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Personal profile

Research interests

My current research involves two main areas:

- Discovering the genetic basis of susceptibility to fungal disease in humans using whole exome sequencing of populations with defined disease phenotypes and controls

- the genomics of pathogenicity and drug resistance in the human fungal pathogen Aspergillus fumigatus

My group works closely with clinicians at UHSM in order to define clinical phenotypes, identify patients and obtain consent to take samples then analyse the samples in the laboratory. We have extensive collaborations with sequencing centres in the UK(EBI) the USA (JCVI) and in Barcelona (CNAG) as well as with Aspergillus researchers worldwide. 

Teaching

Tutor for Personal and Professional Development, yr 1 and 2 medicine

Modules on diagnostics and genetics on the MSc in Medical Mycology

Interviewing UCAS candidates, screening statements

Examining PhD and MSc theses

Methodological knowledge

Bioinformatic analysis of large exome sequence data sets, RNAseq data, genome assembly and comparison of fungal genomes, use of next gen sequencing for bespoke fitness and population studies, microbiome determination and metagenomics of pathogens. Gene manipulation in fungi and human cells.

Qualifications

PhD in Molecular Genetics, University of Sheffield, 1991

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 2 - Zero Hunger
  • SDG 3 - Good Health and Well-being

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