Paul Brownbill

2024

Development of integrated models of the fetal and placental circulations to improve prediction of stillbirth.

Clark, A., Jackson, T., Nagahawatte, N., Poologasundarampillai, G., Brownbill, P., Evangelinos, A., Pennington, A., Darrow, M., Van Loon, R., Chernyavsky, I., Heazell, A. & James, J., 2 Sept 2024, p. e46. 1 p.

Research output: Contribution to conference › Abstract › peer-review

2023

Fetoplacental vascular effects of maternal adrenergic antihypertensive and cardioprotective medications in pregnancy

Tropea, T., Mavichak, W., Evangelinos, A., Brennan-Richardson, C., Cottrell, E., Myers, J., Johnstone, E. & Brownbill, P., 1 Nov 2023, In: J Hypertens. 41, 11, p. 1675-1687 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2021

A massively multi-scale approach to characterising tissue architecture by synchrotron micro-CT applied to the human placenta

Tun, W. M., Poologasundarampillai, G., Bischof, H., Nye, G., King, O. N. F., Basham , M., Tokudome, Y., Lewis, R. M., Johnstone, E., Brownbill, P., Darrow, M. & Chernyavsky, I., 6 May 2021, (Accepted/In press) In: Journal of the Royal Society. Interface.

Research output: Contribution to journal › Article › peer-review

Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction

Renshall, L. J., Beards, F., Evangelinos, A., Greenwood, S. L., Brownbill, P., Stevens, A., Sibley, C. P., Aplin, J. D., Johnstone, E. D., Teesalu, T. & Harris, L. K., 25 Oct 2021, In: Pharmaceutics. 13, 11, p. 1778

Research output: Contribution to journal › Article › peer-review

Open Access

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142 Downloads (Pure)

2020

Pulsatility effects of flow on vascular tone in the fetoplacental circulation

Brownbill, P., Higgins, L. & Westwood, M., 2020, In: Placenta. 101, p. 163-168 6 p.

Research output: Contribution to journal › Special issue › peer-review

Open Access

2019

Correction

Brook, A., Hoaksey, A., Gurung, R., Yoong, E. E. C., Sneyd, R., Baynes, G. C., Bischof, H., Jones, S., Higgins, L. E., Jones, C., Greenwood, S. L., Jones, R. L., Gram, M., Lang, I., Desoye, G., Myers, J., Schneider, H., Hansson, S. R., Crocker, I. P. & Brownbill, P., May 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 5, p. 6682

Research output: Contribution to journal › Article › peer-review

Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networks

Erlich, A., Nye, G. A., Brownbill, P., Jensen, O. E. & Chernyavsky, I. L., 16 Aug 2019, In: Interface Focus.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Cell free hemoglobin in the fetoplacental circulation: A novel cause of fetal growth restriction?

Brook, A., Hoaksey, A., Gurung, R., Yoong, E. E. C., Sneyd, R., Baynes, G. C., Bischof, H., Jones, S., Higgins, L. E., Jones, C., Greenwood, S. L., Jones, R. L., Gram, M., Lang, I., Desoye, G., Myers, J., Schneider, H., Hansson, S. R., Crocker, I. P. & Brownbill, P., 1 Oct 2018, In: Faseb Journal. 32, 10, p. 5436-5446 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Ex Vivo Dual Perfusion of the Human Placenta: Disease Simulation, Therapeutic Pharmacokinetics and Analysis of Off-Target Effects

Brownbill, P., Sebire, N., McGillick, E., Ellery, S. & Murthi, P., 2018, Methods in Molecular Biology: Preeclampsia. Vaillancourt, C. & Murthi, P. (eds.). 1 ed. Switzerland: Springer Nature, Vol. 1710. p. 173-189 16 p. 14. (Methods in Molecular Biology).

Research output: Chapter in Book/Conference proceeding › Chapter › peer-review

Human placental oxygenation in late gestation: experimental and theoretical approaches

Nye, G., Ingram, E., Johnstone, E., Jensen, O., Schneider, H., Lewis, R., Chernyavsky, I. & Brownbill, P., Jan 2018, In: Journal of Physiology. 596, 23, p. 5523-5534 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

IFPA meeting 2017 workshop report: Clinical placentology, 3D structure-based modeling of placental function, placental bed, and treating placental dysfunction

Acharya, G., Aplin, J., Brownbill, P., Bulmer, J., Burton, G., Chamley, L., Chernyavsky, I., Clark, A., Collins, S., Cottrell, E., Dilworth, M., Elad, D., Filoche, M. & O'Tierney-Ginn, P., Apr 2018, In: Placenta. 64 Suppl 1, p. S4-S8

Research output: Contribution to journal › Article › peer-review

In vitro human placental studies to support an adenovirusmediated VEGF-DΔNΔC maternal gene therapy for the treatment of severe early-onset fetal growth restriction

Desforges, M., Rogue, A., Pearson, N., Rossi, C., Olearo, E., Forster, R., Lees, M., Sebire, N., Greenwood, S., Sibley, C., David, A. & Brownbill, P., 2018, In: Human gene therapy. Clinical development.

