Paul Kasher

Paul Kasher, PhD


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Personal profile


I am a neuroscientist within the Manchester Stroke Research group. My lab is using zebrafish models to investigate disease mechanisms associated with intracerebral haemorrhage (ICH) - a type of stroke that is caused by spontaneous rupture of blood vessels within the brain. We do not fully understand ICH and unfortunately no specific therapies exist. In broad terms, my research can be divided into 5 themes:

1). Understanding the pathological and neuroinflammatory consequences of ICH.

2). Whole transcriptomic profiling to identify novel candidate targets associated with ICH.

3). Drug screening to identify compounds capable of reducing brain injury following ICH.

4). Investigating mechanisms associated with monogenic forms of haemorrhagic stroke.

5). Risk factors associated with ICH.

Methodological knowledge


Molecular genetics

Cell Biology

Experimental disease modelling


2017 - present: Stroke Association HRH The Princess Margaret Lecturer, University of Manchester

2015 - 2017: Research Fellow, University of Manchester

2011 - 2015: Research Associate, University of Manchester

2009-2011: Research Associate, University of Amsterdam

2005-2009: PhD, Translational Neuroscience, Academic Neurology Unit, University of Sheffield

2004-2005: Research Assistant, University of Sheffield

My collaborations


Primary supervisor - Emily McMahon (MRC DTP)

Primary supervisor - Daisy Flatman (BHF)

Co-supervisor - Ran Zhou (CSC)

Co-supervisor - Carolina Stamboulid (MRC DTP)

Co-supervisor  - Ankur Chaurasia (GOLDEN)


My collaborations


Siobhan Crilly (Research Fellow, NC3Rs)

Victor Tapia (Post-doc, MRC) 


Prof. Stuart Allan (University of Manchester)

Dr Adrian Parry-Jones (University of Manchester)

Dr Siddharth Banka (University of Manchester)

Prof. Graham Pavitt (University of Manchester)

Dr Jean-Pierre Levraud (Institut Pasteur, Paris)

Prof. Yanick Crow (University of Edinburgh; IMAGINE Institut, Paris)

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


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