Research output per year
Research output per year
Personal profile
Overview
Emeritus Professor
Research interests
Research Interests:
- Age-related macular degeneration
- Novel optogenetic therapies to restore vision in the blind
- Hereditary retinal degenerations
- Extracellular matrix and its role in ocular disease
Qualifications
B Med Sci Hons (University of Nottingham)
BM BS (University of Nottingham)
FRCS (London); FRCOphth
PhD (Biochemistry, University of Manchester)
CCT in Ophthalmology (Specialist Training Authority of the UK)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Founder and Director, Complement Therapeutics Limited
Apr 2020 → …
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosome 1q32 and 10q26
Mcharg, S., Booth, L., Perveen, R., Riba Garcia, I., Brace, N., Bayatti, N., Sergouniotis, P., Phillips, A., Day, A., Black, G., Clark, S., Dowsey, A., Unwin, R. & Bishop, P., 21 Mar 2022, (Accepted/In press) In: Proceedings of the National Academy of Sciences.Research output: Contribution to journal › Article › peer-review
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Beyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations
Cipriani, V., Tierney, A., Griffiths, J. R., Zuber, V., Sergouniotis, P. I., Yates, J. R. W., Moore, A. T., Bishop, P. N., Clark, S. J. & Unwin, R. D., 5 Aug 2021, In: American Journal of Human Genetics. 108, 8, p. 1385-1400 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress
Choudhury, R., Bayatti, N., Scharff, R., Szula, E., Tilakaratna, V., Udsen, M., Mcharg, S., Askari, J., Humphries, M. J., Bishop, P. & Clark, S., 8 Jul 2021, In: Scientific Reports. 11, 1, 14175.Research output: Contribution to journal › Article › peer-review
Open Access -
Viral Transduction of Human Rod Opsin or Channelrhodopsin Variants to Mouse ON Bipolar Cells Does Not Impact Retinal Anatomy or Cause Measurable Death in the Targeted Cells
Wright, P., Rodgers, J., Wynne, J., Bishop, P. N., Lucas, R. J. & Milosavljevic, N., 3 Dec 2021, In: International Journal of Molecular Sciences. 22, 23, p. 13111 13111.Research output: Contribution to journal › Article › peer-review
Open Access -
Analysis of opticin binding to collagen fibrils identifies a single binding site in the gap region and a high specificity towards thin heterotypic fibrils containing collagens II, and XI or V/XI
Hansen, U., Holmes, D., Bruckner, P. & Bishop, P., 24 Jul 2020, (Accepted/In press) In: P L o S One.Research output: Contribution to journal › Article › peer-review
Projects
- 1 Finished
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Restoring vision in advanced retinal degeneration using human rod opsin: validation in mice
Lucas, R. (PI) & Bishop, P. (CoI)
1/04/16 → 15/11/19
Project: Research
Impacts
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Seeking novel treatments for Complement-related diseases including age-related macular degeneration (AMD) and creation of spin out company Complement Therapeutics
Unwin, R. (Corresponding participant), Bishop, P. (Participant) & Clark, S. (Participant)
Impact: Health and wellbeing, Economic
Press/Media
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MAIL ONLINE: A blood test could diagnose the world's most common cause of blindness 'YEARS before symptoms develop'
7/02/20
1 item of Media coverage
Press/Media: Research