Research output per year
Research output per year
Proton therapy poses many challenges for computational oncology: from the prediction of the number of patients for each indication, to the molecular processes of detecting and repairing the DNA damage caused by protons. We have established a group to provide mathematical modelling support for the biological and medical issues and problems.
My background is partly in modelling bioprocess engineering systems, but since 2003 has been increasingly focussed on modelling and computational methodologies for assisting medical decision making and treatment optimisation.
Mathematical models of the cell cycle (CelCyMUS)
Models of radiation-DNA interaction
Statistical analysis of clonogenic survival and models of the role of feeder cells.
Models of clinical trials (BBJJK) (Chemo-radio-immunotherapy combinations)
Models of demand for radiotherapy (Malthus)
Prof Karen Kirkby, The Richard Rose Chair in Proton Therapy Physics, University of Manchester
Prof Neil Burnet and Raj Jena (Cambridge)
Prof Catherine West and Gillian Whitfield and colleagues in RRR group in ICS
Dr Tom Mee, Dr Mike Merchant & Dr Mike Taylor, all proton team, RRR/ICS
Institution of Chemical Engineers
Formulation and solution of models in biological mathematics
Ordinary and partial differential equations
Numerical methods for ODEs and PDEs especially cellular automata
Reaction kinetics and transport phenomena in biological systems
Monte Carlo simulation techniques
High performance computing and Fortran 2018
BSc Nottingham Chemical Engineering (1979)
PhD Cambridge Chemical Engineering (1984)
Originally from Leatherhead in Surrey, I attended Kingston Grammar School and then obtained a First in Chemical Engineering at the University of Nottingham and was awarded the Elizabeth and J D Marsden Prize. From there I went to the University of Cambridge to study for a PhD in Chemical Engineering, sponsored by BOC Ltd. My dissertation on gas separation by pressure swing adsorption was awarded the Danckwerts Prize. After my PhD, I condensed into the liquid phase but remained in Cambridge with a two year post doc sponsored by Glaxo where the project was looking at the separation of antibiotics from closely related byproducts again by adsorption.
I then spent 33 years at the University of Surrey serving as lecturer, senior lecturer, reader and professor in the Department of Chemical & Process Engineering. I gained an interest in cell cycle modelling and then in radiotherapy through Neil Burnet, ultimately spending a sabbatical year back in Cambridge on a discipline hopping grant from EPSRC, MRC and BBSRC.
Since January 2015, I have been working part-time in the Precise group at the University of Manchester, a variety of models have been developed and we are very excited about soon being able to test and validate these models in our proton research laboratory.
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Karen Kirkby |
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Norman Kirkby Research Fellow |
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Michael Taylor Lecturer in Proton Therapy Physics |
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Michael Merchant Lecturer in Proton Therapy Physics |
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Thomas Mee Research Associate |
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Amy Chadwick Research Associate |
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Visiting Professor, University of Surrey
1 Jan 2015 → …
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Letter › peer-review
Research output: Contribution to journal › Article › peer-review
Kirkby, K., Aitkenhead, A., Chadwick, A., Kirkby, N., Mackay, R., Mee, T., Merchant, M. & Taylor, M.
1/12/17 → 30/11/21
Project: Research
West, C., Bristow, R., Bruce, I., Burnet, N., Choudhury, A., Evans, D., Faivre-Finn, C., Hoskin, P., Illidge, T., Kirkby, K., Kirkby, N., O'Connor, J. & Van Herk, M.
1/04/17 → 31/03/19
Project: Research
Choudhury, A., Kirkby, N., Mcwilliam, A., Van Herk, M. & West, C.
1/03/17 → 28/06/20
Project: Research
Kirkby, K., Illidge, T., Kirkby, N., Mackay, R., Merchant, M. & Owen, H.
1/07/15 → 30/06/21
Project: Research
Mee, T. (Creator), Jena, R. (Contributor), Kirkby, N. (Contributor), Heritage, S. (Contributor), Sundaram, S. (Contributor) & Kirkby, K. (Contributor), Mendeley Data, 14 Jul 2022
DOI: 10.17632/f5kdzr7hnz.1, https://data.mendeley.com/datasets/f5kdzr7hnz
Dataset
Ingram, S. (Contributor), Henthorn, N. (Contributor), Warmenhoven, J. (Contributor), Kirkby, N. (Contributor), Mackay, R. (Contributor), Kirkby, K. (Contributor) & Merchant, M. (Contributor), Mendeley Data, 16 Nov 2020
DOI: 10.17632/kzycj3n2mm.1, https://data.mendeley.com/datasets/kzycj3n2mm
Dataset