Research output per year
Research output per year
- 1 - 50 out of 418 results
Search results
-
2024
A long-term growth stable Halomonas sp. deleted with multiple transposases guided by its metabolic network model Halo-ecGEM
Zhang, L., Ye, J.-W., Li, G., Park, H., Luo, H., Lin, Y., Li, S., Yang, W., Guan, Y., Wu, F., Huang, W., Wu, Q., Scrutton, N. S., Nielsen, J. & Chen, G.-Q., 1 Jul 2024, In: Metabolic Engineering. 84, p. 95-108 14 p.Research output: Contribution to journal › Article › peer-review
-
Photocobilins integrate B12 and bilin photochemistry for enzyme control
Zhang, S., Jeffreys, L. N., Poddar, H., Yu, Y., Liu, C., Patel, K., Johannissen, L. O., Zhu, L., Cliff, M. J., Yan, C., Schirò, G., Weik, M., Sakuma, M., Levy, C. W., Leys, D., Heyes, D. J. & Scrutton, N. S., Dec 2024, In: Nature Communications. 15, 1, 2740.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Biosynthesis of cannabigerol and cannabigerolic acid, the gateways to further cannabinoid production.
Kearsey, L. J., Yan, C., Prandi, N., Toogood, H. S., Takano, E. & Scrutton, N. S., 27 May 2023, In: Synthetic Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Chemoautotrophic production of gaseous hydrocarbons, bioplastics and osmolytes by a novel Halomonas species
Faulkner, M., Hoeven, R., Kelly, P. P., Sun, Y., Park, H., Liu, L.-N., Toogood, H. S. & Scrutton, N. S., 11 Oct 2023, In: Biotechnology for biofuels and bioproducts. 16, 1, p. 152Research output: Contribution to journal › Article › peer-review
-
Co-production of biofuel, bioplastics and biochemicals during extended fermentation of Halomonas bluephagenesis
Park, H., Toogood, H. S., Chen, G.-Q. & Scrutton, N. S., 1 Feb 2023, In: Microbial Biotechnology. 16, 2, p. 307-321 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
High‐titer Bio‐Styrene Production Afforded by Whole‐cell Cascade Biotransformation
Messiha, H., Scrutton, N. & Leys, D., 4 Jan 2023, (E-pub ahead of print) In: ChemCatChem.Research output: Contribution to journal › Article › peer-review
-
Mapping the Initial Stages of a Protective Pathway that Enhances Catalytic Turnover by a Lytic Polysaccharide Monooxygenase
Zhao, J., Zhuo, Y., Diaz , D. .. E., Shanmugam, M., Telfer, A. J., Lindley, P. J., Kracher, D., Hayashi, T., Seibt, L., Hardy, F., Manners, O., Hedison, T., Hollywood, K., Spiess, R., Cain, K., Diaz-Moreno, S., Scrutton, N., Tovborg, M., Walton, P. H. & Heyes, D. J. & 1 others, , 9 Sept 2023, In: American Chemical Society. Journal .Research output: Contribution to journal › Article › peer-review
Open Access -
Online Omics Platform Expedites Industrial Application of Halomonas bluephagenesis TD1.0
Park, H., Faulkner, M., Toogood, H. S., Chen, G.-Q. & Scrutton, N., 9 May 2023, In: Bioinformatics and Biology Insights. 17, p. 11779322231171779Research output: Contribution to journal › Article › peer-review
Open Access -
Photoinduced Electron Transfer from a 1,4,5,6-Tetrahydro Nicotinamide Adenine Dinucleotide (Phosphate) Analog to Oxidized Flavin in an Ene-Reductase Flavoenzyme
Speirs, M., Hardman, S., Iorgu, A. I., Johannissen, L., Heyes, D., Scrutton, N., Sazanovich, I. V. & Hay, S., 6 Apr 2023, In: Journal of Physical Chemistry Letters. 14, 13, p. 3236-3242Research output: Contribution to journal › Article › peer-review
Open Access -
Redox driven B12-ligand switch drives CarH photoresponse
Poddar, H., Rios-Santacruz, R., Heyes, D. J., Shanmugam, M., Brookfield, A., Johannissen, L. O., Levy, C. W., Jeffreys, L. N., Zhang, S., Sakuma, M., Colletier, J. P., Hay, S., Schirò, G., Weik, M., Scrutton, N. S. & Leys, D., Dec 2023, In: Nature Communications. 14, 1, 5082.Research output: Contribution to journal › Article › peer-review
Open Access -
Structure-based design of small imine reductase panels for target substrates
Yu, Y., Rué Casamajo, A., Finnigan, W., Schnepel, C., Barker, R., Morrill, C., Heath, R., De Maria, L., Turner, N. & Scrutton, N., 5 Sept 2023, In: ACS Catalysis.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
A guide to time-resolved structural analysis of light-activated proteins
