Paul Brownbill

2021

A massively multi-scale approach to characterising tissue architecture by synchrotron micro-CT applied to the human placenta

Tun, W. M., Poologasundarampillai, G., Bischof, H., Nye, G., King, O. N. F., Basham , M., Tokudome, Y., Lewis, R. M., Johnstone, E., Brownbill, P., Darrow, M. & Chernyavsky, I., 6 May 2021, (Accepted/In press) In: Journal of the Royal Society. Interface.

Research output: Contribution to journal › Article › peer-review

Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction

Renshall, L. J., Beards, F., Evangelinos, A., Greenwood, S. L., Brownbill, P., Stevens, A., Sibley, C. P., Aplin, J. D., Johnstone, E. D., Teesalu, T. & Harris, L. K., 25 Oct 2021, In: Pharmaceutics. 13, 11, p. 1778

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2019

Correction

Brook, A., Hoaksey, A., Gurung, R., Yoong, E. E. C., Sneyd, R., Baynes, G. C., Bischof, H., Jones, S., Higgins, L. E., Jones, C., Greenwood, S. L., Jones, R. L., Gram, M., Lang, I., Desoye, G., Myers, J., Schneider, H., Hansson, S. R., Crocker, I. P. & Brownbill, P., May 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 5, p. 6682

Research output: Contribution to journal › Article › peer-review

Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networks

Erlich, A., Nye, G. A., Brownbill, P., Jensen, O. E. & Chernyavsky, I. L., 16 Aug 2019, In: Interface Focus.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Cell free hemoglobin in the fetoplacental circulation: A novel cause of fetal growth restriction?

Brook, A., Hoaksey, A., Gurung, R., Yoong, E. E. C., Sneyd, R., Baynes, G. C., Bischof, H., Jones, S., Higgins, L. E., Jones, C., Greenwood, S. L., Jones, R. L., Gram, M., Lang, I., Desoye, G., Myers, J., Schneider, H., Hansson, S. R., Crocker, I. P. & Brownbill, P., 1 Oct 2018, In: Faseb Journal. 32, 10, p. 5436-5446 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Human placental oxygenation in late gestation: experimental and theoretical approaches

Nye, G., Ingram, E., Johnstone, E., Jensen, O., Schneider, H., Lewis, R., Chernyavsky, I. & Brownbill, P., Jan 2018, In: Journal of Physiology. 596, 23, p. 5523-5534 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

IFPA meeting 2017 workshop report: Clinical placentology, 3D structure-based modeling of placental function, placental bed, and treating placental dysfunction

Acharya, G., Aplin, J., Brownbill, P., Bulmer, J., Burton, G., Chamley, L., Chernyavsky, I., Clark, A., Collins, S., Cottrell, E., Dilworth, M., Elad, D., Filoche, M. & O'Tierney-Ginn, P., Apr 2018, In: Placenta. 64 Suppl 1, p. S4-S8

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In vitro human placental studies to support an adenovirusmediated VEGF-DΔNΔC maternal gene therapy for the treatment of severe early-onset fetal growth restriction

Desforges, M., Rogue, A., Pearson, N., Rossi, C., Olearo, E., Forster, R., Lees, M., Sebire, N., Greenwood, S., Sibley, C., David, A. & Brownbill, P., 2018, In: Human gene therapy. Clinical development.

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Knowledge needed about the exchange physiology of the placenta

Sibley, C., Brownbill, P., Glazier, J. & Greenwood, S., Apr 2018, In: Placenta. 64, p. S9-S15

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2017

Raman spectroscopy as a novel method in placental research: Recognizing the pattern of placental hypoxia

Schlabritz-Loutsevitch, N., Gandhi, K., Soydemir, F., Brownbill, P., Sengar, R., Ventolini, G., Bruillard, P. & Gosink, L., 20 Dec 2017, In: Journal of Raman Spectroscopy. 48, 12, p. 1896-1899 4 p.

Research output: Contribution to journal › Article › peer-review

2016

An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy

Brownbill, P., Chernyavsky, I., Bottalico, B., Desoye, G., Hansson, S., Kenna, G., Knudsen, L. E., Markert, U. R., Powles-Glover, N., Schneider, H. & Leach, L., Sept 2016, In: Reproductive Toxicology. 64

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Open Access

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Image-Based Modeling of Blood Flow and Oxygen Transfer in Feto-Placental Capillaries

Pearce, P., Brownbill, P., Janacek, J., Jirkovska, M., Kubinova, L., Chernyavsky, I. & Jensen, O., 27 Oct 2016, In: PLoS One.. 11, 10, e0165369.

