Patrick Caswell

2024

Graphene oxide activates canonical TGFβ signalling in a human chondrocyte cell line via increased plasma membrane tension

Ogene, L., Woods, S., Hetmanski, J., Lozano, N., Karakasidi, A., Caswell, P., Kostarelos, K., Domingos, M., Vranic, S. & Kimber, S., 21 Mar 2024, In: Nanoscale. 16, 11, p. 5653-5664 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migration

Newman, D., Young, L. E., Waring, T., Brown, L., Wolanska, K. I., MacDonald, E., Charles-Orszag, A., Goult, B. T., Caswell, P. T., Sakuma, T., Yamamoto, T., Machesky, L. M., Morgan, M. R. & Zech, T., 26 Dec 2023, In: Cell Reports. 42, 12, 113554.

Research output: Contribution to journal › Article › peer-review

Open Access

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Wilson, B., Flett, C., Gemperle, J., Lawless, C., Hartshorn, M., Hinde, E., Harrison, T., Chastney, M., Taylor, S., Allen, J., Norman, J. C., Zacharchenko, T. & Caswell, P. T., 15 Jun 2023, In: Journal of Cell Science. 136, 12

Research output: Contribution to journal › Article › peer-review

Open Access

The βI domain promotes active β1 integrin clustering into mature adhesion sites

Mana, G., Valdembri, D., Askari, J. A., Li, Z., Caswell, P., Zhu, C., Humphries, M. J., Ballestrem, C. & Serini, G., 1 Feb 2023, In: Life Science Alliance. 6, 2

Research output: Contribution to journal › Article › peer-review

Open Access

2022

DExCon, DExogron, LUXon: on-demand expression control of endogenous genes reveals differential dynamics of Rab11 family members

Gemperle, J., Harrison, T., Flett, C., Adamson, A. & Caswell, P., 2022, In: eLife.

Research output: Contribution to journal › Article › peer-review

2021

Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration

Hetmanski, J. H. R., Jones, M. C., Chunara, F., Schwartz, J.-M. & Caswell, P. T., 10 Mar 2021, In:  PLoS Computational Biology. 17, 3, p. e1008213 e1008213.

Research output: Contribution to journal › Article › peer-review

Open Access

Intracellular nanovesicles mediate α5β1 integrin trafficking during cell migration

Larocque, G., Moore, D. J., Sittewelle, M., Kuey, C., Hetmanski, J. H. R., La-Borde, P. J., Wilson, B. J., Clarke, N. I., Caswell, P. T. & Royle, S. J., 4 Oct 2021, In: Journal of Cell Biology. 220, 10, e202009028.

Research output: Contribution to journal › Article › peer-review

Open Access

ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

Bolado-Carrancio, A., Lee, M., Ewing, A., Muir, M., Macleod, K. G., Gallagher, W. M., Nguyen, L. K., Carragher, N. O., Semple, C. A., Brunton, V. G., Caswell, P. T. & von Kriegsheim, A., 3 Nov 2021, In: Oncogene. 40, 44, p. 6235-6247 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Microfluidic-assisted preparation of RGD-decorated nanoparticles: exploring integrin-facilitated uptake in cancer cell lines

Spadea, A., Lallana-Ozores, E., Rios De La Rosa, J. M., Donno, R., Lawrence, J., Tirelli, N., Ashford, M., Caswell, P., Puri, S. & Lu, Y., 2 Sept 2020, In: Scientific Reports. 10, 14505.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Control of adhesion and protrusion in cell migration by Rho GTPases

Warner, H., Wilson, B. J. & Caswell, P. T., 1 Feb 2019, In: Current opinion in cell biology. 56, p. 64-70 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Membrane tension orchestrates rear retraction in matrix directed cell migration

Hetmanski, J., de Belly, H., Busnelli, I., Waring, T., Nair, R. V., Sokleva, V., Dobre, O., Cameron, A., Gauthier, N., Lamaze, C., Swift, J., del Campo, A., Starborg, T., Zech, T., Goetz, J. G., Paluch, E. K., Schwartz, J.-M. & Caswell, P., 18 Nov 2019, In: Developmental cell. 51, p. 460-75

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Actin-based cell protrusion in a 3D matrix

Caswell, P. & Zech, T., 2018, In: Trends in Cell Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

Vesicle trafficking pathways that direct cell migration in 3D and in vivo

Wilson, B., Allen, J. & Caswell, P., 2018, In: Traffic (Malden): the international journal of intracellular transport .