Research output: Contribution to journal › Article › peer-review

Open Access

File

394 Downloads (Pure)

Knowledge needed about the exchange physiology of the placenta

Sibley, C., Brownbill, P., Glazier, J. & Greenwood, S., Apr 2018, In: Placenta. 64, p. S9-S15

Research output: Contribution to journal › Article › peer-review

Open Access

File

69 Downloads (Pure)

Targeting the dysfunctional placenta: Novel peptides to deliver drugs to specific uteroplacental compartments

Renshall, L., Wareing, M., Brownbill, P., Beards, F., Greenwood, S., Johnstone, E., Sibley, C., Aplin, J. & Harris, L. K., Sept 2018, p. e60. 1 p.

Research output: Contribution to conference › Abstract › peer-review

2017

Raman spectroscopy as a novel method in placental research: Recognizing the pattern of placental hypoxia

Schlabritz-Loutsevitch, N., Gandhi, K., Soydemir, F., Brownbill, P., Sengar, R., Ventolini, G., Bruillard, P. & Gosink, L., 20 Dec 2017, In: Journal of Raman Spectroscopy. 48, 12, p. 1896-1899 4 p.

Research output: Contribution to journal › Article › peer-review

2016

An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy

Brownbill, P., Chernyavsky, I., Bottalico, B., Desoye, G., Hansson, S., Kenna, G., Knudsen, L. E., Markert, U. R., Powles-Glover, N., Schneider, H. & Leach, L., Sept 2016, In: Reproductive Toxicology. 64

Research output: Contribution to journal › Article › peer-review

Open Access

File

218 Downloads (Pure)

Image-Based Modeling of Blood Flow and Oxygen Transfer in Feto-Placental Capillaries

Pearce, P., Brownbill, P., Janacek, J., Jirkovska, M., Kubinova, L., Chernyavsky, I. & Jensen, O., 27 Oct 2016, In: PLoS One.. 11, 10, e0165369.

Research output: Contribution to journal › Article › peer-review

Open Access

Quantitative assessment of placental morphology may identify specific causes of stillbirth

Ptacek, I., Smith, A., Garrod, A., Bullough, S., Bradley, N., Batra, G., Sibley, C. P., Jones, R., Brownbill, P. & Heazell, A. E. P., 2016, In: BMC Clinical Pathology. 16, 1, p. 1-12 12 p., 16:1 .

Research output: Contribution to journal › Article › peer-review

2015

Dysregulated flow‐mediated vasodilatation in the human placenta in fetal growth restriction

Jones, S., Bischof, H., Lang, I., Desoye, G., Greenwood, S., Johnstone, E., Wareing, M., Sibley, C. & Brownbill, P., 29 Apr 2015, In: The Journal of physiology. 593, 14, p. 3077-3092 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Optimal villi density for maximal oxygen uptake in the human placenta.

Serov, A., Salafia, C., Brownbill, P., Grebenkov, D. & Filoche, M., 7 Jan 2015, In: Journal of Theoretical Biology. 364, p. 383-396 14 p.

Research output: Contribution to journal › Article › peer-review

2014

167 TRPV4; a Potential New Target to Increase Placental Blood Flow in Fetal Growth Restricted Pregnancies?

Lattey, K., Bischof, H., Haywood, C., Jones, S. & Brownbill, P., 2014, In: Heart. 100, Suppl 3, p. A95-A96

Research output: Contribution to journal › Article › peer-review

Fetoplacental vascular alterations associated with fetal growth restriction

Junaid, T., Brownbill, P., Chalmers, N., Johnstone, E. & Aplin, J., Oct 2014, In: Placenta. 35, 10

Research output: Contribution to journal › Article › peer-review

Glucocorticoids inhibit angiogenesis and dysregulate angiogenic factors in the human placenta

Stratta, E., Palin, V., Sibley, C., Brownbill, P., Bischof, H., Jones, S. & Jones, R., Sept 2014, In: Placenta. 35, 9, p. A16 1 p.

