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Personal profile


Prof Brenchley is developing novel therapeutic approaches for autoimmune disease using anti-PLA2R positive membranous nephropathy as a paradigm

Research interests

Since 2009, my group has investigated the autoimmune mechanism causing membranous nephropathy, a rare glomerulopathy associated with heavy proteinuria and the most common cause of nephrotic syndrome in adults.

We have

  • developed the first ELISA for quantitating circulating anti-PLA2R antibodies in patients
  • linked levels of anti-PLA2R with the HLA DQA1 *05:01 DQB1 *02:01 allotype
  • studied the role of anti-PLA2R levels in clinical management of patients over time
  • identified the dominant epitope on PLA2R as a 31mer disulphide bonded structure
  • identified A2t as a coreceptor for PLA2R on podocytes
  • proposed a new structure for PLA2R based on single molecule EM
  • developed an ELISA for the minor autoantigen THSD7A
  • identified a common epitope structure shared by PLA2R and THSD7A
  • contributed to the largest global GWAS in MN which confirms DQA1 and PLA2R as risk genes and identifies NfKB and IRF4 as additional risk genes for MN
  • contributed to the first study of recurrent MN in transplants which identifies a donor specific HLA-D risk factor
  • identified candidate T cell epitopes in PLA2R

My collaborations


In Manchester

  • Dr Tom Jowitt, Wellcome Cell Matrix Centre, Univ of Manchester
  • Maryline Fresquet, Wellcome Cell Matrix Centre, Univ of Manchester
  • Prof Rachel Lennon, Wellcome Cell Matrix Centre, Univ of Manchester
  • Dr Edward McKenzie, FLS, Univ of Manchester
  • Prof Sandip Mitra, Renal Medicine, MFT
  • Dr Durga Kanigicherla, Renal Medicine, MFT
  • Dr Patrick Hamilton, Renal Medicine, MFT & Univ of Manchester
  • Prof Kay Poulton, Transplantation Labs, MFT
  • Dr Steve Roberts, Biostatistics, Univ of Manchester

 In UK

  • Prof IanS Roberts, John Radcliffe Infirmary, Oxford
  • Prof Robert Kleta, Center for Nephrology, University College, London
  • Dr Gavin Welsh, Dept of Nephrology, University of Bristol


  • Dr Dan Cattran, University of Toronto, Canada
  • Dr Fernando Fervenza, Mayo Clinic, Rochester, USA
  • Dr Jack Wetzels, Univ of Nijmegen, The Netherlands
  • Prof Pierre Ronco, Hopital Tenon, Paris
  • Dr Ron Korstanje, Jackson Labs, Bar Harbor, USA


B.Sc. 1971; University of Birmingham

Ph.D. 1975; University of Manchester

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 2 - Zero Hunger
  • SDG 3 - Good Health and Well-being
  • SDG 14 - Life Below Water

Areas of expertise

  • RZ Other systems of medicine
  • Renal Medicine, Immunology
  • Pathology

Research Beacons, Institutes and Platforms

  • Christabel Pankhurst Institute


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