Paul Evelyn Humphreys

Paul Evelyn Humphreys

Dr

Personal profile

Overview

Currently working towards a doctorate in the field of Regenerative Medicine; supervised by Professor Sue Kimber and Professor Rob Lucas.

My project involves manipulating TGFß signalling in pluripotent stem cells through the novel technology of optogenetics. Precise control of TGFß signalling will enable us to investigate and enhance differentiation of human pluripotent stem cells (hPSCs) towards chondrocytes; which will be important in the development of cell-based therapies for osteoarthritis. The main aims of the project are as follows:

1. Develop and optimise a TGFß signalling system

2. Demonstrate and titrate light-activated TGFß signalling with an associated downstream response

3. Fine-tune light dosage during hPSC differentiation to enhance chondrogenesis

 

My research is co-funded by the MRC and EPSRC.

 

My group

Supervised by Prof Sue Kimber and Prof Rob Lucas.

Qualifications

MRes Tissue Engineering for Regenerative Medicine, Distinction, University of Manchester

Bsc (Hons) Biological Sciences, 1st Class, Lancaster University

Social responsibility

I regularly contribute to public engagement and outreach activities such as British Science Week, in which myself and other members of the CDT in Regenerative Medicine hosted a stand where we introduced Regenerative Medicine concepts to secondary school students. 

I also contribute to the FBMH Doctoral Academy blog: Research Hive. My role as scientific sub-editor involves highlighting current and novel work being performed at the University of Manchester, particularly by PhD students and early career researchers. 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 16 - Peace, Justice and Strong Institutions

Education/Academic qualification

Doctor of Philosophy, Optogenetic Control of BMP Signalling to Drive hPSC Chondrogenesis, The University of Manchester

20 Sept 201630 Mar 2021

Award Date: 20 May 2021

Master of Research, Tissue Engineering for Regenerative Medicine, The University of Manchester

21 Sept 201521 Aug 2016

Award Date: 20 Oct 2016

Bachelor of Science, Biological Sciences, Lancaster University

5 Oct 201020 Jun 2013

Award Date: 10 Jul 2013

Research Beacons, Institutes and Platforms

  • Henry Royce Institute

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