Research output: Contribution to journal › Article › peer-review

Glucocorticoids inhibit angiogenesis and dysregulate angiogenic factors in the human placenta

Palin, V., Stratta, E., Sibley, C., Brownbill, P., Bischof, H., Jones, S. & Jones, R., Sept 2014, p. A16-A16.

Research output: Contribution to conference › Poster

Glucocorticoids inhibit angiogenesis and dysregulate angiogenic factors in the human placenta

Stratta, E., Palin, V., Sibley, C., Brownbill, P., Bischof, H., Jones, S. & Jones, R., Sept 2014, In: Placenta. 35, 9

Research output: Contribution to journal › Article › peer-review

Human placental ex vivo studies to support an adenovirus-mediated vascular endothelial growth factor (VEGF) gene medicine for the treatment of severe early onset fetal growth restriction (FGR)

Brownbill, P., Desforges, M., Sebire, N., Greenwood, S. L., Sibley, C. P. & David, A. L., 1 Nov 2014, In: Human Gene Therapy. 25, 11, p. A60-A60 1 p.

Research output: Contribution to journal › Meeting Abstract › peer-review

Hypoxic treatment of human dual placental perfusion induces a preeclampsia-like inflammatory response

Jain, A., Schneider, H., Aliyev, E., Soydemir, F., Baumann, M., Surbek, D., Hediger, M., Brownbill, P. & Albrecht, C., 16 Jun 2014, In: Laboratory Investigation. 94, 8, p. 873-880 8 p.

Research output: Contribution to journal › Article › peer-review

IFPA Meeting 2013 Workshop Report III: Maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta.

Abumaree, M., Brownbill, P., Burton, G., Castillo, C., Chamley, L., Croy, B., Drewlo, S., Dunk, C., Girard, S., Hansson, S., Jones, S., Jurisicova, A., Lewis, R., Letarte, M., Parast, M., Pehrson, C., Rappolee, D., Schneider, H., Tannetta, D. & Varmuza, S. & 4 others, Wadsack, C., Wallace, A., Zenerino, C. & Lash, G., Feb 2014, In: Placenta. 35, Supplement, February 2014, p. S15-S19 5 p.

Research output: Contribution to journal › Article › peer-review

Systematic review of placental pathology reported in association with stillbirth.

Ptacek, I., Sebire, N. J., Man, J. A., Brownbill, P. & Heazell, A. E. P., Aug 2014, In: Placenta. 35, 8, p. 552-562 11 p.

Research output: Contribution to journal › Article › peer-review

2013

FETAL INFLOW HYDROSTATIC PRESSURE MEASUREMENTS IN THE EX-VIVO PERFUSED PLACENTA CORRELATE WITH UMBILICAL ARTERY DOPPLER RI AND PI VALUES

Jones, S., Bischof, H., Johnstone, E., Greenwood, S., Wareing, M., Sibley, C. & Brownbill, P., 9 Aug 2013, In: Placenta. 34, 9, p. A64 1 p.

Research output: Contribution to journal › Article

2010

Adaptation in placental nutrient supply to meet fetal growth demand: implications for programming.

Sibley, C. P., Brownbill, P., Dilworth, M. & Glazier, J. D., Mar 2010, In: Trophoblast Research. 31, p. S70-S74 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

271 Downloads (Pure)

2009

Assessment of the Link between Spiral Artery Diameters, Intervillous Flow and Pre-Eclampsia Pathogenesis Using the In Vitro Dually Perfused Human Placenta

Hutchinson, E. S., Brownbill, P., Baker, P. N., Sibley, C. P. & Crocker, I. P., Mar 2009, In: REPRODUCTIVE SCIENCES. 16, 3, p. 173A-173A 1 p.

Research output: Contribution to journal › Meeting Abstract

In vitro dual perfusion of the human placental lobule as a phantom to investigate the relationship between fetoplacental flow and 3D power Doppler signal

Jones, N. W., Hutchinson, E. S., Brownbill, P., Crocker, I. P., Eccles, D., Bugg, G. J. & Raine-Fenning, N. J., 2009, In: Journal of Anatomy. 214, 5, p. 782-782 1 p.

Research output: Contribution to journal › Article › peer-review

Utero-placental haemodynamics in the pathogenesis of pre-eclampsia

Hutchinson, E. S., Brownbill, P., Jones, N. W., Abrahams, V. M., Baker, P. N., Sibley, C. P. & Crocker, I. P., Jul 2009, In: Placenta. 30, 7, p. 634-641 8 p.

Research output: Contribution to journal › Article › peer-review

2008

Vasoactivity to and endogenous release of vascular endothelial growth factor in the in vitro perfused human placental lobule from pregnancies complicated by preeclampsia

Brownbill, P., Mills, T. A., Soydemir, D. F. & Sibley, C. P., Nov 2008, In: Placenta. 29, 11, p. 950-955 6 p.