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Extracellular matrix promotes clathrin-dependent endocytosis of prolactin and STAT5 activation in differentiating mammary epithelial cells

Bridgewater, R., Streuli, C. & Caswell, P., 2017, In: Scientific Reports. 7, 4572.

Research output: Contribution to journal › Article › peer-review

Open Access

JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells

Caswell, P. T. & Dickens, M., 2017, In: Molecular and Cellular Biochemistry. p. 1-13 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell: cell repulsion

Gundry, C., Marco, S., Rainero, E., Miller, B., Dornier, E., Mitchell, L., Caswell, P. T., Campbell, A. D., Hogeweg, A., Sansom, O. J., Morton, J. P. & Norman, J. C., 2017, In: Nature Communications. 8, 14646.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

A MAPK-driven feedback loop suppresses Rac activity to promote RhoA-driven cancer cell invasion

Hetmanski, J., Zindy, E., Schwartz, J.-M. & Caswell, P., 3 May 2016, In: PL o S Computational Biology. 12, 5, e1004909.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Endocytic Trafficking of Integrins in Cell Migration.

Paul, N. R., Jacquemet, G. & Caswell, P. T., 16 Nov 2015, In: Current biology . 25, 22

Research output: Contribution to journal › Article › peer-review

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration.

Rainero, E., Howe, J. D., Caswell, P. T., Jamieson, N. B., Anderson, K., Critchley, D. R., Machesky, L. & Norman, J. C., 15 Jan 2015, In: Cell Reports.

Research output: Contribution to journal › Article › peer-review

Persistent cell migration and adhesion rely on retrograde transport of β1 integrin.

Shafaq-Zadah, M., Gomes-Santos, C. S., Bardin, S., Maiuri, P., Maurin, M., Iranzo, J., Gautreau, A., Lamaze, C., Caswell, P., Goud, B. & Johannes, L., 7 Dec 2015, In: Nature Cell Biology. 18, p. 54-64

Research output: Contribution to journal › Article › peer-review

α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3

Paul, N. R., Allen, J. L., Chapman, A., Morlan-Mairal, M., Zindy, E., Jacquemet, G., Fernandez Del ama, L., Ferizovic, N., Green, D. M., Howe, J. D., Ehler, E., Hurlstone, A. & Caswell, P. T., 14 Sept 2015, In: The Journal of cell biology. 10, 6, p. 1013-1031 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2014

Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype.

Muller, P. A. J., Trinidad, A. G., Caswell, P. T., Norman, J. C. & Vousden, K. H., 3 Jan 2014, In: The Journal of biological chemistry. 289, 1

Research output: Contribution to journal › Article › peer-review

Podocytopathy in primary renal failure and de-novo membranous nephropathy post transplantation

Lennon, R., Mckenzie, E., Caswell, P., Urquhart, J., Daly, S., Stuart, H., Mcwilliam, L., Roberts, I., Schiffer, M. & Brenchley, P., 26 Feb 2014, In: The Lancet. 383, S68

Research output: Contribution to journal › Article › peer-review

2013

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.

Muller, P. A. J., Trinidad, A. G., Timpson, P., Morton, J. P., Zanivan, S., van den Berghe, P. V. E., Nixon, C., Karim, S. A., Caswell, P. T., Noll, J. E., Coffill, C. R., Lane, D. P., Sansom, O. J., Neilsen, P. M., Norman, J. C. & Vousden, K. H., 7 Mar 2013, In: Oncogene. 32, 10

Research output: Contribution to journal › Article › peer-review

Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway

Jacquemet, G., Morgan, M. R., Byron, A., Humphries, J. D., Choi, C. K., Chen, C. S., Caswell, P. T. & Humphries, M. J., 15 Sept 2013, In: Journal of Cell Science. 126, 18, p. 4121-4135 14 p.

Research output: Contribution to journal › Article › peer-review

Rcp-driven α5β1 recycling suppresses rac and promotes rhoa activity via the racgap1-iqgap1 complex

Jacquemet, G., Green, D., Bridgewater, R. E., Kriegsheim, A. V., Humphries, M. J., Norman, J. C. & Caswell, P. T., 9 Sept 2013, In: Journal of Cell Biology. 202, 6, p. 917-935 18 p.

Research output: Contribution to journal › Article › peer-review

Role of adhesion receptor trafficking in 3D cell migration

Jacquemet, G., Humphries, M. J. & Caswell, P., Oct 2013, In: Current opinion in cell biology. 25, 5, p. 627-632 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2012

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration

Rainero, E., Caswell, P. T., Muller, P. A. J., Grindlay, J., Mccaffrey, M. W., Zhang, Q., Wakelam, M. J. O., Vousden, K. H., Graziani, A. & Norman, J. C., Jan 2012, In: Journal of Cell Biology. 196, 2, p. 277-295 18 p.