Poddar, H., Heyes, D., Schirò, G., Weik , M., Leys, D. & Scrutton, N., 1 Feb 2022, In: The FEBS Journal. 289, 3, p. 576-595 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Baseline proteomics characterisation of the emerging host biomanufacturing organism Halomonas bluephagenesis
Russell, M., Currin, A., Rowe, W., Chen, G.-Q., Barran, P. & Scrutton, N. S., 13 Aug 2022, In: Scientific Data. 9, 1, 492.Research output: Contribution to journal › Article › peer-review
Open Access -
Bioproduction of Linalool From Paper Mill Waste
Rinaldi, M. A., Tait, S., Toogood, H. S. & Scrutton, N. S., 30 May 2022, In: Frontiers in Bioengineering and Biotechnology. 10, p. 892896 892896.Research output: Contribution to journal › Article › peer-review
Open Access -
Combined pulsed electron double resonance EPR and molecular dynamics investigations of calmodulin suggest effect of crowding agents on protein structure
Shanmugam, M., Kutta, R., Scrutton, N., Lovett, J. & Hay, S., 9 Aug 2022, (Accepted/In press) In: Biochemistry.Research output: Contribution to journal › Article › peer-review
-
Co-production of biofuel, bioplastics, and biochemicals during extended fermentation of Halomonas bluephagenesis
Park, H., Toogood, H. S., Chen, G.-Q. & Scrutton, N. S., 29 Sept 2022, (Accepted/In press) In: Microbial Biotechnology.Research output: Contribution to journal › Article › peer-review
-
How a 10-epi-cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity
Whitehead, J. N., Leferink, N. G. H., Komati Reddy, G., Levy, C. W., Hay, S., Takano, E. & Scrutton, N. S., 7 Oct 2022, In: ACS Catalysis. 12, 19, p. 12123–12131Research output: Contribution to journal › Article › peer-review
Open Access -
How Photoactivation Triggers Protochlorophyllide Reduction: Computational Evidence of a Stepwise Hydride Transfer During Chlorophyll Biosynthesis
Johannissen, L., Taylor, A., Hardman, S., Heyes, D., Scrutton, N. & Hay, S., 8 Mar 2022, (Accepted/In press) In: ACS Catalysis.Research output: Contribution to journal › Article › peer-review
-
Molecular determinants of carbocation cyclisation in bacterial monoterpene synthases
Leferink, N., Escorcia, A. M., Ouwersloot, B. R., Johanissen, L. O., Hay, S., van der Kamp, M. W. & Scrutton, N., 10 Jan 2022, In: CHEMBIOCHEM.Research output: Contribution to journal › Article › peer-review
-
Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases
Rose, S. L., Baba, S., Okumura, H., Antonyuk, S. V., Sasaki, D., Hedison, T. M., Shanmugam, M., Heyes, D. J., Scrutton, N. S., Kumasaka, T., Tosha, T., Eady, R. R., Yamamoto, M. & Hasnain, S. S., 26 Jul 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 30, e2205664119.Research output: Contribution to journal › Article › peer-review
Open Access -
Solution-State Inter-Copper Distribution of Redox Partner-Linked Copper Nitrite Reductases: A Pulsed Electron–Electron Double Resonance Spectroscopy Study
Hedison, T. M., Iorgu, A. I., Calabrese, D., Heyes, D. J., Shanmugam, M. & Scrutton, N. S., 22 Jul 2022, In: The journal of physical chemistry letters. p. 6927-6934Research output: Contribution to journal › Article › peer-review
Open Access -
StarCrete: a starch-based regolith biocomposite for extraterrestrial construction
Roberts, A. & Scrutton, N., 30 Nov 2022, (Accepted/In press) In: Open Engineering.Research output: Contribution to journal › Article › peer-review
-
The Mechanism of Action of Flavin-Dependent Halogenases
Barker, R., Yu, Y., De Maria, L., Johannissen, L. & Scrutton, N., 16 Dec 2022, In: ACS Catalysis. 12, 24, p. 15352–15360Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Alternative metabolic pathways and strategies to high-titre terpenoid production in Escherichia coli
Rinaldi, M., Anhel Ferraz, C. & Scrutton, N., 14 Jun 2021, (Accepted/In press) In: Natural Product Reports.Research output: Contribution to journal › Article › peer-review
-
A plasmid toolset for CRISPR-mediated genome editing and CRISPRi gene regulation in Escherichia coli
Jervis, A., Hanko, E., Dunstan, M., Robinson, C., Takano, E. & Scrutton, N., 12 Mar 2021, In: Microbial Biotechnology.Research output: Contribution to journal › Article › peer-review
Open Access -
Blood, sweat and tears: extraterrestrial regolith biocomposites with in vivo binders
