Research output per year
Research output per year
- 30 results
Search results
-
2024
Population Pharmacokinetic Analysis and Simulation of Alternative Dosing Regimens for Biosimilars to Adalimumab and Etanercept in Patients with Rheumatoid Arthritis
Ling, S. F., Ogungbenro, K., Darwich, A. S., Ariff, A. B. M., Nair, N., Bluett, J., Morgan, A. W., Isaacs, J. D., Wilson, A. G., Hyrich, K. L., Barton, A. & Plant, D., 23 May 2024, In: Pharmaceutics. 16, 6, 702.Research output: Contribution to journal › Article › peer-review
Open Access -
Using polygenic risk scores to aid diagnosis of patients with early inflammatory arthritis: results from the Norfolk Arthritis Register
Hum, R. M., Sharma, S., Stadler, M., Viatte, S., Ho, P., Nair, N., Shi, C., Yap, C. F., Soomro, M., Plant, D., Humphreys, J., Macgregor, A., Yates, M., Verstappen, S., Barton, A., Bowes, J. & NOAR collaborators, 17 Jan 2024, (E-pub ahead of print) In: Arthritis and Rheumatology.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
A proteomics study of rheumatoid arthritis patients on etanercept identifies putative biomarkers associated with clinical outcome measures
Ling, S., Yap, C. F., Nair, N., Bluett, J., Morgan, A. W., Isaacs, J. D., Wilson, A. G., Hyrich, K., Barton, A. & Plant, D., 30 Jun 2023, In: Rheumatology.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Downloads (Pure) -
Expression quantitative trait loci analysis in rheumatoid arthritis identifies tissue specific variants associated with severity and outcome
Goldmann, K., Spiliopoulou, A., Iakovliev, A., Plant, D., Nair, N., Cubuk, C., Consortium, T. M., McKeigue, P., Barnes, M. R., Barton, A., Pitzalis, C. & Lewis, M. J., 18 Nov 2023, In: Annals of the rheumatic diseases.Research output: Contribution to journal › Article › peer-review
Open Access -
HLA-DRB1 and HLA-DQA Associated with Immunogenicity to Adalimumab therapy in Patients with Rheumatoid Arthritis
Yap, C. F., Nair, N., BRAGGSS Study Group, de Vries, A., Loeff, F. C., Morgan, A. W., Isaacs, J. D., Wilson, A. G., Hyrich, K., Barton, A. & Plant, D., 12 Sept 2023, In: Annals of the rheumatic diseases.Research output: Contribution to journal › Article › peer-review
Open Access -
Identification of cell‐specific differential DNA methylation associated with methotrexate treatment response in rheumatoid arthritis
Adams, C. (Lead), Nair, N., Plant, D., Verstappen, S., Quach, H. L., L. Quach, D., Carvidi, A., Nititham, J., Nakamura, M., Barton, A., Graff, J., Criswell, L. A. & F. Barcellos, L. (Corresponding), 30 Jan 2023, (E-pub ahead of print) In: Arthritis & Rheumatology (Hoboken).Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Downloads (Pure) -
Non-Trough Adalimumab and Certolizumab Drug Levels Associated with a Therapeutic EULAR Response in Adherent Patients with Rheumatoid Arthritis
Hum, R. M., Ho, P., Nair, N., Jani, M., Morgan, A. W., Isaacs, J. D., Wilson, A. G., Hyrich, K. L., Plant, D., Barton, A. & BRAGGSS Study Group, 1 Jun 2023, In: Rheumatology (Print). 62, 6, p. 2090-2097 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
P042 Using a Genetic PROBability tool (G-PROB) to aid diagnosis of patients with inflammatory arthritis: results from the Norfolk Arthritis Register
Hum, R. M., Devi Sharma, S., Stadler, M., Nair, N., Viatte, S., Yap, C. F., Humphreys, J., MacGregor, A. J., Yates, M., Soomro, M., Verstappen, S., Ho, P., Barton, A., Bowes, J. & collaborators, N., 2023.Research output: Contribution to conference › Abstract
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Pre-treatment calprotectin (MRP8/14) provides no added value to testing CRP alone in terms of predicting response to TNF inhibitors in rheumatoid arthritis in a post-hoc analysis
Smith, S., Alexander, S., Nair, N., Viatte, S., Eyre, S., Hyrich, K., Morgan, A. W., Wilson, A. G., Isaacs, J. D., Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS), Plant, D. & Barton, A., 18 Oct 2023, In: Annals of Rheumatic Diseases. 82, p. 611-620Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Pre-defined gene co-expression modules in rheumatoid arthritis transition towards molecular health following anti-TNF therapy