Research output: Contribution to journal › Article › peer-review

2007

Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro

Cleal, J. K., Brownbill, P., Godfrey, K. M., Jackson, J. M., Jackson, A. A., Sibley, C. P., Hanson, M. A. & Lewis, R. M., 5 Jul 2007, In: Journal of Physiology. 582, 2, p. 871-882 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Vasoactive and permeability effects of vascular endothelial growth factor-165 in the term in vitro dually perfused human placental lobule

Brownbill, P., McKeeman, G. C., Brockelsby, J. C., Crocker, I. P. & Sibley, C. P., 1 Oct 2007, In: Endocrinology. 148, 10, p. 4734–4744 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2006

Endothelium, blood vessels and angiogenesis - a workshop report

Leach, L., Badet, J., Brownbill, P., Harris, L., Keogh, R., Kalionis, B. & Whitley, G., Apr 2006, In: Placenta. 27, Supplement, p. 26-29 4 p.

Research output: Contribution to journal › Article › peer-review

Regulation of transplacental water transfer: the role of fetoplacental venous tone

Brownbill, P. & Sibley, C. P., Jun 2006, In: Placenta. 27, 6-7, p. 560-567 8 p.

Research output: Contribution to journal › Article › peer-review

2003

Neurokinin B is a paracrine vasodilator in the human fetal placental circulation

Brownbill, P., Bell, N., Lowry, P., Page, N. & Sibley, C., 1 May 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 5, p. 2164-2170 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2000

Denudations as paracellular routes for alphafetoprotein and creatinine across the human syncytiotrophoblast

Brownbill, P., Mahendran, D., Owen, D., Swanson, P., Thornburg, K., Nelson, D. & Sibley, C., Mar 2000, In: AJP: Regulatory, Integrative and Comparative Physiology. 278, 3, p. R677-R683 7 p.

Research output: Contribution to journal › Article › peer-review

Expression of BCL-2, BAX and BAK in the trophoblast layer of the term human placenta: a unique model of apoptosis within a syncytium.

Ratts, V., Tao, X., Webster, C., Swanson, P., Smith, S., Brownbill, P., Krajewski, S., Reed, J., Tilly, J. & Nelson, D., May 2000, In: Placenta. 21, 4, p. 361-366 6 p.

Research output: Contribution to journal › Article › peer-review

1999

Effect of ATP on fetomaternal paracellular transfer across the human placenta

Brownbill, P. & Sibley, C. P., Jul 1999, In: Placenta. 20, 5-6, p. A.14- A.14 1 p.

Research output: Contribution to journal › Meeting Abstract

1998

Mechanisms of maternofetal exchange across the human placenta

Sibley, C., Birdsey, T., Brownbill, P., Clarson, L., Doughty, I., Glazier, J., Greenwood, S., Hughes, J., Jansson, T., Mylona, P., Nelson, D. & Powell, T., May 1998, In: Biochem Soc Trans. 26, 2, p. 86-91 6 p.

Research output: Contribution to journal › Article › peer-review

1997

Comparison of the alphafetoprotein permeability of term perfused placental cotyledons from women who had above normal maternal serum alphafetoprotein levels in mid-trimester with those from women who had normal levels

Brownbill, P., Owen, D., Mahendran, D., Nelson, M. & Silbey, C., 1997, In: Placenta. 18, 5-6, p. A14-A14 1 p.

Research output: Contribution to journal › Meeting Abstract

1995

Mechanisms of alphafetoprotein transfer in the perfused human placental cotyledon from uncomplicated pregnancy

Brownbill, P., Edwards, D., Jones, C. J., Mahendran, D., Owen, D., Sibley, C., Johnson, D., Swanson, P. & Nelson, D., 1 Nov 1995, In: Journal of Clinical Investigation. 96, 5, p. 2220-2226 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1993

CHANGES IN UNIDIRECTIONAL MATERNOFETAL NA-22 CLEARANCE (K(MF) AND NA+-K+-ATPASE ALPHA-SUBUNIT EXPRESSION BY THE PLACENTA OF THE ANESTHETIZED RAT DURING THE LAST 3 OF GESTATION

BROWNBILL, P., ATKINSON, D., GLAZIER, J., SIBLEY, C. & WARHURST, G., 1993, In: JOURNAL OF PHYSIOLOGY-LONDON. 467, p. P368-P368 1 p.

Research output: Contribution to journal › Meeting Abstract

Paul Brownbill, PhD

Research output

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