Patrick Caswell, MSc, PhD

Search results

• 2022

  DExCon, DExogron, LUXon: on-demand expression control of endogenous genes reveals differential dynamics of Rab11 family members

  Gemperle, J., Harrison, T., Flett, C., Adamson, A. & Caswell, P., 2022, In: eLife.

  Research output: Contribution to journal › Article › peer-review

  • Light 100%
  • Nested Gene 75%
  • Dynamics 50%
  • Protein 50%
  • Gene Expression 25%
• 2021

  Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration

  Hetmanski, J. H. R., Jones, M. C., Chunara, F., Schwartz, J. & Caswell, P. T., 10 Mar 2021, In: 
PLoS Computational Biology. 17, 3, p. e1008213 e1008213.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dynamics 100%
  • Cells 100%
  • Complexity 50%
  • Mathematical Modelling 50%
  • Stochastic Simulation 50%
• 2020

  Microfluidic-assisted preparation of RGD-decorated nanoparticles: exploring integrin-facilitated uptake in cancer cell lines

  Spadea, A., Lallana-Ozores, E., Rios De La Rosa, J. M., Donno, R., Lawrence, J., Tirelli, N., Ashford, M., Caswell, P., Puri, S. & Lu, Y., 2 Sep 2020, In: Scientific Reports. 10, 14505.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Integrin 100%
  • Peptide 71%
  • Nanoparticle 71%
  • Cell Line 28%
  • Microfluidics 28%
• 2019

  Control of adhesion and protrusion in cell migration by Rho GTPases

  Warner, H., Wilson, B. J. & Caswell, P. T., 1 Feb 2019, In: Current opinion in cell biology. 56, p. 64-70 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Migration 100%
  • Adhesion 60%
  • Rho Family of GTPases 40%
  • Force 20%
  • Association 20%

• Membrane tension orchestrates rear retraction in matrix directed cell migration

  Hetmanski, J., de Belly, H., Busnelli, I., Waring, T., Nair, R. V., Sokleva, V., Dobre, O., Cameron, A., Gauthier, N., Lamaze, C., Swift, J., del Campo, A., Starborg, T., Zech, T., Goetz, J. G., Paluch, E. K., Schwartz, J-M. & Caswell, P., 18 Nov 2019, In: Developmental cell. 51, p. 460-75

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cells 100%
  • Membrane 66%
  • Membrane Tension 66%
  • Association 33%
  • Cell Migration 33%
• 2018

  Actin-based cell protrusion in a 3D matrix

  Caswell, P. & Zech, T., 2018, In: Trends in Cell Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cells 100%
  • Actin 75%
  • Tissues 50%
  • Serositis 50%
  • Comprehension 25%

• Modeling Rho GTPase dynamics using Boolean logic

  Hetmanski, J., Schwartz, J-M. & Caswell, P., 31 Jul 2018, Rho GTPases: Methods and Protocols. Rivero, F. (ed.). Second ed. Springer Nature, Vol. 1821. p. 37-46 (Methods in Molecular Biology ; vol. 1821).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

• Rationalizing Rac1 and RhoA GTPase signaling: A mathematical approach

  Hetmanski, J., Schwartz, J-M. & Caswell, P. T., May 2018, In: Small GTPases. 9, 3, p. 224-229

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Rho Guanine Nucleotide Binding Protein 100%
  • GTPase 50%
  • Electric Potential 50%
  • Dynamics 50%
  • In Vitro 25%

• Vesicle trafficking pathways that direct cell migration in 3D and in vivo

  Wilson, B., Allen, J. & Caswell, P., 2018, In: Traffic (Malden): the international journal of intracellular transport .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Migration 100%
  • Surface Property 66%
  • Chemokine Receptor 66%
  • Eicosanoid Receptor 66%
  • In Vivo 66%
• 2017

  Extracellular matrix promotes clathrin-dependent endocytosis of prolactin and STAT5 activation in differentiating mammary epithelial cells

  Bridgewater, R., Streuli, C. & Caswell, P., 2017, In: Scientific Reports. 7, 4572.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prolactin 100%
  • Endocytosis 83%
  • STAT5 66%
  • Clathrin 50%
  • Phosphorylation 33%

• JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells

  Caswell, P. T. & Dickens, M., 2017, In: Molecular and Cellular Biochemistry. p. 1-13 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Kinase 100%
  • Amino Terminal Sequence 88%
  • Synapsin II 88%
  • N-Terminus 88%
  • Growth Cone 33%

• Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell: cell repulsion

  Gundry, C., Marco, S., Rainero, E., Miller, B., Dornier, E., Mitchell, L., Caswell, P. T., Campbell, A. D., Hogeweg, A., Sansom, O. J., Morton, J. P. & Norman, J. C., 2017, In: Nature Communications. 8, 14646.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein 100%
  • Phosphorylation 25%
  • Receptor Tyrosine Kinase 25%
  • Integrin 25%
  • Tyrosine Kinase 25%
• 2016

  A MAPK-driven feedback loop suppresses Rac activity to promote RhoA-driven cancer cell invasion

  Hetmanski, J., Zindy, E., Schwartz, J-M. & Caswell, P., 3 May 2016, In: PL o S Computational Biology. 12, 5, e1004909.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein 100%
  • Actin 100%
  • Spike 100%
  • Feedback System 66%
  • Cancer Cell 66%

• Modelling GTPase dynamics to understand RhoA-driven cancer cell invasion

  Hetmanski, J., Schwartz, J-M. & Caswell, P., 2 Dec 2016, In: Biochemical Society Transactions. 44, 6, p. 1695-1700

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Cells 100%
  • Drive 100%
  • Actin 66%
  • Cell Migration 66%
  • Metastatic Carcinoma 66%
• 2015

  Endocytic Trafficking of Integrins in Cell Migration.

  Paul, N. R., Jacquemet, G. & Caswell, P. T., 16 Nov 2015, In: Current biology . 25, 22

  Research output: Contribution to journal › Article › peer-review

  • Integrin 100%
  • Intracellular Signaling 33%
  • Eicosanoid Receptor 22%
  • Cell Migration 22%
  • Extracellular Matrix 22%

• Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration.

  Rainero, E., Howe, J. D., Caswell, P. T., Jamieson, N. B., Anderson, K., Critchley, D. R., Machesky, L. & Norman, J. C., 15 Jan 2015, In: Cell Reports.

  Research output: Contribution to journal › Article › peer-review

  • Integrin 100%
  • Ligand 44%
  • Endocytosis 33%
  • Nutrient 33%
  • Lysosome 33%

• Persistent cell migration and adhesion rely on retrograde transport of β1 integrin.

  Shafaq-Zadah, M., Gomes-Santos, C. S., Bardin, S., Maiuri, P., Maurin, M., Iranzo, J., Gautreau, A., Lamaze, C., Caswell, P., Goud, B. & Johannes, L., 7 Dec 2015, In: Nature Cell Biology. 18, p. 54-64

  Research output: Contribution to journal › Article › peer-review

  • Integrin 100%
  • Cell Migration 42%
  • Cell Adhesion 42%
  • Cell Membrane 28%
  • Mouse 14%

• α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3

  Paul, N. R., Allen, J. L., Chapman, A., Morlan-Mairal, M., Zindy, E., Jacquemet, G., Fernandez Del ama, L., Ferizovic, N., Green, D. M., Howe, J. D., Ehler, E., Hurlstone, A. & Caswell, P. T., 14 Sep 2015, In: The Journal of cell biology. 10, 6, p. 1013-1031 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  319 Downloads (Pure)
• 2014

  Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype.

  Muller, P. A. J., Trinidad, A. G., Caswell, P. T., Norman, J. C. & Vousden, K. H., 3 Jan 2014, In: The Journal of biological chemistry. 289, 1

  Research output: Contribution to journal › Article › peer-review

  • Dicer 100%
  • Mutant 75%
  • P53 62%
  • Processing 25%
  • MicroRNA 25%

• Podocytopathy in primary renal failure and de-novo membranous nephropathy post transplantation

  Lennon, R., Mckenzie, E., Caswell, P., Urquhart, J., Daly, S., Stuart, H., Mcwilliam, L., Roberts, I., Schiffer, M. & Brenchley, P., 26 Feb 2014, In: The Lancet. 383, S68

  Research output: Contribution to journal › Article › peer-review
• 2013

  Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.

  Muller, P. A. J., Trinidad, A. G., Timpson, P., Morton, J. P., Zanivan, S., van den Berghe, P. V. E., Nixon, C., Karim, S. A., Caswell, P. T., Noll, J. E., Coffill, C. R., Lane, D. P., Sansom, O. J., Neilsen, P. M., Norman, J. C. & Vousden, K. H., 7 Mar 2013, In: Oncogene. 32, 10

  Research output: Contribution to journal › Article › peer-review

  • Cells 100%
  • Protein P53 100%
  • P53 87%
  • Mutant 75%
  • Protein 25%

• Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway

  Jacquemet, G., Morgan, M. R., Byron, A., Humphries, J. D., Choi, C. K., Chen, C. S., Caswell, P. T. & Humphries, M. J., 15 Sep 2013, In: Journal of Cell Science. 126, 18, p. 4121-4135 14 p.