Sutcliffe, M., Nair, N., Oliver, J., Morgan, A. W., Isaacs, J. D., Wilson, A., Verstappen, S., Viatte, S., Hyrich, K., Morris, A., Barton, A. & Plant, D., 4 Apr 2022, In: Rheumatology (Oxford).Research output: Contribution to journal › Article › peer-review
Open Access -
Therapeutic Drug Levels to Achieve Good Eular Response in Patients with Rheumatoid Arthritis Receiving Adalimumab: Results From the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (braggss) Cohort
Hum, R., Ho, P., Nair, N., Plant, D., Morgan, A., Isaacs, J., Wilson, A. G., Hyrich, K. & Barton, A., Jun 2022, p. 1297-1298. 2 p.Research output: Contribution to conference › Abstract
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2021
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics
Maciejewski, M., Sands, C., Nair, N., Ling, S., Verstappen, S., Hyrich, K., Barton, A., Ziemek, D., Lewis, M. R. & Plant, D., 1 Dec 2021, In: Scientific Reports. 11, 1, 7266.Research output: Contribution to journal › Article › peer-review
Open Access -
The effect of season of birth on brain epigenome-wide DNA methylation of older adults
Didikoglu, A., Nair, N., Robinson, A. C., Roncaroli, F., Pendleton, N., Payton, A. & Canal, M. M., 2021, In: Journal of Developmental Origins of Health and Disease. p. 1-11 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile120 Downloads (Pure) -
Transcriptome-wide study of TNF-inhibitor therapy in rheumatoid arthritis reveals early signature of successful treatment
Oliver, J., Nair, N., Orozco, G., Smith, S., Hyrich, K., Morgan, A. W., Isaacs, J. D., Wilson, A., BRAGGSS., Barton, A. & Plant, D., 10 Mar 2021, In: Arthritis Research & Therapy. 23, 1, 80.Research output: Contribution to journal › Article › peer-review
Open AccessFile82 Downloads (Pure) -
2020
A restricted spectrum of missense KMT2D variants cause a multiple malformations disorder distinct from Kabuki syndrome
Cuvertino, S., Garner, T., Nair, N., Faundes Gomez, V., Sellers, R., Barton, A., Kimber, S., Banka, S. & et al., 2020, In: Genetics in Medicine.Research output: Contribution to journal › Article › peer-review
Open Access -
Correction: A restricted spectrum of missense KMT2D variants cause a multiple malformations disorder distinct from Kabuki syndrome.
Cuvertino, S., Hartill, V., Colyer, A., Garner, T., Nair, N., Al-Gazali, L., Canham, N., Faundes, V., Flinter, F., Hertecant, J., Holder-Espinasse, M., Jackson, B. & Banka, S., May 2020, In: Genetics in medicine : official journal of the American College of Medical Genetics.Research output: Contribution to journal › Article
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Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between IL18RAP expression and treatment response
Cherlin, S., Lewis, M. J., Plant, D., Nair, N., Goldmann, K., Tzanis, E., Barnes, M. R., McKeigue, P., Barrett, J. H., Pitzalis, C., Barton, A., MATURA Consortium & Cordell, H. J., 12 Oct 2020, In: Annals of the rheumatic diseases. 79, 11, p. 1446-1452 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Latent Class Trajectory Modeling of 2-Component Disease Activity Score in 28 Joints Identifies Multiple Rheumatoid Arthritis Phenotypes of Response to Biologic Disease-Modifying Antirheumatic Drugs
BRAGGSS Study Group, 1 Oct 2020, In: Arthritis & Rheumatology (Hoboken). 72, 10, p. 1632-1642 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Lymphocyte DNA methylation mediates genetic risk at shared immune mediated disease loci
Clark, A. D., Nair, N., Anderson, A. E., Thalayasingam, N., Naamane, N., Skelton, A. J., Diboll, J., Barton, A., Eyre, S., Isaacs, J. D., Pratt, A. G. & Reynard, L. N., 2020, In: The Journal of allergy and clinical immunology.Research output: Contribution to journal › Article › peer-review