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Open Access

Quantitative assessment of placental morphology may identify specific causes of stillbirth

Ptacek, I., Smith, A., Garrod, A., Bullough, S., Bradley, N., Batra, G., Sibley, C. P., Jones, R., Brownbill, P. & Heazell, A. E. P., 2016, In: BMC Clinical Pathology. 16, 1, p. 1-12 12 p., 16:1 .

Research output: Contribution to journal › Article › peer-review

2015

Dysregulated flow‐mediated vasodilatation in the human placenta in fetal growth restriction

Jones, S., Bischof, H., Lang, I., Desoye, G., Greenwood, S., Johnstone, E., Wareing, M., Sibley, C. & Brownbill, P., 29 Apr 2015, In: The Journal of physiology. 593, 14, p. 3077-3092 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Optimal villi density for maximal oxygen uptake in the human placenta.

Serov, A., Salafia, C., Brownbill, P., Grebenkov, D. & Filoche, M., 7 Jan 2015, In: Journal of Theoretical Biology. 364, p. 383-396 14 p.

Research output: Contribution to journal › Article › peer-review

2014

167 TRPV4; a Potential New Target to Increase Placental Blood Flow in Fetal Growth Restricted Pregnancies?

Lattey, K., Bischof, H., Haywood, C., Jones, S. & Brownbill, P., 2014, In: Heart. 100, Suppl 3, p. A95-A96

Research output: Contribution to journal › Article › peer-review

Fetoplacental vascular alterations associated with fetal growth restriction

Junaid, T., Brownbill, P., Chalmers, N., Johnstone, E. & Aplin, J., Oct 2014, In: Placenta. 35, 10

Research output: Contribution to journal › Article › peer-review

Glucocorticoids inhibit angiogenesis and dysregulate angiogenic factors in the human placenta

Stratta, E., Palin, V., Sibley, C., Brownbill, P., Bischof, H., Jones, S. & Jones, R., Sept 2014, In: Placenta. 35, 9

Research output: Contribution to journal › Article › peer-review

Glucocorticoids inhibit angiogenesis and dysregulate angiogenic factors in the human placenta

Stratta, E., Palin, V., Sibley, C., Brownbill, P., Bischof, H., Jones, S. & Jones, R., Sept 2014, In: Placenta. 35, 9, p. A16 1 p.

Research output: Contribution to journal › Article › peer-review

Hypoxic treatment of human dual placental perfusion induces a preeclampsia-like inflammatory response

Jain, A., Schneider, H., Aliyev, E., Soydemir, F., Baumann, M., Surbek, D., Hediger, M., Brownbill, P. & Albrecht, C., 16 Jun 2014, In: Laboratory Investigation. 94, 8, p. 873-880 8 p.

Research output: Contribution to journal › Article › peer-review

IFPA Meeting 2013 Workshop Report III: Maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta.

Abumaree, M., Brownbill, P., Burton, G., Castillo, C., Chamley, L., Croy, B., Drewlo, S., Dunk, C., Girard, S., Hansson, S., Jones, S., Jurisicova, A., Lewis, R., Letarte, M., Parast, M., Pehrson, C., Rappolee, D., Schneider, H., Tannetta, D. & Varmuza, S. & 4 others, Wadsack, C., Wallace, A., Zenerino, C. & Lash, G., Feb 2014, In: Placenta. 35, Supplement, February 2014, p. S15-S19 5 p.

Research output: Contribution to journal › Article › peer-review

Systematic review of placental pathology reported in association with stillbirth.

Ptacek, I., Sebire, N. J., Man, J. A., Brownbill, P. & Heazell, A. E. P., Aug 2014, In: Placenta. 35, 8, p. 552-562 11 p.

Research output: Contribution to journal › Article › peer-review

2013

FETAL INFLOW HYDROSTATIC PRESSURE MEASUREMENTS IN THE EX-VIVO PERFUSED PLACENTA CORRELATE WITH UMBILICAL ARTERY DOPPLER RI AND PI VALUES

Jones, S., Bischof, H., Johnstone, E., Greenwood, S., Wareing, M., Sibley, C. & Brownbill, P., 9 Aug 2013, In: Placenta. 34, 9, p. A64 1 p.

