bertelsen, S., Jeng, A. T., Cooper, B., Skorupa, T., Carrell, D., Levitch, D., Hsu, S., Choi, J., Ryten, M., Hardy, J. & Trabzuni, D. & 60 others, Weale, M. E., Ramasamy, A., Smith, C., Sassi, C., Bras, J., Gibbs, J. R., Hernandez, D. G., Lupton, M. K., Powell, J., Forabosco, P., Ridge, P. G., Corcoran, C. D., Tschanz, J. T., Norton, M. C., Munger, R. G., Schmutz, C., Leary, M., Demirci, F. Y., Bamne, M. N., Wang, X., Lopez, O. L., Ganguli, M., Medway, C., Turton, J., Lord, J., Braae, A., Barber, I., Brown, K., Passmore, P., Craig, D., Johnston, J., McGuinness, B., Todd, S., Heun, R., Kölsch, H., Kehoe, P. G., Hooper, N. M., Vardy, E. R. L. C., Mann, D. M., Pickering-Brown, S., Kalsheker, N., Lowe, J., Morgan, K., David Smith, A., Wilcock, G., Warden, D., Holmes, C., Pastor, P., Lorenzo-Betancor, O., Brkanac, Z., Scott, E., Topol, E., Rogaeva, E., Singleton, A. B., Kamboh, M. I., St George-Hyslop, P., Cairns, N., Morris, J. C., Kauwe, J. S. K. & Goate, A. M., 23 Jan 2014, In: Nature. 505, 7484, p. 550-554 4 p.

Research output: Contribution to journal › Article › peer-review

2013

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design

Mok, N. Y., Chadwick, J., Kellett, K. A. B., Casas-Arce, E., Hooper, N. M., Johnson, A. P. & Fishwick, C. W. G., 14 Mar 2013, In: Journal of Medicinal Chemistry. 56, 5, p. 1843-1852 9 p.

Research output: Contribution to journal › Article › peer-review

Neuronal zinc regulation and the prion protein

Watt, N. T., Griffiths, H. H. & Hooper, N. M., May 2013, In: Prion. 7, 3, p. 203-208 5 p.

Research output: Contribution to journal › Article › peer-review

Prion Protein Is Decreased in Alzheimer's Brain and Inversely Correlates with BACE1 Activity, Amyloid-β Levels and Braak Stage

Whitehouse, I. J., Miners, J. S., Glennon, E. B. C., Kehoe, P. G., Love, S., Kellett, K. A. B. & Hooper, N. M., 5 Apr 2013, In: PLoS ONE. 8, 4, e59554.

Research output: Contribution to journal › Article › peer-review

Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1

Rushworth, J. V., Griffiths, H. H., Watt, N. T. & Hooper, N. M., 29 Mar 2013, In: Journal of Biological Chemistry. 288, 13, p. 8935-8951 16 p.

Research output: Contribution to journal › Article › peer-review

Nigel Hooper

Research output

Search results