Nisha Nair, PhD

Search results

• 2023

  Identification of cell‐specific differential DNA methylation associated with methotrexate treatment response in rheumatoid arthritis

  Adams, C., Nair, N., Plant, D., Verstappen, S., Quach, H. L., L. Quach, D., Carvidi, A., Nititham, J., Nakamura, M., Barton, A., Graff, J., Criswell, L. A. & F. Barcellos, L., 30 Jan 2023, (E-pub ahead of print) In: Arthritis & Rheumatology (Hoboken).

  Research output: Contribution to journal › Article › peer-review

  • Methotrexate 100%
  • Rheumatoid Arthritis 87%
  • DNA Methylation 87%
  • Inflammatory Arthritis 87%
  • Cells 75%

• Pre-treatment calprotectin (MRP8/14) provides no added value to testing CRP alone in terms of predicting response to TNF inhibitors in rheumatoid arthritis in a post-hoc analysis

  Smith, S., Alexander, S., Nair, N., Viatte, S., Eyre, S., Hyrich, K., Morgan, A. W., Wilson, A. G., Isaacs, J. D., Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS), Plant, D. & Barton, A., 12 Jan 2023, (Accepted/In press) In: Annals of Rheumatic Diseases.

  Research output: Contribution to journal › Article › peer-review

  • Rheumatoid Arthritis 100%
  • Patient 85%
  • Association 57%
  • Time 28%
  • Enalapril Maleate 28%
• 2022

  Non-Trough Adalimumab and Certolizumab Drug Levels Associated with a Therapeutic EULAR Response in Adherent Patients with Rheumatoid Arthritis

  Hum, R. M., Ho, P., Nair, N., Jani, M., Morgan, A. W., Isaacs, J. D., Wilson, A. G., Hyrich, K. L., Plant, D., Barton, A. & BRAGGSS Study Group, 17 Sep 2022, (Accepted/In press) In: Rheumatology (Print).

  Research output: Contribution to journal › Article › peer-review

  • Drug 100%
  • Adalimumab 46%
  • Rheumatoid Arthritis 7%
  • Tumor Necrosis Factor Inhibitor 7%
  • Observational Study 7%

• Pre-defined gene co-expression modules in rheumatoid arthritis transition towards molecular health following anti-TNF therapy

  Sutcliffe, M., Nair, N., Oliver, J., Morgan, A. W., Isaacs, J. D., Wilson, A., Verstappen, S., Viatte, S., Hyrich, K., Morris, A., Barton, A. & Plant, D., 4 Apr 2022, In: Rheumatology (Oxford).

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Therapeutic Procedure 100%
  • Patient 100%
  • Rheumatoid Arthritis 83%
  • TNF Inhibitor 83%
  • Tumor Necrosis Factor Inhibitor 83%
• 2021

  Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics

  Maciejewski, M., Sands, C., Nair, N., Ling, S., Verstappen, S., Hyrich, K., Barton, A., Ziemek, D., Lewis, M. R. & Plant, D., 1 Dec 2021, In: Scientific Reports. 11, 1, 7266.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Methotrexate 100%
  • Patient 66%
  • Rheumatoid Arthritis 66%
  • Lipid Level 66%
  • Inflammatory Arthritis 66%

• The effect of season of birth on brain epigenome-wide DNA methylation of older adults

  Didikoglu, A., Nair, N., Robinson, A. C., Roncaroli, F., Pendleton, N., Payton, A. & Canal, M. M., 2021, In: Journal of Developmental Origins of Health and Disease. p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Birth 100%
  • Light 66%
  • DNA Methylation 66%
  • Brain 66%
  • Nested Gene 50%
  66 Downloads (Pure)

• Transcriptome-wide study of TNF-inhibitor therapy in rheumatoid arthritis reveals early signature of successful treatment

  Oliver, J., Nair, N., Orozco, G., Smith, S., Hyrich, K., Morgan, A. W., Isaacs, J. D., Wilson, A., BRAGGSS., Barton, A. & Plant, D., 10 Mar 2021, In: Arthritis Research & Therapy. 23, 1, 80.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Transcriptome 100%
  • Adalimumab 80%
  • Quantitative Reverse Transcription Polymerase Chain Reaction 80%
  • Inflammatory Arthritis 80%
  • Time 40%
  43 Downloads (Pure)
• 2020