Research output: Contribution to journal › Article

2009

In vitro dual perfusion of the human placental lobule as a phantom to investigate the relationship between fetoplacental flow and 3D power Doppler signal

Jones, N. W., Hutchinson, E. S., Brownbill, P., Crocker, I. P., Eccles, D., Bugg, G. J. & Raine-Fenning, N. J., 2009, In: Journal of Anatomy. 214, 5, p. 782-782 1 p.

Research output: Contribution to journal › Article › peer-review

Utero-placental haemodynamics in the pathogenesis of pre-eclampsia

Hutchinson, E. S., Brownbill, P., Jones, N. W., Abrahams, V. M., Baker, P. N., Sibley, C. P. & Crocker, I. P., Jul 2009, In: Placenta. 30, 7, p. 634-641 8 p.

Research output: Contribution to journal › Article › peer-review

2008

Vasoactivity to and endogenous release of vascular endothelial growth factor in the in vitro perfused human placental lobule from pregnancies complicated by preeclampsia

Brownbill, P., Mills, T. A., Soydemir, D. F. & Sibley, C. P., Nov 2008, In: Placenta. 29, 11, p. 950-955 6 p.

Research output: Contribution to journal › Article › peer-review

2007

Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro

Cleal, J. K., Brownbill, P., Godfrey, K. M., Jackson, J. M., Jackson, A. A., Sibley, C. P., Hanson, M. A. & Lewis, R. M., 5 Jul 2007, In: Journal of Physiology. 582, 2, p. 871-882 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Vasoactive and permeability effects of vascular endothelial growth factor-165 in the term in vitro dually perfused human placental lobule

Brownbill, P., McKeeman, G. C., Brockelsby, J. C., Crocker, I. P. & Sibley, C. P., 1 Oct 2007, In: Endocrinology. 148, 10, p. 4734–4744 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2006

Endothelium, blood vessels and angiogenesis - a workshop report

Leach, L., Badet, J., Brownbill, P., Harris, L., Keogh, R., Kalionis, B. & Whitley, G., Apr 2006, In: Placenta. 27, Supplement, p. 26-29 4 p.

Research output: Contribution to journal › Article › peer-review

Regulation of transplacental water transfer: the role of fetoplacental venous tone

Brownbill, P. & Sibley, C. P., Jun 2006, In: Placenta. 27, 6-7, p. 560-567 8 p.

Research output: Contribution to journal › Article › peer-review

2003

Neurokinin B is a paracrine vasodilator in the human fetal placental circulation

Brownbill, P., Bell, N., Lowry, P., Page, N. & Sibley, C., 1 May 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 5, p. 2164-2170 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2000

Denudations as paracellular routes for alphafetoprotein and creatinine across the human syncytiotrophoblast

Brownbill, P., Mahendran, D., Owen, D., Swanson, P., Thornburg, K., Nelson, D. & Sibley, C., Mar 2000, In: AJP: Regulatory, Integrative and Comparative Physiology. 278, 3, p. R677-R683 7 p.

Research output: Contribution to journal › Article › peer-review

Expression of BCL-2, BAX and BAK in the trophoblast layer of the term human placenta: a unique model of apoptosis within a syncytium.

Ratts, V., Tao, X., Webster, C., Swanson, P., Smith, S., Brownbill, P., Krajewski, S., Reed, J., Tilly, J. & Nelson, D., May 2000, In: Placenta. 21, 4, p. 361-366 6 p.

Research output: Contribution to journal › Article › peer-review

1998

Mechanisms of maternofetal exchange across the human placenta

Sibley, C., Birdsey, T., Brownbill, P., Clarson, L., Doughty, I., Glazier, J., Greenwood, S., Hughes, J., Jansson, T., Mylona, P., Nelson, D. & Powell, T., May 1998, In: Biochem Soc Trans. 26, 2, p. 86-91 6 p.

Research output: Contribution to journal › Article › peer-review

1995

Mechanisms of alphafetoprotein transfer in the perfused human placental cotyledon from uncomplicated pregnancy

Brownbill, P., Edwards, D., Jones, C. J., Mahendran, D., Owen, D., Sibley, C., Johnson, D., Swanson, P. & Nelson, D., 1 Nov 1995, In: Journal of Clinical Investigation. 96, 5, p. 2220-2226 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Paul Brownbill, PhD

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