Roberts, A., Whittall, D., Breitling, R., Takano, E., Blaker, J., Hay, S. & Scrutton, N., 3 Sept 2021, (Accepted/In press) In: Materials Today Bio.Research output: Contribution to journal › Article › peer-review
-
Combinatorial Use of Environmental Stresses and Genetic Engineering to Increase Ethanol Titres in Cyanobacteria
Andrews, F., Faulkner, M., Toogood, H. & Scrutton, N., 5 Dec 2021, (Accepted/In press) In: Biotechnology for Biofuels.Research output: Contribution to journal › Article › peer-review
-
Enzyme immobilisation on wood-derived cellulose scaffolds via carbohydrate-binding module fusion constructs
Roberts, A., Payne, K., Cosgrove, S., Tilakaratna, V., Penafiel, I., Finnigan, W., Turner, N. & Scrutton, N., 25 May 2021, (Accepted/In press) In: Green Chemistry.Research output: Contribution to journal › Article › peer-review
-
Inflammation control and improvement of cognitive function in COVID-19 infections: Is there a role for kynurenine 3-monooxygenase inhibition?
Collier, M. E. W., Zhang, S., Scrutton, N. & Giorgini, F., 18 Feb 2021, In: Drug discovery today.Research output: Contribution to journal › Article › peer-review
Open AccessFile61 Downloads (Pure) -
Isopentenol utilization pathway for the production of linalool in Escherichia coli using an improved bacterial linalool/nerolidol synthase
Ferraz, C. A., Leferink, N. G. H., Kosov, I. & Scrutton, N., 3 May 2021, (E-pub ahead of print) In: CHEMBIOCHEM.Research output: Contribution to journal › Article › peer-review
Open AccessFile75 Downloads (Pure) -
Making molecules with photodecarboxylases: a great start or a false dawn?
Hedison, T., Heyes, D. & Scrutton, N., 14 Dec 2021, (Accepted/In press) In: Current Research in Chemical Biology.Research output: Contribution to journal › Article › peer-review
-
Predictive engineering of class I terpene synthases using experimental and computational approaches
Leferink, N. & Scrutton, N. S., 20 Oct 2021, (E-pub ahead of print) In: CHEMBIOCHEM.Research output: Contribution to journal › Article › peer-review
-
Prototyping of microbial chassis for the biomanufacturing of high-value chemical targets
Robinson, C. J., Tellechea-luzardo, J., Carbonell, P., Jervis, A. J., Yan, C., Hollywood, K. A., Dunstan, M. S., Currin, A., Takano, E. & Scrutton, N. S., 8 Jun 2021, In: Biochemical Society Transactions.Research output: Contribution to journal › Article › peer-review
-
The evolving art of creating genetic diversity: from directed evolution to synthetic biology
Currin, A., Parker, S., Robinson, C., Takano, E., Scrutton, N. & Breitling, R., 26 Apr 2021, (Accepted/In press) In: Biotechnology Advances.Research output: Contribution to journal › Article › peer-review
-
2020
A biological route to conjugated alkenes: microbial production of hepta-1,3,5-triene
Messiha, H., Payne, K., Scrutton, N. & Leys, D., 10 Dec 2020, (Accepted/In press) In: ACS Synthetic Biology.Research output: Contribution to journal › Article › peer-review
-
Active Intermediates in Copper Nitrite Reductase Reactions Probed by a Cryotrapping‐Electron Paramagnetic Resonance Approach
Hedison, T. M., Shanmugam, M., Heyes, D. J., Edge, R. & Scrutton, N., 30 Apr 2020, (E-pub ahead of print) In: Angewandte Chemie International Edition.Research output: Contribution to journal › Article › peer-review
Open Access -
Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases
Zhang, S., Collier, M. E. W., Heyes, D., Giorgini, F. & Scrutton, N., 1 Dec 2020, (E-pub ahead of print) In: Archives of Biochemistry and Biophysics.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Downloads (Pure) -
Dual Role of the Active Site ‘Lid’ Regions of Protochlorophyllide Oxidoreductase in Photocatalysis and Plant Development
Zhang, S., Godwin, A., Taylor, A., Hardman, S., Jowitt, T., Johannissen, L., Hay, S., Baldock, C., Heyes, D. & Scrutton, N., 31 Aug 2020, (E-pub ahead of print) In: The FEBS Journal.Research output: Contribution to journal › Article › peer-review
Open Access -
Engineering Escherichia coli towards de novo production of gatekeeper (2S)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol.
