Research output per year
Research output per year
Personal profile
Overview
I am a Wellcome Trust Research Fellow in Microbial Evolution Research Manchster (MERman) and the Manchester Fungal Infection Group (MFIG, http://www.inflammation-repair.manchester.ac.uk/mfig).
My main research interests are: One Health and Fungal infections, Antimicrobial Resistance (AMR), Climate change and Genetic tools in non-model organisms (Fungal pathogens)
Biography
I started my Research career at the University of Manchester obtaining my PhD. This project was focused on transcriptional regulation during Aspergillus fumigatus infection of the mammalian lung through high-throughput screening of mutants. As an example, we screened the library for azole sensitivity and resistance where my passion for AMR came from.
During my PhD project we have developed CRISPR methodologies for genome editing of A. fumigatus. The focus was on CRISPR-mediated protein tagging and point mutations to avoid using dominant selection markers during transformation. This methodology is widely adopted now in several research laboratories and is still driving much of my research.
I am currently working on a project linking climate change to antifungal resistance, working on dual-use fungicides and novel antifungals. I work on evolution in soil through various techniques combining environmental microbiology, molecular fungal biology and infection biology.
Qualifications
2010-2014: BSc (Hons) Biology, Leiden University, the Netherlands
2014-2015: MSc (Dis) Medical Mycology, University of Manchester, United Kingdom
2015-2019: PhD in Molecular Biology, University of Manchester, United Kingdom
Memberships of committees and professional bodies
Microbiology Society (Member and Local Champion, 2019-2024)
Biochemical Society (Early career, member since 2016)
BSMM, British Society for Medical Mycology (member since 2017)
ISHAM (member since 2019)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Bio ECR Editorial Board, MBio
2024 → …
Student committee member, British Mycological Society
1 Oct 2016 → 1 Jan 2020
ECR Executive Member, British Society for Medical Mycology
Research Beacons, Institutes and Platforms
- Global inequalities
Keywords
- Mycology
- Microbiology
- Aspergillus
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Climate Change: Shifting Boundaries of Fungal Disease in Europe and Beyond
Bottery, M., Sedik, S., Schwartz, I. S., Hoenigl, M. & Van Rhijn, N., 8 Jun 2025, In: Thorax.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection
Alves de Castro, P., Figueiredo Pinzan, C., Dos Reis, T. F., Valero, C., Van Rhijn, N., Menegatti, C., de Freitas Migliorini, I. L., Bromley, M., Fleming, A. B., Traynor, A. M., Sarikaya-Bayram, Ö., Bayram, Ö., Malavazi, I., Ebel, F., Barbosa, J. C. J., Fill, T., Pupo, M. T. & Goldman, G. H., 2 Jan 2024, In: Nature Communications. 15, 1, 33.Research output: Contribution to journal › Article › peer-review
Open Access -
Aspergillus fumigatus strains that evolve resistance to the agrochemical fungicide ipflufenoquin in vitro are also resistant to olorofim
van Rhijn, N., Storer, I. S. R., Birch, M., Oliver, J. D., Bottery, M. J. & Bromley, M. J., 1 Jan 2024, In: Nature Microbiology. 9, 1, p. 29-34 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Beyond bacteria: the growing threat of antifungal resistance
van Rhijn, N., Arikan-Akdagli, S., Beardsley, J., Bongomin, F., Chakrabarti, A., Chen, S.C.-A., Chiller, T., Lopes Colombo, A., Govender, N. P., Alastruey-Izquierdo, A., Kidd, S. E., Lackner, M., Li, R. & Hagen, F., 14 Sept 2024, In: Lancet (London, England). 404, 10457, p. 1017-1018 2 p.Research output: Contribution to journal › Letter › peer-review
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Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance
Bottery, M. J., van Rhijn, N., Chown, H., Rhodes, J. L., Celia-Sanchez, B. N., Brewer, M. T., Momany, M., Fisher, M. C., Knight, C. G. & Bromley, M. J., 16 Dec 2024, In: Nature Communications. 15, 1, 10654.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 1 Active
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MFIG: Manchester Fungal Infection Group (MFIG)
Bromley, M. (PI), Bertuzzi, M. (PI), Gago, S. (PI), Denning, D. (PI), Kosmidis, C. (PI), Bowyer, P. (PI), Amich Elias, J. (PI), Richardson, M. (PI), Richardson, R. (PI), Van Rhijn, N. (PI) & Bottery, M. (PI)
15/08/13 → …
Project: Research
Datasets
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Supplementary Table 2 DESeq2 - CR 4h RNA-seq
Rhijn, N. V. (Creator), University of Manchester Figshare, 23 Mar 2021
DOI: 10.48420/14252756.v1, https://figshare.manchester.ac.uk/articles/dataset/Supplementary_Table_2_DESeq2_-_CR_4h_RNA-seq/14252756/1
Dataset
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Supplementary Table 4 DESeq2 - 4 Day RNA-seq
Rhijn, N. V. (Creator), University of Manchester Figshare, 23 Mar 2021
DOI: 10.48420/14252759.v1, https://figshare.manchester.ac.uk/articles/dataset/Supplementary_Table_4_DESeq2_-_4_Day_RNA-seq/14252759/1
Dataset
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Supplementary Table 3 Sterol & SM
Rhijn, N. V. (Creator), University of Manchester Figshare, 23 Mar 2021
DOI: 10.48420/14252768.v1, https://figshare.manchester.ac.uk/articles/dataset/Supplementary_Table_3_Sterol_SM/14252768/1
Dataset
Press/Media
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ITV - More than 39 million could die from antibiotic-resistant infections by 2050, study says
16/09/24
1 Media contribution
Press/Media: Expert comment
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More than 39m could die from antibiotic-resistant infections by 2050 – study
16/09/24
1 Media contribution
Press/Media: Expert comment
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NBC News: The threat of fungal infections is growing. Why is it so hard to make new drugs?
11/02/24
1 Media contribution
Press/Media: Expert comment
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El pais: El despertar de los hongos ‘asesinos’
Van Rhijn, N., Bottery, M. & Bromley, M.
30/01/24
1 Media contribution
Press/Media: Research
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Financial Times: Crop chemicals boost drug resistance of killer fungi, scientists warn
Denning, D., Bromley, M., Van Rhijn, N. & Bottery, M.
9/01/24
1 item of Media coverage
Press/Media: Research
Thesis
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A genome scale census of virulence factors in the major mould pathogen of human lungs, Aspergillus fumigatus
Van Rhijn, N. (Author), Rattray, M. (Supervisor), Bromley, M. (Supervisor) & Bignell, E. (Supervisor), 1 Aug 2020Student thesis: Phd
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