Open Access -
Pharmacogenetics of TNFi Response in Rheumatoid Arthritis Utilising the Two-Component Disease Activity Score
Gilani, S. S. A., Nair, N., Plant, D., Hyrich, K., Morgan, A. W., Morris, A., Wilson, A. G., Isaacs, J. D., Barton, A. & Bluett, J., 17 Aug 2020, (Accepted/In press) In: Pharmacogenomics.Research output: Contribution to journal › Article › peer-review
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Predicting treatment response to IL6R blockers in rheumatoid arthritis
Nouri, B., Nair, N. & Barton, A., 31 Aug 2020, In: Rheumatology. 59, 12, p. 3603-3610Research output: Contribution to journal › Article › peer-review
Open Access -
Proteomic analysis to define predictors of treatment response to adalimumab or methotrexate in rheumatoid arthritis patients
Ling, S., Nair, N., Verstappen, S., Barton, A., Zucht, H.-D., Budde, P., Schulz-Knappe, P., MATURA & Plant, D., 2020, In: The Pharmacogenomics Journal. p. 1-8 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39
Spiliopoulou, A., Colombo, M., Plant, D., Nair, N., Cui, J., Coenen, M. J. H., Ikari, K., Yamanaka, H., Saevarsdottir, S., Padyukov, L., Bridges, S. L., Kimberly, R. P., Okada, Y., Van Riel, P. L. C. M., Wolbink, G., Van Der Horst-Bruinsma, I. E., De Vries, N., Tak, P. P., Ohmura, K. & Canhão, H. & 12 others, , 2019, In: Annals of the rheumatic diseases. 78, 8, p. 1055-1061Research output: Contribution to journal › Article › peer-review
Open Access -
Differential DNA Methylation Correlates with Response to Methotrexate in Rheumatoid Arthritis
MATURA Consortium, 10 Oct 2019, (E-pub ahead of print) In: Rheumatology (Oxford).Research output: Contribution to journal › Article › peer-review
Open Access -
Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis
Anderson, A. E., Maney, N. J., Nair, N., Lendrem, D. W., Skelton, A. J., Diboll, J., Brown, P. M., Smith, G. R., Carmody, R. J., Barton, A., Isaacs, J. D. & Pratt, A. G., 1 Jul 2019, In: Rheumatology (United Kingdom). 58, 7, p. 1250-1258 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Genetics of Chronic Musculoskeletal Pain
Nair, N., Holliday, K., Thomson, W. & Mcbeth, J., 2019, Oxford Textbook of Rheumatology. RA, W., PG, C., C, D., H, F., J, I. & U, M.-L. (eds.). Revised 4th ed. Oxford University Press, 45Research output: Chapter in Book/Conference proceeding › Chapter › peer-review
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Profiling of gene expression biomarkers as a classifier of methotrexate nonresponse in patients with rheumatoid arthritis
Plant, D., Maciejewski, M., Smith, S., Nair, N., MATURA Consortium, RAMS Co-Investigators, Hyrich, K., Ziemek, D., Barton, A. & Verstappen, S., 2019, In: Arthritis and Rheumatology. 71, 5, p. 678-684Research output: Contribution to journal › Article › peer-review
Open Access -
2018
CD4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in untreated early arthritis: implications for causal gene identification
Thalayasingam, N., Nair, N., Skelton, A. J., Massey, J., Anderson, A. E., Clark, A. D., Diboll, J., Lendrem, D. W., Reynard, L. N., Cordell, H. J., Eyre, S., Isaacs, J. D., Barton, A. & Pratt, A. G., 2018, In: Arthritis and Rheumatology. 70, 3, p. 361-370Research output: Contribution to journal › Article › peer-review
Open Access -
2017
DNA methylation as a marker of response in rheumatoid arthritis
Nair, N., Wilson, A. G. & Barton, A., 2017, In: Pharmacogenomics. 18, 14, p. 1323-1332 10 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile161 Downloads (Pure) -
2016
Differential methylation as a biomarker of response to etanercept in patients with rheumatoid arthritis
Plant, D., Webster, A., Nair, N., Oliver, J., Smith, S. L., Eyre, S., Hyrich, K., Wilson, A., Morgan, A., Isaacs, J., Worthington, J. & Barton, A., 2016, In: Arthritis Care & Research. 68, 6, p. 1353–1360Research output: Contribution to journal › Article › peer-review
Open Access