Research output: Contribution to journal › Article › peer-review

Integrin trafficking at a glance.

Bridgewater, R., Norman, J. & Caswell, P., 15 Aug 2012, In: Journal of Cell Science. 125, 16, p. 3695-3701 6 p.

Research output: Contribution to journal › Article › peer-review

Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression

Dozynkiewicz, M. A., Jamieson, N. B., MacPherson, I., Grindlay, J., vandenBerghe, P. V. E., vonThun, A., Morton, J. P., Gourley, C., Timpson, P., Nixon, C., McKay, C. J., Carter, R., Strachan, D., Anderson, K., Sansom, O. J., Caswell, P. T. & Norman, J. C., 17 Jan 2012, In: Developmental cell. 22, 1, p. 131-145 14 p.

Research output: Contribution to journal › Article › peer-review

2011

The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration

Zech, T., Calaminus, S. D. J., Caswell, P., Spence, H. J., Carnell, M., Insall, R. H., Norman, J. & Machesky, L. M., 15 Nov 2011, In: Journal of Cell Science. 124, 22, p. 3753-3759 6 p.

Research output: Contribution to journal › Article › peer-review

2010

Rab11 and its effector rab coupling protein contribute to the trafficking of β1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells

Eva, R., Dassie, E., Caswell, P. T., Dick, G., Ffrench-Constant, C., Norman, J. C. & Fawcett, J. W., 1 Sept 2010, In: Journal of Neuroscience. 30, 35, p. 11654-11669 15 p.

Research output: Contribution to journal › Article › peer-review

2009

Integrins: Masters and slaves of endocytic transport

Caswell, P. T., Vadrevu, S. & Norman, J. C., Dec 2009, In: Nature Reviews Molecular Cell Biology. 10, 12, p. 843-853 10 p.

Research output: Contribution to journal › Article › peer-review

Mutant p53 Drives Invasion by Promoting Integrin Recycling

Muller, P. A. J., Caswell, P. T., Doyle, B., Iwanicki, M. P., Tan, E. H., Karim, S., Lukashchuk, N., Gillespie, D. A., Ludwig, R. L., Gosselin, P., Cromer, A., Brugge, J. S., Sansom, O. J., Norman, J. C. & Vousden, K. H., 24 Dec 2009, In: Cell. 139, 7, p. 1327-1341 14 p.

Research output: Contribution to journal › Article › peer-review

Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells

Valdembri, D., Caswell, P. T., Anderson, K. I., Schwarz, J. P., König, I., Astanina, E., Caccavari, F., Norman, J. C., Humphries, M. J., Bussolino, F. & Serini, G., Jan 2009, In: PLoS Biology. 7, 1, e1000025.

Research output: Contribution to journal › Article › peer-review

VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching

Jones, M. C., Caswell, P. T., Moran-Jones, K., Roberts, M., Barry, S. T., Gampel, A., Mellor, H. & Norman, J. C., 2009, In: Traffic (Malden): the international journal of intracellular transport . 10, 6, p. 754-766 12 p.

Research output: Contribution to journal › Article › peer-review

2008

Endocytic transport of integrins during cell migration and invasion

Caswell, P. & Norman, J., Jun 2008, In: Trends in cell biology. 18, 6, p. 257-263 6 p.

Research output: Contribution to journal › Article › peer-review

Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion

Kim, M., Jang, H. R., Kim, J. H., Noh, S. M., Song, K. S., Cho, J. S., Jeong, H. Y., Norman, J. C., Caswell, P. T., Kang, G. H., Kim, S. Y., Yoo, H. S. & Kim, Y. S., Mar 2008, In: Carcinogenesis. 29, 3, p. 629-637 8 p.

Research output: Contribution to journal › Article › peer-review

Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

Caswell, P. T., Chan, M., Lindsay, A. J., McCaffrey, M. W., Boettiger, D. & Norman, J. C., 6 Oct 2008, In: Journal of Cell Biology. 183, 1, p. 143-155 12 p.

Research output: Contribution to journal › Article › peer-review

2007

Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments

Caswell, P. T., Spence, H. J., Parsons, M., White, D. P., Clark, K., Cheng, K. W., Mills, G. B., Humphries, M. J., Messent, A. J., Anderson, K. I., McCaffrey, M. W., Ozanne, B. W. & Norman, J. C., 9 Oct 2007, In: Developmental cell. 13, 4, p. 496-510 14 p.

Research output: Contribution to journal › Article › peer-review