  Research output: Contribution to journal › Article › peer-review

  • IQ Motif Containing Guanosine Triphosphatase Activating Protein 1 100%
  • Integrin 77%
  • Filamin A 77%
  • Cell Migration 33%
  • Fibronectin 22%

• Rcp-driven α5β1 recycling suppresses rac and promotes rhoa activity via the racgap1-iqgap1 complex

  Jacquemet, G., Green, D., Bridgewater, R. E., Kriegsheim, A. V., Humphries, M. J., Norman, J. C. & Caswell, P. T., 9 Sep 2013, In: Journal of Cell Biology. 202, 6, p. 917-935 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Fibronectin 100%
  • Protein Kinase B 66%
  • Mutant 33%
  • Phosphorylation 33%

• Role of adhesion receptor trafficking in 3D cell migration

  Jacquemet, G., Humphries, M. J. & Caswell, P., Oct 2013, In: Current opinion in cell biology. 25, 5, p. 627-632 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adhesion Receptor 100%
  • Adhesion 100%
  • Comprehension 66%
  • Receptor Trafficking 66%
  • In Vitro 33%
• 2012

  Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration

  Rainero, E., Caswell, P. T., Muller, P. A. J., Grindlay, J., Mccaffrey, M. W., Zhang, Q., Wakelam, M. J. O., Vousden, K. H., Graziani, A. & Norman, J. C., Jan 2012, In: Journal of Cell Biology. 196, 2, p. 277-295 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Mutant 66%
  • Diacylglycerol Kinase 66%
  • Integrin 50%
  • Phosphatidic Acid 50%

• Integrin trafficking at a glance.

  Bridgewater, R., Norman, J. & Caswell, P., 15 Aug 2012, In: Journal of Cell Science. 125, 16, p. 3695-3701 6 p.

  Research output: Contribution to journal › Article › peer-review

• Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression

  Dozynkiewicz, M. A., Jamieson, N. B., MacPherson, I., Grindlay, J., vandenBerghe, P. V. E., vonThun, A., Morton, J. P., Gourley, C., Timpson, P., Nixon, C., McKay, C. J., Carter, R., Strachan, D., Anderson, K., Sansom, O. J., Caswell, P. T. & Norman, J. C., 17 Jan 2012, In: Developmental cell. 22, 1, p. 131-145 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Lysosome 100%
  • Integrin 66%
  • Drive 33%
  • Electric Potential 16%
  • Conformation 16%
• 2011

  The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration

  Zech, T., Calaminus, S. D. J., Caswell, P., Spence, H. J., Carnell, M., Insall, R. H., Norman, J. & Machesky, L. M., 15 Nov 2011, In: Journal of Cell Science. 124, 22, p. 3753-3759 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Integrin 100%
  • Actin 50%
  • Force 33%
  • Cell Membrane 33%
  • Membrane 16%
• 2010

  Rab11 and its effector rab coupling protein contribute to the trafficking of β1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells

  Eva, R., Dassie, E., Caswell, P. T., Dick, G., Ffrench-Constant, C., Norman, J. C. & Fawcett, J. W., 1 Sep 2010, In: Journal of Neuroscience. 30, 35, p. 11654-11669 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Integrin 100%
  • Neuron 42%
  • Protein 35%
  • Neurite Outgrowth 35%
  • Growth Cone 28%
• 2009

  Integrins: Masters and slaves of endocytic transport

  Caswell, P. T., Vadrevu, S. & Norman, J. C., Dec 2009, In: Nature Reviews Molecular Cell Biology. 10, 12, p. 843-853 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Integrin 100%
  • Drive 25%
  • Receptor 25%
  • Cell Migration 25%
  • Cancer Cell 25%

• Mutant p53 Drives Invasion by Promoting Integrin Recycling

  Muller, P. A. J., Caswell, P. T., Doyle, B., Iwanicki, M. P., Tan, E. H., Karim, S., Lukashchuk, N., Gillespie, D. A., Ludwig, R. L., Gosselin, P., Cromer, A., Brugge, J. S., Sansom, O. J., Norman, J. C. & Vousden, K. H., 24 Dec 2009, In: Cell. 139, 7, p. 1327-1341 14 p.