Dunstan, M., Robinson, C., Jervis, A., Yan, C., Carbonell, P., Hollywood, K., Currin, A., Swainston, N., Le Feuvre, R., Micklefield, J., Faulon, J.-L., Breitling, R., Turner, N., Takano, E. & Scrutton, N., 6 Aug 2020, In: Synthetic Biology . 5, 1, ysaa012.Research output: Contribution to journal › Article › peer-review
Open Access -
Exploiting Single Domain Antibodies as Regulatory Parts to Modulate Monoterpenoid Production in E. coli
Wilkes, J., Scott-tucker, A., Wright, M., Crabbe, T. & Scrutton, N., 16 Oct 2020, In: ACS Synthetic Biology. 9, 10, p. 2828-2839 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile132 Downloads (Pure) -
Exploring Novel Bacterial Terpene Synthases
Komati Reddy, G., Leferink, N., Umemura, M., Ahmed, S., Breitling, R., Scrutton, N. & Takano, E., 10 Apr 2020, (Accepted/In press) In: P L o S One.Research output: Contribution to journal › Article › peer-review
-
Flavin doesn’t put all oxygens in one basket
Leys, D. & Scrutton, N. S., 22 Apr 2020, In: Nature chemical biology. 16, 5, p. 485-486Research output: Contribution to journal › Article
Open AccessFile123 Downloads (Pure) -
Hierarchically porous silk/activated-carbon composite fibres for adsorption and repellence of volatile organic compounds
Roberts, A., Lee, J.-S. M., Magaz, A., Smith, M. W., Dennis, M., Scrutton, N. & Blaker, J., 7 Mar 2020, In: Molecules. 25, 5, p. 1-7 7 p., 1207.Research output: Contribution to journal › Article › peer-review
Open Access -
In conversation with Nigel Scrutton
Dhillon, P. & Scrutton, N. S., 29 Dec 2020, In: The FEBS Journal.Research output: Contribution to journal › Article
Open Access -
Insights into the H2O2 ‐driven catalytic mechanism of fungal lytic polysaccharide monooxygenases
Hedison, T. M., Breslmayr, E., Shanmugam, M., Karnpakdee, K., Heyes, D. J., Green, A. P., Ludwig, R., Scrutton, N. S. & Kracher, D., 23 Dec 2020, In: The FEBS Journal.Research output: Contribution to journal › Article › peer-review
Open Access -
In silico design and automated learning to boost next-generation smart biomanufacturing
Carbonell, P., Le Feuvre, R., Takano, E. & Scrutton, N., 17 Oct 2020, (E-pub ahead of print) In: Synthetic Biology . 5, 1Research output: Contribution to journal › Article › peer-review
Open Access -
Low Carbon Strategies for Sustainable Bio-alkane Gas Production and Renewable Energy
Amer, M., Wojcik, E., Sun, C., Hoeven, R., Hughes, J., Faulkner, M., Yunus, I. S., Tait, S., Johannissen, L., Hardman, S., Heyes, D., Chen, G.-Q., Smith, M. H., Jones, P. R., Toogood, H. & Scrutton, N., 19 May 2020, In: Energy & Environmental Science.Research output: Contribution to journal › Article › peer-review
Open Access -
Non-covalent protein-based adhesives for transparent substrates – bovine serum albumin vs. recombinant spider silk
Roberts, A., Finnigan, W., Kelly, P., Faulkner, M., Breitling, R., Takano, E., Scrutton, N., Blaker, J. & Hay, S., 10 Jul 2020, In: Materials Today Bio. 7, p. 100068Research output: Contribution to journal › Article › peer-review
Open Access -
Photochemical mechanism of light-driven fatty acid photodecarboxylase
Heyes, D. J., Lakavath, B., Hardman, S. J. O., Sakuma, M., Hedison, T. M. & Scrutton, N. S., 19 Jun 2020, In: ACS Catalysis. 10, 12, p. 6691-6696 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Photocycle of cyanobacteriochrome TePixJ
Hardman, S. J. O., Heyes, D. J., Sazanovich, I. V. & Scrutton, N. S., 18 Aug 2020, In: Biochemistry. 59, 32, p. 2909-2915 7 p.Research output: Contribution to journal › Article › peer-review
Open Access