Research output per year
Research output per year
Personal profile
Research interests
My current research involves two main areas:
- Discovering the genetic basis of susceptibility to fungal disease in humans using whole exome sequencing of populations with defined disease phenotypes and controls
- the genomics of pathogenicity and drug resistance in the human fungal pathogen Aspergillus fumigatus
My group works closely with clinicians at UHSM in order to define clinical phenotypes, identify patients and obtain consent to take samples then analyse the samples in the laboratory. We have extensive collaborations with sequencing centres in the UK(EBI) the USA (JCVI) and in Barcelona (CNAG) as well as with Aspergillus researchers worldwide.
Teaching
Tutor for Personal and Professional Development, yr 1 and 2 medicine
Modules on diagnostics and genetics on the MSc in Medical Mycology
Interviewing UCAS candidates, screening statements
Examining PhD and MSc theses
Methodological knowledge
Bioinformatic analysis of large exome sequence data sets, RNAseq data, genome assembly and comparison of fungal genomes, use of next gen sequencing for bespoke fitness and population studies, microbiome determination and metagenomics of pathogens. Gene manipulation in fungi and human cells.
Qualifications
PhD in Molecular Genetics, University of Sheffield, 1991
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Development of a novel mycobiome diagnostic for fungal infection
Weaver, D., Novak-Frazer, L., Palmer, M., Richardson, M., Bromley, M. & Bowyer, P., 19 Feb 2024, In: BMC Microbiology. 24, 1, 63.Research output: Contribution to journal › Article › peer-review
Open Access -
Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging
van Rhijn, N., Zhao, C., Al-Furaiji, N., Storer, I. S. R., Valero, C., Gago, S., Chown, H., Baldin, C., Grant, R.-F., Bin Shuraym, H., Ivanova, L., Kniemeyer, O., Krüger, T., Bignell, E., Goldman, G. H., Amich, J., Delneri, D., Bowyer, P., Brakhage, A. A. & Haas, H. & 1 others, , 11 Jun 2024, In: Nature Communications. 15, 1, p. 4984Research output: Contribution to journal › Article › peer-review
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Aneuploidy is associated with azole resistance in Aspergillus fumigatus
Khateb, A., Gago, S., Bromley, M., Richardson, M. & Bowyer, P., 28 Mar 2023, In: Antimicrobial Agents and Chemotherapy. 67, 4, e01253-22.Research output: Contribution to journal › Article › peer-review
Open Access -
Pathogenicity and virulence of Aspergillus fumigatus
Earle, K., Valero, C., Conn, D. P., Vere, G., Cook, P. C., Bromley, M. J., Bowyer, P. & Gago, S., Dec 2023, In: Virulence. 14, 1, p. 2172264Research output: Contribution to journal › Review article › peer-review
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Aspergillus fumigatus ffmA Encodes a C2H2-Containing Transcriptional Regulator That Modulates Azole Resistance and Is Required for Normal Growth
Paul, S., Bowyer, P., Bromley, M. & Moye-Rowley, W. S., 23 Feb 2022, In: mSphere. 7, 1, p. e0093821Research output: Contribution to journal › Article › peer-review
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MFIG: Manchester Fungal Infection Group (MFIG)
Bromley, M. (PI), Bertuzzi, M. (PI), Gago, S. (PI), Denning, D. (PI), Kosmidis, C. (PI), Bowyer, P. (PI), Amich Elias, J. (PI), Richardson, M. (PI), Richardson, R. (PI), Van Rhijn, N. (PI) & Bottery, M. (PI)
15/08/13 → …
Project: Research
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Point of Care Tests in the Diagnosis of Chronic and Allergic Aspergillosis.
Kosmidis, C. (PI), Bowyer, P. (CoI), Denning, D. (CoI) & Fowler, S. (CoI)
1/04/19 → 31/03/21
Project: Research
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Defining Novel Pathways for the Development of Fungal Allergy.
Bowyer, P. (PI) & Gago, S. (Grant contributor)
1/01/19 → 31/12/19
Project: Research
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Development of New Experimental Models to Understand the Genetic Basis of Allergic Bronchopulmonary Aaspergillosis (ABPA).
Bowyer, P. (PI) & Gago, S. (Grant contributor)
12/01/17 → 12/04/19
Project: Research
Impacts
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Defining global antifungal azole resistance in Aspergillus – enhancing diagnostics and driving drug discovery
Denning, D. (Participant), (Participant), Bromley, M. (Participant), Bowyer, P. (Participant) & Moore, C. (Participant)
Impact: Health and wellbeing, Policy, Economic
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Diagnostics and novel life-saving therapies for aspergillosis
Denning, D. (Participant), Anderson, M. J. (Participant), Moore, C. (Participant), (Participant), Bowyer, P. (Participant), Bromley, M. (Participant), Smith, N. (Participant), (Participant) & (Participant)
Impact: Health impacts
Datasets
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Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study
Overton, N. (Contributor), Denning, D. (Contributor), Bowyer, P. (Contributor) & Simpson, A. (Contributor), figshare , 27 Sept 2016
DOI: 10.6084/m9.figshare.c.3627629.v1, https://figshare.com/collections/Genetic_susceptibility_to_allergic_bronchopulmonary_aspergillosis_in_asthma_a_genetic_association_study/3627629/1
Dataset