  A restricted spectrum of missense KMT2D variants cause a multiple malformations disorder distinct from Kabuki syndrome

  Cuvertino, S., Garner, T., Nair, N., Faundes Gomez, V., Sellers, R., Barton, A., Kimber, S., Banka, S. & et al., 2020, In: Genetics in Medicine.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Kabuki Syndrome 100%
  • Diseases 60%
  • Exon 60%
  • Clinical Feature 40%
  • Patient 20%

• Correction: A restricted spectrum of missense KMT2D variants cause a multiple malformations disorder distinct from Kabuki syndrome.

  Cuvertino, S., Hartill, V., Colyer, A., Garner, T., Nair, N., Al-Gazali, L., Canham, N., Faundes, V., Flinter, F., Hertecant, J., Holder-Espinasse, M., Jackson, B. & Banka, S., May 2020, In: Genetics in medicine : official journal of the American College of Medical Genetics.

  Research output: Contribution to journal › Article

• Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between IL18RAP expression and treatment response

  Cherlin, S., Lewis, M. J., Plant, D., Nair, N., Goldmann, K., Tzanis, E., Barnes, M. R., McKeigue, P., Barrett, J. H., Pitzalis, C., Barton, A., MATURA Consortium & Cordell, H. J., 12 Oct 2020, In: Annals of the rheumatic diseases. 79, 11, p. 1446-1452 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-18 Receptor 100%
  • Gene Expression 83%
  • Association 66%
  • Erythrocyte Sedimentation Rate 66%
  • Inflammatory Arthritis 50%

• Latent Class Trajectory Modeling of 2-Component Disease Activity Score in 28 Joints Identifies Multiple Rheumatoid Arthritis Phenotypes of Response to Biologic Disease-Modifying Antirheumatic Drugs

  BRAGGSS Study Group, 1 Oct 2020, In: Arthritis & Rheumatology (Hoboken). 72, 10, p. 1632-1642 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DAS28 100%
  • Therapeutic Procedure 50%
  • Patient 40%
  • Rheumatoid Arthritis 40%
  • Comorbidity 40%

• Lymphocyte DNA methylation mediates genetic risk at shared immune mediated disease loci

  Clark, A. D., Nair, N., Anderson, A. E., Thalayasingam, N., Naamane, N., Skelton, A. J., Diboll, J., Barton, A., Eyre, S., Isaacs, J. D., Pratt, A. G. & Reynard, L. N., 2020, In: The Journal of allergy and clinical immunology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rheumatoid Arthritis 100%
  • Inflammatory Arthritis 100%
  • Diseases 80%
  • T-Helper Cell 80%
  • DNA Methylation 60%

• Pharmacogenetics of TNFi Response in Rheumatoid Arthritis Utilising the Two-Component Disease Activity Score

  Gilani, S. S. A., Nair, N., Plant, D., Hyrich, K., Morgan, A. W., Morris, A., Wilson, A. G., Isaacs, J. D., Barton, A. & Bluett, J., 17 Aug 2020, (Accepted/In press) In: Pharmacogenomics.

  Research output: Contribution to journal › Article › peer-review

  • Single Nucleotide Polymorphism 100%
  • DAS28 100%
  • TNF Inhibitor 50%
  • Tumor Necrosis Factor Inhibitor 50%
  • Patient 33%

• Predicting treatment response to IL6R blockers in rheumatoid arthritis

  Nouri, B., Nair, N. & Barton, A., 31 Aug 2020, In: Rheumatology. 59, 12, p. 3603-3610

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biological Product 100%
  • Treatment 75%
  • Patient 50%
  • Drug 50%
  • Biological Marker 50%

• Proteomic analysis to define predictors of treatment response to adalimumab or methotrexate in rheumatoid arthritis patients

  Ling, S., Nair, N., Verstappen, S., Barton, A., Zucht, H-D., Budde, P., Schulz-Knappe, P., MATURA & Plant, D., 2020, In: The Pharmacogenomics Journal. p. 1-8 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Inflammatory Arthritis 100%
  • Autoantibodies 75%
  • Peptide Antibody 62%
  • Association 12%
  • Methotrexate 12%
• 2019

  Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39

  Spiliopoulou, A., Colombo, M., Plant, D., Nair, N., Cui, J., Coenen, M. J. H., Ikari, K., Yamanaka, H., Saevarsdottir, S., Padyukov, L., Bridges, S. L., Kimberly, R. P., Okada, Y., Van Riel, P. L. C. M., Wolbink, G., Van Der Horst-Bruinsma, I. E., De Vries, N., Tak, P. P., Ohmura, K., Canhão, H., & 12 othersGuchelaar, H. J., Huizinga, T. W. J., Criswell, L. A., Raychaudhuri, S., Weinblatt, M. E., Wilson, A. G., Mariette, X., Isaacs, J. D., Morgan, A. W., Pitzalis, C., Barton, A. & McKeigue, P., 2019, In: Annals of the rheumatic diseases. 78, 8, p. 1055-1061

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Association 100%
  • TNF Inhibitor 75%
  • Methotrexate 37%
  • Drug Response 25%
  • Nested Gene 12%

• Differential DNA Methylation Correlates with Response to Methotrexate in Rheumatoid Arthritis

  MATURA Consortium, 10 Oct 2019, (E-pub ahead of print) In: Rheumatology (Oxford).

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rheumatoid Arthritis 100%
  • Inflammatory Arthritis 100%
  • Patient 66%
  • Methotrexate 66%
  • Joint 66%

• Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis

  Anderson, A. E., Maney, N. J., Nair, N., Lendrem, D. W., Skelton, A. J., Diboll, J., Brown, P. M., Smith, G. R., Carmody, R. J., Barton, A., Isaacs, J. D. & Pratt, A. G., 1 Jul 2019, In: Rheumatology (United Kingdom). 58, 7, p. 1250-1258 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcription 100%
  • Signal Transduction 100%
  • Cell Signaling 100%
  • T-Helper Cell 66%
  • Nested Gene 50%

• Genetics of Chronic Musculoskeletal Pain

  Nair, N., Holliday, K., Thomson, W. & Mcbeth, J., 2019, Oxford Textbook of Rheumatology. RA, W., PG, C., C, D., H, F., J, I. & U, M-L. (eds.). Revised 4th ed. Oxford University Press, 45

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

• Profiling of gene expression biomarkers as a classifier of methotrexate nonresponse in patients with rheumatoid arthritis

  Plant, D., Maciejewski, M., Smith, S., Nair, N., MATURA Consortium, RAMS Co-Investigators, Hyrich, K., Ziemek, D., Barton, A. & Verstappen, S., 2019, In: Arthritis and Rheumatology. 71, 5, p. 678-684

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Methotrexate 100%
  • Rheumatoid Arthritis 83%
  • Patient 66%
  • Enalapril Maleate 66%
  • Classifier 66%
• 2018

  CD4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in untreated early arthritis: implications for causal gene identification

  Thalayasingam, N., Nair, N., Skelton, A. J., Massey, J., Anderson, A. E., Clark, A. D., Diboll, J., Lendrem, D. W., Reynard, L. N., Cordell, H. J., Eyre, S., Isaacs, J. D., Barton, A. & Pratt, A. G., 2018, In: Arthritis and Rheumatology. 70, 3, p. 361-370

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Expression Quantitative Trait Loci 100%
  • CD4 71%
  • Nested Gene 42%
  • Lymphocyte 42%
  • Genetic Risk 28%
• 2017

  DNA methylation as a marker of response in rheumatoid arthritis

  Nair, N., Wilson, A. G. & Barton, A., 2017, In: Pharmacogenomics. 18, 14, p. 1323-1332 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Patient 100%
  • Rheumatoid Arthritis 100%
  • DNA Methylation 100%
  • Diseases 50%
  • Disease Activity 25%
  110 Downloads (Pure)
• 2016

  Differential methylation as a biomarker of response to etanercept in patients with rheumatoid arthritis

  Plant, D., Webster, A., Nair, N., Oliver, J., Smith, S. L., Eyre, S., Hyrich, KL., Wilson, AG., Morgan, AW., Isaacs, J., Worthington, J. & Barton, A., 2016, In: Arthritis Care & Research. 68, 6, p. 1353–1360

  Research output: Contribution to journal › Article › peer-review

  Open Access