  Research output: Contribution to journal › Article › peer-review

  • P53 100%
  • Mutant 62%
  • Integrin 50%
  • Epidermal Growth Factor Receptor 25%
  • Tumor Suppressor Protein 25%

• Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells

  Valdembri, D., Caswell, P. T., Anderson, K. I., Schwarz, J. P., König, I., Astanina, E., Caccavari, F., Norman, J. C., Humphries, M. J., Bussolino, F. & Serini, G., Jan 2009, In: PLoS Biology. 7, 1, e1000025.

  Research output: Contribution to journal › Article › peer-review

  • Neuropilin 1 100%
  • Vascular Endothelial Growth Factor 61%
  • C-Terminus 30%
  • Fibronectin 30%
  • Protein C 30%

• VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching

  Jones, M. C., Caswell, P. T., Moran-Jones, K., Roberts, M., Barry, S. T., Gampel, A., Mellor, H. & Norman, J. C., 2009, In: Traffic (Malden): the international journal of intracellular transport . 10, 6, p. 754-766 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Cells 100%
  • Integrin 100%
  • Angiogenesis 100%
  • Vasculotropin 100%
  • Fibronectin 100%
• 2008

  Endocytic transport of integrins during cell migration and invasion

  Caswell, P. & Norman, J., Jun 2008, In: Trends in cell biology. 18, 6, p. 257-263 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Integrin 100%
  • Cell Migration 57%
  • Probe 42%
  • Comprehension 14%
  • Cancer Cell 14%

• Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion

  Kim, M., Jang, H. R., Kim, J. H., Noh, S. M., Song, K. S., Cho, J. S., Jeong, H. Y., Norman, J. C., Caswell, P. T., Kang, G. H., Kim, S. Y., Yoo, H. S. & Kim, Y. S., Mar 2008, In: Carcinogenesis. 29, 3, p. 629-637 8 p.

  Research output: Contribution to journal › Article › peer-review

  • PKD1 100%
  • Cancer Cell 30%
  • Methylation 30%
  • Cell Migration 23%
  • Promoter Region 23%

• Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

  Caswell, P. T., Chan, M., Lindsay, A. J., McCaffrey, M. W., Boettiger, D. & Norman, J. C., 6 Oct 2008, In: Journal of Cell Biology. 183, 1, p. 143-155 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Integrin 66%
  • Association 50%
  • Fibronectin 33%
  • Dynamics 16%
• 2007

  Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments

  Caswell, P. T., Spence, H. J., Parsons, M., White, D. P., Clark, K., Cheng, K. W., Mills, G. B., Humphries, M. J., Messent, A. J., Anderson, K. I., McCaffrey, M. W., Ozanne, B. W. & Norman, J. C., 9 Oct 2007, In: Developmental cell. 13, 4, p. 496-510 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Integrin 100%
  • Matrix 50%
  • Association 33%
  • Tumor Cell 33%
  • Extracellular Matrix 33%

• αvβ3 and α5β1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration

  White, D. P., Caswell, P. T. & Norman, J. C., 7 May 2007, In: Journal of Cell Biology. 177, 3, p. 515-525 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Integrin 100%
  • Cells 66%
  • Cell Migration 66%
  • Fibroblast 66%
  • Protein Kinase 66%
• 2006

  Endocytic recycling pathways: emerging regulators of cell migration

  Jones, M. C., Caswell, P. T. & Norman, J. C., Oct 2006, In: Current opinion in cell biology. 18, 5, p. 549-557 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell Migration 100%
  • Integrin 33%
  • Growth Factor Receptor 33%

• Integrin trafficking and the control of cell migration

  Caswell, P. T. & Norman, J. C., Jan 2006, In: Traffic (Malden): the international journal of intracellular transport . 7, 1, p. 14-21 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Integrin 100%
  • Cell Migration 40%
  • Introspection 20%
  • Electric Potential 20%
  • Regulatory Mechanism 20%
• 2004

  PKD1/PKCμ promotes αvβ3 integrin recycling and delivery to nascent focal adhesions

  Woods, A. J., White, D. P., Caswell, P. T. & Norman, J. C., 7 Jul 2004, In: EMBO Journal. 23, 13, p. 2531-2543 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Integrin 100%
  • PKD1 87%
  • Association 37%
  • Kinase 25%
  • Focal Adhesion 25%